- Stacey Grenrock-Woods - Receptionist
- Kevin Nealon - Johnny Knightley
- Jason Stuart - McG's Assistant
- Bill Smitrovich - John McGuire
- Jeff Zucker - Jeff Zucker
- Wallace Shawn - Dr. Von Oy
- Connie Stevens - Kirstie's Mother
- Mayim Bialik - Mayim Bialik
- Kid Rock - Kid Rock
- Merv Griffin - Merv Griffin
- Larry King - Larry King
- Melissa Gilbert - Melissa Gilbert
- Rhea Perlman - Rhea Perlman
- Michael McDonald - Sam Rascal
- Christopher McDonald - Jimmy
- Mo Collins - Female Guard
- Carmen Electra - Carmen Electra
- John Travolta - John Travolta
- Geoffrey Lewis - Kirstie's Father
- Edie McClurg - Nosy Lady
- Yvette Nicole Brown - Woman at Restaurant
- Phil Morris - Man at Counter
- A.J. Buckley - McG Stand-In
- Ken Weiler - EMT
- Kelly Preston - Quinn Taylor Scott
- Mark Curry - Max Cooper
- Deren Tadlock - Cop #1
- Tait Ruppert - Chuck Manson
- Jaime Aymerich - Little Jorge
- Bob Glouberman - Carmen's Friend
- Jackie Harris Greenberg - Canadian Angel
- Jim Meskimen - Scottish Crowman
- Maggie Wheeler - Woman Diapering Baby
- Alex Zimmerman - Paparazzi #2
- Leah Remini - Leah Remini
- Vené L. Arcoraci - Leah's Friend
- Danielle Franke - Leah's Friend #2
- Laura Dash - Little Person #1
- Joseph S. Griffo - Little Person #2
- David Guzman - Little Person #3
- Selene Luna - Little Person #4
- Susan Rossitto - Little Person #5
- Joe Gieb - Angel
- Carl Banks - Cop #1
- Willie Gault - Cop #2
- Butch Klein - Man in Car #1
- Sam Pancake - Man in Car #2
- Michael Wiseman - Stephen Wilcox
- Harvey J. Newmark - Party Musician #1
- Hiram Kasten - Agent
- Kirstie Alley
- Brenda Hampton
Capítulo disponible en las siguientes plataformas: