- Angela Paton - Mrs. Lukesh
- Rubén Blades - Conrad Lozano
- Willie Garson - Quinton 'Roach' Freely
- Adam Baldwin - Knowle Rohrer
- Jodie Foster - 'Betty' (voice)
- Peter Boyle - Clyde Bruckman
- Deep Roy - Beggar Man
- Harriet Sansom Harris - Dr. Sally Kendrick / Eve 6
- Callum Keith Rennie - Cemetery Groundskeeper
- George Murdock - Elder #2
- Holmes Osborne - Mark Johnson
- Lili Taylor - Marty Glenn
- Guy Torry - Shorty
- Kathy Griffin - Betty Templeton / Lulu Pfeiffer
- Kurtwood Smith - Agent Bill Patterson
- Téa Leoni - Dana Scully / Tea Leoni
- M. Emmet Walsh - Arthur Dales
- William Sanderson - Edward Funsch
- John Diehl - Wilson Pinker Rawls
- Bruce A. Young - Pierre Beauvais
- Jesse Ventura - Man in Black #1
- Cary Elwes - Brad Follmer
- Michael Emerson - Oliver Martin
- Benito Martinez - Orderly
- Brad Dourif - Luther Lee Boggs
- Shawnee Smith - Jessie O'Neil
- Vincent Schiavelli - Lanny
- Tobin Bell - Ashman / Darryl Weaver
- Dick Anthony Williams - Agent Reggie Purdue
- O-Lan Jones - Nurse Rebecca Waite
- Susan Blommaert - Phyllis Paddock
- Adam Nelson - Mr. Van De Kamp / Husband
- Pruitt Taylor Vince - Gerry Schnauz
- Frances Fisher - Lizzy Gill
- Kim Greist - Lisa Underwood
- Dylan Kussman - Med Student
- Joe Morton - Martin Wells
- Lucy Liu - Kim Hsin
- Harris Yulin - Cardinal O'Fallon
- Diana Scarwid - Linda Bowman
- Xander Berkeley - Dr. Hodge
- Nora Dunn - JoAnne Fletcher
- Christopher Wynne - Base Cop
- Lance Henriksen - Frank Black
- Neal McDonough - Robert Comer
- Tony Shalhoub - Dr. Chester Ray Banton
- Brian Thompson - Alien Bounty Hunter
- Robert Patrick - John Doggett
- Leland Orser - Jason Ludwig
- Isaac C. Singleton Jr. - 1st Roughneck
- Martin Ferrero - Shooter
- Michael Bowen - Dwight Cooper
- Brian Reddy - Big Fritz
- Wayne Duvall - Agent Jerry Lamana
- Greg Ellis - 3rd British Crewman
- Ray McKinnon - Mad Wayne
- Daniel von Bargen - Jacob Steven Haley
- James Remar - Josef Kobold
- William O'Leary - Gas Station Man
- Eric Keenleyside - Lance Kernof
- Denise Crosby - Dr. Mary Speake
- Rick Marzan - Holding Cell Officer
- Mark Pellegrino - Derwood Spinks
- Marshall Bell - Colonel Calvin Henderson
- Stephen McHattie - Red-Haired Man
- Giovanni Ribisi - Darin Peter Oswald
- Charles Martin Smith - Dr. Osbourne
- Dan Shor - 2nd ER Nurse
- Billy Drago - Orel Peattie
- David James Lewis - Young Agent
- Glen Morgan
- Rick Millikan
- Chris Carter
- Mark Snow
Angela Paton hace el papel de Mrs. Lukesh.
Rubén Blades hace el papel de Conrad Lozano.
Willie Garson interpreta a Quinton 'Roach' Freely en la serie.
Adam Baldwin interpreta a Knowle Rohrer en la serie.
Jodie Foster interpreta a 'Betty' (voice) en la serie.
Peter Boyle hace el papel de Clyde Bruckman.
Deep Roy interpreta a Beggar Man en la serie.
Harriet Sansom Harris interpreta a Dr. Sally Kendrick / Eve 6 en la serie.
Callum Keith Rennie interpreta a Cemetery Groundskeeper en la serie.
George Murdock interpreta a Elder #2 en la serie.
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