- Richard Kind - Paul Daly
- Amanda Setton - Gemma Bar-Lev
- Roe Hartrampf - Oliver Esten
- Chance Kelly - Deputy Commissioner Baia
- Nora Armani - Terrified Woman
- Alesandra Assante - Melody
- D.K. Bowser - Jacob Clay
- Raul Casso - Benito Gaez
- Odette Annable - ADA Kat O'Connor
- Stephanie Brait - Natasha Radkovich
- Robbie Sublett - Frank Kilgore
- McCaleb Burnett - Brad Knopfler
- James Biberi - Robert Kilgore
- Samantha Buck - Tara Brunell
- Thaddeus Daniels - Chief Corb
- Chinasa Ogbuagu - Kendra Dupray
- Eric William Morris - Deputy Mayor Carlton Holbrook
- Corey Hawkins - Evander
- Turron Kofi Alleyne - Marcus
- Michael Basile - EMT
- Nick Chinlund - Lt. Vince Madrid
- Valarie Pettiford - Maxine Owen
- Valarie Pettiford - Maxine
- Alison Bartlett - Jeanie Novak
- Andrea Navedo - Lorraine Arroyo
- William Sadler - Police Commissioner Jack Dowdell
- Jermel Howard - Kyle Burton
- Patrick Murney - Portis Walker
- Polly Draper - Nora Clark
- Michael Aronov - Dominic Quinlan
- Susan Kelechi Watson - April McGee
- Mario D'Leon - Muscle Head
- Danny Henriquez - Landis Murphy
- Curtiss Cook - Lyle Creasmen
- Paul Fitzgerald - Nathan Drexler
- James Naughton - Marvin Drexler
- Joey Auzenne - Edward Rodrigue
- Rachel Barrer - Claudia Drexler
- Elizabeth Alderfer - Angie McGuire
- Kevin O'Donnell - Devlin Lehane
- Tobias Segal - Ronan Burke
- John Finn - Ed McKenzie
- Arthur Gerunda - George Riddle
- Brandon Gill - Phillip Cole (Aide)
- Deep Katdare - Ballistics Tech
- Trieste Kelly Dunn - Margot Dixon
- Andrew Stewart-Jones - Tyler Neville
- Steve Lord - Alex Zelichenok
- Tamara Tunie - Mrs. Nevel
- Jim R. Coleman - Gary Carson
- Audrey Esparza - Lucy Barrone
- Hisham Tawfiq - Father Steven Truitt
- Alexander Cendese - Drazen Babic
- Juri Henley-Cohn - Julian Rutherford
- Sue Kim - EMT
- Timothy Adams - David Reed
- Anastasia Barzee - Linda Taylor
- Jeb Brown - Hank Taylor
- Christopher Evan Welch - Neil Jacobs
- Albert Jones - Martin Olsen
- Charles Malik Whitfield - Darrell Reed
- Michelle Hurd - Louise Reed
- Michael Madsen - Walter Clark Sr.
- Rosa Arredondo - Lisa Harris
- Brian Avers - Jordan Wiser
- Lola Glaudini - Colleen Diaco
- Dan Hedaya - Francis Diaco
- Robert John Burke - Andrew Lightstone
- Alexandra Vino - Gina
- Parisa Fitz-Henley - Andrea Gundersen
- Nicholas Logan - Jackson Dell
- Jason Furlani - Steve 'Bratty' Kudsinowski
- Nicolette Pierini - Abigail Brunell
- Greg Berlanti
- Blake Neely
Michael Madsen interpreta a Walter Clark Sr. en la serie.
Curtiss Cook interpreta a Lyle Creasmen en la serie.
Theo James hace el papel de Detective Walter Clark.
Chi McBride hace el papel de Detective Don Owen.
Kevin Alejandro interpreta a Detective Christian Arroyo en la serie.
Bonnie Somerville interpreta a Detective Deb McKenzie en la serie.
Stella Maeve interpreta a Agnes Clark en la serie.
Holt McCallany hace el papel de Detective Joe Diaco.
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