- Mackenzie Mauzy - Abigail Morgan
- Raul Casso - Carter Pilson
- Birkett Turton - Paul Gould
- Katie Paxton - Emily Sontag
- Gary Basaraba - Norman Sontag
- Blair Brown - Fawn Mahoney Ames
- Emily Kinney - Jennifer Schroeder
- Auden Thornton - Sarah Clancy
- Burn Gorman - Adam
- Barbara Eve Harris - Lt. Marcia Roark
- Shamika Cotton - Anita
- Danny Deferrari - Jo's man
- Olga Maliouk - Russian woman
- Jack Koenig - Captain
- Lee Tergesen - Hans Koehler
- Lou Ferguson - Old african slave
- James McCaffrey - Browning
- Dave Quay - Paul
- Lawrence Arancio - Alex Hulquist
- Rachael Emrich - Vicky
- Lakisha May - Sophomore girl
- Royce Johnson - Campus security
- Mather Zickel - Dr. Frederick Gardner
- Christina Bennett Lind - Sasha Savchenko
- Eric William Morris - Dr. James Carter
- Kathleen Chalfant - Gloria Carlyle
- Jack Gilpin - Conrad Carlyle
- Janie Brookshire - Young Gloria
- Michael Oberholtzer - Lance Sharp
- Sonya Harum - Sophia Carlyle
- Timothy Britten Parker - Ray Berkowitz
- Tom Titone - Arty Berkowitz
- Erika Rolfsrud - Marta Rosko
- Rufus Collins - Museum director
- James Colby - Tommy Delgros
- Cornelius Smith, Jr. - Fabian North
- Julian Gamble - Landlord
- Rosalind Chao - Frenchman
- Paul Fitzgerald - Mark
- Andy Murray - Abberline
- Mick Hazen - Devin Bentley
- Hilarie Burton - Iona Payne
- Robert Petkoff - Cliff Wadlow
- Victoria Haynes - Nora Morgan
- Jane Seymour - Maureen Delacroix
- Christina Brucato - Gwyneth Gaines
- Jason Babinsky - Richard Gaines
- Joel Leffert - Psychiatrist
- Jimmy Palumbo - Jon Worley
- Brian Berrebbi - Studio tech
- Frankie Faison - Pepper Evans
- Tia Dionne Hodge - Ella Williams
- Tarik Lowe - Isaiah 'Izzy' Williams
- Laura Fraser - Patricia Abbott
- James McDaniel - Al Rainey
- Edoardo Ballerini - Clark Walker
- Geoffrey Cantor - Alienist
- Arash Mokhtar - Raj Patel
- Mike Massimino - Bellevue guard
- Emmanuel Brown - Cop #1
- Lawrence Ballard - Detective
- Clarke Peters - Jerry Charters
- Sepideh Moafi - Melanie Sparo
- Daniel Abeles - Val Kaplan
- William Baldwin - Oliver Clarion
- Michael Godere - Kevin Crachiolla
- Steven Kaplan - Teen Abe
- Anne Horak - Hannah Dalford
- Shane McRae - Detective Hugh Dunn
- Andy Karl - Sean Moore
- Roger Rees - Priest
- Megan Tusing - Celia Brown
- Tyler Elliot Burke - Aaron Brown
- Tom Alan Robbins - Phil Fleishman
- Angel Desai - Diane Clark
- Jessica Keenan Wynn - Dina
- Meryl Jones Williams - Cassandra Mueller
- Duke Lafoon - Medical Examiner
- Michael Crane - Forensic Tech
- Nicky Torchia - Boy
- Victor Joel Ortiz - Liam
- Frank Anello - Detective (uncredited)
Capítulo disponible en las siguientes plataformas:
