- Josh Stamberg - Sam Rothberg
- Juani Feliz - Alejandra Lopez
- Ashley Austin Morris - Roxanne Hertz
- Jenny Powers - Miriam Rothberg
- Joy Suprano - Cyndi Leffer
- Eric William Morris - Todd Leffer
- Zack Robidas - Rich Hertz
- Ralph Adriel Johnson - Phillip
- John Patrick Hayden - David Cooper
- Tara Summers - Tess
- Josh Radnor - Adam Epstein
- Jimmy Fallon - Self
- Ariel Ash - Young Woman #1
- Kimberly Chesser - Young Woman #2
- Erinn Holmes - Young Woman #3
- Jhordan Munn - Jenny
- Mariana Novak - Writer
- Oscar Bennett - Miles Epstein
- Lucinda Lee Dawson Gray - Sasha Epstein
- Abbey Hafer - Lexi Leffer
- Meghan Marx - "I Woke Up Like This" Mom
- Stephanie Rocio - "Eat Sleep Spin Repeat" Mom
- Bonnie Rose - Waitress
- Kathryn Prescott - Woman (uncredited)
- Lauren Yaffe - Pedestrian (uncredited)
- Brian Miskell - Clay Clifton
- Brian Miskell - Clay
- Michael Gaston - Dr. Donald Bartuck
- Mozhan Marnò - Nahid
- Peter Grosz - Camp Director
- Pearl Sun - Dr. Janice Wong
- Cynthia Sosa - Sandra
- Tobin Cleary - Zach
- Christine McBurney - Ida
- Clem Cheung - Dr. Loo
- Pamela Jayne Morgan - Caretaker
- Vincenzo Amato - Dr. Romalino
- Seth Barrish - Toby's Father
- Tal Ben Menashe - Israeli Law Student
- Daniel Hepner - Resident #1
- Justin Ahdoot - Resident #2
- Dipti Mehta - Delivery Room Nurse #2
- Jessica Leccia - Dr. Zaffarano
- Anne L. Nathan - Sharon Fleishman
- J. Smith-Cameron - Barbara Hiller
- Kwabena Ampofo - Marco Lintz
- Erin Breen - Allison
- Azia Celestino - Newscaster
- Charles Everett - Golden Doorman
- Matt Hopkins - Man in Park
- Nina Kassa - Annie
- Tara Westwood - Amy
- Todd Faulkner - Doorman Albert
- Todd Faulkner - Toby's Doorman Albert
- Julianna Zinkel - Suburban Mom
- Christian Slater - Archer Sylvan
- Jake Tapper - Actual Jake Tapper
- Neil Fleischer - Mover Alonger
- Yaron Lotan - Brian
- Maggie Alexander - Some App Woman
- Nate Washburn - Waiter
- Siraj Huda - Man on Street
- Nathaniel Levin - Bro #1
- Matthew J. Harris - Bro #3
- Tom Junod - Men's Magazine Writer
- Hayley Podschun - Britney Spears (uncredited)
- Miriam Silverman - Avigayil
- Steve Rosen - Mord
- Fredi Bernstein - Adi
- Nicole Rodenburg - Lisa
- Julian Silver - Editor #1
- David Beck - Editor #2
- Ken Holmes - Israel Reunion Party Guest (uncredited)
- Robin S. Walker - Hallway Nurse
- Katie Lee Hill - Sage
- Alexandra Bradley - Teen Rachel
- Denis Ooi - Scream Therapist
- Maryann Towne - Rape Counselor
- Nicole Orabona - Support Group Woman #1
- Unique Jenkins - Support Group Woman #2
- Teresa Meza - Support Group Woman #3
- Helena Betancourt - Support Group Woman #4
- Tracy Weiler - Prenatal Yoga Mom
- Anaïs Blake - Pilates Instructor
- Raul Torres - Porter
- Gigi Grace - Catherine #1
- Eva Jette Putrello - Catherine #3
- Sophie Tananbaum - Catherine #4
- Angelina Boris - Catherine #5
- Jonathan Lipnicki - Rabbi Turko
- Christopher J. Domig - John
- Michelle Beck - Michelle
- Jonathan Dayton
- Valerie Faris
- Carl Beverly
- Sarah Timberman
- Susannah Grant
- Taffy Brodesser-Akner
- Caroline Shaw
Clem Cheung interpreta a Dr. Loo en la serie.
Christian Slater interpreta a Archer Sylvan en la serie.
Jesse Eisenberg interpreta a Toby Fleishman en la serie.
Claire Danes hace el papel de Rachel Fleishman.
Lizzy Caplan interpreta a Libby Epstein en la serie.
Adam Brody interpreta a Seth Morris en la serie.
Meara Mahoney Gross interpreta a Hannah Fleishman en la serie.
Maxim Swinton interpreta a Solly Fleishman en la serie.
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