- Caitlin Gallogly - Young Mom
- Robert Catrini - Lt. Miller
- Ronnie Clark - Rick
- Ross Crain - Lt. Michaels
- Anthony Hill - Malcolm
- Londale Theus Jr. - Tyler
- Susan James Berger - Line Person
- Constance Ejuma - Professor Apongyo
- Ian Gary - Head Lab Tech
- Alice Lo - Kyung Lee
- Randall Taylor - Bus Passenger
- Jen Zaborowski - Cindy
- Martin Starr - Lyle Karofsky
- Pamela Shaddock - Marigold
- Britt Lower - Jeri Elizabeth Lang
- Carolyn Hennesy - Wanda
- Megan Hayes - SIGORN-E (Voice)
- Lilan Bowden - Fox
- Jeremy Fitzgerald - Scary Figure #1
- Will Forte - CASSIN-E
- Christian J. Simon - Lil Jimmy McGurgan
- Keith David - Dr. Elias Kronish
- Carla Gallo - Dingo
- Jon Daly - Owl
- Eddie Driscoll - P.I.
- Robert Craighead - Detective Vincent Skarsgaard
- Corey Hart - Corey Hart
- Kevin Caliber - Blaze
- Beth Crosby - Angry Driver
- Alexis Lynne Baumert - Sowing Kid Singer
- Lili Brennan - Sowing Kid Singer
- Kerri Kenney - Forceps
- Evan Kishiyama - Sowing Kid Singer
- Rowan Smyth - Sowing Kid Singer
- Terral Altom - Jesus
- Staci Lynn Fletcher - Rivet
- Kristen Schaal - Screw
- Holger Moncada Jr. - Jorge Santiago
- Holger Moncada Jr. - Miguel Santiago
- Seth Rogen - Susan
- Diego Delpiano - Young Wolf
- Kurtwood Smith - Vise
- Jaime Moyer - Clamp Barrowmaker
- David Theune - Binx
- Marcy Goldman - Funnel
- Katherine LaNasa - Athena / Dr. Hogeveen
- Joe Sachem - Lockjaw Smasher
- Hillary Anne Matthews - Shiva
- Andrew Friedman - Jefferson Breakfast
- Tim Johnson Jr. - Jimmy McGurgan
- Lehi Makisi Falepapalangi - Chisel Pitboss
- Patricia Vecchio - Shears Hairslicer
- Jefferson Cox - Dad
- Troy Brenna - Apollo
- Timothy Simons - Xenu
- Diona Reasonover - Estelle Kronish
- Dave Silva - Taco Vendor
- Rati Gupta - Rake
- Patrick Cox - Wrench
- Jade Catta-Preta - Level
- Alyvia Alyn Lind - Lugnut
- Sara Amini - Thimble
- Timothy Hornor - Lathe
- Ricky Mabe - Pump
- Shaun Brown - Hatchet
- Artemis Pebdani - Dr. Mina Ahmadi
- Ron Funches - Ray
- Emily Hinkler - Dr. Benson
- Dennis Keiffer - Lead Biker
- Megan Suri - Daughter
- Kavi Ladnier - Mom
- Patrick Carlyle - Young Skarsgaard
- Jason Scott Jenkins - Carl
- Drew James - Young Gabe Futturman
- Mary Manofsky - Grandma Futturman
- Paul Scheer - Paul
- Awkwafina - Woman at Video Game Store
- Cedric Sanders - Young Kronish
- Brian Oerly - Lead Biker
- Dan Sachoff - Reporter
- Corey Dorris - Frat Brother
- Taylor Autumn Bertman - Young Tiger
- Taylor Autumn Bertman - 10-Year-Old Ty-Anne
- Joshua Walker - Frat Brother
- Raven Bowens - Jennifer
- Joanna DeLane - Maria Santiago
- Jeremy Lawson - Rob
- Matt Medrano - Pena
- Greg Bryan - Richards
- Johnny Smith - Budtender
- Keith Blaney - Lyft Driver
- Bill Kottkamp - Head Caterer
- Bárbara Garófalo - Caterer
- David Koechner - Barry Futturman
- Kathryn Taylor Smith - Melinda
- J.T. Jackson - Julius Seneca
- Nikhil Pai - Kotler
- Parker Young - Chase
- Keedar Whittle - Leslie
- Cloie Wyatt Taylor - Young Marigold
- Meghan Falcone - Duvay
- Stu 'Large' Riley - Jimmy
- Jordan L. Jones - Ticket Taker
- Amber Higgins - Female Volleyball Player
- Charlie McDermott - Young Barry Futturman
- James Austin Johnson - Young Gabe
- Emily Goss - Vanessa
- Gwen Hollander - Young Diane
- Jamal Duff - Burly Security Guard
- Michele Panu - Tiffany
- Hana Hayes - Debbie
- James Frey - Security Guard
- Steve Terada - Greg
- Tim Mikulecky - Lance
- Kolten Kirschke - Bully
- Shakira Ja'nai Paye - Female Customer
- Ginette Rhodes - Maureen Skarsgaard
- Dorien Davies - Other Diner
- Joshua Armando Ticas - T-Bone
- Kash Abdulmalik - Ladder
- Isla Farris - Bean Kid
- Farelle Walker - Customer
- Rahm Braslaw - Sowing Kid Singer
- Sydney Mae Estrella - Sowing Kid Singer
- April Marshall-Miller - Sowing Kid Singer
- Kaliayh Rhambo - Sowing Kid Singer
- Mia Lynn Bangunan - Little Girl
- Emily Alyn Lind - Teenage Ty-Anne
- Aris Mendoza - Police Officer
- Dennis Mencia - Test Subject
- Krista Kalmus - Relaxed Test Subject
- Libby Matthews - Networking
- Serena Laney - Cavewoman
- Christian Prentice - Uniformed Dandy
- Heléne Yorke - Randall
- Kimberly Hebert Gregory - Mathers
- Matthew Gagnon - Tech
- David Francis - Old Man
- Vieslav Krystyan - Vladimir Ovechkin
- Nobuya Shimamoto - Samurai
- Scott Dion Brown - Bloodies Time Constable
- Sean Curley - PA
- Laura Baranik - Dasha Ovechkin
- Teneisha Collins - Kenneth
- Nicolas Grimes - The Killing Machine
- Anne-Lise Nadeau - Victorian Time Constable
- Alexander Peganov - Army Officer
- Picardy Jean-Pierre - Victorian Time Constable
- Jonathan Vanderzon - Victorian Time Constable
- Fajer Kaisi - Bin Laden
- Michelle Thrush - Medicine Woman
- Emmanuel Charest - Jacques
- Emmanuel Charest - Pierre
- Wayne Charles Baker - Chief Kenthe
- Nicholas Wyman - Abraham Lincoln
- Laurent Pitre - Big Time
- Braulio Elicer - Ritchie Valens
- Carlisle J. Williams - Martin Luther King Jr.
- Johnny Cortes - Juan Pablo
- Josh Cruddas - Vincent Van Gogh
- Holly Deveaux - Marilyn Monroe
- Melissa Toussaint - Electron
- Christopher Tramantana - Jesus
- Paul Zinno - James Dean
- Chala Hunter - Amelia Earhart
- Chris Mark - Bruce Lee
- Lorna Kidjo - Bride
Kurtwood Smith interpreta a Vise en la serie.
Josh Hutcherson interpreta a Josh Futturman en la serie.
Eliza Coupe interpreta a Tiger en la serie.
Derek Wilson interpreta a Wolf en la serie.
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