- Bradley Whitford - Daniel Trepkos
- Doug Hutchison - Eugene Victor Tooms
- Dan Butler - Jim Ausbury
- Jayne Atkinson - Willa Ambrose
- Steve Railsback - Duane Barry
- Harriet Sansom Harris - Dr. Sally Kendrick / Eve 6
- Matthew Bennett - First Workman
- Carl Lumbly - Marcus Duff
- Raymond Cruz - Eladio Buente
- Peter Boyle - Clyde Bruckman
- Paul McCrane - Leonard Morris Betts
- Luke Wilson - Sheriff Hartwell
- Tony Shalhoub - Dr. Chester Ray Banton
- Pruitt Taylor Vince - Gerry Schnauz
- Jed Rees - Lucas Menand
- Michael O'Neill - Patrol Captain Van Gelder
- Scott Hylands - Gen. Benjamin Bloch
- Nick Tate - Dr. Eugene Openshaw
- John O'Hurley - Dr. Pollidori
- Marnie McPhail - Cami Schroeder
- Charles Nelson Reilly - Jose Chung
- Lucy Liu - Kim Hsin
- Lili Taylor - Marty Glenn
- Dirk Blocker - Mayor Gilmore
- Bruce Campbell - Wayne Weinsider
- Lily Tomlin - Lydia
- Melinda Culea - Karin Berquist
- Joel McKinnon Miller - Deputy Greer
- John Hawkes - Phillip Padgett
- Diana Scarwid - Linda Bowman
- Kristin Lehman - Esther Nairn / Invisigoth
- Guy Torry - Shorty
- Nick Chinlund - Donald Addie Pfaster
- Jodie Foster - 'Betty' (voice)
- Richard Belzer - John Munch
- John Towey - Dr. Kenneth Orgel
- Roy Thinnes - Jeremiah Smith
- Amanda Tapping - Carina Sayles
- Richard Beymer - Dr. Jack Franklin
- Fritz Weaver - Senator Albert Sorenson
- David Denman - Wallace Schiff
- Cary Elwes - Brad Follmer
- Richard Ruccolo - Agent Peyton Ritter
- W. Earl Brown - Robert M. Fassl
- Tuesday Knight - Jackie Gurwitch
- Channon Roe - Derek Banks
- Sydney Lassick - Chuck Forsch
- Anthony Rapp - Jeff Glaser
- Joe Spano - Mike Millar
- Darren E. Burrows - Bernard
- Dick Anthony Williams - Agent Reggie Purdue
- Ed Lauter - Col. Marcus Aurelius Belt
- William Sanderson - Edward Funsch
- Noel Gugliemi - Gangbanger #1
- Carrie Snodgress - Darlene Morris
- Xander Berkeley - Dr. Hodge
- Maggie Wheeler - Det. Sharon Lazard
- Alyson Reed - Maggie Lupone
- Titus Welliver - Doug Spinney
- Perrey Reeves - Kristen Kilar
- Judith Hoag - Dr. Mindy Rinehart
- Brent Hinkley - Brother Andrew
- Brittany Tiplady - Jordan Black
- Stacy Haiduk - Margaret 'Maggie' Waterston
- Bobbie Phillips - Dr. Bambi Berenbaum
- Frederick Coffin - Chief Joseph McGrath
- Judson Mills - Deputy Keith Wetzel
- Christopher Allport - Agent Jack Willis
- R. D. Call - Sheriff Maurice Daniels
- Teryl Rothery - Michelle Charters
- Michael Bower - Lo-Fat
- Dan Shor - 2nd ER Nurse
- Jewel Staite - Amy Jacobs
- Brad Dourif - Luther Lee Boggs
- Ashley Edner - Michelle Crittendon
- Branden Williams - Bill / Cap'n Dare
- Billy Drago - Orel Peattie
- Gavin Fink - Tommy Conlon
- Kathy Griffin - Betty Templeton / Lulu Pfeiffer
- Wayne Federman - Wayne Federman
- Zuleikha Robinson - Yves Adele Harlow / Lois Runce
- James Remar - Josef Kobold
- Emilio Rivera - Brigham
- Rodney Scott - Tony Reed
- Michael Welch - Trevor
- Michael McKean - Morris Fletcher
- Jennifer Hammon - ICU Nurse
- Lee Reherman - Yuri Volkoff
- Tobin Bell - Ashman / Darryl Weaver
- Robert LaSardo - Cissy Alvarez
- David Faustino - Michael Daley
- Will Sasso - Leslie Stokes
- John Finn - Michael Kritschgau
- Don Swayze - Terry Pruit
- Lawrence Pressman - Mr. Milsap
- Anthony Heald - Harold Piller
- Colton James - Josh Underwood
- Ken Jenkins - Deputy Chief Karras
- Arye Gross - Dr. Tom Puvogel
- Natalie Radford - Marie Hangemuhl
- Ellen Greene - Vicki Louise Burdick
- Randy Oglesby - Reverend Samuel Mackey
- Gene Dynarski - Ernie Stefaniuk
- Alex Trebek - Man in Black #2
- James Hong - Hard-Faced Man
- Michael Cram - Officer Corning
- Mark Holden - Agent Eugene Chandler
- Joseph Fuqua - Jason Nichols
- Stuart Charno - The Puppet
- Donna White - Therapist
- Jennifer Hetrick - Sharon Skinner
- O-Lan Jones - Nurse Rebecca Waite
- Rubén Blades - Conrad Lozano
- Michael Bailey Smith - Guard
- Ted Cole - 2nd Paramedic
- Tuan Tran - Fong
- Catherine Dent - June Gurwich
- Ricky Jay - The Amazing Maleeni / Herman Pinchbeck / Albert Pinchbeck
- Ed Asner - Maurice
- Cynthia Martells - District Attorney Carter
- Brent Butt - Coroner
- Carrie Hamilton - Pam
- Tucker Smallwood - Sheriff Andy Taylor
- Daniel von Bargen - Jacob Steven Haley
- Junior Brown - Virgil Nokes
- Signy Coleman - Susanne Modeski
- John Billingsley - Timothy 'Timmy the Geek' Landau
- Clayton Rohner - Daryl Mootz
- Tom Virtue - Dave Kline
- Rodney Rowland - Edward Jerse
- Geoffrey Lewis - Alfred Fellig
- Jesse L. Martin - Josh Exley
- David Groh - Jacob Weiss
- Eric Keenleyside - Lance Kernof
- Bruce Weitz - Agent Bocks
- Ernie Prentice - Leo Kreutzer
- Ernie Banks - Maurice
- Donal Logue - Agent Tom Colton
- Susanna Thompson - Michelle Generoo
- Felicity Huffman - Dr. Nancy Da Silva
- William O'Leary - Gas Station Man
- Giovanni Ribisi - Darin Peter Oswald
- Michael Horse - Sheriff Charles Tskany
- Morgan Woodward - Old Harry Cokely
- Harris Yulin - Cardinal O'Fallon
- Daniel Benzali - Colonel Wharton
- Jason Beghe - Larry Moore
- Alan Boyce - Young John Barnett
- John Cygan - Sheriff Spencer
- Jason Schombing - Dupre
- Allison Smith - Patti
- Constance Zimmer - Phoebe
- Chad Donella - Robert 'Rob' Roberts
- Scott Bairstow - Samuel Hartley
- Barry Primus - Robert Dorlund
- Amanda Pays - Phoebe Green
- Cliff DeYoung - Dr. Jay Nemman
- Kim Greist - Lisa Underwood
- Zach Grenier - Dr. Herman Stites
- Dan Desmond - Harry Odell
- Lisa Darr - Attorney Jana Fain
- Tracy Middendorf - Gracie O'Connor
- Nicki Aycox - Chastity Raines
- Ramón Franco - Nestor
- Brian Poth - Gabe Rotter
- Caroline Lagerfelt - Rustic Woman
- Jim Hanna - Koko's Manager
- George D. Wallace - Bertram Mueller
- Wendy Schaal - Martha Crittendon
- Andi Chapman - Dr. Monique Sampson
- John Aylward - Dr. John Rietz
- James Franco - Officer #2
- Casey Biggs - Saksa
- Kevin Weisman - Anson Stokes
- James Morrison - Dr. Robert Wieder
- Penny Johnson Jerald - Dr. Hellura Lyle
- Tara Karsian - Coroner's Assistant
- William Devane - General Mark Suveg
- Dennis Boutsikaris - Dr. Peter Voss
- Colby French - Deputy
- Erick Avari - Dr. Herb Fountain
- Caitlin Fein - Mia Dukes
- John Kapelos - Special Agent Fordyce
- Zeljko Ivanek - Roland Fuller / Dr. Arthur Grable
- Leland Orser - Jason Ludwig
- Thomas Kopache - General Thomas Callahan
- Stefan Arngrim - Prisoner
- Steven M. Porter - Harold Spuller
- Diana Maria Riva - Angela Villareal
- Jolie Jenkins - FBI Agent Leyla Harrison
- Veronica Cartwright - Cassandra Spender
- Dana Lee - Yee
- Bryan Cranston - Patrick Crump
- Zakes Mokae - Diabria
- Christine Cavanaugh - Amanda Nelligan
- Carolyn Tweedle - Jane Froelich
- Paul Willson - Ted
- Michael Milhoan - Dep. Arky Stevens
- C. Ernst Harth - Huge Man
- Jillian Bach - Maggie
- Scott Wilson - Rev. Orison
- Nicholas Worth - Mr. Haas
- Victoria Jackson - Sheila Fontaine
- Abraham Benrubi - Big Mike Raskin
- Sharon Alexander - Mary Lefante
- Katharine Isabelle - Lisa Baiocchi
- Patti Allan - Mrs. Kernoff
- Jenny Gago - Dr. Katrina Cabrera
- Patrick Renna - Ronnie Strickland
- Michael Fairman - Older Jason Nichols
- Frank Novak - Raybert Fellowes
- BD Wong - Det. Glen Chao
- Neil Denis - Catcher
- Andrew Arlie - Attorney
- Tyler Binkley - Terry Fletcher
- Lucy Lawless - Shannon McMahon
- Michael Bryan French - Paul Mossinger
- Justina Vail Evans - The Unholy Spirit
- Lombardo Boyar - Deputy Juan Molina
- Megan Leitch - Samantha Mulder
- Bellamy Young - Attorney Janet Wilson
- Sage Allen - Landlady
- Mike Gomez - Jorge Concepcion
- Dan Lett - Sir Malcolm Marsden
- Marshall Bell - Colonel Calvin Henderson
- Ty Miller - Lyle Parker
- Andrea Libman - Michelle Bishop
- David Ross Paterson - John Barnett (uncredited)
- Cec Verrell - Lula Phillips
- Rob LaBelle - Brad Wilczek
- Mitch Pileggi - Walter Skinner
- Mitch Pileggi - Walter Skinner / SS Sturmbannfuehrer
- Michelle Joyner - Ellen Adderly
- George Gerdes - Reverend Calvin Hartley
- Bruce A. Young - Pierre Beauvais
- Dana Wheeler-Nicholson - Det. Angela White
- Steve Hytner - Dr. Denny Murphy
- Dan Leegant - Myron Stefaniuk
- Mark Acheson - Ted Bertram
- Wade Williams - Ray Pearce
- Michael Childers - Reverend Enoch O'Connor
- Danielle Savre - Marcia Brady
- Karl T. Wright - First Associate
- M.C. Gainey - Bo Taylor
- Maggie Baird - Sharon Pearl
- Mimi Paley - Young Samantha
- Rusty Schwimmer - Driver
- Richard Cox - Daniel Brimley
- Sarah Benoit - Evelyn Mountjoy
- Burt Reynolds - Mr. Burt
- Octavia Spencer - Nurse
- Mark Pellegrino - Derwood Spinks
- Raye Birk - Dr. Jeff Eckerle
- Sarah Koskoff - Theresa Nemman
- Judith Scott - Dr. Kai Bowe
- Gil Colon - Agent Rice
- Gene LeBell - Bartender
- Jordan Warkol - Quinton
- Samaire Armstrong - Natalie Gordon
- Ann Dowd - Mrs. Reed
- Kellie Waymire - Tammi Peyton
- Aaron D. Spears - Guard
- Elayn J. Taylor - Nurse #2
- Frank Roman - Domingo Salmeron
- Cyril O'Reilly - Ed Kelso
- Steven Flynn - Man on the Street
- Scott Paulin - Jeffrey Conlon
- Annie Abbott - Older Social Worker
- Ashlyn Gere - Bonnie McRoberts
- Susan Blommaert - Phyllis Paddock
- Paul Sand - Gird Thomas
- Lance Guest - Kyle Lang
- Michael Kopsa - Rick Culver
- Jennifer Clement - Michele Wilkes
- Tom O'Brien - Sgt. Louis Frisch
- Don Stewart - Businessman (uncredited)
- Scott Heindl - Boyfriend
- John Diehl - Wilson Pinker Rawls
- Jeremy Roberts - George Vincent
- Grace Phillips - Betsy Monroe
- Leon Russom - Detective Miles
- Debra Christofferson - Pat Verlander
- Mike Nussbaum - Dr. Charles Goldstein
- Susannah Hoffmann - Melissa Turner
- Darren McGavin - Agent Arthur Dales
- David Manis - Holman Hardt
- Yau-Gene Chan - Woo
- Scott Burkholder - Agent Kinsley
- Caroline Kava - Doris Kearns
- William Lucking - Roky Crikenson
- John Juliani - Dr. Harrison Lloyd
- Jody Racicot - Father Gregory
- Nestor Serrano - Ken Naciamento
- Carly McKillip - Caitlin Ross
- Scott Bellis - Max Fenig
- Sam Anderson - Leamus
- Suanne Spoke - Woman Customer
- Kenneth Tigar - Dr. Plant
- Dey Young - Judy Bishop
- Tony Longo - Dominic
- Dennis Lipscomb - Leonard Vance
- Tom Dahlgren - Dr. Irving Thalbro
- Duncan Fraser - Beatty
- Claire Stansfield - The Jersey Devil
- Terry David Mulligan - Mission Controller
- Bradford English - Detective Abbott
- Michael Chieffo - Carl Wade
- Joy Coghill - Linda Thibedeaux
- Rodney Eastman - Ronald Purnell
- Eric Christmas - Stan Phillips
- Paul Ben-Victor - Dr. Aaron Monte
- Peter Stebbings - Marty (Male)
- Wendy Benson-Landes - Margi Kleinjan
- Graham Jarvis - NIH Doctor
- Gina Mastrogiacomo - Jenny Uphouse
- Deanna Milligan - Satin
- Jeff Kober - Bear
- Kathryn Joosten - Agent Edie Boal
- Michael Bowen - Dwight Cooper
- Chris Ellis - Sheriff Lance Hindt
- Maura Soden - Trevor's Mother
- Adam Nelson - Mr. Van De Kamp / Husband
- Scott Cooper - Max Harden
- Arthur Rosenberg - Lead Counsel
- Jay Underwood - Jeb Dukes
- Randall "Tex" Cobb - Bert Zupanic
- Mary Kathleen Gordon - Woman
- Tim Halligan - Darren Mountjoy
- Robert Curtis Brown - Assistant D.A. Damon Kaylor
- Steve Ryan - Sheriff Jack Coogan
- Conor O'Farrell - Sheriff Ciolino
- Danny Trejo - Cesar Ocampo
- Krista Allen - Jade Blue Afterglow / Maitreya
- Stan Shaw - Stephen Murdoch
- Bill Lee Brown - Mr. Rice
- Minnie Driver - Cinema Audience (uncredited)
- Jennifer Parsons - Nora Pearce
- Aaron Paul - David 'Sky Commander Winky' Winkle
- Michael Emerson - Oliver Martin
- Holmes Osborne - Mark Johnson
- Rene Rivera - First Cop
- Jim Maniaci - Bullethead #1
- Eric Nenninger - Jared Chirp
- Judson Scott - Absalom
- Angela Paton - Mrs. Lukesh
- Shawnee Smith - Jessie O'Neil
- Janyse Jaud - Nurse (uncredited)
- Igor Morozov - Pudovkin
- David Lovgren - Kurt Crawford
- Lillian Hurst - Flakita
- Jesse Ventura - Man in Black #1
- Michael Yama - Hsin
- Monique Edwards - Head Teller
- Byrne Piven - Robert Sparks
- Lisa Jane Persky - Laura Weinsider
- James M. Connor - Jake Conroy
- Charles Martin Smith - Dr. Osbourne
- Jonathan Walker - Chuck Lukerman
- James Sutorius - Babcock
- Tom Gallop - Win Shroeder
- Nancy J. Lilley - Liposuction Patient (uncredited)
- Brian Leckner - Hayes Michel
- Richard Fitzpatrick - Charles Wesley Gotts
- Frankie Ingrassia - Cindy Culpepper
- Steve Rankin - U.S. Marshal Daddo
- Michael Ensign - Dr. Barnes
- Robyn Lively - Angela Schiff
- CCH Pounder - Agent Lucy Kazdin
- Douglas Smith - Pitcher
- Lucia Walters - EMT (uncredited)
- Nancy Fish - Nurse Innes
- Brian Thompson - Alien Bounty Hunter
- Emily Perkins - Dara Kernoff / Paula Koklos / Roberta Dyer
- Michael B. Silver - Howard Grodin
- Silas Weir Mitchell - Dougie
- Bokeem Woodbine - Sammom Roque
- Kevin Zegers - Kevin Kryder
- Jamil Walker Smith - Chester Bonaparte
- Anne DeSalvo - Dr. Anne Carpenter
- Ken Kirzinger - Richter
- F. William Parker - Dr. Blankenship
- Beth Grant - Iris Finster
- David Barry Gray - Hank Gulatarski
- Tyronne L'Hirondelle - Databank Scientist
- Frances Bay - Dorothy
- Seth Green - Emil
- Paula Sorge - Jenn
- Tom O'Rourke - Steve Humphreys
- Jimmy Herman - Ish
- Jim Rose - Dr. Blockhead
- Deborah Strang - Inspector B.J. Morrow
- Garry Shandling - Fox Mulder / Garry Shandling
- Tim Progosh - Mr. Fiebling
- Tamara Clatterbuck - Larina Jackson
- Vyto Ruginis - Lt. Bianco
- Jane Lynch - Mrs. Anne T. Lokensgard
- Frances Fisher - Lizzy Gill
- Lance Henriksen - Frank Black
- Tom Bower - Sheriff Harden
- Deep Roy - Beggar Man
- Ming Lo - Dr. Kim
- Jack McGee - Bob Danfous
- Eve Brenner - Mrs. McKesson
- Bruce Wright - Gary Garber
- Keith Szarabajka - Anthony Tipet
- Patrick Kilpatrick - Randall Cooper
- Erich Anderson - Doug Underwood
- Dee Freeman - Sgt. Paula Duthie
- Kate McNeil - Nan Wieder
- Lou Richards - Officer Custer
- Zitto Kazann - Caballero
- Nicolas Surovy - Dr. Daniel Waterston
- Joe Morton - Martin Wells
- Lois Foraker - Sylvia Jassy
- Zachary Ansley - Billy Miles
- Miguel Sandoval - Martin Ortega
- Diana Stevan - Mrs. Adams
- Steve Eastin - Sheriff Mazeroski
- Jose Yenque - Soledad Buente
- Rita Bozi - Ms. Vansen (uncredited)
- Chad Lindberg - Bobby Rich
- Garret Dillahunt - Edward Skur
- Rick Cramer - Guard
- George Murdock - Elder #2
- Valente Rodriguez - Walter Suarez
- Jim Beaver - Coroner
- Lisa Picotte - Stacey Muir
- Jeffrey Schoeny - Trevor
- Juliana Donald - Nancy Kline
- Judith Maxie - Mrs. Barbara Taylor
- Celine Lockhart - The Skin-Peel Patient (uncredited)
- Danny Kamin - Detective Hudak
- Henri Lubatti - Dr. Wilkenson
- Lenora May - Ms. Britton
- Lorraine Landry - Pathologist Vicki Belon
- Marjorie Lovett - Elaine Tanner
- Jason Gaffney - Harold Lamb
- Nora Dunn - JoAnne Fletcher
- Al Ruscio - Elder #4
- M. Emmet Walsh - Arthur Dales
- Stephen Mendel - Dark Suited Man #2
- Frank Cassini - Detective Cline
- Simon Longmore - Marty Fox
- Marion Killinger - Detective (uncredited)
- Jack Blessing - Dr. Jack Preijers
- Todd Jeffries - Lead Agent Mayfield
- Richard Sali - Leon Felder
- David Hay - Clean Suited Man
- Brian George - Project Doctor
- Ramy Zada - Joe Cutrona
- Chad Willett - Jim Summers
- Laurie Paton - Mrs. Marsden
- Marilyn McIntyre - Widow
- Wayne Grace - Sheriff Hamilton
- Sab Shimono - Gung Bituen
- Carol Banker - Carol
- Janet Hodgkinson - Waitress
- Rick Marzan - Holding Cell Officer
- Tony Ketcham - Gary Sacks
- Michael Shamus Wiles - Black-Haired Man
- Stephen Snedden - Jimmy Bond
- Patience Cleveland - Arbutus Ray
- Shannon O'Hurley - Anne Voss
- Cara Jedell - Lucy Wieder
- Spencer Garrett - Harry Bring
- Gregory Cruz - Diego Garza
- Hank Harris - Dylan Lokensgard
- Clement Blake - Holy Spirit Man #2
- Ray McKinnon - Mad Wayne
- Art Evans - Argyle Saperstein
- Conrad Roberts - Primitive African Man
- Kenneth Meseroll - Owen Harris
- Troy Mittleider - Dr. Kenneth Richman
- Eduardo Antonio Garcia - Mariano Molina
- Annie O'Donnell - Elderly Woman
- Brianne Prather - Young Woman
- Pat Skipper - Bill Scully Jr.
- David Wells - Mr. Babbitt
- Andy Hubbell - Quinton's Father
- Ron Chartier - Inspector Puett
- Glenn Morshower - Aaron Starkey
- Dara Hollingsworth - Christine Fletcher
- Benito Martinez - Orderly
- Brian D. Johnson - Man
- Laurie Holden - Marita Covarrubias
- Arlene Mazerolle - Dr. Shannon
- Michael Massee - Vernon Ephesian
- Roger W. Morrissey - Übermenscher
- Tom Noonan - John Lee Roche
- Janine Venable - Vicky Crump
- Peter Williams - Jackson
- Michael Rothhaar - Dr. Couvillion
- Thomas F. Duffy - Jeffrey Cahn
- Fredric Lehne - Young Arthur Dales
- David Wohl - Kenneth Ungar
- Austin Basile - The Bellman (uncredited)
- Scott Oughterson - Old Orderly
- Mik Scriba - Lieutenant Kraskow
- Nichole Pelerine - Sara Shipley
- Cynthia Preston - Nancy Aaronson
- Vic Trevino - Dr. Alonso Bilac
- David Bowe - Robert Werther
- Constance Barnes - O.R. Nurse (uncredited)
- Shia LaBeouf - Richie Lupone
- Aundrea MacDonald - Pretty Woman
- Robyn Driscoll - Detective Joe Darnell
- Tony Pantages - Lt. Fraser
- Jackson Davies - Agent Bruskin
- Tuck Milligan - Dr. Adam Pierce
- Joanna Sanchez - Trina Galvez
- Jamie Marsh - Ivan Martinez
- Frank Military - The Son / John
- Les Lannom - Deputy Foster
- Mimi Lieber - Anita Fiore
- Saxon Trainor - Mary Hendershot
- Stanley Anderson - Agent Schoniger
- Curtis C. - Edy
- Matthew Sutherland - Records Clerk
- Philip Lenkowsky - Holy Spirit Man #1
- John Mese - Sheriff Phil Adderly
- Kim Darby - Kathy Lee Tencate
- Kirk B.R. Woller - Agent Gene Crane
- Rob Szatkowski - Burt's Opponent
- Dennis Keiffer - Bullethead #2
- Bernard White - Dr. Desai
- Del Zamora - Mr. Barreiro
- Grant Heslov - Andre Bormanis
- Jim Cody Williams - Cal Jeppy
- R. Nelson Brown - Ansel Bray
- Michael Wiseman - Dr. Rocky Bronzino
- Ty Upshaw - Officer #1
- Dayna Beilenson - Roberta Toews
- Fitz Houston - Station Manager
- Pamela Paulshock - Brittany
- Scott MacDonald - Curt Delario
- Lisa Ann Beley - Student
- Sarah Sawatsky - Chrissy Giorgio
- Maxine Guess - Flight Attendant
- Bethoe Shirkoff - Old Woman (uncredited)
- Jonathan Whittaker - Curt Brunjes
- Rob Daprocida - Bunny
- Adrian G. Griffiths - Sherman Peacock
- Cynde Harmon - Patti Rich
- Greg Ellis - 3rd British Crewman
- Vin Scully - Baseball Announcer (voice) (uncredited)
- John Apicella - Greg Pincus
- Jeff Bowser - Redhead Geek
- Frank Buckley - Nevada News Anchor
- Steven Anderson - Dr. James Parenti
- Wendie Malick - Assistant Director J. Maslin
- Birkett Turton - Brit (uncredited)
- James McDonnell - Detective Van Allen
- Kurt Evans - Sports Store Employee
- Keith Brunsmann - Bo
- Joe Pascual - Examiner
- Henry Beckman - Old Man
- Henry Beckman - Detective Frank Briggs
- J.C. Wendel - Agent Stonecypher
- Irene Muzzy - Waitress
- Max Kasch - Evan Shipley
- David Fresco - Hal Arden
- Dom Magwili - Mr. Ng
- Jane MacDougall - Laura Dalton
- Charles Hoyes - Howard Crittendon
- Kristen Cloke - Melissa Rydell Ephesian
- Kristen Cloke - Wendy (voice)
- Simon Webb - Dr. William Secare
- Gary Bullock - Tall George
- John R. Taylor - Husband
- David Brisbin - Second Doctor (uncredited)
- Christopher Gray - Jimmie
- Mimi Rogers - Agent Diana Fowley
- Mimi Rogers - Agent Diana Fowley (uncredited)
- Matt Hill - Private Harry Dunham
- Jack Shearer - Judge Kinberg
- Lisa Bunting - Doctor #1
- Mark Chaet - Bank Officer
- Rueben Grundy - Forensic Tech
- Randy Walker - SWAT Cop
- Bill Jacobson - Thug
- Murray Lowry - The Fisherman (uncredited)
- Michael Canavan - Cameron McPeck
- Sheila Shaw - Marcia Purnell
- Ron Canada - Det. Franklin Potter
- Romy Walthall - Second Agent
- F.J. Rio - Cop
- Arthur J. Nascarella - Duke Tomasick
- Michele Harrell - Mrs. Murdoch
- Katy Boyer - Dr. Lisa Holland
- Aeryk Egan - Camera Dude
- Pat Destro - Joan Scobie
- Calvin Remsberg - Mr. Potocki
- Megan Follows - Kath McCready
- Scott Vance - Healer
- Jordan Marder - Creature
- Joe Sabatino - Captain Triguero
- Marcus Giamatti - John Gillnitz
- Mari Weiss - ICU Nurse
- Adam Baldwin - Knowle Rohrer
- J.W. Smith - Steve
- Billy Ray Gallion - Retro
- John McGonegle - Uniformed Cop
- Bob Frazer - Gary Kane
- Ken Jones - Bearded Man (uncredited)
- Jillian Fargey - Kaye Schilling
- Helene Clarkson - Maggie Holvey
- Mindy Seeger - Coroner
- Trevor Goddard - 1st British Crewman
- Dan Gifford - Local News Anchor
- Robert Peters - Sergeant
- Jesse James - Poor Boy
- David Starwalt - Frank Fiedler
- Patricia Idlette - Desk Clerk
- Tim Bagley - Gordy
- Morgan Weisser - Lee Harvey Oswald
- Greg Michaels - Scott Garrett
- David Moreland - Roy Cohn
- Bob Dawson - Phil Rich
- Rebecca Harker - Housekeeper
- Ron Halder - Dr. Floyd Fazio
- Michael Chinyamurindi - Dr. Solomon Merkmallen
- Charles Rocket - Grant Ellis
- Willie Amakye - Samuel Aboah
- Sonia Norris - Marleen Ross (uncredited)
- Gary Bristow - Howard Salt
- Cory Blevins - Missionary #1
- Bryan Rasmussen - Sheriff's Deputy
- David Kirby - Ted Watkins
- French Tickner - Preacher
- Susan Slome - Woman at O.A.
- Randall Bosley - Ed Truelove
- Alex Doduk - Young Samuel
- William Forward - Funeral Director
- Micole Mercurio - Mrs. Stodie
- Dale Dickey - Game Warden
- Gillian Carfra - Christine Ranford
- Leslie Sachs - Lisa's Friend
- Greg Boniface - Gangbanger #2
- Lee Duncan - Al Cawdry
- Paul McGillion - Angry Husband
- Paul McGillion - FBI Metallurgical Expert (uncredited)
- Aaron Braxton - Radiology Tech
- Colleen Quinn - Owen's Wife
- Sherri Howard - Female Employee
- Ed Beechner - Deputy
- Sandy Tucker - Helene Riddicock (uncredited)
- Paul Lieber - Micah Hoffman
- Cheryl White - Nurse #3
- Dondré Whitfield - Agent
- Justin Williams - Paul Hangemuhl
- Jane Yamamoto - News Ancho
- Jacob Handy - Luke Doggett
- Larry Udy - Middle-Aged Man
- Ron Marasco - Doctor
- Robert Beckwith - FBI Cadet
- Wendy Gazelle - Katha Dukes
- Cory Parravano - Jason McPeck
- Phyllis Franklin - Middle Aged Woman
- Vernee Watson-Johnson - Nurse Whitney Edwards
- Allan Lysell - Able Gardner
- Allan Lysell - Chief Rivers
- Dmitri S. Boudrine - Russian Engineer
- Leslie Carlson - Dr. Troisky
- Jack Rader - Ed Meecham
- Nina Roman - Jill Holwagerm (uncredited)
- Julie Bond - Woman
- John Pyper-Ferguson - Det. John Kresge
- John Pyper-Ferguson - Paul
- Michael MacRae - August Bremer
- Michael MacRae - Ranger Peter Brullet
- Alison Matthews - Doctor
- Madison Mason - Captain Yip Harburg
- Ed Corbin - Guard
- Michael Mantell - Dr. James Riley
- Christine Firkins - Thea Sprecher
- Allan Franz - Dr. Ben Keyser
- David Purdham - Dr. Lev
- Cory Fry - Batter
- Douglas Roy Dack - Mighty Man (uncredited)
- Gerard Plunkett - Dr. Calderon
- Douglas Arthurs - Skin-Head Man
- Shelley Adam - Young Mrs. Mulder
- Tim O'Halloran - The Sergeant (uncredited)
- Jane Perry - Dorothy Bahnsen
- Denis Forest - Lone Man
- Tom Mason - Detective Waltos
- John Dadey - Local Agent (uncredited)
- Chris Nelson Norris - Swat Lieutenant
- Sally Stevens - Radio Singer
- Daniel Weber - Figgis (uncredited)
- Jeff Gulka - Gibson Andrew Praise
- Brenda Crichlow - Reporter
- Kiara Hunter - Coed
- Randy Lee - Paramedic
- Marshall Manesh - Mr. Jank
- Barry Cullison - Sheriff Sanchez
- Myles Ferguson - Joey Agostino
- Myles Ferguson - Boy in the Bus (uncredited)
- Donnelly Rhodes - Jim Parker
- Donnelly Rhodes - General Francis
- Freda Perry - Mrs. Wright
- Iris Quinn - Lillian Daniels
- Tony Okungbowa - Barnes' Driver
- Stevie Johnson - EMT
- Christine Upright-Letain - Ms. Wells
- Chris Jacobs - E.R. Doctor
- Keegan MacIntosh - Michael
- Phillip MacKenzie - Medic
- Jan D'Arcy - Judge Kann
- Tony Morelli - Cop
- Cheryl Francis Harrington - E.R. Nurse
- Fred Henderson - Agent Rich
- Fred Henderson - Agent Thomas
- John Michael Vaughn - Soundman
- Rachel Winfree - Nurse
- J. Patrick McCormack - Brent Tufeld
- Steve Wilcox - Ed Dell
- Benito Prezia - Old Italian Man
- Dion Anderson - Sheriff Frass
- Paul Vincent O'Connor - Warden Brian Hutchinson
- Cynthena Sanders - ER Nurse
- Dan Rice - Uniform Cop
- John Payne - Guard
- John Payne - Jerald Glazebrook
- Caryn West - Dr. Libby Nance
- Dylan Kussman - Med Student
- Mimi Savage - Teacher
- John Bisom - News Anchor #2
- Warren Sweeney - Dr. Harriman
- Gibby Brand - Arthur Gaffin
- Diana Castle - Delivery Nurse
- Joe Basile - Lead Guard
- David Figlioli - Victor Dale Potts
- Louise Latham - Marjorie Butters
- Ralph Alderman - Manager
- Ralph Alderman - Hotel Manager (uncredited)
- John Casino - Roland McFarland
- Mark Rolston - Richard Odin
- Mark Rolston - Bud LaPierre
- Freddy Andreiuci - Det. Norman
- Callum Keith Rennie - Tommy
- Callum Keith Rennie - Cemetery Groundskeeper
- David Kaye - Doctor (uncredited)
- David Kaye - Reporter
- Zinaid Memišević - The Cruel-Faced Man (uncredited)
- Terry Arrowsmith - Major Robert Charles Vallee (uncredited)
- Stacy Grant - Judy Fairly
- Arnie Walters - Father McCue
- John Hainsworth - Gaunt Man (uncredited)
- Chris Ufland - Sam
- Kate Luyben - Nurse Nancy
- George Touliatos - Larry Winter
- George Touliatos - Dr. Katz
- Kurt Max Runte - Ranger
- Patricia Dahlquist - Susan Chambliss
- Jan Rubeš - Vassily Peskow
- Jan Rubeš - Vassily Peskow (uncredited)
- Treva Tegtmeier - Peggy
- Denise Crosby - Dr. Mary Speake
- Kate Twa - Marty (Female)
- Kate Twa - Detective Kelly Ryan
- Neal McDonough - Robert Comer
- Martin Ferrero - Shooter
- Terry O'Quinn - Lt. Brian Tillman
- Terry O'Quinn - Shadow Man
- Eddie Kaye Thomas - Gary
- Eddie Kaye Thomas - Gary Edward Cory
- Dexter Bell - Alfred Kittel (uncredited)
- Susan Lee Hoffman - Lisa Ianelli
- Jay Acovone - Duffy Haskell
- Jay Acovone - Detective Curtis
- Sean Allen - Dr. Kevin Scanlon
- Ed Hong-Louie - Money Man (uncredited)
- Michelle Hart - Trace Agent
- Phil Abrams - Little Fritz
- Bill Nunn - Gen. John Steffan
- Rick Dobran - Sergeant Armando Gonzales
- Julia Vera - Lana Chee
- Marie Stillin - Dr. Sally Sanford
- Elizabeth McCarthy - Shopper
- John B. Lowe - Dr. Leavitt
- George Josef - Calusari #4
- George Josef - Orchard Keeper
- Marcus Turner - Young Fox Mulder
- Robin Douglas - Computer Tekkie
- Fort Atkinson - Detective #1
- Steve Adams - Prosecution Counsel Myers
- Andy Umberger - Agent Chesty Short
- Steve Stapenhorst - Principal
- Jack Forbes - Ray's Double
- John Marrott - Security Guard
- Elyse Donalson - Elderly Woman
- Dwight McFee - Commander
- Dwight McFee - Suspect
- Dwight McFee - Detective Havez
- Jacqueline Schultz - Irene McPeck
- Christopher Michael - Trusty
- Austin Tichenor - Dr. James Langenhahn
- Brian Markinson - Tony Fiore
- Brian Markinson - Gary Lambert
- Larry Dorf - Pathology Assistant
- Frank C. Turner - Doctor Collins
- Frank C. Turner - Dr. Del Hakkie
- Roger Hewlett - Tall Guard
- Mary-Margaret Lewis - Mrs. Dowdy
- John Harnagel - World Weary Dad
- Roz Witt - Night Nurse
- Esther Mercado - Mrs. Barreiro
- Jay Brazeau - Prof. Varnes
- Jay Brazeau - Dr. Daly
- Stephen Ramsey - First Agent
- Jacob Franchek - Red-Headed Kid
- Brad Loree - Security Guard
- Brad Loree - Fireman
- Ric Sarabia - Prison Trustee
- Jay Caputo - Salamander Man
- Jay Caputo - The Bat Thing
- Shane Nickerson - Police Photographer
- Oliver Becker - 2nd Doctor
- Lindsey Ginter - Crew Cut Man
- Lindsey Ginter - The Cleaner
- Don Ackerman - Night Attendant (uncredited)
- Ken Collins - Gas Station Attendant
- Lynda Boyd - Elizabeth
- Lynda Boyd - Woman in Bar
- Barry Greene - Perkins
- Barry Greene - Dr. Emile Linzer
- Sarah-Jane Redmond - Karin Matthews
- Sarah-Jane Redmond - Young Mom
- Alvin Sanders - Deputy Sheriff Jason Wright
- Alvin Sanders - Bus Driver
- Jerry Giles - Security Guard
- Marc Gomes - Agent Danny Mosley
- G.W. Stevens - 2nd British Crewman
- Benjamin Ochieng - Second African Man
- Lou Beatty Jr. - Black Coach
- Steven Griffith - Paramedic
- Dean Aylesworth - Young Bill Mulder
- Kim Robillard - Homer
- Lisa Joann Thompson - Kelly
- Brian Reddy - Big Fritz
- Matthew Walker - Arlinsky
- Matthew Walker - Dr. Ronald Surnow
- Colleen Flynn - Michele Fazekas
- Colleen Flynn - Colleen Azar
- Adam Vernier - Driver
- Christine Estabrook - Agent Henderson
- Catherine Lough Haggquist - Dr. Richmond
- Ashley Knutson - Baby William
- Michele Goodger - Barbara Ausbury
- Michele Goodger - Sister Abigail
- Alan Davidson - Bearded Man
- David Sawyer - Security Man
- Randy Ross - Nike Man
- Richard McGonagle - Dr. Francis Orovetz
- John O'Brien - Missionary #2
- Winston Story - Bellboy
- Tracey Ellis - Audrey Pauley
- Tracey Ellis - Lucy Householder
- Colleen Winton - Therapist
- Colleen Winton - Examiner
- Dwight Hicks - Prison Armed Guard
- Ken Tremblett - Uniformed Officer
- Ken Tremblett - Dyer
- Eulan Middlebrooks - Young Cop
- Ryan Cutrona - The Captain
- Matthew Glave - Special Agent Kallenbrunner
- Blu Mankuma - Det. Pennock
- Blu Mankuma - Claude Peterson
- Christopher Stanley - Agent Farah
- Veronica Brown - Payphone Woman
- Gerry Rousseau - Mechanic
- David Palffy - Dark Man
- Chapelle Jaffe - Dr. Patou
- Dean Barrett - Cohn's Assistant (uncredited)
- Laura Leigh Hughes - Kersh's Assistant
- Owen Walstrom - Mark Backus (uncredited)
- Ken Medlock - White Coach
- William S. Taylor - Gen. Leitch
- Rick Millikan - Sandy
- Christopher Dahlberg - State Trooper
- Stephen Dimopoulos - Detective
- Stephen Dimopoulos - Ionesco
- Andrew Robinson - Dr. Ian Detweiler
- Peter Hanlon - Aide
- Peter Hanlon - Dr. Bailey
- Allan Zinyk - Blaine Faulkner
- Mike Rad - Randy
- Ben Reed - Young Officer
- Steven Barr - Courier Guard
- Michael Dempsey - Sheriff
- Shane Sinutko - Lead Cop
- Joe Maffei - Guard #1
- Renae Morriseau - Gwen Goodensnake
- Renae Morriseau - Josephine Doane
- Lucy Rodriguez - Operator
- Timothy Landfield - Scientist / Cobra
- Timothy Landfield - Professor Douglas Houghton
- Greg Poland - Second Windbreaker Man
- Jake Fritz - Luke Doggett
- Bill Millar - Director
- James Parks - Agent Terry Sullivan
- Joe Nieves - Barreiro's Son
- Tom Bailey - Apartment Manager
- Paul Kim Jr. - Customer #2
- Wayne A. King - Homeless Man
- Paul Bittante - Team Leader Lt. Reagan
- Paul Bittante - Local Cop
- Kerrie Keane - Nurse
- Colin Lawrence - First Cop
- Colin Lawrence - The Troop Leader (uncredited)
- Dana Gladstone - Dr. Landon Prince / Gregor
- Anatol Rezmeritsa - Commandant
- Anthony Ashbee - Corporal (uncredited)
- Nelson Mashita - Dr. Lim
- Gabrielle Rose - Anita Budahas
- Gabrielle Rose - Dr. Zenzola
- McNally Sagal - Overcoat Woman
- Cory Dagg - Bartender
- Jonathan Palmer - Principal
- Scott Eberlein - Black Haired Man
- Mitchell Kosterman - Detective Horton
- Mitchell Kosterman - Sheriff
- Mitchell Kosterman - Fornier
- Gardiner Millar - Mr. Baiocchi
- Gardiner Millar - Man in Suit
- Robert Thomas Beck - 1st Mate
- Laara Sadiq - Female EMT
- Gary Hetherington - Kennedy
- Gary Hetherington - Lewin
- Darin Cooper - Deputy Ray Hoese
- Hiro Kanagawa - Peter Tanaka
- Hiro Kanagawa - Dr. Yonechi
- Hiro Kanagawa - Garner
- Mikal Dughi - Dr. Pamela Karetzky
- Kathleen Duborg - Prostitute
- Kathleen Duborg - Mother
- Fritz Greve - Bearded Man
- Richard Zobel - Al
- Jeff Xander - Detective #2
- Lorena Gale - Attorney
- Lorena Gale - Nurse Wilkins
- Lorena Gale - Ellen Bledsoe
- Charlie Hartsock - Lawyer
- James Howell - Homicide Detective
- Kelly McNair - Teenage Girl
- David Alan Grier - Cinema Audience (uncredited)
- Sheila Paterson - Anna Fugazzi
- Sheila Paterson - Gina Watkins
- Peter Mele - Mob Man (uncredited)
- Robert Thurston - Jackson Toews
- Robert Thurston - Dr. Larry Steen
- Peter LaCroix - Ranheim / Frank Druce
- Peter LaCroix - Dwight
- Peter LaCroix - Nathaniel Teager
- Lennie Loftin - Coranado
- Sheila Tousey - Native American Nurse
- Garvin Cross - Repairman
- Garvin Cross - Red Head Kid
- Robert Arce - Bald-Headed Man
- Dave Grohl - Lobby Passerby (uncredited)
- Barbara Dyke - Dr. Alepin
- Merrilyn Gann - Prosecuting Attorney
- Merrilyn Gann - Mrs. Asekoff
- Arthur Taxier - Assistant Director P. Bart
- Scott Williamson - CDC Leader
- Brien Blakely - Reporter
- Kim Restell - Newspaper Clerk
- Ron Gilbert - Sheriff #2
- Brian Chenoweth - Koko's Manager #1
- David Doty - Minister
- Donna Yamamoto - Female Agent
- Donna Yamamoto - Night Nurse
- Christian Svensson - Soldier #2
- Fulvio Cecere - Priest
- Fulvio Cecere - Aide
- Jeff Austin - Dr. Nordlinger
- Alan Dale - Toothpick Man
- John Sampson - Marksman #1
- Marek Wiedman - Investigator
- Frank Ertl - Elder #5
- Nick Meaney - 4th British Crewman
- Judd Trichter - Richie
- Steve Oatway - Supervisor (uncredited)
- Klodyne Rodney - Medic
- Joe Colligan - Driver Agent
- Derick Alexander - Bailiff
- Steve Kiziak - Steve
- Steve Kiziak - Man Who Looks Like Mulder
- Mary Wickliffe - Nurse
- Kevin E. West - Navy Seal
- Guido Föhrweißer - 2nd Nazi
- Jenny-Lynn Hutcheson - Polly Turner
- Jenny-Lynn Hutcheson - Little girl from the trailer (uncredited)
- Jenny-Lynn Hutcheson - Addie Sparks (uncredited)
- Willy Ross - Quiet Willy (uncredited)
- Richard Sargent - Captain
- Jamie McShane - Injured Soldier
- Larry Rippenkroeger - Deckhand
- Brian Catalano - Passenger Agent
- Robb Reesman - Macon Cop
- Tim Henry - Federal Marshall
- Peter Macdissi - Prison Guard
- Kevin McCorkle - Cult Man #2
- Isaac C. Singleton Jr. - 1st Roughneck
- Tom Butler - CIA Agent Ambrose Chapel
- Tom Butler - Drake
- Patrick St. Esprit - Guard #2
- Brad Kalas - Cult Man
- Kai Wulff - Third Nazi
- Anne-Marie Johnson - Vicky Wells (uncredited)
- Randy Hall - U-Haul Driver
- Jim Fyfe - James 'Jimmy the Geek' Belmont
- Jim Fyfe - Kimmy the Geek
- Brent Sexton - Gravedigger
- Brent Sexton - Steven Melnick
- Janie Woods-Morris - Lorraine Kelleher
- Janie Woods-Morris - Ms. Lange
- Andrew Johnston - Agent Barry Weiss
- Andrew Johnston - Medical Examiner
- Andrew Johnston - Lt. Col. Robert Budahas
- Michael J Rogers - 1st Crewman
- Michael J Rogers - Lt. Griffin
- Ken Roberts - Motel Proprietor
- Ken Roberts - Clerk
- Mandy Levin - Angie
- Jennifer Griffin - Dr. Miryum
- Bill Dow - Charles Burks
- Bill Dow - Chuck Burk
- Bill Dow - Dad
- Bill Dow - Dr. Rick Newton
- Bill Dow - Chuck Burks
- Bill Dow - Pangborn
- Colin Cunningham - Lt. Terry Wilmer
- Colin Cunningham - Dr. Stroman
- Colin Cunningham - Escalante
- Paul Hayes - Jay Gilmore
- Mark Wilson - The Pilot
- Allan Gray - Dr. Peter Valedespino
- Kevin Porter - Motivational Speaker
- Fred Keating - Ray Thomas
- Peter Bryant - The Uniformed Cop
- Chris Carter - Another Agent (uncredited)
- Chris Carter - Cinema Audience (uncredited)
- Barry W. Levy - Dr. Vitagliano
- Barry W. Levy - Navy Doctor
- Sebastian Spence - Deputy Barney Paster
- Gretchen Becker - Greta
- Sheila Moore - Mrs. Dawson
- Sheila Moore - Verla McLennen
- Mike Mitchell - 1st Uniformed Cop
- J. Douglas Stewart - Male EMT
- J. Douglas Stewart - Landlord
- Rick Garcia - News Anchor
- Sal Landi - Nicholas Regali
- Sal Landi - Agent Landau
- Jane Daly - Mrs. Holt
- Dan Shea - Deputy (uncredited)
- Don S. Davis - Captain William Scully
- Scott Alan Smith - Prison Doctor
- BJ Harrison - Hannah
- BJ Harrison - Clerk
- Lamont Johnson - Whaley
- Tom McBeath - Scientist
- Tom McBeath - Detective Gwynn
- Tom McBeath - Dr. Lewton
- Mark Saunders - Doctor #2
- Mark Saunders - Agent Busch
- Michael McGrady - Sheriff Kurt Frey
- Dylan Haggerty - Erwin Timothy Lukesh
- Bo Kane - Marine Sergeant McCormick
- Campbell Lane - Senator Romine
- Campbell Lane - Calusari #3
- Campbell Lane - Hohman's Father
- Christopher Wynne - Deputy
- Christopher Wynne - Base Cop
- David Abbott - Judge Maibaum
- Abdoulaye NGom - Driver
- Raoul Ganeev - Dmitri
- Brent Stait - Timothy Mayhew
- Brent Stait - Corporal Taylor
- Felicia Shulman - Motel Manager
- Natasha Vasiluk - Store Owner (uncredited)
- Tyler Thompson - Louis Asekoff
- María Celedonio - Chantara Gomez
- Perla Walter - Mexican Lady
- Christine Willes - Karen Kosseff
- Christine Willes - Agent Karen E. Kosseff
- Christine Willes - Sister Mary
- Terrance Leigh - Snorkel Dude
- George Sharperson - Security Guard
- Amanda Fein - Mia Dukes
- Mark Thompson - Reporter #2
- Robert Moloney - Worker
- Robert Moloney - Bruce Bearfeld
- Dave Adams - Dr. Francis Girardi
- Chase Hampton - Hungry Guy
- Howard Storey - Fire Chief
- Pat Bermel - Frank Ranford
- Pat Bermel - The Therapist (uncredited)
- Dean Wray - Tow Truck Driver
- Dean Wray - Rich Turner
- Lisa Kaseman - Pathology Assistant
- Kari Whitman - Roxanne
- George Gordon - Detective
- Elisabeth Rosen - Katie
- Terry Barclay - Officer Imhof
- Philip Maurice Hayes - Driver #1
- Tasha Simms - Laura Kelly
- Tasha Simms - Jay Cassal
- Tasha Simms - Ellen Reardon
- Dwight Koss - Detective Rudy Barbala
- James Otis - Arlen Sacks
- Martin Grey - Agent Flagler
- Scott Allan Campbell - Jeff Smoodge
- Vitaly Kravchenko - J.J. (uncredited)
- Miriam Smith - Elizabeth Pollidori
- Dalias Blake - Second Cop
- Steve Makaj - Scott Ostelhof
- Steve Makaj - Frank Kiveat
- Steve Makaj - Patrolman
- Jerry Springer - Jerry Springer
- Lloyd Berry - Old Man Pollidori
- Chilton Crane - Sharon Graffia
- Chilton Crane - Margaret Hohman
- Chilton Crane - Mother (at bus station)
- Forbes Angus - Funeral Director
- Forbes Angus - M.D.
- Forbes Angus - Government Scientist
- Xantha Radley - Waitress
- Jonathan Palis - Postal Worker (uncredited)
- William MacDonald - Agent Kazanjian
- William MacDonald - Officer Trott
- William MacDonald - Dr. Oppenheim
- William MacDonald - Deputy Buddy Riggs
- William MacDonald - Federal Marshall
- Lisa Arch - Call Girl
- Jennifer Jasey - Female Private
- Stacy Fair - Flight Attendant (uncredited)
- Michael Ryan - Agent Cameron Hill
- Michael Ryan - Overcoat Man
- Bill Croft - Calusari #2
- Bill Croft - Comrade Svo
- Annet Mahendru - Sveta
- Marc Baur - Agt. Brisentine
- Marc Baur - Man in Suit
- Marc Baur - Matlock (uncredited)
- Giacomo Baessato - Doctor
- Rance Howard - Old Man
- Don MacKay - Charlie
- Don MacKay - Oates (uncredited)
- Don MacKay - Judge
- Bob Morrisey - Dr. Vinet
- Bob Morrisey - Dr. Simon Bruin
- Patrick Keating - Donald Gelman
- Patrick Keating - Beggar
- Jonathan Whitesell - Kyle Gilligan
- Rebecca Wisocky - Jackie Goldman
- Doug Savant - Augustus Goldman
- Aaron Douglas - Lindquist
- Vik Sahay - Gupta
- P. Lynn Johnson - Deborah Brown
- P. Lynn Johnson - Health Department Doctor
- P. Lynn Johnson - Dr. Sheila Braun
- Ryan Robbins - Murphy
- Jerry Schram - Larold Rebhun
- Jerry Schram - Boyce
- Kacey Rohl - Agnes
- Christopher Logan - Dr. Sanjay
- Omari Newton - Rogers
- Bob Wilde - Rand
- Bob Wilde - Detective
- Bob Wilde - George Vincent Dyer (uncredited)
- Alison Wandzura - Cynthia
- Rhys Darby - Guy Mann
- Kumail Nanjiani - Pasha
- Lauren Diewold - Emily Sim
- Lauren Diewold - Emily Sim / Young Melissa Scully
- Timothy Webber - Jess Harold
- Timothy Webber - Dr. Paul Farraday
- Timothy Webber - Detective Talbot
- Jerry Wasserman - Doctor Plith
- Jerry Wasserman - Dr. John Grago
- D.J. 'Shangela' Pierce - Annabelle
- Ken Camroux-Taylor - Senior Agent
- Ken Camroux-Taylor - 2nd Senior Agent
- Ken Camroux-Taylor - Third Man
- Richard Newman - Dr. Rumanovitch
- Walter Marsh - Judge
- Walter Marsh - Druggist
- Jade Pawluk - Naked Lair Victim
- Laurie Murdoch - Coroner
- Laurie Murdoch - Lydon
- Tim Armstrong - Trashman
- Daryl Shuttleworth - Daryl Landry
- Peggy Jo Jacobs - Nancy Huff
- Stephen E. Miller - Coroner Truitt
- Stephen E. Miller - Tactical Commander
- Stephen E. Miller - Wayne Morgan
- Alessandro Juliani - Joseph Cutler
- Chris Shields - Detective Gross
- Robert Lewis - Officer
- Robert Lewis - ER Doctor
- John DeSantis - Band-Aid Nose Man
- Gary Sekhon - Forensic Technician
- Sachin Sahel - Jack Budd
- Malcolm Stewart - Dr. Sacks
- Malcolm Stewart - Commander Carver
- Malcolm Stewart - Agent Bonnecaze
- Malcolm Stewart - Dr. Glass
- Jannen Karr - Nurse Taillie
- Seth Whittaker - Fitzpatrick
- Daniel Jacobsen - Proudley
- Deryl Hayes - Army Doctor
- Deryl Hayes - Webster
- Deryl Hayes - Agent Morris
- Stephen Lobo - Man in Suit 1
- Shaine Jones - Man in Suit 2
- Janet Kidder - Nurse
- Artin John - Shiraz
- Nina Nayebi - Noora
- Garry Chalk - Mad Dog
- Marci T. House - Angry Woman
- Julian Christopher - Dr. Rubell
- Aliza Vellani - O.R. Nurse
- Aliza Vellani - Nurse Sandeep
- Mik Byskov - Accosting Man
- Darren Dolynski - Man in Suit
- Alf Humphreys - Dr. Pomerantz
- Alf Humphreys - Michael Asekoff
- Alf Humphreys - 2nd Controller
- Nancy Kerr - Agent Hedin
- Nancy Kerr - Nurse
- Lauren Ambrose - Agent Einstein
- Nneka Croal - Squad Leader
- Robbie Amell - Agent Miller
- Barbara Hershey - Erika Price
- Paul Jarrett - Upshaw
- Paul Jarrett - James Earl Ray
- Anjali Jay - Dr. Joyet
- Sandrine Holt - Dr. Karah Hamby
- A.C. Peterson - Mr. Y
- Dejan Loyola - Agent Colquitt
- Wayne Alexander - Older Agent
- Wayne Alexander - Senior Agent
- Wayne Alexander - A.D. Arnold
- Denise Dowse - Dr. Babsi Russel
- Alison Araya - Nurse Vickie Easton
- Lossen Chambers - Nurse Peggy Easton
- Robin Mossley - Dr. Joe Ridley
- Robin Mossley - Dr. Vance Randolph
- Robin Mossley - Dr. Kingsley Looker
- Brian Huskey - Reggie Something
- Johnny Cuthbert - Commanding Officer
- Johnny Cuthbert - Jerry Tiernan
- Stuart Margolin - Dr. Thaddeus Q. They
- Sean Campbell - The Soldier (uncredited)
- Sean Campbell - Local Cop
- Sean Campbell - Officer Sean
- Louis Ferreira - Detective Costa
- François Chau - Peter Wong
- Cameron Forbes - Dr. Harris
- Sunita Prasad - Dr. Aliyeh Scholz
- Jude Zachary - Jones (uncredited)
- Jude Zachary - Winston
- Michael Dobson - Marksman #2
- Michael Dobson - Sargeant Hynek
- Michael Dobson - U.S. Marshal
- Michael Dobson - BATF Agent
- Kerry Sandomirsky - Tracy
- Kerry Sandomirsky - Joanne
- Devon Alexander - Barista
- Cory Rempel - Young Walter Skinner
- Brendan Patrick Connor - Sheriff Mac Stenzler
- Keith Arbuthnot - Mr. Chuckleteeth
- Keith Arbuthnot - Alien
- Keith Arbuthnot - Ghouli
- Peter Hall - Dr. Matthew Wegweiser
- Peter Kelamis - O'Dell
- Peter Kelamis - Second Husband
- Peter Kelamis - Assistant D.A. Daniel Costa
- Peter Kelamis - Lt. Foyle
- Robert Mann - Hillbilly Ed
- Shane Symons - Other Marine
- Johnson Phan - Quon
- Candus Churchill - Shirley
- Ashley Lambert - Bigly Customer Service (voice)
- Matt Corboy - Voice of Science (voice)
- Alan Robertson - Grey-haired Man
- Alan Robertson - Carl Roosevelt
- Sitara Attaie - E-Norm-Uz Customer Service (voice)
- Alex Carter - Chief Strong
- Miles Robbins - Jackson Van De Kamp
- Miles Robbins - Jackson Van De Kamp / William
- Jason Gray-Stanford - Officer Eggers
- Erin Chambers - Anna Strong
- Sharon Taylor - Diana Eggers
- Ken Kramer - Dr. Terrance Allen Berube
- Ken Kramer - Dr. Ivanov
- Ken Kramer - Dr. Browning
- Sebastian Billingsley-Rodriguez - Andrew Eggers
- Emma Oliver - Emily Strong
- Ken Godmere - Melvin Peter
- Kwesi Ameyaw - Judge
- Fiona Vroom - Barbara Beaumont / Sitcom Barbara
- Roger Haskett - Coroner
- Roger Haskett - Deputy Dennis Tyson
- Carlena Britch - Juliet 'La Avispa' Bocanegra
- James Leard - Captain Roy Lacerio
- James Leard - Sgt. Al Dixon
- Jere Burns - Dr. Randolph Luvenis
- Viv Leacock - Price
- Samuel Patrick Chu - Warren
- Fabiola Colmenero - Josephine Bocanegra
- Genevieve Buechner - Kayla
- Larry Musser - Detective Manners
- Larry Musser - Denny Markham
- Larry Musser - Sheriff John Oaks
- Larry Musser - Jack Bonsaint
- Albert Nicholas - Agent Bill Bludworth
- Aidan Kahn - Agent Colquitt
- Jay Hindle - Sitcom Joe
- Shaker Paleja - O.R. Surgeon
- Brent Chapman - Security Cop
- Brent Chapman - Traffic Cop
- Brent Chapman - Robert (uncredited)
- Gillian Barber - Penny Northern
- Gillian Barber - Beth Kane
- Gillian Barber - Jane Spiller
- West Duchovny - Maddy
- Zak Santiago - Mr. Green
- Ben Cotton - Mr. Paulsen
- Sarah Jeffery - Brianna Stapleton
- Madeleine Arthur - Sarah Turner
- Ty Olsson - Young Orderly
- Joel McHale - Tad O'Malley
- Darin Morgan - Eddie Van Blundht
- Darin Morgan - Flukeman
- Jeremy Jones - Sergeant
- Chris Turner - Kid #2 (uncredited)
- Thabo Ketshabetswe - Guard
- Kevin McClatchy - James Leeds
- Jessica Schreier - Dr. Bonita Sayre (uncredited)
- Jessica Schreier - Dr. Bonita Charne-Sayre
- Lawrence King-Phillips - Lucas Henry
- Tom McFadden - Doctor
- Jett Klyne - Young Spender
- Vanessa Morley - Young Samantha Mulder
- Vanessa Morley - Samantha Mulder
- Vanessa Morley - Samantha
- Vanessa Morley - Young Samantha Mulder Clone (uncredited)
- Leslie Jones - Gretchen Starns
- James Sloyan - Dr. Frank Nollette
- Gordon Tipple - Joe Crandall
- Gordon Tipple - Hepcat Helm
- Gordon Tipple - Assistant Manager
- Hrothgar Mathews - Man on Phone (uncredited)
- Hrothgar Mathews - Jack
- Hrothgar Mathews - Mental Patient
- Hrothgar Mathews - Galen Muntz
- Mark Sheppard - Bob the Caretaker / Cecil L'Ively
- Jonathan Silver Scott - Blue Beret (uncredited)
- Michal Suchánek - Young Jeffrey Spender
- Victoria Gallegos - Follmer's Secretary
- Victoria Gallegos - Receptionist
- Linden Banks - Joseph Patnik
- Linden Banks - Reverend Sistrunk
- Jon Gries - Salvatore Matola
- Tony Todd - Augustus Cole
- Anna Hagan - Dr. Charyn
- J. B. Bivens - Truck Driver
- J. B. Bivens - Sharpshooter
- J. B. Bivens - Field Agent
- David Fredericks - Security Guard
- David Fredericks - The Director
- David Fredericks - Director
- David Fredericks - Larsen
- Barbara Pollard - Gwen
- Sarah Strange - Kimberly
- Tosca Baggoo - Clerk
- Brent Sheppard - Prosecutor
- Brent Sheppard - Doctor
- Jenn Forgie - Cindy Savalas - Ed's Ex-wife (uncredited)
- Jenn Forgie - Nurse
- Frank Ferrucci - Inspector Nettles
- Roger Allford - Garrett Lorre
- Richard Yee - David Yung
- Ian Robison - Detective Smith
- Ian Robison - Ranger
- Gustavo Moreno - The Father
- John Tierney - Dr. Jacobs
- Kevin Conway - Private McAlpin
- Kevin Conway - 2nd Uniformed Cop
- Nicola Cavendish - Nurse Owens
- Eileen Pedde - Mrs. Skur
- Eileen Pedde - Angie
- Veena Sood - Dr. Louise Colquitt
- Veena Sood - Ms. Saunders
- Peter Flemming - Officer #1
- James Pickens Jr. - Alvin Kersh
- James Pickens Jr. - Alvin Kersh / Jamaican Crewman
- Anthony Harrison - MTA Officer (uncredited)
- Anthony Harrison - FBI Agent Riggins
- Anthony Harrison - Fourth Man
- Kate Robbins - Mrs. Oswald
- Kate Robbins - Lisa's Aunt
- Maggie O'Hara - Young Woman
- Brenda McDonald - Mrs. Loach
- Brenda McDonald - Auntie Janet
- Megan Hilty - Deceased Girl Jessica (uncredited)
- Marty Zagon - Landlord
- Marty Zagon - Mr. Coeben
- Crystal Verge - Woman Reading Words
- Michael St. John Smith - Major General Fryatt (uncredited)
- Michael St. John Smith - The CIA Operative (uncredited)
- Tony Sampson - Brad
- Gerry Nairn - 1st Man
- Brian Knox McGugan - 1st Officer
- Garry Davey - Dr. Keats
- Garry Davey - Captain
- Garry Davey - Bob Spitz
- Kimberly Unger - Joan Gauthier
- Kimberly Unger - Karen Koretz
- Heather McComb - Shannon Ausbury
- Shaun Johnston - Pete Calcagni
- Paul Batten - Brother Wilton
- Paul Batten - Dr. Seizer
- Paul Anthony McLean - Special Agent Kautz
- Paul Anthony McLean - Dr. Josephs
- Paul Anthony McLean - Coast Guard Officer Peters
- Travis MacDonald - Dave Duran
- Michael David Simms - Senior FBI Agent
- Michael David Simms - FBI Agent
- Michael David Simms - Senior Agent
- Laura Harris - Andrea
- Janine Cox - Kate (uncredited)
- Josh Epstein - Josh (uncredited)
- Doug Abrahams - Harbaugh
- Doug Abrahams - Agent #2
- Doug Abrahams - Paul Vitaris
- Doug Abrahams - Patrolman #1
- Doug Abrahams - Detective Neary
- Glynis Davies - Defense Counsel Nelson
- Glynis Davies - Ellen Brumfield
- Glynis Davies - Monica
- Finn Michael - Guard (uncredited)
- Eric Breker - Dark Suited Man #1
- Eric Breker - Ambulance Driver (uncredited)
- Eric Breker - Admitting Officer Michael Fazekas
- Eric Breker - SP Agent Brem
- David Stuart - Seaman (uncredited)
- Katya Gardner - Peggy O'Dell
- Katya Gardner - Robin
- Donald Trump - Self (archive footage) (uncredited)
- Michael Flynn - Self (archive footage) (uncredited)
- Angelo Vacco - Doorman
- Angelo Vacco - Guido / Bartender
- Angelo Vacco - Angelo Garza
- Angelo Vacco - Kevin
- David James Lewis - Young Agent
- David James Lewis - Vosberg
- David James Lewis - Young Officer
- Jody St. Michael - Sophie
- Charles Andre - Ray Floyd
- Bonnie Hay - Field Doctor
- Bonnie Hay - Night Nurse (uncredited)
- Bonnie Hay - Night Nurse
- Bonnie Hay - Woman
- Tom Glass - Trucker
- Alfonso Quijada - Roberto (uncredited)
- Laura Lee Connery - Karen Swenson (uncredited)
- Tim Ransom - Ethan Minette (uncredited)
- Dan Zukovic - Agent
- Dan Zukovic - Martin
- June B. Wilde - Nurse Cooley (uncredited)
- Guyle Fraizer - Officer (uncredited)
- Guyle Fraizer - Officer #1
- Monica Parker - Ladonna
- Lalainia Lindbjerg - Zoe
- Vince Metcalfe - Kissell
- Doc Harris - Mr. McLennen
- John Savage - Henry Trondheim
- Ric Reid - Asst. Coroner
- Ric Reid - Steve Holvey
- David Cubitt - Captain Barclay
- Vladimir Kulich - Olafsson
- Claire Riley - Dr. Laskos
- Robert Metcalfe - Nurse
- Alex Diakun - Buddy / Devil
- Alex Diakun - Curator
- Alex Diakun - Manager
- Alex Diakun - Dr. Fingers
- Alex Diakun - Tarot Dealer
- John McConnach - Sailor (uncredited)
- John Moore - 2nd Elder
- John Moore - 3rd Elder
- John Moore - 2nd Elder (uncredited)
- Terence Kelly - George Usher
- James Bell - Det. Johnson
- Rob Morton - Kramer
- Harrison Coe - Government Man #3 (uncredited)
- Harrison Coe - Isaac Luria
- Harrison Coe - Dave the Butcher
- Michael J. Anderson - Mr. Nutt
- The Enigma - The Conundrum
- Vincent Schiavelli - Lanny
- Lilyan Chauvin - Golda
- Kay E. Kuter - Calusari #1
- Alvin Law - Reverend
- Lesley Ewen - Renee Davenport
- Lesley Ewen - Carina Maywald
- Lesley Ewen - Agent #1
- Lesley Ewen - Receptionist
- Denis Simpson - Hermaphrodite waitress (uncredited)
- Blair Slater - Robert Glazebrook, The Oldest Son (uncredited)
- Dean Norris - Marshal Tapia
- Joel Palmer - Charlie / Michael Holvey
- Joel Palmer - Kevin Morris
- Maria Herrera - Customer #1
- Maria Herrera - Guard #2
- John Tench - Steve
- Bobby Stewart - Deputy
- Bobby Stewart - Resident #2
- Kim Kondrashoff - Bobby Torrence
- Bill Rowat - Dr. Torrence
- Michael Cavanaugh - Sheriff Jack Withers
- Donald Gibb - Kip
- Shelley Owens - Tessa
- Akiko Morison - Leza Atsumi
- Glen Roald - M.E. Worker
- Charles Cioffi - Section Chief Scott Blevins
- Tyler Labine - Stoner
- Tyler Labine - Stoner #1
- Nathaniel DeVeaux - Detective Barron
- Robert Rozen - Doctor
- Michael Puttonen - Motel Manager
- Michael Puttonen - Dr. Pilsson
- Michael Puttonen - Conductor
- Roger Cross - Private Kittel
- Roger Cross - Swat Lieutenant
- Roger Cross - Officer Green (uncredited)
- Roger Cross - Officer Wentworth
- Roger Cross - Agent Rice
- L. Harvey Gold - Patrick Newirth (uncredited)
- Wayne Tippit - Detective Thompson
- Norma Jean Wick - Reporter
- Norma Jean Wick - Newscaster
- Mar Andersons - Halverson (uncredited)
- Mar Andersons - Jack Hammond
- Gregory Sierra - Dr. Diamond
- Jill Teed - Glenna
- Tamsin Kelsey - Ellenn
- Andrew Airlie - Rob
- Jayme Knox - Mom
- Scott Swanson - First Officer
- Sean O'Byrne - Second Officer
- Karin Konoval - Little Judy Poundstone / Little Chucky Poundstone
- Karin Konoval - Mrs. Peacock
- Karin Konoval - Madame Zelma
- Lisa Waltz - Lauren Kyte
- Kelli Fox - Pathologist
- Chris Owens - Jeffrey Spender
- Chris Owens - FBI Special Agent Jeffrey Spender
- Chris Owens - Young Cigarette Smoking Man
- Chris Owens - Young Smoking Man
- Chris Owens - Daniel Miller / Jeffrey Spender
- Chris Owens - Jeffrey Spender / SS Untersturmfuehrer
- Chris Owens - Mutato
- Tom Pickett - Cop
- Nora McLellan - Jane Morris
- Don Thompson - Henry Willig
- Don Thompson - Holtzman
- Don Thompson - Lt. Col. Victor Stans
- Anna Ferguson - Ms. Winn
- John Milford - Walter Chaco
- Gary Grubbs - Sheriff Tom Arens
- John Maclaren - George Kearns
- Beatrice Zeilinger - Burly Nurse
- Beatrice Zeilinger - Paramedic
- Wayne Duvall - Agent Jerry Lamana
- Bill Finck - Sandwich Man
- Theodore Thomas - Clyde
- Bernie Coulson - The Thinker
- Byron Chief-Moon - Father (uncredited)
- Jack Black - Bart 'Zero' Liquori
- Ernie Lively - Sheriff John Teller
- Karen Lorre - Sharon Kiveat
- Peter Donat - William Mulder
- Jerry Hardin - Deep Throat - Ronald
- Aurelio Dinunzio - Antonio (uncredited)
- Walter Gotell - Victor Klemper
- Peter Anderson - Stan Buxton
- John Neville - Well-Manicured Man
- Melinda McGraw - Melissa Scully
- Dakota House - Eric Hosteen
- Rebecca Toolan - Teena Mulder
- Floyd 'Red Crow' Westerman - Albert Hosteen
- Benita Ha - Tour Guide
- Cavan Cunningham - Paramedic #2 (uncredited)
- Cory Chetyrbok - Red Museum Member (uncredited)
- Cory Chetyrbok - Hospitalized Soldier (uncredited)
- Sheila Larken - Margaret Scully
- Sheila Larken - Margaret Scully (voice) (uncredited)
- Aaron Poole - Bystander (uncredited)
- Ken Ryan - Walt Eubanks
- Suleka Mathew - Lisa Dole
- Suleka Mathew - Agent Linda Caleca
- Henry O. Watson - Bailiff (uncredited)
- Tim Dixon - Dr. R.W. Godfrey
- Tim Dixon - Bob
- Robert Clothier - Old Man
- Robert Clothier - Commander Christopher Johansen
- Ellie Harvie - Ticket Agent (uncredited)
- Ellie Harvie - OPO Staffer
- Kevin McNulty - Agent Fuller
- Kevin McNulty - Dr. Christopher Davey
- Kevin McNulty - Agent Brian Fuller
- Denalda Williams - Zirinka
- Denalda Williams - Marilyn
- Jason Griffith - Uniformed Officer (uncredited)
- Jason Griffith - Paramedic #1
- Meredith Bain Woodward - Defense Attorney
- Meredith Bain Woodward - Dr. Ruth Slaughter
- David Hurtubise - Barrington
- David Hurtubise - Pathologist
- Craig Bruhnanski - Security Guard
- Craig Bruhnanski - Guard
- Ron Sauvé - Mr. Decker
- Ron Sauvé - Foreman
- Erin Fitzgerald - Waitress (uncredited)
- Steven Williams - Mr. X
- Steven Williams - Mr. X (voice) (uncredited)
- Karri Turner - Tara Scully
- Carrie Cain-Sparks - Train Station Clerk (uncredited)
- Carrie Cain-Sparks - Maid
- Carrie Cain-Sparks - Duty Nurse
- Dmitry Chepovetsky - Supervisor
- Dmitry Chepovetsky - Lt. Harper
- Dmitry Chepovetsky - 1st Government Man
- Jim Jansen - Dr. Heitz Werber
- Tom Heaton - Resident #1
- Tom Heaton - Groundskeeper
- Paul Raskin - Dr. Eric Ilaqua
- Paul Raskin - Ullrich
- William B. Davis - CGB Spender
- William B. Davis - SS Oberfuehrer / Smoking Man
- William B. Davis - Cigarette Smoking Man / True Name Carl Gerhard Busch
- William B. Davis - Cancer Man
- Steve Bacic - SWAT Commander
- Steve Bacic - Officer #2
- Steve Bacic - Agent Collins
- John Mahon - General Wegman
- Gabrielle Miller - Paula
- Gabrielle Miller - Brenda
- Durrell Nelson - Maggie's Dad (uncredited)
- Al Kaplon - Ump
- Téa Leoni - Dana Scully / Tea Leoni
- D. Neil Mark - S.W.A.T. Team Officer
- D. Neil Mark - Deputy Scott Kerber
- Lenno Britos - Hispanic Man
- Lenno Britos - Luis Cardinal
- Lenno Britos - Janitor (uncredited)
- Thomas R. Martin - Pathology Assistant
- Morris Panych - Gray Haired Man
- Morris Panych - Dr. Simon Auerbach
- Alex Bruhanski - Angelo Pintero
- Alex Bruhanski - Dr. Bugger
- Beverley Elliott - Raven (uncredited)
- Dean Mckenzie - Lt. Blaine (uncredited)
- P.J. Prinsloo - Tagger (uncredited)
- Jacques Lalonde - Henry
- Ernie Foort - Security Guard
- Ernie Foort - Lobby Guard
- Willie Garson - Henry Weems
- Willie Garson - Quinton 'Roach' Freely
- David MacKay - Young Husband
- Greg Anderson - Photographer
- Badja Djola - Napoleon 'Neech' Manley
- John Toles-Bey - John Speranza
- Ken Foree - Vincent Parmelly
- April Grace - Danielle Manley
- Greg Thirloway - Agent Greg Nemhauser
- Greg Thirloway - Dr. Mitchell Kaplan
- J.T. Walsh - Warden Leo Brodeur
- Greg Rogers - Daniel Charez
- Tom Scholte - Michael Sloan
- Tom Scholte - Young Johansen
- Denny Arnold - Key Guard
- Robert Underwood - Paramedic
- Susan Bain - Agent Sarah Sheherlis
- Susan Bain - County Coroner
- Sam Bottoms - Michael Kryder
- Kenneth Welsh - Simon Gates
- Michael Berryman - Owen Lee Jarvis
- Don S. Williams - Elder
- Don S. Williams - Elder #1
- Don S. Williams - 1st Elder
- Hayley Tyson - Susan Kryder
- R. Lee Ermey - Reverend Patrick Findley
- Jaap Broeker - The Stupendous Yappi
- Haley Joel Osment - Young John 'Kitten' James / Davey James
- Joseph Patrick Finn - Chaplain
- Mig Macario - Tattooed Prisoner (uncredited)
- Bruce Pinard - Executioner (uncredited)
- Timothy Carhart - Virgil Incanto
- Catherine Paolone - Ellen Kaminsky
- James Handy - Detective Alan Cross
- Aloka McLean - Jesse
- Suzy Joachim - Jennifer
- Randi Lynne - Lauren
- Nancy Sorel - Capt. Janet Draper
- Ian Tracey - Leonard 'Rappo' Trimble
- Paula Shaw - Ward Nurse
- Rob Lee - Amputee
- Nicholas Lea - Alex Krycek
- Nicholas Lea - Michel
- D. Harlan Cutshall - The Guard (uncredited)
- Brennan Kotowich - Trevor Callahan (uncredited)
- Bruce Harwood - John Fitzgerald Byers
- Bruce Harwood - John Fitzgerald Byers (voice)
- Warren Takeuchi - Japanese Escort (uncredited)
- Nicole Robert - Mrs. Tynes
- Alexa Mardon - Sadie Jacobs (uncredited)
- Corrine Koslo - Lottie Holloway
- Lori Triolo - Diane
- Nicole Parker - Chick
- A.J. Buckley - Dude
- Stephen McHattie - Red-Haired Man
- Dean Haglund - Richard 'Ringo' Langly
- Robert Ito - Dr. Shiro Zama
- Tom Braidwood - Melvin Frohike
- Raymond J. Barry - Senator Richard Matheson
- Sean Allan - Customer #2
- Wren Roberts - Orderly
- Jo Bates - Jeraldine Kallenchuk
- Ari Solomon - Gauthier
- Russell Ferrier - Medic
- Rochelle Greenwood - Waitress
- Joel Silverstone - Engineer #1
- David Neale - Navy Base Guard
- Fiona Roeske - Customer #5
- David Bloom - Stress Man
- Barbara Patrick - Barbara Doggett
- Tegan Moss - Young Dana Scully
- John Destry - Customer #3 (uncredited)
- Tony Marr - Motel Manager (uncredited)
- Lisa Robin Kelly - Terri Roberts
- Ryan Reynolds - Jay De Boom
- Michael Bublé - Submarine Sailor (uncredited)
- Darcy Laurie - Engineer #2 (uncredited)
- Russell Porter - Scott Simmons
- Peter Scoular - Sick Crewman (uncredited)
- Peter Scoular - Sick Crewman
- Frances Flanagan - Nurse
- Brendan Beiser - Agent Pendrell
- Jeremy Radick - Young Man
- Levan Uchaneishvili - John Mostow
- Kurtwood Smith - Agent Bill Patterson
- Kasper Michaels - Young Agent
- Zoran Vukelic - Model
- Martin Evans - Major Domo
- Vic Polizos - Agent Frank Burst
- Julia Arkos - Holly
- Darren Lucas - Lead Swat Cop
- Janne Mortil - Mona Wustner
- Gordon Tootoosis - Shaman
- Robert Wisden - Robert Patrick Modell
- Derek Lowe - Johnny Lo
- Donald Fong - Vase Man
- Diana Ha - Dr. Wu
- Stephen Chang - Large Man
- Paul Wong - Wiry Man
- Peter White - Gene Gogolak
- Rob Freeman - Marshall Sim
- Rob Freeman - Detective Rempulski
- Tom Jourden - Carlton Chase
- Nicholas Walker - Carl Wormus
- John Mack - Customer #3
- Pamela Diaz - Maria Dorantes
- Glen Morgan
- Rick Millikan
- Chris Carter
- Mark Snow
Angela Paton interpreta a Mrs. Lukesh en la serie.
Rubén Blades interpreta a Conrad Lozano en la serie.
Willie Garson interpreta a Quinton 'Roach' Freely en la serie.
Adam Baldwin interpreta a Knowle Rohrer en la serie.
Jodie Foster interpreta a 'Betty' (voice) en la serie.
Peter Boyle interpreta a Clyde Bruckman en la serie.
Deep Roy hace el papel de Beggar Man.
Harriet Sansom Harris interpreta a Dr. Sally Kendrick / Eve 6 en la serie.
Callum Keith Rennie interpreta a Cemetery Groundskeeper en la serie.
George Murdock interpreta a Elder #2 en la serie.
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