- Jennifer Esposito - Jackie Curatola
- Dominique Fishback - Charelle Tyler
- Taylor Rose - Danielle Levine
- Vanessa Ray - Eddie Janko
- Vanessa Ray - Eddie Reagan
- Gregory Jbara - Garrett Moore
- Robert Clohessy - Sid Gormley
- Abigail Hawk - Abigail Baker
- Marisa Ramirez - Maria Baez
- Steve Schirripa - Anthony Abetemarco
- Tony Terraciano - Jack Reagan
- Long Nguyen - Tuan Dinh
- Rich Henkels - Billy Rafferty
- David McKittrick - Captain
- Ryan Faucett - Will Stone
- Sami Gayle - Nicky Reagan-Boyle
- Sami Gayle - Nicky
- Megan Ketch - Kate Lansing
- Flex Alexander - Demarcus King
- Jessica Collins - Becky Walenski
- Chance Kelly - Dillon Carney
- Mary Elizabeth Mastrantonio - Sophia Lanza
- Victoria Cartagena - Letitia Williams
- Brian Avers - Zachary Danhart
- Audrey Esparza - Jana Garza
- James Francis Ginty - FBI Agent Anthony Cook
- Grizz Chapman - Tiny Giondo
- Jarod Einsohn - Dylan Sanders
- Beth Chamberlin - Amy Seabrook
- Jenna Gavigan - Tess Cahill
- Sondra James - Retiree Lady
- Boris McGiver - Trevor Holt
- Lucas Papaelias - Kenneth
- Sebastian Sozzi - Vinny Cruz
- Nasser Faris - Imam Jadid
- Peter Onorati - Vince D'Amato
- Adrienne Warren - Rachel Manning
- Dana Ashbrook - Tommy Banks
- Bhavesh Patel - Jared Mehra
- Samantha Buck - Sheri Dean
- Anthony J. Gallo - Superintendant
- Amy Morton - Amanda Harris
- Charlotte Sullivan - Lacey
- Brian J. Smith - Robert Carter
- Zack Robidas - Officer Peter Grasso
- Briana Marin - Luisa Salazar
- William Abadie - Alex Schecter
- Seth Barrish - Alex Lawlor
- Grant Monohon - Steve Nathan
- Kamar de los Reyes - Santana
- Joanna Gleason - Grace Newhouse
- Rick Gonzalez - Ricky
- Ana Nogueira - Nona Palmeira
- Jeanette Dilone - Noni
- Omar Maskati - Hector Santiago
- David Ramsey - Mayor Carter Poole
- Juan Carlos Hernández - Raul
- Curtiss Cook - Detective Jones
- John Rue - Chief of Detectives Ed Hines
- Malcolm Goodwin - Angelo Reid
- John Ventimiglia - Dino Arbogast
- James Martinez - Officer Salazar
- Ali Wentworth - Naomi
- Tom Kemp - Herb Eastman
- Marc Blucas - Russell Berke
- Kevin Kilner - Keller
- Armando Riesco - Delgado
- Ron Canada - Mason
- Sean Meehan - Lt. Nash
- Jake B. Miller - Michael Hudson
- Cindy Cheung - Judge Andros
- C.S. Lee - Mr. Lin
- Ki Hong Lee - David Lin
- E.J. Carroll - Bernard Goodwin
- Morgan Turner - Stacey Clarke
- Marsha Dietlein - Mrs. Clarke
- Mariko Takai - Mrs. Lin
- Jose Soto - Luis
- David Vadim - Vigor Kovacs
- Maury Ginsberg - Scott Holden
- Frank Wood - Father Markhum
- Alison Wright - Brijita Holden
- Daniel Eric Gold - Grady
- Connie Ray - Ruth
- Robert Sella - Brian - Clerk
- Tabitha Holbert - TARU Tech
- Luke Guldan - Ralphie Vitale
- Jeff Lima - Tomas Lugo
- Charisma Carpenter - Marianne Romano
- Stink Fisher - Joe Frye
- Michael Pemberton - Sgt. Clancy
- Shirley Roeca - Aunt Marisol
- Andrew Kober - Joey Marsh
- Frank Whaley - Gary Heller
- Haaz Sleiman - Teri Damiri
- Aida Turturro - Miss Dominga
- Matthew Humphreys - Arthur Phillips
- Elliot Villar - James Montero
- Christian Keiber - Arelli Lawrence
- C. Thomas Howell - Alex Polanski
- Jason Ralph - Jake Singer
- J. Mallory McCree - Mallory McCree
- Linda Powell - Pauline
- Simon Feil - ADA Howard Lombardi
- April Yvette Thompson - Letitia
- Chazz Palminteri - Angelo Gallo
- Kirk Acevedo - Jave 'Tic-Tac' Baez
- William Hill - Sgt. Gormley
- Remy Auberjonois - Preston Ellis
- Geraldine Hughes - Meara McGuire
- Scott Sowers - Russo
- January LaVoy - Denise Donohue
- Anita Gillette - Colleen McGuire
- Frank Anello - NYPD Lieutenant
- Frank Anello - NYPD Lietenant
- Frank Anello - NYPD Lieutenant (uncredited)
- Samrat Chakrabarti - Parmar Hameed
- Laura Breckenridge - Dana
- Andrew Stewart-Jones - Officer Kamins
- Sepideh Moafi - Aaliya Zaki
- Tom Degnan - Fire Marshall Rick Kelly
- Karim Sioud - Mustafa Haddad
- Alok Tewari - Imam Ansar
- Angela Pietropinto - Mrs. Sudarsky
- Rebecca Budig - Connie
- Mark Tallman - Officer Wallace
- Erik Jensen - Jimmy
- Julia Goldani Telles - Morgan
- Sasha Allen - Carmen Hill
- Donnetta Lavinia Grays - EMT
- Willa Fitzgerald - Lacey Sutherland
- Ben Livingston - Gavin Sutherland
- Karen Allen - Betty Lowe
- Chad Michael Collins - John Russell
- Terry Serpico - Major Harrison
- Doug E. Doug - Lamar Roberts
- Jeremie Harris - Lyle Trevino
- Jeremy Luke - Det. Douglas
- Kelli Barrett - Maryann Russell
- Jinkx Monsoon - Dennis / Tallulah
- Larry Mitchell - Mickey O'Donnell
- Sharon Washington - Doris Cooper
- Reed Birney - Burden Maxwell
- Rebecca Naomi Jones - Barbara Keyes
- Michael Potts - Thorton Mead
- Joe Maruzzo - Sal Laduca
- Robert Farrior - Skip Ballister
- Patrick Breen - Joseph Scott
- Quincy Dunn-Baker - Mark Wallace
- Greg Germann - Dr. Michael Raskins
- Jayne Houdyshell - Roseanne Galecki
- Bruce Cutler - Himself
- Diane Davis - Karen Wallace
- David Pittu - Agent Jason Tomasetti
- Elle Fairbanks - Maria Romano
- Daisy Tahan - Stacy Goldman
- Colleen Clinton - Agent Anderson
- Malachi Weir - Agent Cisco
- David Anzuelo - Mr. Campos
- Marlene Lawston - Nicky Reagan-Boyle
- Kim Roberts - Judge Waters
- Victor Williams - Oliver
- Alani iLongwe - Handsome
- Frankie Faison - Jeffords
- Aja Naomi King - Denise
- Hannah Hodson - Yolanda
- Sai Lang - Jennings
- Ronald Guttman - Claudio Calso
- James Colby - Walter Ryder
- Florencia Lozano - Sophia Calso
- James Preston - Blake Woods
- Alexandra Metz - Courtney Thurman
- Melissa Benoist - Renee
- Lars Stevens - Pietro
- Dominic Chianese - Happy Jack
- Robert John Burke - Jyle Hogan
- Michael Aronov - Ricky Vintano
- David Lee Russek - Jimmy Costello
- Joel Marsh Garland - Street Light Andy
- Peter Jay Fernandez - Inspector
- George R. Sheffey - Ganley
- Kate Skinner - Alice
- Danny Hoch - Billy Leo
- James Naughton - Chief Bell
- Waleed Zuaiter - Adam Hassan
- Mousa Kraish - Khalid Hassan
- Kerry Butler - Mary Jo Clarkson
- Joseph Latimore - Mills
- Bess Rous - Jill Gallagher
- Shelley Hennig - Maya
- Annie Wersching - Joyce Carpenter
- Liza Lapira - Taru
- Kristen Bush - Carol Hoffman
- Peter Gerety - Bishop Donovan
- David Aaron Baker - Father Leo
- Ella Rae Peck - Caitlin Breyer
- Sean Cullen - Tom Breyer
- Alice Kremelberg - Alyson Duvitz
- Mark Lotito - Mr. Foster
- Yoriko Haraguchi - Rachel
- Bobby Cannavale - Charles Rosselini
- Francis Capra - Pablo Torres
- Adam Mucci - Linkner
- Max Arciniega - Esteban Torres
- Scott Cohen - Dr. Warren Wakefield
- Hoon Lee - Detective Tuan
- Nick Sandow - Lt. Alex Bello
- James Saito - Dennis Eng
- Michelle Krusiec - Nancy Wakefield
- James Chen - Nelson Chiu
- Ali Marsh - Patricia Restin
- Chris Beetem - Matthew Restin
- Tom Titone - PBA Lawyer
- Jennifer Lim - Wai-Chee
- Jo-Anne Lee - Clinic Receptionist
- Ed Wheeler - Councilman Welch
- Doua Moua - Big Eyes
- Phil Nee - Dr. Yi
- Rey Lucas - Miguel
- Michael Rivera - Grumpy
- Danny Henriquez - Chavo
- Dominic Colón - Omar
- Margaret Anne Florence - Angela
- Toby Leonard Moore - Dick Reed
- Henry Zebrowski - Hugh Stayton
- Bianca Amato - Cindy Perry
- Joey Auzenne - Mondo
- Michelle Hurst - Councilwoman Collins
- Patrick Murney - James Ratchet
- Erin Mackey - Rachel
- Gloria Votsis - Sabrina
- Caitlin FitzGerald - Benita
- Kieran Campion - Vince Walker
- Richard Short - Lemon
- Gary Basaraba - Jimmy Burke
- Carrie Yaeger - Sabrina's Lawyer
- Erik Heger - Guy
- Taylor Black - Girl #2
- Rob Leo Roy - Vince's Attorney
- Li Jun Li - Nicka
- Christopher Mann - Deputy Commissioner of Ops
- Michael T. Weiss - Sonny Malevsky
- Donnie Keshawarz - Johnny Vega
- Christine Evangelista - Jolene
- Gwynneth Bensen - Anna
- David Beach - Bruce Bruckner
- Jon Lindstrom - Judge Fenton
- Stephen Barker Turner - Richard Hansen
- Chip Brookes - Stuart Lemarque
- Kristin Griffith - Laura Gates
- Sean Weil - Theodore Wessel
- Carter Roy - Pellegrino
- Olek Krupa - Maximilian Gruschenko
- Lola Glaudini - Anna
- Pawel Szajda - Sergei Sokoloff
- Luke Robertson - Boris
- Jimmy Palumbo - Chief Winston
- Ralph Byers - Randy St. Clair
- Josh Casaubon - Josh Saunders
- Dylan Chalfy - Kevin Firestone
- Sofia Sokolov - Sofia
- Topher Mikels - Mischa Gruschenko
- Anna Eilinsfeld - Svetlana Bayul
- Vladimir Bibic - Yuri
- Dieter Riesle - Vladmir Sarbonis
- Mahira Kakkar - Dr. Gupta
- Larisa Polonsky - Chelsea Cole
- Sanjit De Silva - Sammy Khan
- Matt Servitto - Soren
- Heather Lind - Melissa Samuels
- Ramsey Faragallah - Imam
- Debargo Sanyal - Malik
- Ami Sheth - Farrah
- Kelvin Hale - Detective Hawks
- Scott Winters - Doctor
- Tim Wright - Coach
- Sam Robards - Roger Carson
- Amy Wilson - Elaine Carson
- Ryann Shane - Chloe Carson
- Olga Merediz - Inez
- Khan Baykal - Lizard
- Paige Turco - Detective Ryan
- Annie Q. - Lila
- Brad Calcaterra - Taze
- Alexis Suarez - Cop #3
- Alexis Suarez - Uniformed Cop
- David Shih - CSU Tech
- Ali Ahn - Ella Ryu
- Lucy Walters - Vanessa
- John Bedford Lloyd - Vincenzo
- Kevin O'Rourke - Mons. Walter Donahue
- Jack Gwaltney - Kevin Brennan
- E.J. Bonilla - Julio
- Patricia Kalember - Dr. Keller
- Otto Sanchez - Diego
- Tracy Howe - Rory Brennan
- Mark Margolis - Whitey Brennan
- Michael Rispoli - Jack Condo
- Michael Rispoli - Vitale
- Nneoma Sampson - Easter
- Victor Verhaeghe - Dave Greenwald
- Stuart Zagnit - Karl
- Fiona Choi - Tech
- Mark Zeisler - President Travis
- Noelle Beck - Sue Connors
- Austin Lysy - Howard Markham
- Griffin Newman - Sam Johnson
- Neal Matarazzo - Mr. Vickers
- Julia Gibson - Mrs. Vickers
- Selenis Leyva - M.E. Craig
- Jo Armeniox - Tiffani
- Marceline Hugot - Mrs. Carmichael
- Marcus Carl Franklin - Tom Mackey
- Jake Boyd - Marshall Huntington
- Richard Shoberg - Truscott Huntington
- Angel Caban - Nestor
- Andrew Halliday - Hotel Manager
- Donovan Patton - Bellhop
- Darlene Violette - Maid
- Neal Bledsoe - Cassidy
- Joseph Sikora - Mark Phelan
- Aaron Dean Eisenberg - Michael Oates
- Daniel Gerroll - Ray Curston
- Louisa Krause - Kimberly
- Victor Slezak - Bryce Helfond
- Victor Slezak - Chief of Intel
- Victor Slezak - Inter Chief
- José Ramón Rosario - Francisco Lopez
- Leia Thompson - Bartender
- Michael Izquierdo - Ian Seroy
- Ian Blackman - Lawyer
- Samuel Smith - Security Guy
- Raul Aranas - Clerk
- Izzy Ruiz - Officer 1
- Vincent Laresca - Salazar
- Jim True-Frost - Lyle Greene
- Corey Parker Robinson - Mark Taylor
- Stephanie Berry - Mrs. Taylor
- Amanda Setton - Sylvia
- Miles Grose - Luis
- Juan Javier Cardenas - Fake Detective
- Valence Thomas - John
- John Dossett - Father McMurray
- Stacey Yen - Doctor
- Sonya Harum - Sofie Lightner
- Annalaina Marks - Atlanta
- Hank Chen - Harry
- Andrew Pastides - Dorian
- Marina Squerciati - Cameron
- Kate Udall - Lara
- Tara Westwood - Margaret Olson
- Gbenga Akinnagbe - Pierre
- Geovanni Gopradi - Waiter
- Antoinette LaVecchia - Vicky Savecchio
- Antoinette LaVecchia - Elaine
- Liz Fye - Maya
- Marc Bonan - Brian Stratton
- Thomas Poarch - Reporter #1
- Jennifer Restivo - ME Laura Trent
- Greg Connolly - Mark
- John Patrick Hayden - Carl
- Neal Mayer - Reporter #3
- Nathaniel Marston - Ronnie Cleary
- Gretchen Egolf - Ann Cleary
- Sean Patrick Reilly - Al Cleary
- Andrea Navedo - Yolanda Gonsalves / Lydia Gonsalves
- Jane Dashow - Neighbor
- Darien Sills-Evans - ESU Guy
- Tijuana Ricks - ESU Woman
- Mike Colter - Cliff Reacher
- Natalie Knepp - Laura Peck
- James Snyder - Billy Coffin
- Robert Turano - Captain
- Ezra Knight - Don Sperling
- Michael J. Burg - Detective Trotta
- Jordan Lage - Damon Camia
- Becky London - Alice O'Brien
- John Speredakos - Gerry O'Brien
- John Mainieri - Father Duff
- Josh Segarra - Mike Rose
- Sharrieff Pugh - Third Person Thorpe
- Julito McCullum - Willie Hayward
- John Behlmann - Officer Timothy Doherty
- Shannon Michael Wamser - Sergeant
- Richard Brevard - Bartender
- Karina Ortiz - Thorpe's Girl
- Tony Bennett - Tony Bennett
- Carrie Underwood - Carrie Underwood
- Steve Cirbus - Kiril
- Eric William Morris - Noble Sanfino
- Valentina de Angelis - Nikolina
- Kurt McKinney - Agent Stark
- Billy Griffith - Darrell
- Cassidy Gifford - Mandy
- Bruce Altman - Mayor Frank Russo
- Bruce Altman - Robert Levitt
- Grant Rosenmeyer - Brian
- Laila Robins - Mrs. Lee
- Lusia Strus - Angela Jackson
- Joe Urla - Officer Tedesco
- Anthony Mangano - Detective
- Anthony Mangano - Cop
- Reyna de Courcy - Lydia
- Todd Julian - Tyler Lee
- Eric Leviton - Rudy Jackson
- Rikki Klieman - Judge Fowler
- Rikki Klieman - Katrina McCarthy
- David Lavine - Doctor
- Monica Raymund - Luisa Sosa
- Will Chase - William Flood
- Jason Kolotouros - Kevin Moran
- Deidre Goodwin - Administrator Marie
- William DeMeo - Vinny Vario
- Jeff Berg - Willis
- Mark Morettini - TARU Sheen
- Mark Morettini - Det. Powell
- Karen Tsen Lee - Woman
- Nicole Sudhaus - Marlene
- Joshua Burrow - Miles Thomas
- Todd Faulkner - TARU Officer
- Todd Faulkner - Taru Tech
- Philip Ettinger - John-John
- Anastasia Barzee - Elizabeth Fox
- Billy Kay - Xavier Sardina
- Eric Nelsen - Alex Kasper
- Gillian Alexy - Ellen Sloan
- David Wilson Barnes - Doc
- David Wilson Barnes - Dr. Alex Dawson
- Juri Henley-Cohn - Luke Avila
- Samuel Ray Gates - Reporter #1
- Therese Plaehn - Reporter #3
- Elena Hurst - Rosalita
- Al Sapienza - Phil Sanfino
- Gary Wilmes - Roth
- Laura Campbell - Tess
- Mara Davi - Bianca Sanfino
- Maya Days - Sgt. Donner
- Nick Westrate - Liam
- Michael Borrelli - Richie
- Mike Houston - Uniformed Cop
- Mike Houston - Officer Mowery
- Ricky Garcia - Cargo Driver
- Tobias Truvillion - Otto
- Danny Johnson - ESU Captain
- Blanchard Ryan - Female Reporter
- Brian Sgambati - Detective
- Brian Sgambati - Detective Kelsey
- Rob Morgan - Guy in the Crowd
- Jason Griffith - Suit
- Simon MacLean - Attorney Maxwell
- Ned Eisenberg - Sandy
- Roe Hartrampf - Bryan Parker
- Tom Mason - Rick
- Matthew Porretta - Congressman Albom
- Asa Somers - Frank
- Marnie Schulenburg - Coreen
- Frederick Weller - Jacob Krystal
- Frank De Julio - David
- Chris Stack - Kyle Freelander
- Marjan Neshat - Meliha Demir
- Sakina Jaffrey - Mrs. Demir
- Tibor Feldman - Chief ME
- Tibor Feldman - M.E. Dr. Craig Esterbrook
- Babak Tafti - Hafiz Demir
- Paul Fitzgerald - Detective Deleon
- Paul Fitzgerald - Anthony Deleon
- Leslie Lyles - Mrs. Freelander
- Jon DeVries - Mr. Freelander
- Lyndsey Anderson - Homeless Woman
- Stuart Rudin - Homeless Guy
- Teddy Sears - Sam Croft
- Dan Grimaldi - Tommy Barrone, Sr.
- Tom Lipinski - Johnny Tesla
- Norbert Leo Butz - Detective Kramer
- Aaron Lohr - Tommy Barrone, Jr.
- Jack O'Connell - Stanich
- Gino Cafarelli - Tony - Hard Hat 1
- Roxanna Hope - Jenna Milo
- Jay Patterson - Dennis Driscoll
- Robert T. Bogue - Parker
- Kelly AuCoin - Jack Cavanaugh
- Adam Scarimbolo - Billy Reese
- Tyagi Schwartz - Ray Milo
- Neal Lerner - Jerry Randall
- Robert Funaro - Captain Browne
- Christopher Jon Gombos - Joey Sava
- Victor Cruz - Tech Flores
- Tom Pelphrey - Mike Galatis
- Tom Mardirosian - Connie
- Bill Buell - Ralph
- Matt Walton - Kevin Schmidt
- Alfredo Narciso - Det. Montero
- Maureen Mueller - Molly McKenna
- Brian Haley - Wayne Rivano
- Tim Hopper - Carl Patrick
- Molly Price - Hollie Rivano
- C.J. Wilson - Bruce Richmond
- F. Murray Abraham - Leon Goodwin
- Aubrey Dollar - Sandy Huffman
- Amy Hargreaves - Dr. Karen Folson
- James Murtaugh - Ret. Det. Loggia
- Saidah Arrika Ekulona - Leslie Fuller O.R. Pharm.
- Bryan Scott Johnson - Det. Paul Collins
- Dominic Comperatore - Monsignor Lauro Ferraro
- Timothy Busfield - Charles Bynes
- James Rebhorn - Archbishop McGovern
- Kal Parekh - Dr. Pruit
- Victor Pagan - Jose Duran
- Patricia Rae - Mrs. Ortiz
- Joe Forbrich - ESU Captain
- Joe Forbrich - ESU Captain Dempsey
- Theo Stockman - Timothy Abbey
- Richard Gallagher - Tech
- Babs Olusanmokun - Phantom
- Priscilla Lopez - Mrs. Fernandez
- Nestor Serrano - Derek Elwood
- Nestor Serrano - Capt. Elwood
- Albert Jones - Roland Gates
- John Earl Jelks - Ray Bell
- Don Wallace - Nelson Ortiz
- Yancey Arias - Detective Juan Cruz
- Margaret Colin - Melanie Maines
- T. Ryder Smith - Miles
- Will Rogers - Owen
- Leslie Denniston - Joan
- Zabryna Guevara - Angela
- Tom Wopat - Craig Iverson
- John Rothman - Walter Harris
- Jayne Atkinson - Sharon Harris
- Aunjanue Ellis-Taylor - Sylvia Marshall
- Stephen McKinley Henderson - Judge Harlan Haywood
- Jay O. Sanders - Jimmy Reagan
- Peter Rini - Roger Kelly
- Christina Brucato - Ann Delamar
- Ellen Parker - Mrs. Polanski
- Tarik Lowe - Robber #1 / Terrence Banks
- Jeremy Beiler - Tech
- Aldous Davidson - Jimmy the Sketch Artist
- Afton Williamson - Officer Perez
- J.D. Williams - Benjamin Banks
- Jacqueline Torres - Maria De La Cruz
- Frank Deal - Detective Alan Batalli
- David Fierro - Super
- Charlie Tahan - Michael Keenan
- Kate Hodge - Theresa Keenan
- David Bishins - Inspector Reid
- Chris Cardona - Repairman
- Berto Colon - Det. Torres
- Alexia Rasmussen - Sophia Babikov
- Bob Dishy - Judge
- Misha Kuznetsov - Uri Denko
- Juney Smith - Doorman
- Dennis Boutsikaris - Jack Quayle
- Billy Magnussen - Rand Hilbert
- Casey Siemaszko - Josh Thorp
- Marc Kudisch - Terry Longacre
- Brett Dalton - Phillip Gibson
- Sarah Wilson - Sara Allen
- Slate Holmgren - Bob
- Aisha de Haas - Traffic Agent
- Leo Fitzpatrick - Leo Packer
- Joe Lisi - NYPD Chief of Counterterrorism
- Rodrigo Lopresti - Keith Daley
- Larry Pine - NYPD Chief Surgeon
- Wrenn Schmidt - Anna Goodwin
- Stewart J. Zully - Under Secretary Price
- Murphy Guyer - Sam Ellis
- Michael Madsen - John
- Marcella Lowery - Mrs. Greer
- Christopher J. Domig - Charles Zappa
- Brian D. Coats - Dispatcher
- Aaron Lazar - Dr. Levin
- Norm Lewis - DA James Campbell
- Mason Pettit - Dean Charlton
- Jenny Powers - Marilyn
- Samantha Soule - Joyce
- Lucas Salvagno - Miles Tarshis
- Ken Arnold - Fat Cat
- Jeffrey Omura - Patrick Dunleavy
- Richard Burgi - Councilman Tommy Mancini
- Lili Mirojnick - Angela Ferrera
- Chris Tardio - Kevin Carr
- Paul Calderon - Lieutenant Perez
- Danny Mastrogiorgio - Detective Freehill
- David Fonteno - NYPD Chief of Intel
- David Fonteno - ESU Captain
- Justin Martin - Jordan Silva
- Eden Marryshow - Mark Rivera
- Deborah Offner - Judge Katrina McCarthy
- Marisol Sacramento - Lily Rivera
- Shane McRae - Johnny Evans
- Tony Plana - President Velverde
- Mckean Rand - Eddie
- Justine Cotsonas - Alyson
- Michelle Hurd - CIA Anne Reynolds
- Louis Ozawa - Abdul Sayid
- Lauren Bittner - Alyssa Mulrow
- Brendan Griffin - Bobby Mulrow
- Mandy Bruno Bogue - Antonia Salducci
- Reg Rogers - Vance Bradley
- Jon Patrick Walker - Dr. Ed Greenfield
- Judith Delgado - Maude
- Andre Ware - Sergeant
- Tawny Cypress - Patrice
- Thomas Schall - Father Francis Xavier Ainsworth
- Ken Howard - Malcolm
- Barbara Vincent - NYPD Officer
- Dash Mihok - Eddie Stone
- Malcolm Gets - Prof. Brian Devlin
- Geneva Carr - Sally Burton
- Sean Dugan - Father Quinn
- Ryan Lynn - Anthony Kasper
- Kathy Searle - Diane Reade
- Joseph Melendez - Emilio Flores - Hitman
- Matthew Rauch - Lawrence Skolnick
- Matthew Rauch - Lawrence Skolnik
- Neal Huff - Leaf Memphis
- Sally Wheeler - Doctor
- Paul Anthony Stewart - Peter Westlake
- Owiso Odera - Detective Sidney Jeffries
- Daniel London - Tyler Green
- Bob Jesser - Office Manager
- Jeremy Bobb - Jonathan Gelman
- Daryl Edwards - Russ Howard
- Margot White - Vanessa
- Susie Essman - Judge Clarice Karl
- Thom Barry - Saul Ward
- Michael Kostroff - Mr. Wojcik
- Joe Coots - ESU Commander
- Mark Moses - Curtis Swint
- Megan Boone - Detective Candice McElroy
- McCaleb Burnett - Jimmy Deleo
- Vincent Pastore - Richie Tomlin
- Jason Kravits - Dave Greenwald
- Teddy Cañez - Congressman Suarez
- Nick Gregory - Stephen
- Luke Kirby - Detective Wolf Landsman
- Stephen Kunken - Jacob
- Darren Goldstein - Asher Lefko
- Melissa Errico - Rivka Morganthal
- Susan Misner - Karen Waters
- Sarah Steele - Rebecca
- David Margulies - Solomon
- Yuval Boim - Levi
- James Biberi - Kola
- James Biberi - Dan McCormick
- Fyvush Finkel - Moishe
- Sheetal Sheth - Isabelle Nassar
- Carolyn McCormick - Joyce Powers
- Franky G - Sgt. Russell
- Fidel Vicioso - Darryl
- Rachel Ticotin - Carmen Castillo
- Eric Mabius - Richard Rorke
- Jordan Gelber - Bobby
- Travis Schuldt - Ken
- John Cunningham - Preston Rorke
- Tony Campisi - Gerry O'Grady
- Dana Cuomo - Gina
- Clarke Peters - Nathan Anderson
- James Carpinello - Russell Price
- Leslie Hendrix - Mrs. Judith Wilson
- Bill Irwin - Cardinal Brennan
- Frank Pando - Alex Fuentes
- Boomer Esiason - Himself
- Tonya Glanz - Officer Kara Walsh
- Michael Mulheren - Chris Scanlon
- Daniel Sauli - Agent Rick Siblano
- Jordan Baker - Chelsey Parker
- Jordan Baker - Eveline
- Tanya Perez - Agent Martinez
- Chelsea Lopez - Tina McDermott
- Philip Hoffman - Lawyer
- Philip Hoffman - Attorney
- Hunter Emery - Little G
- Bernie McInerney - Oscar
- John Bolton - Tom Pincus
- Alexandria Suarez - Teresa
- Sol Miranda - Mrs. Campos
- Richard Waugh - Donald Banse
- Robbie Sublett - Spencer Croft
- Duane Murray - P.D. Adelman
- Gregg Edelman - Seymour Kerwin
- Chris McKinney - Bobby Flores
- Steve Arbuckle - Oliver Peele
- Janet Zarish - Valerie Daniels
- Michael Braun - Jeremiah Kade
- Jay Devore - Milo Finley
- Emma Adele Galvin - Maggie Parker
- Charlie Semine - Officer Randy Cutter
- Angela Sarafyan - Frannie Ferguson
- Vincent Curatola - Chief Norm Valenti
- Gabriel Rush - Tyler Jeffries
- Judy Marte - Vivian
- Kevin Kane - Officer Bill Becker
- Haviland Morris - Linda Tomlin
- Glenn Fleshler - Det. Walt Finney
- Jen Ponton - Kasia Mazurski
- Leo Solomon - Baltazar Aboud
- Demosthenes Chrysan - Bartosz Mazurski
- Charles Borland - Lt. James McCarthy
- Michael Buscemi - Owen Stapleton
- Noah Fleiss - Paul
- Okieriete Onaodowan - Damon Williams
- Nathan Darrow - Officer Reynolds
- Eric Laneuville - Marcus Greene
- Danny McCarthy - Jerrie Demarest
- Kevin O'Donnell - Detective Mike Hofferman
- Jason Cerbone - Detective Johnny Vassallo
- Alice Ripley - Beverly Elvers
- Julian Gamble - Chief Ronnie Monroe
- Heather Burns - Sister Mary
- Fredric Lehne - Lieutenant Trumball
- Anthony Fazio - Willie the Junkie
- Jon David Casey - Homeless Romeo
- Colleen Zenk - Joan
- Rebecca Mader - Tori Parsons
- Daniel Stewart Sherman - John Coogan
- Gabe Fazio - Jimmy Wallace
- David Deblinger - Meyer Black
- Marcia Jean Kurtz - Marion Davis
- Heidi Armbruster - Michele Grande
- Anthony Lee Medina - Rudy Williams
- Portia - Penny
- Eva Kaminsky - Brittany Davis
- Norah O'Donnell - Norah O'Donnell
- Mela Hudson - Helpful Stranger
- Ashley Gerasimovich - Claire
- Patch Darragh - Joe Kaplan
- George Katt - Officer Horvat / Davor Vlasic
- Quinn VanAntwerp - Robert Rattner
- Michael Godere - Starvos Constantine
- Liza J. Bennett - Mrs Gibson
- Michael DeLorenzo - Fausto
- Amanda Quaid - Diana Corning
- Ashlie Atkinson - Sandra Colby
- Alice Barden - Defense Attorney
- Erin Dilly - Gwen Rice
- Donald Sage Mackay - Lt. Mike Collier
- Celina Jade - Marisa Lee
- James McCaffrey - Sgt. Kevin Coolidge
- James McCaffrey - Det. William Carter
- Richie Stephens - Vlad
- Catherine Chadwick - Judge Keller
- Kevin Corrigan - Jimmy Pearson
- Jesse Ray Sheps - Malik Nejari
- Alex Sgambati - Mindy Gummerman
- Robin Skye - Judge Adrian Jones
- Auden Thornton - Angie
- Zach Appelman - Sean Bartch
- Abbi Snee - Jennifer Crowley
- Parisa Fitz-Henley - Lizzy Hughes
- Jeremy Holm - David Rossi
- Will Meyers - Nick Rossi
- MiMi Ryder - Nicole Rossi
- Jimmie Saito - Sergeant Martinetz
- Lovie Simone - Gina Walker
- Robert Ray Manning Jr. - Sam Walker
- Joel Hurt Jones - Charles Klein
- Jessica Angleskhan - Nurse
- Scotty Crowe - Officer Johnson
- Harlin C. Kearsley - Lawyer
- Rudy Mungaray - Lupino
- Derek Chadwick - Sam
- Peter Appel - Joe Salducci
- Sadie Sink - Daisy Carpenter
- Rosemary De Angelis - Mrs. Goldfarb
- Matt Mulhern - Steve Brandt
- Delaney Williams - Bureau Chief Dennis Egan
- Gary Lee Mahmoud - Herbert Talbott
- Geoffrey Owens - Sergant Weller
- Tamara Tunie - Monica Graham
- Ernie Hudson - Darryl Ward
- Raphael Sbarge - Mickey Tate
- Flor De Liz Perez - Anna Chavez
- Terayle Hill - Jojo Reese
- Shenell Edmonds - Theresa Jones
- Jacinto Taras Riddick - Chief Edwards
- Cecelia Antoinette - Gail Carter
- Antonio Ortiz - Hector Alou
- Tia Carrere - Chow Lin
- Natalie Carter - Diane Vickers
- Miriam A. Hyman - ME Emile Cooper
- Dan Bittner - Dr. Brian McByrne
- Lorraine Bracco - Margaret Dutton
- Lorraine Bracco - Mayor Margaret Dutton
- Geisha Otero - Woman from Neighborhood
- Vanessa Aspillaga - Rosalie Morales
- Joanna Rhinehart - Mli
- Louis Cancelmi - Thomas Wilder
- Katie Maguire - Officer Flanagan
- Leslie Hope - Anne Farrell
- Dikran Tulaine - Lech Choinski
- Izabella Miko - Milena
- Birkett Turton - Lukas Gorski
- Emily Althaus - Christina Henley
- Jake Cherry - Victor Bajek
- Jonathan Gordon - Trevor Reid
- Kelli O'Hara - Lisa
- Kelli O'Hara - Lisa Farragaut
- Kerri Lynn Miller - Jess Weinstein
- Marquis Rodriguez - Eric
- Peter Coyote - Senator Ted McCreary
- Drew Beasley - Dylan Russo
- Sean Kleier - Bobby Jones
- Tim Barker - Sgt. Mulhearn
- Regan Mizrahi - Wyatt Richmond
- Sticky Fingaz - Clinton Wallace
- Denzel Whitaker - Curtis Turner
- Quincy Tyler Bernstine - Faith Turner
- Traci Hovel - Girlfriend #1
- Angela Rambourg - Sharyn Sarni
- Thomas Bair - Kyle Rice
- Lou Diamond Phillips - Louis Delgado
- Shaun Rey - Cartel Member #2
- Robert Wuhl - Captain Ward Gibson
- Al Nazemian - Aruna Patel
- Kris Arnold - Father Denby
- Jerry DiLeo - Police Officer / Italian Mobster
- Caleb McLaughlin - ToneLane
- Craig Bierko - Ray Cross
- Jenna Williams - Cara Simpson
- Justin Walker White - ADA Martin Richardson
- John Palladino - Billy Conroy
- Richard H. Blake - Dennis Whitney
- Bebe Neuwirth - Kelly Peterson
- Maxwell Whittington-Cooper - Officer Jordan
- Jordon Bolden - Ronnie Diaz
- Richard Thomas - Richard Walters
- Angela Oh - Detective Amy Prisk
- Mark Linn-Baker - Carlton Miller
- Tom Cavanagh - Mickey Patrick
- Tom Cavanagh - Mickey
- Josh Salt - Luke Harris
- Matthew Miniero - T.J. Stewart
- Holt McCallany - Robert McCoy
- LaTanya Richardson Jackson - Lt. Dee Ann Carver
- Nadia Alexander - Tonya Hill
- Diane Neal - Kelly Blake
- Ana Reeder - Louise Kendrick
- Brooke Hoover - Neighbor
- Mhari Sandoval - Amy Bell
- Mark DiConzo - Marty Ellis
- Fulvio Cecere - Captain Dennis Wainright
- Hamilton Clancy - Doug Lynch
- Steven Hauck - Ted
- Howard W. Overshown - Scott Fuller
- Chelsea Watts - KARLYNN
- Benjamin Snyder - Matthew D'Angelo
- Danny Bolero - Owner
- Jasmine Cephas Jones - Shania Costa
- James DuMont - Thomas Wallace
- RayJonaldy Rodriguez - Luis Rosas
- Dan Amboyer - Nicholas Papadopoulos
- Jeff Adler - Officier Walsh
- Alex Hazen Floyd - Nigel Lewis
- Derek Goh - Colin Taylor
- Cormac Cullinane - Ryan Young
- Michael Iacono - Altar Boy (uncredited)
- Odette Warder Henderson - Senator
- Darby Lynn Totten - Woman
- Bonnie Rose - Secretary
- Jenny Maguire - Sue Lockhart
- Rutanya Alda - Mrs Harton
- Dean Ciallella - Wedding Guest (uncredited)
- Rosalyn Coleman - Lisa Kelly
- Pamela Dunlap - Djuge Dolan
- Luna Lauren Velez - Special agent Veronica Molina
- Lenny Platt - Joe Ferraro
- Liza Colón-Zayas - Ana Baez
- Alex Esola - Paul Romano
- John Mazurek - Dr Ben Steiner
- Ben Davis - Lieutenant Jonathan Harvey
- Jere Shea - Mark Forman
- Welker White - Susan Roberts
- Michael Quinlan - Jim Beresford
- Susan Barrett - Desk Clerk
- Whoopi Goldberg - Regina Thomas
- Zachary Golinger - Wesley Abbott
- David J. Cork - Winslow Martin
- Alex Webb - Richard Lockhart
- Daniel Bellomy - Warren Pratt
- Deborah Green - Fertility Patient
- Justin Marcel McManus - Uniform 1
- Harry Bouvy - Alan Raby
- Joseph Kamal - Dr. Mehta
- Chris D'Amato - Barry
- Erin Cummings - Lori D'Angelo
- Noah Robbins - Richie Turner
- Ato Essandoh - Reverend Darnell Potter
- Carmen M. Herlihy - Han Tran
- Calvin Dutton - Larry Knoll
- Jenn Gambatese - Naomi Chesnick
- Silvestre Rasuk - Jason Chavez
- Callie Thorne - Maggie Gibson
- David Lee Huynh - Minh Tran
- Tom Paolino - Arrenega Soares
- Emmet Smith - Eli Chesnick
- Gary Lavard - Michael Gillette
- Matthew R. Staley - Glenn Kilmer
- Lori Hammel - Marcia Wells
- Jason Altman - Simon Rinke
- John Pigate - Doctor
- Logan Crawford - Reporter #2
- Blair Baker - Woman
- Salar Ghajar - Yeshiva Bus Driver
- Lynn Marocola - NYPD Officer (uncredited)
- Lynn Marocola - NYPD Police Officer (uncredited)
- Lynn Marocola - Police Officer (uncredited)
- Lynn Marocola - Police Officer
- Lynn Marocola - FDNY Emt (uncredited)
- Lynn Marocola - FDNY Paramedic (uncredited)
- Erwin Falcon - Karaoke MC
- Annemarie Lawless - Wendy Munson
- Ian Bedford - Captain Skelly
- Shannon Wallace - Tyce Dickson
- Daniel Cosgrove - Det. Felix Evans
- Shane Patrick - Max Fagan
- Jeremy Crutchley - Kenny Cook
- Gloria Reuben - Rachel Weber
- Bryant Carroll - Manager
- Jenny Anne Hochberg - Charlotte
- Rahim Omar - Manager #2
- Garrett C. Phillips - Tyler
- James P. Rees - Sam Sullivan (uncredited)
- Steve Rizzo - Mr. Watkins (uncredited)
- Latrisha Talley - Uniform (uncredited)
- Sean Allan Krill - Elon Lubin
- Louis Mustillo - Lenny
- Audrey Lynn Weston - Sandy Daniels
- Sandra Daley - Winnie
- Charlie Fersko - Jerome
- Gameela Wright - TV Reporter Lucinda
- Gameela Wright - Reporter Helen
- Gameela Wright - Stand-up Reporter
- Joshua Wills - Harold
- Joshua Wills - Harold Roberts
- Jason Bowen - Detective Luke Raines
- Jason Bowen - Detective Raines
- Janelle McDermoth - Detective Peterson
- Casey Waller - Woman
- Katie Kreisler - Jill Carmago
- Ben Bailey - Emmett Fells
- Ilana Becker - Ricki Blanton
- Ben Rosenblatt - Ira Pressly
- Jerry Dixon - Lars Hall
- Patrick Brennan - Dave Hobbs
- James Le Gros - Don Voorhees
- Jessica Jain - Officer Chabra
- Deborah Fennelly - Elaine 'Doc' Pressly
- Jimi Stanton - Andrew Miles
- Eric Tabach - Charles Hayes
- Jim Santangeli - John Romano
- Rikki Kleiman - Judge Fowler
- Nancy Rodriguez - Leona Hayes
- Tammy Pescatelli - Lorraine Carpacci
- Kwabena Ampofo - Sullivan
- R.A. Guirand - EMT #2
- Nati Rabinowitz - Legal Aid Attorney
- Benjamin Frankenberg - Lineup Guy #1
- Scott Bryce - Craig Perlmutter
- Scott Bryce - Dr. Alex Garland
- Ivory Aquino - Ashley Roberts
- Ed Squires - Tommy Simms
- Sherman Howard - Christian Ward
- Tim Rogan - Mark
- Peter O'Hara - Detective Pete Castellano
- Carolina Do - Mayor's Assistant
- Kevin Michael Murphy - Officer Lawrence
- Ian O'Boyle - Tough Guy #2
- Kabir Bery - Tough Guy #3
- Alex Brightman - Ralph Lamont
- Bahar Beihaghi - Yelena
- Brandon Gilpin - Deon Williams
- Georgia Warner - Megan Mills
- Elizabeth Stanley - Karen
- Christopher Sieber - Mike Dougherty
- Joy Jones - Alice Williams
- David Zayas - Governor Martin Mendez
- Wesley Volcy - Dante Williams
- Constantin Tripes - Eamon
- Michael Imperioli - Robert Lewis
- Kathryn Gallagher - Diane Butler
- Bobbi Bordley - Keisha Smith
- Gabrielle Reid - Mrs. Smith
- David Roberts - Lieutenant
- Hechter Ubarry - Handbag Store Owner
- Mounir Quazzani - Malik Wilson
- Thiree Pinnock - Harrison
- Erin Neufer - Alison Gable
- Angel Desai - Judy Farrow
- Jamie Jackson - Boris Vache
- Mike Carlsen - Douglas Mckenzie
- Mark Borkowski - Desk Sergeant Wolinski
- Nico Greetham - Scott Marino
- Don Scimé - Joel Ross
- Kasey Marr - Nurse
- Kate Rockwell - Claire Gilmore
- Jim Klock - Captain Keith Butler
- Josh Breckenridge - Officer Wendell
- Trian Long Smith - Angela Bennett
- Caralyn Kozlowski - Susan Turner
- Tricia Paoluccio - Judge Enid Kramer
- Mason Versaw - Donald Turner
- Lorraine Farris - Dawn Ross
- Magdalena Borlando - Christine Rizzo
- Brian Keane - David Bowles
- Sophia Gennusa - Jennifer
- Kristine Nielsen - Ms. Wilson
- Cameron Scoggins - Ted Bradley Jr.
- Opal Alladin - Robin Waits
- Lou Martini Jr. - Murray
- Leah Pressman - Alyssa Bowles
- Bob Roseman - Store Manager
- Charley Brucato - Reina's Driver
- Jared Morrison - Taru Tech Walker
- Jared Morrison - TARU Tech Walker (uncredited)
- Ali Stroker - Detective Allison Mulaney
- KeiLyn Durrel Jones - Officer Ray Flores
- Heather Simms - Diana Brooks
- Michael Marc Friedman - Richard Farmer
- Ethan Hova - Dr. Ibrahim
- Ari Barkan - Leo
- Chelsea Reed Davis - Young Woman
- John Finn - David Cummings
- John Finn - Fire Marshal Chieco
- John Cashin - Number 3
- Arthur J. Nascarella - Dominic Reina
- Andy Prosky - Reina's Lawyer
- Isaiah Negrón - Marcus
- Aasif Mandvi - Samar Charwell
- Christopher Cassarino - John Marconi
- Alan R. Rodriguez - Goggins
- Andrew Burdette - Futuro Marconi
- Isabel Ellison - Mother
- Emma Pearson - Jenny
- Jean Chung - Woman
- Bonnie Somerville - Paula Hill
- Tom Riis Farrell - Bradley Loomis
- Tom Riis Farrell - Fred Rosebrock
- Danielle Davenport - Nia Martin
- Jamila Velazquez - Camila Garcia
- Reynaldo Piniella - Teddy Valdez
- Roman Maldonado - Cortez
- Jess Nahikian - Amy Taylor
- Frank García - Bodega Owner
- Stacey Sargeant - Mia Martinez
- Edward Akrout - Samson James
- Shayvawn Webster - Jules Sarina
- Aime Donna Kelly - Angelique Loomis
- Lauren Patten - Rachel Witten
- Lauren Patten - Officer Rachel Witten
- Matthew J. Harris - Scotter Smith
- Dane Clarke II - Devon Jackson
- Trent Stone - Scooter's Lawyer
- Angela Petruzziello - Consumer
- Anthony Notarile - Sales Associate
- John-Michael Carlton - Nate Towers
- Mark Deklin - Donnie Hassett
- Susan Blommaert - Polly Riley
- Will Stout - Officer Jeff Lyons
- Tony Carlin - Captain Simms
- Stephen Rowe - Johnny Lyons
- Jennifer Bowles - Alice Dornan
- Stephen Payne - John Riley
- Melissa Joyner - Alex Moore
- Joshua Dye - Jackson Wilks
- Mister Fitzgerald - Civilian #1
- Charlie Sausa - Derick
- Greg Jackson - Hassett's Lawyer
- Annabella Sciorra - Faith Marconi
- Annabella Sciorra - Dr. Grace Meherin
- Samantha Browne-Walters - Pedestrian / Onlooker (uncredited)
- Matt Consalvo - Officer Meyers
- Matt Consalvo - Uniform #1
- Chris Walker - Detective #1
- Charles Everett - Detective #2
- Sean Grandillo - Charles Morrow
- Soraya Broukhim - Mrs. Sayeed
- Peter Hermann - Jack Boyle
- Dylan Walsh - Mayor Peter Chase
- Jennifer Ikeda - Jennifer Power
- Grayson Taylor - Ryan Stone
- Jeff Wincott - Captain Mancuso
- Jeff Wincott - ESU Captain
- Treat Williams - Lenny Ross
- Vaishnavi Sharma - Maya Hassan
- Fawad Siddiqui - Muhammed Qadir
- Samuel María Gómez - John Sinclair Esq.
- Neimah Djourabchi - Zahid Hassan
- Darik Bernard - Officer Irving
- Simone Policano - Tess Ross
- Gina Jun - Attorney / Restaurant Patron
- Ariane Rinehart - Tara
- Jadah Marie - Ashley Reed
- Dave Quay - David Shaw
- Kate Villanova - Angie De Grazia
- Curtis Lyons Jr. - Barry Trask
- Tanesha Marie Gary - Det. Carrie Ewbanks
- Nesha Ward - Prison Guard
- Dani Martineck - Officer Hoffman
- Michael Cullen - Armin Janko
- Joe Carroll - Kyle Dorsey
- Ty Jones - David Anderson
- Ellie Ricker - Nadia Atonov
- Leigh Ann Larkin - Medical Examiner Megan Carson
- Chantal Jean-Pierre - Lisa Johnson
- Chris Gray - Noah Barber
- Chris Chirdon - Mark Adams
- Jarid Faubel - Brian Baker
- Abby C. Smith - Gina Adams
- Lee Baptiste - Chief Clark
- Fenton Lawless - Bill Brennan
- Jared Canfield - Father McDougal
- Adeola Role - Leticia Harris
- Cheryl Freeman - Sandra Harris
- Juan Francisco Villa - Arturo Muñoz
- Brandon Rush - Officer DeNoon
- Gugun Deep Singh - Ram Singh
- Brandhyze Stanley - Grace Michaels
- Kelly Miller - Reporter Nick
- Vien Hong - Bao Pham
- James Nuciforo - Nuciforo
- James Nuciforo - Himself
- James Nuciforo - Jim
- James Nuciforo - James (uncredited)
- James Nuciforo - Detective Jimmy Nuciforo
- James Nuciforo - Det. Jim Nuciforo
- James Nuciforo - Escort
- James Nuciforo - Detective Nuciforo
- Tiffany Rothman - Linh Pham
- Anthony Cochrane - Bernie Moskowitz
- Francisco Solorzano - Ray Gardner
- Viet Vo - Clothing Shop Store
- Julie T. Pham - Fruit Shop Owner
- Dietrich Teschner - Detective
- Jill Durso - Detective's Wife
- Johnny Tran - Shop Owner #3
- Diane Dehn - Photographer
- Matthew Lawler - Kurt Quinn
- Donny Burke - Orlando Burns
- Bobby James Evers - Buddy
- Alex Kingston - Commander Sloane Thompson
- Anthony DeSando - Joey Ruscoli
- Anthony DeSando - Joey Razzano
- Gabby Beans - Cora Felton
- Elizabeth Keifer - Iris Williams
- Gillian Glasco - Detective Patricia Fett
- Frank Boyd - Gavin Powers
- Alet Taylor - René
- Lawrence Oliver Cherry - Lucas Burke
- Sarah Naughton - Bartender
- Theresa Tirone - Officer Fucci
- Joseph Raymond Lucero - Juan Carlos Lopez
- Josh Crotty - Officer Christopher Zeal
- DeLance Minefee - Jason Reeves
- Regina Taylor - Irene Terrell
- Jeanine Bartel - Nicole
- Jimmy Buffett - Jimmy Buffett / Dickie Delaney
- Philip Estrera - Wilson
- Suzen Baraka - Jennifer
- Adel Telesia - Uniform (Squad)
- Erika Henningsen - Madeline Gleeson
- Daniel Reece - Mark Roland
- Brandon Lindsay - Lamar White
- Finnerty Steeves - Joyce Stein
- Natalie Melo - Ruiz's Daughter
- Stephanie Ruiz de Chávez Manjarez - Mrs. Ruiz
- Kara Jackson - Sarah O'Neill
- Derek Gaines - Bugs
- Sean Nelson - Marcus
- Eric B. - Lt. Mike Gee
- Eric B. - LT. Mike Gee
- Eric B. - Lt. Gee
- Lee Aaron Rosen - Peter O'Neill
- Luis Vega - Detective Joe O'Connor
- Keri Safran - Lila Abenthy
- Miriam Silverman - Alcie Abenthy
- Traci Wolfe - Ellie
- Евгения Оруджева - Yelena Popova
- Will Hochman - Joe Hill
- Will Hochman - Joseph Hill
- David Chen - Tee
- Matthew Taylor Zuniga - Guy #2
- Christopher Martinez - Devon
- Max Weinberg - Mario Vangelis
- Tony Danza - Raymond Moretti
- Rosa Arredondo - Katie Williams
- Christiani Pitts - Deanna Parker
- Geoffrey Cantor - Frank Willis
- Sara Chase - Tina
- Triney Sandoval - Bill Martinez
- Jennifer C. Johnson - Ashley Rogers
- Nicole Michelle - Receptionist
- Nathaniel Levin - Jimmy Moretti
- Laura Spaeth - Cheryl Moretti
- Mike Donovan - John Romano Jr.
- Artie Brennan - DA Investigator #4
- Andrea Boehlke - Toweled Girl
- Luis Antonio Ramos - Robert Espinoza
- Jill Abramovitz - Jeanine Hoffman
- Richard Kline - Judge Angioli
- Didi Conn - Mrs. Devlin
- Trevor F. Salter - Officer Santos
- Michael Tow - Mike Huang
- Andy Karl - Will Farmer
- Charlie Tassone - Emmy Farmer
- Anthony Goss - Offier Harris
- Jennifer Lamb - Elderly Lady
- Eileen Weisinger - Mrs. Watkins (uncredited)
- Eileen Weisinger - Ms. Romano
- Joseph Tudisco - Super
- Ross Beschler - Alan Marter
- Gabriel Sloyer - Benny Fernandez
- Rod McLachlan - Charlie Peterson
- Joe O'Connor - Officer Malone
- Joe O'Connor - Officer Malone (as Joseph John O'Connor)
- Ilfenesh Hadera - Angela Reddick
- Michael Cyril Creighton - Jonathan
- André De Shields - Mitchell
- Ross Wellinger - Roger
- Chanel Carroll - Officer Carroll
- Jayson Wesley - Russo
- Randall Marquez - DA Investigator #1
- Odysseus Bailer - DA Investigator #3
- Ed Aristone - DA Investigator #5
- Erick Betancourt - Leo Stutz
- Marcus Giamatti - Gerry Gertz
- Ryan Woodle - Arty Kangiser
- Claudia Logan - K.J.
- Jen Jacob - Amber Zazzarino
- Tom Galantich - Robert Spence
- Caitlin Hammond - Grace Spence
- Justin S Kirkland - Officer Burgess
- Jeffrey Schecter - Michael Davis
- Emerson Brooks - Chuck Phillips
- Jenna Leigh Green - Robin Pruitt
- Alexis Cruz - Mike
- Jared Johnston - Tommy Reinhart
- Biko Eisen-Martin - Maurice Bell
- Marcin Paluch - Todd Berner
- Leo James Davis - Jimmy
- Bernadette Quigley - Cameron Miller
- Bernadette Quigley - Judge Cameron Miller
- Opal Besson - Defense Attorney
- Ronelle Thomas - Wife
- Jennifer Tsay - Heather
- Germaine Brooks - Tweaker
- John Shea - Dr. Kirk Connor
- Jim Bracchitta - IAB Sgt. Carl Bannon
- Ann Harada - IAB Lieutenant Sloan
- Steve Rosen - Lenny Katz
- James Yaegashi - Peter Chou
- Erin Mosher - Joan
- Phuong Kubacki - Layla
- Madeline Grey DeFreece - Officer Grey
- Stacy Keach - Kevin Kearns
- Stacy Keach - Archbishop Kevin Kearns
- Roslyn Ruff - Kimberly Crawford
- Greta Quispe - Margo Ruiz
- Annelise Cepero - Elena Marquez
- Julio Cesar Ruiz - Carlos Sanchez
- Kyndra Sanchez - Soli Ruiz
- Mark McKinnon - Officer Miller
- Mark McKinnon - Cop
- David Kallaway - Newiler
- Maggie Shirk - Doctor
- Mike Funk - John
- Kimberly Stern - Shop Owner
- Candy Santana - Psych Nurse
- Ratnesh Dubey - Store Owner
- Emma Diner - Teen Employee
- Liz Ramos - Barbara
- Pat Kiernan - New Anchor
- Joanne Lamstein - Uniform #2
- Spencer House - Parker Mack
- John Clarence Stewart - Officer Keith Roosevelt
- J. Alphonse Nicholson - Schlenger
- Dan Godlin - Cop #4
- Kisha Barr - Reporter #2
- Kisha Barr - Reporter #4
- Drew Moerlein - Skip Fuller
- Shannon Thornton - Sara
- Christine Jones - Latayna Thomas
- Amelia Rose Blaire - Sarah Grant
- Lucy Martin - Mama Marconi
- Czarina Mada - Uniform
- John Scherer - Sal Marino
- Ian Quinlan - Luis Badillo
- Ian Quinlan - Officer Luis Badillo
- Dario Vazquez - Andre Castillo
- Natalie Buck - Megan
- Natalie Buck - Jack's Assistant Megan
- Patricia DiMango - Judge Hall
- Anais Almonte - Sofia Costillo
- Tim Eliot - Trauma Surgeon
- Tony Crane - Detective Giorgio
- Tony Crane - Detective Hannigan
- Shane Johnson - Dr. Knight
- Stephanie Kurtzuba - Captain McNichols
- Stephanie Kurtzuba - Captain Paula McNichols
- Stephanie Kurtzuba - Sergeant McNichols
- Kim Director - Arriana
- Mick Szal - Milan
- James Hiroyuki Liao - Lt. Fleming
- Morgane Bensadoun - Audrey Knight
- Helena Betancourt - Housekeeper #1
- Nicholas Podany - Officer Mark Cooper
- Steven Maier - Officer Zach Christodoulopoulos
- Lyle Lovett - Major Waylon Gates
- Lyle Lovett - Waylon Gates
- Rob McClure - Teddy Marks
- Celeste Oliva - Detective Maria Reynolds
- Allen McCullough - Alan Josephson
- Kristopher Kling - Brad Haller (as Kris Kling)
- Zach Wegner - James Baxter
- Elan Zafir - Andrew Green
- Jennifer Plotzke - Leslie Prentiss
- Omar Ezat - Hip Jeweler
- Meghann Fahy - Lacey Chambers
- Ralph Rodriguez - Richard Turkel
- Robert Stanton - Connor Kelly
- Corey Knight - Jay
- Isabella Pisacane - Jackie / Morgan
- Dorothy Lyman - Elizabeth
- Richie Allan - Martin
- John Plumpis - Pietr Papatonis
- Michael Jibrin - Lt. Greer
- Zachary Garmers - Protestor 2
- Pascal Arquimedes - Citizen 1
- Miriam Habib - Citizen 2
- Chris Richards - Medical Examiner
- Rachel Resheff - Sarah Longo
- Kumiko Konishi - Diane Jones
- Lateefah Holder - Sharon Martin
- Frank Rodriguez - Andre Lopez
- Mark Green - Officer Anderson
- Mark Green - Officer Anderson (as Mark Christopher Green)
- Gustavo Márquez - Manny Vargas
- Christopher Laing - Panos
- Chip Carriere - Super
- Hal Miers - Officer James
- Michael Oberholtzer - Officer John Hayes
- Alexandra Turshen - Robert Davis
- Kyle Harris - Adam Reynolds
- Kate Miller - Vivian Abetemarco
- Damien Jimenez - Maurice
- Mark Stolzenberg - Stavros
- Leasen Beth Almquist - Waitress
- Desi Waters - Woman
- Darren Valinotti - Boy #2
- Amanda KC - Old Woman
- Marcus R. Smith - Bartender
- Kellan Rhude - Officer Stokes
- Roger Anthony - Tommy Wong
- Đan Nguyên - Gang Member
- Huy Nguyen - Vietnamese Gambler #2
- Barron Leung - Vietnamese Man
- Matthew Piazzi - Malcolm Argus
- Vincent Yacovelli - Mayor Chase's Son (uncredited)
- Erika Slezak - Donna Duvall
- Erin Anderson - Naomi Dixon
- Jim C. Ferris - Carl (as Jim Ferris)
- Justin Rodriguez - Felix
- Austin Elle Fisher - Elyse
- Michael Cash - Colin
- Hunter Thore - Wayne
- Joe Holt - Donald
- David Castro - Louis Edwards
- Kate Boyer - Michele
- Eddie Cahill - Chief Paul Gallagher
- Aizzah Fatima - Liquor Store Clerk
- Paul Gee - Thug #2
- Liam Craig - Director
- McKenna Kerrigan - Chief #2
- Matt Grossman - Uniform
- Anya Krawcheck - Saleswoman
- Alan Chen - Businessman (uncredited)
- David Call - Liam Gill
- Colby Lewis - Eric Hutchins
- Jessica Pimentel - Laura Acosta
- Jeorge Bennett Watson - Saint Nick
- Quincy Giles - Damien Richards
- Daniel Marcus - Dominic
- Danny Marin - College Kid
- Grace Porter - Angela Jackson
- Jaime Zevallos - Gustavo Abreu
- Gene Gabriel - Craig Stutz
- Evgeniya Radilova - Milla
- DazMann Still - Marcus
- Mario Peguero - Desk Sergeant
- Johnath Davis - Tully Richards
- María Álvarez - Maria Abreau
- Brian Colin Foley - Man
- Mather Zickel - Dr. Leonard Walker
- Brian McCormack - Martin Langley
- Blake Roman - Peter
- Marc Reign - Julia Tragadara
- Tara Medina - Nurse
- Judith Franklin - Secretary
- Olivia Koukol - Melanie
- Afsheen Misaghi - Orderly #2
- Alison Fraser - Bobbi Gallo
- Sumaya Bouhbal - Trina
- Erinn Ruth - Janet Bullock
- Travis Doughty - Officer Rouse
- T.L. Flint - Jayden Wilson
- Jacob Augustin - Daquan (as Jacob Alexander Augustin)
- Delphi Harrington - Emily
- Jerii Aquino - EMT
- Jerii Aquino - Paramedic
- Crede Cooper - Mikey
- Samantha Blain - Officer Zaccaro
- Donna Glaesener - Serg. Bellows
- Maddie Dyer - Sarah
- Nili Bassman - Susan
- Annie Pisapia - Dinner Patron
- Laiona Michelle - Naomi
- Nicole Shalhoub - Lisa Reynolds
- Imani Lewis - Shayla Alexander
- Gabe Bowling - Det. Paul Franklin
- Erick McAllister - Agent Martin
- Rob Figueroa - Agent Sanchez
- Helen Coxe - Det. Jane Ricci
- Tyler Brooks - Scott Taylor
- Thomas Michael Allen - Dave Duggan
- Kaitlyn Frank - Officer #1
- Christopher Alexander Chukwueke - Reporter #2
- Sofia Vassilieva - Officer Carlie Gillson
- Alysha Umphress - Tracy
- Winslow Bright - Sydney Sloan
- Michael Aurelio - Mauricio
- Sam Wolf - Officer Justin
- Stephanie Rocio - Officer Lacks
- Keith Contreras - Officer Martinez
- Ashlee Jimenez - Shivering Witness
- Francesca Shipsey - Officer Ross
- Erin Noel Grennan - Lorraine Duckworth
- Savannah DesOrmeaux - Process Server
- Carlos Gómez - Diego 'El Granjero' Rodriguez
- Carlos Gómez - Diego Rodriguez
- Gianmarco Soresi - Reporter #1
- Daniel Morgan Shelley - Uniform #1
- Eric Arriola - Gangbanger #2
- Matt Raimo - Actor
- Peter Conboy - New York City Police Officer
- Atif Lanier - Football Player
- Dre Davis - Diane Tobin
- Marguerite Stimpson - Emily Mathews
- Matthew Daddario - John DiPierro
- Gabriella Piazza - Francesca DiPierro
- Bo Dietl - Carmine Romano
- Roya Shanks - Melissa Phillips
- Larry Manetti - Sam Velucci
- Kristen Martin - Officer Cassandra
- Daniela Dakich - Mayor's Aid (uncredited)
- Lexi Lawson - Dana Carter
- Terrence Shingler - Moses
- Marcus Anderson - Freddie James
- Olivia Nicole Hoffman - Amanda Oliver
- Amber Reauchean Williams - Female Clerk
- Tyerise Foreman - Federal Prison Guard
- Cristian Castro - Javier
- Dion Costelloe - Erik Rys
- David R. Nash - Sam Evans
- Ruth Gottschall - Ms. Evans
- David Wenzel - Heavy #2
- Hayden Choate - Gustave
- Shyrley Rodriguez - Louise Johnson
- dL Sams - Radio Show Host
- Benjamin Thys - Doctor Jeremy Stevens
- Ben Rameaka - Defense Attorney
- Lamar Richardson - Reporter #6
- Suzanne Shepherd - Lucille Abetemarco
- Daniel Abeles - Officer Richard Clark
- Snoop - Roxy Barnes
- Malachi Omega - Terrell Spaulding
- Nafeesa Monroe - Bank Manager
- Sean Crespo - Larry Hale
- Michael Barra - Dominick Barbosa
- Chris Lanceley - Guy
- Hannah McKechnie - Waitress
- Sebastian Coates - Jack's Friend
- Mike Whaley - Cop
- Gianpaolo Venuta - Jared
- Christine Wright - Paramedic
- Jason Furlani - Uniform
- Jay Schmidt - Liquor Store Employee
- Joseph Barbara - Chris Kelly
- Charles Mesure - Garda Commissioner Farrelly
- Aaron Abrams - Hader
- Igby Rigney - Evan Scott
- Teresa Avia Lim - Leslie Chang
- Nicolette Pierini - Penelope Drake
- Max Malas - Brendan Todd
- Miriam Cruz - Grandmother
- Austin Green - Elyse's Dad
- Tabatha Gayle - Audrey's Friend
- Phyllis Somerville - Beth Del Rio
- Yohance Myles - Lee Baldokoski
- Tina Benko - Lauren Vickers
- John Enos III - Jimmy Vitale
- Kevin T. Collins - Sully
- Annunziata Gianzero - Maria
- Ben Getz - Reynaldo
- Diane Cossa - Mother
- Jorge Vega - Little Kid
- Steven DeMarco - Long-Haired Biker
- Coy DeLuca - Biker (uncredited)
- David Shumbris - John Johanssen (uncredited)
- Michael Nouri - Nick Constantine
- Bonnie Root - Kathy Elliot
- Kecia Lewis - Sandi Harper
- Jonathan Walker - Jeffrey Durning
- Audrie Neenan - Imelda
- Vince Gatton - Podcast Engineer
- Joseph D Fisher - Undercover Detective (uncredited)
Stacy Keach interpreta a Archbishop Kevin Kearns en la serie.
C. Thomas Howell hace el papel de Alex Polanski.
Paul Calderon hace el papel de Lieutenant Perez.
Whoopi Goldberg hace el papel de Regina Thomas.
Kim Roberts interpreta a Judge Waters en la serie.
Susan Blommaert interpreta a Polly Riley en la serie.
Franky G hace el papel de Sgt. Russell.
Blanchard Ryan interpreta a Female Reporter en la serie.
Mary Elizabeth Mastrantonio hace el papel de Sophia Lanza.
Karen Allen hace el papel de Betty Lowe.
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