- Christine Woods - Janis Hawk
- Peyton List - Nicole Kirby
- Lindsay Crouse - Mrs. Kirby
- Jessica Tuck - Agent Levy
- Frank John Hughes - Press Secretary
- Keir O'Donnell - Ned Ned
- Ashley Jones - Camille
- James Frain - Gordon Myhill
- Annabeth Gish - Lita
- Lynn Whitfield - Anastasia Markham
- Julio Oscar Mechoso - Detective Rick Malchiodi
- James Remar - James Ermine
- Gina Hecht - Dr. Fleming
- Barry Shabaka Henley - Shelly Vreede
- Barbara Williams - Joyce Clemente
- Gil Bellows - Timothy
- Elizabeth Sung - Saayo Noh
- Bob Morrisey - Oncologist
- Alan Ruck - Tomasi
- Thomas Kretschmann - Stefan Krieger
- Navi Rawat - Maya
- Michael Massee - D. Gibbons
- Alex Kingston - Fiona Banks
- Callum Keith Rennie - Jeff Slingerland
- James Cosmo - Phillip
- Arjay Smith - Louis
- Ivar Brogger - Paul Becker
- Elizabeth Rodriguez - Ingrid Alvarez
- Stephnie Weir - Didi Gibbons
- Talia Balsam - Anita Ralston
- Dominic Rains - Kahmir DeJean
- Anthony Azizi - Samad
- Shohreh Aghdashloo - Nhadra Udaya
- Lawrence Mandley - Kent Nelson
- Timbaland - Evidence Agent
- Lee Thompson Young - Al Gough
- Carrie Genzel - FBI Agent Conner
- Lisa Darr - Principal Byrne
- Michael Ealy - Marshall Vogel
- Gina Torres - Felicia Wedeck
- Ricky Jay - Man in Warehouse
- Kim Dickens - Kate Stark
- Milauna Jackson - Susan
- Sean O'Bryan - Father Seabury
- Hira Ambrosino - Yuuka Arahida
- Neil Jackson - Lucas Hellinger
- Genevieve Padalecki - Tracy Stark
- Michael Cavanaugh - Warren Moore
- Curt Lowens - Rudolf Geyer
- Masami Kosaka - Host
- Gabrielle Union - Zoey Andata
- Paula Newsome - Dr. Callie Langer
- Jeff Richards - Jerome Murphy
- James Gleason - Rev. David Mullen
- Lennon Wynn - Charlie Benford
- Bryce Robinson - Dylan Simcoe
- Blair Redford - Joel
- Sufe Bradshaw - Ms. Gerber
- Curtis Harris - Zack
- Ray Proscia - Baecker
- Justin Dray - Meade
- Adam Tsekhman - Vladimir Petrov
- Glynn Turman - Senator Noland
- Michael O'Neill - CIA Director Keller
- Emerson Brooks - Connelly
- Mieko Hillman - Renee Garrigos
- Scott Kelly Galbreath - Jim
- Seth MacFarlane - Agent Jake Curdy
- Seth MacFarlane - FBI Agent
- Micole Mercurio - Maureen
- James DiStefano - Ernesto
- Myron Natwick - Romanchak
- Clint Culp - Jack Barrow
- Gigi De Leon - Nadine
- Gary 'G. Thang' Johnson - James
- Kiyoko Yamaguchi - Suki
- Erika Ringor - Harriet
- Creagen Dow - Billy
- Cory Blevins - Neil Parofsky
- Bo Kane - High Roller
- Patti Yasutake - Mia Kondo
- Amy Rosoff - Vice President Joyce Clemente
- Amy Rosoff - Marcie Turoff
- Toshi Toda - Mr. Nakahara
- Eijiro Ozaki - Jiro
- Atsushi Hirata - Ryuu
- Rodney Rowland - Simon's Victim
- Rodney Rowland - Victor
- Reila Aphrodite - Hitomi
- Mel Rodriguez - Oscar Obregon
- Karl Herlinger - Quarry
- Elise Robertson - Outraged Woman
- John Prosky - Mr. Dunkirk
- Ginifer King - Paige
- Marc Menchaca - Wheeler
- Omid Abtahi - Ed Fiore
- Dana Sorman - Agent Galloway
- Conroe Brooks - Sergio
- Patrick J. Adams - Ed
- Claire Jacobs - Lorraine Campos
- Brian Skala - Adam Campos
- Josh Kelly - Graham Campos
- Paul Bates - Phil
- Seana Kofoed - Charlene Collins
- Ryan Wynott - Dylan Simcoe
- Hannah Marks - Annabelle Campos
- Laura Marano - Young Tracy
- Kavita Patil - Dr. Jane Parker
- Mackenzie Foy - Kate Erskine
- Josh Wingate - Guard
- Jonathan Levit - Martin Dewey
- Jonathan Levit - Dewey
- Robert Neary - Statham
- Owiso Odera - Abdi Khalif
- David Haley - Major Blauvelt
- David Haley - Marine Major Blauvelt
- Zora Bikangaga - Awaale
- Travis Johns - Malveaux
- Adrian Kali Turner - Korfa
- Nina Onuora - Somali Woman
- Larkin Campbell - Carl
- Rafael Petardi - Agent Danforth Crowley
- Rafael Petardi - Agent Crowley
- Kortney Manns - Khant
- Vinicius Zorin-Machado - Emil Guterriez
- Kerri Higuchi - Hitomi
- Antonia Stout - Nurse Kim Jones
- Kent Shocknek - Hansen
- Kent Shocknek - Medical Correspondent
- Jonathan Spencer - SFPD Detective John Smith
- Chris Coy - Ross Weber
- Stefan Marks - Assistant U.S. Attorney
- Blake Robbins - Special Agent Buckner
- Geoffrey Owens - Dr. Julian Ebbing
- Cynthia Addai-Robinson - Debbie
- Cynthia Addai-Robinson - Nurse
- Norma Maldonado - Judge Sandoz
- James Callis - Gabriel McDow
- Ravi Kapoor - Malik
- Ron Orbach - Professor Corey
- Sarah Ripard - Dr. Rupin Verma
- Catherine McGoohan - Dr. Candace Weaver
- Stacy Hall - Ralph
- Tim Rock - Michael Zamperion
- Michelle Hurd - Liz Kayson
- Rachel Roberts - Alda Hertzog
- Rizwan Manji - Maneesh Sandhar
- Shaun Duke - Dr. Lahar Bahti
- Lee Garlington - Carline
- Lee Garlington - Carlene
- Lena Georgas - Celia Quiñones
- Robbie Tucker - Child
- Chelsea Rendon - Kyra
- Guy Kent - Chad
- Marina Black - Sheriff Keegan
- Nadine Ellis - Angie Tremont
- John Deignan - Andy Weeks
- Daniel Zacapa - Hector
- Kate Fuglei - Laurie
- Peter Coyote - Dave Segovia
- Jon Braver - Merc
- Dominic Bogart - Keith Connor
- Mark Famiglietti - Mike Willingham
- Jake Johnson - Powell
- Yoko Misawa - Teek
- Nena Za - Young Nhadra
- Lindsay Pulsipher - Adult Charlie Benford
- Robb Skyler - Cabbie
- Jeremy Radin - Guard
- Carlease Burke - Francine
- Kelly Galindo - Distressed Woman
- Loren Lester - Neurologist
- Ken Rudulph - Pundit
- Ted Garcia - Pundit
- Ammar Daraiseh - Arabic Man
- Raj Maan - Arabic Man
- Brandon P. Bell - Paramedic
- Peter Koch - Paramedic
- Jim Lau - Asian Man
- Chyna Layne - Nervous Woman
- Cooper Huckabee - Trucker
- Drake Kemper - Teenaged Boy
- James Carraway - Older Man
- Derwin Jordan - Person in the Crowd
- Piper Mackenzie Harris - Child
- Taylor Geare - Child
- Joe Rose - Bartender
- Guido Föhrweißer - Schultz - Prison Guard
- Anna Khaja - Older Woman
- Jacob Cooney
- David S. Goyer
- Brannon Braga
- Jessika Borsiczky
- Vince Gerardis
- Wendy O'Brien
- David Klotz
- Ramin Djawadi
- Mark D. Fleming
Callum Keith Rennie interpreta a Jeff Slingerland en la serie.
Paul Bates hace el papel de Phil.
Alan Ruck interpreta a Tomasi en la serie.
James Cosmo hace el papel de Phillip.
Thomas Kretschmann hace el papel de Stefan Krieger.
James Remar hace el papel de James Ermine.
Joseph Fiennes hace el papel de Mark Benford.
John Cho interpreta a Demetri Noh en la serie.
Courtney B. Vance interpreta a Stanford Wedeck en la serie.
Dominic Monaghan interpreta a Simon Campos en la serie.
Capítulo disponible en las siguientes plataformas:
