- David Kaufman - Dexter Douglas (voice)
- Tracy Rowe - Steff (voice)
- Kenneth Mars - Dr. Hunterhanker (voice)
- Elisabeth Moss - Kathy (voice)
- Scott Menville - Toby Danger (voice)
- Granville Van Dusen - Dash O'Pepper (voice)
- Mary Scheer - Sandra Danger (voice)
- David Warner - The Lobe (voice)
- Don Messick - Dr. Vernon Danger
- John P. McCann - Douglas Douglas (voice)
- John P. McCann - Hero Boy (voice)
- Jess Harnell - Wakko (voice)
- Jess Harnell - Singer (voice)
- Googy Gress - Duncan Douglas (voice)
- Frank Welker - Mr. Chubbikins (voice)
- Frank Welker - Gulliver (voice)
- Frank Welker - Gen. Toku (voice)
- Frank Welker - Fred the Guard (voice)
- Frank Welker - Dinosaur (voice)
- Frank Welker - Big Snake (voice)
- Randy Crenshaw - Attendant #1 (voice)
- Randy Crenshaw - Waiter #1 (voice)
- John Rubinow - Attendant (voice)
- Ricardo Montalban - Armondo Guitierrez (voice)
- Marc Drotman - Fatman (voice)
- Larry Cedar - Oblongata (voice)
- Larry Cedar - Chip (voice)
- Larry Cedar - Anton (voice)
- Maurice LaMarche - Longhorn (voice)
- Maurice LaMarche - The Brain (voice)
- Maurice LaMarche - Dan (voice)
- Tress MacNeille - Debbie Douglas (voice)
- Tress MacNeille - Cobra Queen (voice)
- Tress MacNeille - Mary Beth (voice)
- Tress MacNeille - Secretary (voice)
- Tress MacNeille - Babeheart (voice)
- Tress MacNeille - Speaker Voice (voice)
- Tress MacNeille - Anchorwoman (voice)
- Craig Ferguson - Roddy MacStew (voice)
- Craig Ferguson - Roddy Mac Stew (voice)
- Mari Devon - Tammy (voice)
- Jeff Bennett - Cave Guy (voice)
- Jeff Bennett - Candle Jack (voice)
- Jeff Bennett - The Huntsman (voice)
- Jeff Bennett - Keir (voice)
- Jeff Bennett - Jeepers (voice)
- Jeff Bennett - Attendant (voice)
- Jeff Bennett - Mike (voice)
- Jeff Bennett - Bearded Archeologist (voice)
- Jeff Bennett - Medulla (voice)
- Jeff Bennett - Manager (voice)
- Dorian Harewood - Singer #4 (voice)
- Dorian Harewood - Singer #1 (voice)
- Dorian Harewood - Deep Voiced Singer (voice)
- Ed Gilbert - Professor Heiny (voice)
- Jim Cummings - Janos (voice)
- Jim Cummings - Semiconductor (voice)
- Jim Cummings - The Wolfman (voice)
- Jim Cummings - Ape Monster (voice)
- Bob Joyce - Singer #3 (voice)
- Bob Joyce - Attendant #2 (voice)
- Julie Bernstein - Singer #2 (voice)
- Richard Moll - Vorn the Unspeakable (voice)
- Andrea Martin - Female Neighbor (voice)
- Elizabeth Lamers - Female Singer (voice)
- Elizabeth Lamers - Singer #1 (voice)
- Tim Curry - Dr. Mystico (voice)
- Leonard Maltin - Himself (voice)
- Jon Joyce - Singer #4 (voice)
- Corey Burton - Invisibo (voice)
- John Rhys-Davies - Professor Beasthead (voice)
- Rob Paulsen - Pinky (voice)
- Rob Paulsen - Francois (voice)
- Rob Paulsen - Mohammed-Abdul (voice)
- Rob Paulsen - Yakko (voice)
- Brian George - Doc (voice)
- Brian George - Warden Riba (voice)
- Dave Coulier - Teenage Boy (voice)
- Norm Abram - Norm Abram (voice)
- Clive Revill - Hermil Sioro (voice)
- Jonathan Harris - Professor Jones (voice)
- Bebe Neuwirth - Deadpan (voice)
- Jack Valenti - Himself (voice)
- Neil Ross - Board Member (voice)
- Mitch Schauer - The Door Keeper (voice)
- Mitch Schauer - Lonnie Tallbutt (voice)
- Cree Summer - Jill (voice)
- Rich Arons
- Mitch Schauer
- Tom Ruegger
- John P. McCann
- Paul Rugg
- Steven Spielberg
Ricardo Montalban interpreta a Armondo Guitierrez (voice) en la serie.
David Warner interpreta a The Lobe (voice) en la serie.
John Rhys-Davies interpreta a Professor Beasthead (voice) en la serie.
Paul Rugg interpreta a Freakazoid (voice) en la serie.
Ed Asner hace el papel de Sgt. Cosgrove (voice).
Joe Leahy hace el papel de Our Announcer (voice).
Capítulo disponible en las siguientes plataformas:
