- Frank Welker - Nibbler (voice)
- Frank Welker - Tardigrades (voice)
- Frank Welker - Mountain Lion (voice)
- Frank Welker - Nibbler / Pygmy Hyena Moles (voice)
- Walter Koenig - Walter Koenig (voice)
- Claudia Schiffer - Claudia Schiffer's head (voice)
- Hank Azaria - Harold Zoid (voice)
- Dick Clark - Dick Clark's Head (voice)
- Phil Hendrie - Free Waterfall Junior (voice)
- Rich Little - Rich Little's Head (voice)
- Donovan - Himself
- Bob Barker - Bob Barker (voice)
- Jan Hooks - Anglelyne (voice)
- Bea Arthur - Femputer (voice)
- Conan O'Brien - Conan O'Brien
- Adam Horovitz - Ad-Rock / MCA (voice)
- Nora Dunn - Morgan Proctor (voice)
- Suzie Plakson - Amazonian (voice)
- John Goodman - Robot Santa Claus (voice)
- Sigourney Weaver - Planet Express Ship (voice)
- Nancy Cartwright - Bart Simpson Doll (voice)
- Parker Posey - Umbriel
- Leonard Nimoy - Leonard Nimoy's Head (Voice)
- Michael Diamond - Mike D's head (voice)
- William Shatner - William Shatner (voice)
- Jonathan Frakes - Jonathan Frakes (voice)
- Gary Gygax - Gary Gygax (voice)
- Nichelle Nichols - Nichelle Nichols' Head (voice)
- Todd Susman - Announcer (voice)
- Pauly Shore - Pauly Shore (voice)
- Bob Uecker - Bob Uecker (voice)
- Hank Aaron - Hank Aaron (voice)
- Roseanne Barr - Roseanne Barr (voice)
- Emilia Clarke - Marianne (voice)
- Craig Ferguson - Susan Boil (voice)
- Chris Elliott - V-Giny (voice)
- Katee Sackhoff - Grrrl (voice)
- Matt Groening - Self (voice)
- David X. Cohen - Computer (voice)
- Sergio Aragonés - Sergio Aragonés (voice)
- Mark Mothersbaugh - Mark Mothersbaugh (voice)
- Al Gore - Al Gore (voice)
- Coolio - Kwanzaabot (voice)
- Patton Oswalt - Unattractive Giant Monster (voice)
- Buzz Aldrin - Buzz Aldrin (voice)
- Wanda Sykes - Bev (voice)
- Stephen Hawking - Stephen Hawking (voice)
- Jill Talley - Trainer (voice)
- Estelle Harris - Velma Farnsworth (voice)
- Patrick Stewart - Huntmaster (voice)
- George Takei - George Takei's Head (voice)
- Larry Bird - Larry Bird (voice)
- Dan Castellaneta - Robot Devil (voice)
- Robert Wagner - Robert Wagner's Head (voice)
- Adam West - Adam West (voice)
- Pamela Anderson - Dixie (voice)
- Pamela Anderson - Pamela Anderson's head (voice)
- Burt Ward - Burt Ward (voice)
- Seth MacFarlane - Seymour (voice)
- Dawnn Lewis - LaBarbara Conrad (voice)
- Dawnn Lewis - Jackie Anderson (voice)
- Dawnn Lewis - LaBarbara Conrad / Hermes' Mother (voice)
- Sarah Silverman - Michelle (voice)
- Tara Strong - Tanya (voice)
- Lucy Liu - Lucy Liu's Head (voice)
- Karen Maruyama - Amazonian (voice)
- Tony Denman - (voice)
- Raye Birk - (voice)
- Tom Kenny - Yancy Fry Jr. (voice)
- Tom Kenny - Abner Doubledeal (voice)
- Tom Kenny - Abner Doubledeal / Yancy Fry Jr. / Gamester Alien (voice)
- Patric M. Verrone - Patric M. Verrone (voice)
- Kath Soucie - Michelle / Rude Boy / Head Museum Feeder (voice)
- Kath Soucie - Princess Num Num (voice)
- Kath Soucie - Cubert Farnsworth / Little Kids (voice)
- Kath Soucie - Punk Kid (voice)
- Kath Soucie - Albert / Nina (voice)
- Feodor Chin - Leo Wong (voice)
- Feodor Chin - Scoop Chang (voice)
- Ego Nwodim - Dung Beetle Shaman (voice)
- Mark Hamill - Chanukah Zombie (voice)
- Bill Nye - Bill Nye the Science Head (voice)
- Dee Bradley Baker - Rusty the Donkey (voice)
- Dee Bradley Baker - (voice)
- Kathy Griffin - Captain Cranky (voice)
- Beck - Beck's head (voice)
- Kevin Michael Richardson - URL (voice)
- Kevin Michael Richardson - Barbados Slim (voice)
- Kevin Michael Richardson - (voice)
- Kevin Michael Richardson - URL / Barbados Slim / Curly Joe (voice)
- Cara Delevingne - Makeup Robot (voice)
- Cara Delevingne - Owl (voice)
- Cara Delevingne - Cara Delevingne (voice)
- Cara Delevingne - TV Special Screams (voice)
- Bob Odenkirk - Chaz (voice)
- Dan Vebber - Norwegian seed guard (voice)
- Kyle MacLachlan - Kyle MacLachlan's Head (voice)
- Kyle MacLachlan - Dung Beetle (voice)
- Danny Trejo - Doblando Rodriguez (voice)
- Carlos Alazraqui - (voice)
- Gabriel Romero - (voice)
- Diana Elizabeth Torres - (voice)
- Renée Victor - (voice)
- Ana Ortiz - Marquita (voice)
- Tim Gunn - Tim Gunn's Head (voice)
- Aleque Reid - (voice)
- LeVar Burton - Unlicensed Hologram of LeVar Burton (voice)
- Neil deGrasse Tyson - Neil deGrasse Tyson (voice)
- Peter Avanzino
- Cody Ziglar
- Ariel Ladensohn
- David X. Cohen
- Bill Odenkirk
- Matt Groening
- Eric Horsted
- Ken Keeler
- Christopher Tyng
- Shaun Cunningham
- Carlos Sotolongo
Mark Hamill interpreta a Chanukah Zombie (voice) en la serie.
Kathy Griffin interpreta a Captain Cranky (voice) en la serie.
Tony Denman interpreta a (voice) en la serie.
Patrick Stewart interpreta a Huntmaster (voice) en la serie.
Jonathan Frakes hace el papel de Jonathan Frakes (voice).
Lucy Liu interpreta a Lucy Liu's Head (voice) en la serie.
Nora Dunn interpreta a Morgan Proctor (voice) en la serie.
Dan Castellaneta interpreta a Robot Devil (voice) en la serie.
Nancy Cartwright interpreta a Bart Simpson Doll (voice) en la serie.
John Goodman interpreta a Robot Santa Claus (voice) en la serie.
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