- John Shrapnel - Dr Jacobs
- Andrew Schofield - Peter Grenville
- Alan Igbon - Teddy
- Michael Angelis - Martin Niarchos
- David Ross - Mr Weller
- Philip Whitchurch - Franky Murray
- Daniel Massey - Grosvenor
- Jane Danson - Eileen Critchley
- Peter-Hugo Daly - Bubbles McGuire
- Paul Daneman - Mervyn Sloan
- Bill Stewart - Geoff
- Julia St. John - Diane Niarchos
- Gareth Tudor Price - Richard Grenville
- Colin Douglas - Frank Twist
- Jimmy Mulville - Philip
- John Henshaw - Murray's Minder
- Anna Friel - Susan Nelson
- Hayley Fairclough - Jessica Nelson
- Edward Mallon - Mark Nelson
- Daniel Street-Brown - Robbie Burns
- Serena Harragin - Miss Hutchinson
- Stephen Hall - Young Michael Murray
- Michelle Atkinson - Young Barbara
- Ayesa Toure - Monica
- Michael Fernandez - Jake
- Paul Oldham - Joey
- Gary Mavers - Billy
- Wayne Foskett - Macker
- Niall Tóibín - Michael Murray Snr
- Steve Halliwell - Bubbles' Friend
- Clifford Rose - Judge Critchley
- William Gaunt - Hunningdon
- Amanda Mealing - Beth
- Cliff Howells - Joseph Cartwright
- Paul Butterworth - Terry
- David J. Nicholls - Poacher Terry
- Freddie Fletcher - Poacher Vic
- Peter Armitage - Mr Burns
- Arthur Spreckley - Grandfather Burns
- Jean Anderson - Dr Goldup
- William Franklyn - Distinguished Gent
- James Tomlinson - Stan
- Jake Abraham - Black Waiter
- Noreen Kershaw - Maureen Murray
- Chris Hargreaves - Scrawny Thug
- Judith Barker - Margie
- Debra Gillett - Sylvia
- Chris Darwin - Barry
- Ken Kitson - Vince
- Kulvinder Ghir - Ravi
- Norman Mills - Redneck Councillor
- Anthony Benson - Norman
- Keith Clifford - Coach Driver
- Robert Young
- Alan Bleasdale
- Verity Lambert
- Elvis Costello
John Shrapnel interpreta a Dr Jacobs en la serie.
Michael Palin interpreta a Jim Nelson en la serie.
Robert Lindsay interpreta a Michael Murray en la serie.
Lindsay Duncan interpreta a Barbara Douglas en la serie.
Julie Walters hace el papel de Mrs. Murray.
Dearbhla Molloy interpreta a Laura Nelson en la serie.
Tom Georgeson hace el papel de Lou Barnes.
Andrew Schofield interpreta a Peter Grenville en la serie.
Alan Igbon hace el papel de Teddy.
Michael Angelis interpreta a Martin Niarchos en la serie.
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