- Karen Black - Barbara Sanders
- Michael Tolan - Keith Newton
- Kaz Garas - Phil Briggs
- Carolyn Jones - Martha Alcott
- James A. Watson, Jr - Police Sgt. Appleton
- Jason Robards - Elliot Brent
- Stella Stevens - Joanna Brent
- Jack Kelly - Motorist
- Stuart Whitman - Ed Lucas
- John McLiam - Titus Paul
- Gena Rowlands - Kate Lucas
- James Franciscus - Paul Dover
- Skip Ward - Tommy Harper
- Walter Burke - Daniel
- Elizabeth Ashley - Karen Dover
- Burr Smidt - Jud
- Eugenia Stewart - Katherine Harker
- Jeremy Slate - Rafe Norris
- Hayden Rorke - Newsman (uncredited)
- Glenn R. Wilder - Capt. Jonathan Harker
- Lloyd Gough - The Doctor
- Lorie Busk - Young Emily
- Sandra Deel - Angie
- Lisa James - Emily Dover
- Skip Homeier - Steve
- George McCallister - Rafe Norris, Jr.
- Ellen Geer - Marian
- Karl Swenson - Ed Barnes
- Med Flory - Ed Talbot
- Steve Forrest - Andrew Alcott
- Judson Pratt - The Judge
- Curt Conway - Mr. Prescott
- William Windom - Charlie Pender
- Florida Friebus - Mrs. Prescott
- Regis Toomey - Sam Streeter
- Helen Hayes - Miss Gilden
- Charles Aidman - Jack Cameron
- Pamela Franklin - Christina Burgess / Lisa Burgess
- Darlene Conley - Ruth Jerrold
- Gene Andrusco - Davey
- Eleanor Parker - Paula Burgess
- Melvyn Douglas - Grandpa
- Harvey Fisher - Plumber
- Collin Wilcox Paxton - Molly Cameron
- Signe Hasso - Mrs. Eliscu
- Jodie Foster - Judy
- Wayne Heffley - Postman
- Geoffrey Horne - Mr. Harkness
- Stephen Brooks - Ethan
- Mildred Dunnock - Mrs. Rule
- Doug McClure - Dan Hollis
- Mark Russell - Milkman (uncredited)
- Phyllis Love - Joan Howard
- Andrew Duggan - Jeremy
- Joan Hotchkis - Fran
- Lauri Peters - Mariah Hollis
- Hal Linden - David Wells
- Janet MacLachlan - Mrs. Dillon
- Taylor Lacher - Charlie Eliscu
- Richard Mulligan - Tom
- Mariette Hartley - Sheila Conway
- Marlyn Mason - Laura Benton
- Michael-James Wixted - Robert Cameron
- Tod Andrews - Andrew Burgess
- Alan Fudge - Dr. Parker
- Jackie Cooper - Dumpy Doyle
- Mike Farrell - Frank Simmons
- Louis Quinn - Taxi Driver
- Brad Savage - Kevin
- Arthur O'Connell - Chief Owen Huston
- Clint Ritchie - Second Cowboy
- Geraldine Page - Hattie
- Richard Benedict - Mr. Parker
- John Milford - Det. Lt. Thorpe
- Rip Torn - Jonathon
- Hanna Landy - Mrs. King
- Susan Foster - Fern
- Lynn Loring - Janet
- Patricia Eltinge - The Co-ed
- Richard Angarola - Gray
- Angie Dickinson - Carol Finney
- Heather North - Dana Evans
- Stacy Harris - James Dillon
- John Ireland - Arthur Mundy
- Patricia Neal - Ellen Alexander
- Jan Clayton - The Mother
- Madlyn Rhue - Georgia Strauss
- Craig Stevens - Brett
- Larry Fleischman - The Mailboy
- Larry Fleischman - The Moving Man
- George D. Wallace - The Sheriff
- Mary Murphy - Maggie Mundy
- Bob Harks - Workman (uncredited)
- Bob Harks - Professor (uncredited)
- Meg Foster - Julie Barnes
- Meg Foster - Penny Wiseman
- Alice Ghostley - Betty Carter
- Michael Bell - Harry Collins
- Robert Donner - Ralph
- Elliott Montgomery - Harry Alexander
- Mark Tapscott - The Security Guard
- Frank Whiteman - The Desk Clerk
- Bruce Kimmel - The Bellhop
- Lynn Hamilton - The Attendant
- Robert P. Lieb - The Drunk
- Robert Mandan - Ted Murray
- Robert Mandan - Walter Jerrold
- Maggie Malooly - The Nurse
- Mel Gallagher - Policeman
- Nelson D. Cuevas - Ambulance Doctor
- Don 'Red' Barry - First Cowboy
- Don 'Red' Barry - Charlie Durham
- Tony Ballen - The Keno Caller
- Ondine Vaughn - The Keno Girl
- Jannis Durkin - The Cocktail Waitress
- Janet Leigh - Carol
- Frank Converse - Sam Richards
- Betty Ann Carr - The Pool Waitress
- Rory Calhoun - Larry
- Joan Blackman - Ellen Parrish
- Merritt Smith - Man
- Gene Nelson - Steve
- Tim McIntire - Jake Freeman
- Dorothy Meyer - Woman
- Doreen Lang - Mrs. Norman
- Tyne Daly - Anna Freeman
- Sebastian Cabot - Winston Essex - Host
- Ayn Ruymen - The Young Gypsy Woman
- Kim Darby - Cindy
- Douglas Henderson - George Carter
- Douglas Henderson - Jack Willis
- Brooke Bundy - Holly McCory
- Barry Nelson - Jim
- Joshua Bryant - The Doctor
- Martin Sheen - Frank
- Scott Marlowe - Paul Cepeda
- Sheila Larken - Marne Simmons
- Sheila Larken - Holly Brown
- Susan Dey - Peggy
- Madeleine Taylor Holmes - The Old Gypsy
- Shelly Novack - Art
- Oliver Clark - Marks
- Henry Jones - Truthers
- Shirley Knight - Beth
- Patty Duke - Linda Colby
- January L'Angelle - Girl (uncredited)
- Dabbs Greer - Harry Bell
- Leif Garrett - Robert
- Neva Patterson - Mary
- John Astin - Fred Colby
- Jon Cypher - Keith
- Joe Renteria - Johnny Horne
- Scott Thomas - The Man
- Kathryn Hays - Janet
- James Luisi - Rick
- Paul Picerni - Dr. Richardson
- Carolyn Stellar - The Woman
- Paul Carr - Bill Johnson
- John Ventantonio - Al Gordon
- Royce Wallace - The Nurse
- Bridget Hanley - Dana
- Anthony Eldridge - Royal Warlock
- Eric Gethers - Royal Warlock
- Skip Riley - Royal Warlock
- Roger Garrett - Royal Warlock
- Tab Hunter - Bob Herrick
- David Garfield - Royal Warlock
- Susan Oliver - Ellen Pritchard
- Louise Sorel - Nisa King
- I. Stanford Jolley - The Wolfman
- Christopher Connelly - Chuck
- Gary Conway - John Walsh
- Hal Bokar - The Apeman
- Don Knight - Dr. Phillip Pritchard
- Pat Harrington, Jr. - Mark Riceman
- Mathias Reitz - The Claw
- Jim Boles - Dr. Death
- Alex Rocco - Joseph Moretti
- Paul Winchell - Mr. Carlson
- Allen Jaffe - The Hunchback
- Rick Lenz - Dr. Stephen Crosley
- Phillip Pine - Dolf Ellis
- William Castle - J.B. Filmore
- Barbara Stuart - Nurse Georgia Grant
- Myron Healey - Police Lt. Maloney
- David Soul - James Barlow
- Lee Kroeger - Nurse Mary Starman
- William Boyett - The Foreman
- Larry J. Blake - Mr. Mobley
- Darwin Joston - Danny Ferro
- Murray Matheson - Mathews
- Joe Petrullo - The Tenant
- Victor Jory - The Old Man
- Meg Wyllie - The Old Woman
- Dennis Lee Smith - Boy
- Judie Stein - Girl
- Dawn Lyn - Jane
- William Castle
Karen Black interpreta a Barbara Sanders en la serie.
Michael Tolan interpreta a Keith Newton en la serie.
Kaz Garas interpreta a Phil Briggs en la serie.
Carolyn Jones hace el papel de Martha Alcott.
James A. Watson, Jr hace el papel de Police Sgt. Appleton.
Jason Robards interpreta a Elliot Brent en la serie.
Stella Stevens hace el papel de Joanna Brent.
Jack Kelly interpreta a Motorist en la serie.
Stuart Whitman hace el papel de Ed Lucas.
John McLiam interpreta a Titus Paul en la serie.
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