- Richard Kind - Paul Daly
- Amanda Setton - Gemma Bar-Lev
- Roe Hartrampf - Oliver Esten
- Chance Kelly - Deputy Commissioner Baia
- Nora Armani - Terrified Woman
- Alesandra Assante - Melody
- D.K. Bowser - Jacob Clay
- Raul Casso - Benito Gaez
- Odette Annable - ADA Kat O'Connor
- Stephanie Brait - Natasha Radkovich
- Robbie Sublett - Frank Kilgore
- McCaleb Burnett - Brad Knopfler
- James Biberi - Robert Kilgore
- Samantha Buck - Tara Brunell
- Thaddeus Daniels - Chief Corb
- Chinasa Ogbuagu - Kendra Dupray
- Eric William Morris - Deputy Mayor Carlton Holbrook
- Corey Hawkins - Evander
- Turron Kofi Alleyne - Marcus
- Michael Basile - EMT
- Nick Chinlund - Lt. Vince Madrid
- Valarie Pettiford - Maxine Owen
- Valarie Pettiford - Maxine
- Alison Bartlett - Jeanie Novak
- Andrea Navedo - Lorraine Arroyo
- William Sadler - Police Commissioner Jack Dowdell
- Jermel Howard - Kyle Burton
- Patrick Murney - Portis Walker
- Polly Draper - Nora Clark
- Michael Aronov - Dominic Quinlan
- Susan Kelechi Watson - April McGee
- Mario D'Leon - Muscle Head
- Danny Henriquez - Landis Murphy
- Curtiss Cook - Lyle Creasmen
- Paul Fitzgerald - Nathan Drexler
- James Naughton - Marvin Drexler
- Joey Auzenne - Edward Rodrigue
- Rachel Barrer - Claudia Drexler
- Elizabeth Alderfer - Angie McGuire
- Kevin O'Donnell - Devlin Lehane
- Tobias Segal - Ronan Burke
- John Finn - Ed McKenzie
- Arthur Gerunda - George Riddle
- Brandon Gill - Phillip Cole (Aide)
- Deep Katdare - Ballistics Tech
- Trieste Kelly Dunn - Margot Dixon
- Andrew Stewart-Jones - Tyler Neville
- Steve Lord - Alex Zelichenok
- Tamara Tunie - Mrs. Nevel
- Jim R. Coleman - Gary Carson
- Audrey Esparza - Lucy Barrone
- Hisham Tawfiq - Father Steven Truitt
- Alexander Cendese - Drazen Babic
- Juri Henley-Cohn - Julian Rutherford
- Sue Kim - EMT
- Timothy Adams - David Reed
- Anastasia Barzee - Linda Taylor
- Jeb Brown - Hank Taylor
- Christopher Evan Welch - Neil Jacobs
- Albert Jones - Martin Olsen
- Charles Malik Whitfield - Darrell Reed
- Michelle Hurd - Louise Reed
- Michael Madsen - Walter Clark Sr.
- Rosa Arredondo - Lisa Harris
- Brian Avers - Jordan Wiser
- Lola Glaudini - Colleen Diaco
- Dan Hedaya - Francis Diaco
- Robert John Burke - Andrew Lightstone
- Alexandra Vino - Gina
- Parisa Fitz-Henley - Andrea Gundersen
- Nicholas Logan - Jackson Dell
- Jason Furlani - Steve 'Bratty' Kudsinowski
- Nicolette Pierini - Abigail Brunell
- Greg Berlanti
- Blake Neely
Michael Madsen hace el papel de Walter Clark Sr..
Curtiss Cook interpreta a Lyle Creasmen en la serie.
Theo James hace el papel de Detective Walter Clark.
Chi McBride hace el papel de Detective Don Owen.
Kevin Alejandro hace el papel de Detective Christian Arroyo.
Bonnie Somerville hace el papel de Detective Deb McKenzie.
Stella Maeve interpreta a Agnes Clark en la serie.
Holt McCallany hace el papel de Detective Joe Diaco.
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