- Jeffrey Dean Morgan - JD Richter
- Sydelle Noel - Deputy
- Kirk B.R. Woller - Sheriff
- Jeff Schine - Ray
- Sam Golzari - Danny
- Joshua Malina - Dr. Gavin Beck
- Jonathan Palmer - Dr. Calder
- Anne Ramsay - Laurie Vinson
- Tami Roman - Cass Hendy
- Arlen Escarpeta - Tim Dawkins
- Lee Garlington - Principal
- Jimmy Jean-Louis - Pierre Lyon
- Larisa Oleynik - Phillips
- Fred Maske - Griggs
- Lynette DuPree - Landlady
- John Billingsley - Dr.Mize
- Vivan Dugré - Journaliste
- Elaine Ann Hu - Valerie
- Shelley Robertson - Frankie
- Rick Kelly - Segers
- Kenzo Lee - Tech
- Christine Donlon - Karen
- Max Page - Andrew
- Paris Benjamin - Kryger's Mother
- Jonathan Craig Williams - Bill Hendy
- Alisha Boe - Brynn Hendy
- Yaani King Mondschein - Mom
- Scott Beehner - Rob
- Lila Dupree - Lena
- Olivia Sanabia - Becca
- Andrew Kirsanov - Sergei
- Kevin Ryan - Balloon Vendor
- Kevin Ryan - Man with Phone
- Costa Ronin - Anton
- Ryan Carlberg - Billy
- Barry Wiggins - ISEA Security Guard
- Tommy Dickie - Underling
- Eric Pumphrey - Russel
- Eme Ikwuakor - Black Ops Commander
- Phillip DeVona - Luther
- Ross Mackenzie - Dr. Henry Meehan
- JoBeth Williams - Leigh Kern
- Tessa Ferrer - Katie Sparks
- Doug Simpson - Chief Tech Davis
- Brad Beyer - Harmon Kryger
- Adam O'Byrne - Ryan Jackson
- Annie Wersching - Femi Dodd
- Stacie Greenwell - Mrs Kent
- Stacie Greenwell - Woman
- Esther Scott - Esther Wimberley
- Owain Yeoman - Dr. Mason
- Jeannetta Arnette - Anya Sparks
- Enver Gjokaj - Sean Glass
- Charlie Bewley - Odin James
- Rocco Vienhage - Derek Pearce
- Nazanin Nour - Camera Tech
- McKenna Kerrigan - Revive Team Leader
- Kathryn Zenna - Board Member
- Billy Malone - Police Officer
- Aline Elasmar - Tech
- Stephen Anthony Bailey - Tech
- Keegan Boos - Boy
- Lisa Yamada - Japanese Girl
- Megan Uesugi - Japanese Girl
- Michael Dempsey - Sheriff Dugan
- Deborah Puette - Deputy Nancy Bench
- David Moses - Earl Wimberley
- Carl Ciarfalio - Service Truck Driver
- Michael Broderick - Yasumoto Tower Security Guard
- Shree Crooks - Young Katie Sparks
- Teresa Huang - EMT
- Eijiro Ozaki - Chief Scientist
- Yamil Urena - Operative Sanders
- Gabrielle Conforti - Waitress
- Reginald James - Security Guard
- Cheyenne Nguyen - Little Girl
- Danny Vasquez - Operative
- Lynnanne Zager - G.I.N.A. (voice)
- Lynnanne Zager - G.I.N.A.
- Casey Adams - Operative
- Jerry T. Adams - Operative
- Eric Martsolf - B.E.N. (voice)
- Nicolas Pajon - Mattieu
- Sumiko Braun - ISEA Security Guard
- Anthony M. Bertram - Man
- Anthony M. Bertram - Ed Kent
- Barry Shabaka Henley - Senator Gabel
- Christina Chang - Dr. Dowling
- Omar Gooding - Dave
- Jamila Webb - Nurse Aziza
- Edgar Blackmon - Lab Assistant
- Ryan Deal - Lead Marshal
- Eileen Fogarty - Reporter
- Kristina Jimenez - Bar Woman
- Greg Vaughan - Man
- Seril James - Aide
- Brian Oblak - Security Chief Norwak
- Brian Oblak - Nowak
- Alexandra Breckenridge - Zoe Grant
- David Clayton Rogers - Mike Grant
- Leslie Thurston - Attendant
- Craig Tsuyumine - Virtual Doctor
- Shannon Merrill Brown - Offspring
- Candace Kozak - Oya
- Jo McGinley - Landlady
- Brody Nicholas Lee - Teenage Offspring
- Kurt Ela - Coroner
- James Earl - Coroner
- Roy Werner - Top Dog
- Adam Zastrow - Drug Dealer
- Joey Abril - Nose Ring
- Mary Gallagher - Pregnant Woman
- Henderson Wade - Adhu
- Henderson Wade - Offspring
- Billy 'Sly' Williams - Klebald
- Jennifer Say Gan - Nurse
- Joe Sabatino - Building Inspector
- Chris Johnen - GSC Security Guard
- Michael Spellman - Husband
- Tehmina Sunny - Iris
- Asher Deva - Josiah
- James Ferris - Roughneck
- Necar Zadegan - Velez
- Necar Zadegan - Shayna Velez
- Aria Lyric Leabu - Toby's Niece
- Kim Rhodes - Nicole
- Hilarie Burton - Anna Schaefer
- Steven Allerick - Tech
- Steven Allerick - GSC Tech
- McKenna Roberts - Terra
- Matt Malloy - Rogers
- Mark Adair-Rios - GSC Tech
- Mark Adair-Rios - Tech
- Melissa Tang - Mei Fong
- Duncan Bravo - Government Official
- Leyna Nguyen - Reporter
- Jason Wesley - Hybrid
- Louis Gossett Jr. - Quinn
- Christopher Allen - GSC Security Guard
- Sara Amini - Humanich Tech
- Bryan Krasner - GSC Security Guard
- Jack Guzman - Carnival Security Guard
- Scott Vance - Carny
- Evan Olman - Tommy
- Cassidey Fralin - Nine-Year Old Molly
- David Morrissey - Tobias Shepherd
- Michael Gladis - Nate Malone
- Genneya Walton - Terra
- Genneya Walton - Teenage Terra
- Bianca Lopez - Fiona's Aide
- Aaron Scotti - Edward
- Carly Steel - News Reporter
- Keith David - Nicholas Calderon
- Briana Lane - Corrine
- Lyndon Smith - Kelsey Richter
- Patrick Johnson - Lucas
- Jessica Borden - Barista
- David Douglas - Vendor
- Robert Loftin - Customer
- Glen Mac - Euclid Security
- Jimmy Chhiu - Humanich Soldier
- Rushi Kota - Humanich Tech
- Jerry Wolf - Humanich Sentry
- Kiersey Clemons - Lucy
- Kate Burton - Fiona Stanton
- Richard T. Jones - JD's Friend
- Melina Kanakaredes - Dorothy
- Cleo Anthony - Ares
- Craig Shapiro
- Darryl Frank
- Justin Falvey
- Brooklyn Weaver
- Steven Spielberg
- Halle Berry
Jeannetta Arnette interpreta a Anya Sparks en la serie.
Mark Adair-Rios interpreta a GSC Tech en la serie.
Halle Berry interpreta a Molly Woods en la serie.
Pierce Gagnon hace el papel de Ethan Woods.
Grace Gummer interpreta a Julie Gelineau en la serie.
Tyler Hilton hace el papel de Charlie Arthurs.
Jeffrey Dean Morgan hace el papel de JD Richter.
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