- Román Zaragoza - Sasappis
- Martin Sims - Officer Jim
- Christina Filippidis - Meg Eckenrod
- Aidan Vissers - Robbie
- Olivia Viggiani - Trick-or-Treater’s Mom
- Chad Andrews - Baxter
- Ryan Bommarito - Soldier
- Rachael Harris - Sheryl
- Nadine Djoury - Peggy Sue
- Rodrigues Williams - Dennis
- Punam Patel - Bela Arondekar
- Rodrigo Fernandez-Stoll - Todd Pearlman
- Enrico Colantoni - Michael Davenport
- Matt Walsh - Elias Woodstone
- Katharine Isabelle - Liz
- Chris Sandiford - Kenny
- Gregory Zaragoza - Naxasi
- Tamara Podemski - Dr. Long
- Tristan D. Lalla - Mark
- Cat Lemieux - Cholera Victim Catherine
- Arthur Holden - Cholera Victim Creepy Dirk
- Caroline Aaron - Carol
- Odessa A'zion - Stephanie
- Kathryn Greenwood - Margaret Farnsby
- Mark Linn-Baker - Henry Farnsby
- John Hartman - Nigel Chessum
- Lindsey Broad - Judy
- Betsy Sodaro - Nancy
- Hudson Thames - Crash
- Ravi Patel - Lewis
- Crystle Lightning - Shiki
- Tacey Adams - Mrs. Brimble
- Sean Whalen - William
- David Chan - Doctor
- Mark Holzum - Honeymoon Male
- Jett Wilder - Honeymoon Female
- Marcel Jeannin - Doctor Fred
- Domenic Di Rosa - TV Installer Steve
- Elizabeth Eveillard - Doctor Studebaker
- Nigel Downer - Cholera Victim Nigel
- Stuart Fink - Cholera Victim Stuart
- Robert Bazzocchi - Pinkus
- Carolyn Taylor - June
- Punkie Johnson - Ally
- Hannah Rose May - Molly
- Darrin Baker - Randy
- Meagen Fay - Debbie
- Alonzo Bodden - Alonzo
- Don Lake - Tom
- Mercedes Morris - Clara Brown
- Drew Tarver - Micah
- Caroline Day - Alana
- Izad Etemadi - Norm
- P.J. Byrne - Dan
- P.J. Byrne - Lawyer
- Dallas Goldtooth - Bob
- Mathew Baynton - Actor Pete
- Julius Cho - Neal
- Julius Cho - Chet
- Rose Abdoo - Paula
- Amir Talai - Director Daniel
- Tara Spencer-Nairn - Young Carol
- Dana Gourrier - Jennifer
- Nelson Franklin - Elliot
- Kaliko Kauahi - Inspector Sherry
- Mark Andrada - Cyrus
- Neil Crone - Ben Franklin
- Andrew Leeds - Eric
- Hillary Anne Matthews - Beatrice
- Nichole Sakura - Jessica
- Mike Lane - Freddie
- Jake Cannavale - Marco
- Laraine Newman - Esther
- Chip Zien - Lenny
- Tara Reid - Tara Reid
- Chris Eckert - George
- Flula Borg - Soren
- Ilana Becker - Isabel
- Ashley D. Kelley - Alicia
- Alex Boniello - Crash
- Tyler Alvarez - Ralph
- Jessie Ennis - Kelsey
- Christian Jadah - Bjorn
- Nico DeCastris - McNair
- Jonathan Valvano - Blane
- Hudson Robert Wurster - Little Pete
- Emily Mitchell - Young Laura
- Jon Glaser - Jeremy
- Lamorne Morris - Saul
- Geoffrey Owens - Gene
- Deniz Akdeniz - Chris
- Steven Yaffee - Baxter
- David Baby - Jerry
- Holly Gauthier-Frankel - Laura
- Zachary Amzallag - 'It's Getting Hot in Here' Host
- Heidi Foss - Robot Officer
- Heidi Foss - Sue
- Heidi Foss - Police Officer
- Heidi Foss - Officer Sue
- Dominique Desmarais - Ashley I.
- Lindura - Ashley S.
- Jamie Mayers - Winky
- Jon Blair - Ted the Hippie
- Jayson Alexander - Frank the Hippie
- Tori Barban - Brenda the Hippie
- Adam Bernett - Ira
- Tricia Black - Channelle
- Andrew Carter - Reporter
- Matt Keyes - Paramedic
- Emily Lê - YouTuber
- Paul Ash - Pest Control Guy
- K.C. Coombs - Sondra
- Rob Huebel - Ari (Present Day)
- Brian Cook - David Woodstone
- Blair Penner - Ari (Flashback)
- Dakota Taylor - Tad
- Georgia Bradner - Kelly
- Kelly Lee - Delivery Person
- Larry Day - Josh
- Scott Humphrey - Delivery Guy
- Daniel Brochu - Club Owner
- Rj Copan - Mobster
- Josh Johnston - Delivery Man
- Maria Herrera - Megan
- Thomas Wilkinson Fullerton - Protestor
- Francesca Gosselin - Ulster Worker
- Hazgary Colin - Ted the Arborist
- Kelly Craig - Olga
- Robert J. Tavenor - Mike
- Felicia Shulman - Sharon
- Marc-Antoine Kelertas - Crew Guy Gary
- Connor McMahon - Stunt Coordinator
- Nathaniel Appiah - College Friend
- Jaden Goetz - Blick Johnstone
- Josée Laviolette - Nurse
- Nicholas Mongiardo-Cooper - Boston Guy
- Rachelle Glait - Mrs. Greenstein
- Toby Berner - Ted
- Adam Cawley - Alan
- Daniel Rindress-Kay - Thomas Woodstone
- Alison Lawrence - Emotional Customer
- Melissa Carter - Eileen
- Ali Badshah - Terry
- Kimmy Choi - Lily
- Paola Della Malva - The Menu Hunter
- Duy Nguyen - Paul
- Michael Boatman - Spencer
- Jeremy Luke - Al Capone
- Brooks Brantly - Earl
- Timothy Stack - Reverse Mortgage Guy
- Al Connors - Schmitty
- Chris Cavener - Announcer
- Mélanie Dumais - Dancer
- Ernie Johnson - Ernie Johnson Jr. / Dream Announcer
- Douglas Sills - Samuel
- Christine Ko - Sasha
- John Reynolds - Nico
- Brandon Knox - Marvin
- Sam Ashe Arnold - Young Trevor
- David Kohlsmith - Young Jeremy
- Brian Huskey - George Appleton
- Dan Beirne - Reginald
- Gwyneth McFall-Gorman - Marion
- Adrian Martinez - Mike
- Irene White - Gloria
- Kathryn Kirkpatrick - Customer
- Allegra Edwards - Donna
- Marc-André Boulanger - Butcher Ghost
- Mat Brunet - Funyo
- Mary Holland - Patience
- John Hodgman - Minister Nathaniel
- Dean Norris - Frank
- Melinda McGraw - Diane
- Matthew Cardarople - Jamie
- Gardiner Millar - Duffy
Caroline Aaron interpreta a Carol en la serie.
Tara Reid interpreta a Tara Reid en la serie.
Rose McIver hace el papel de Samantha Arondekar.
Utkarsh Ambudkar interpreta a Jay Arondekar en la serie.
Brandon Scott Jones interpreta a Isaac Higgintoot en la serie.
Danielle Pinnock hace el papel de Alberta Haynes.
Richie Moriarty hace el papel de Pete Martino.
Asher Grodman interpreta a Trevor Lefkowitz en la serie.
Rebecca Wisocky hace el papel de Hetty Woodstone.
Sheila Carrasco interpreta a Flower en la serie.
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