- Kurt Fuller - Dr. Kurt Boggs
- Christine Lahti - Sheryl Luria
- Marti Matulis - The Manager / Quareen / Hairy Demon
- Marti Matulis - George / Devil Therapist / Ghoul Orderly
- Marti Matulis - George / Devil Therapist / Jinn / Brother Paul / Demon
- Marti Matulis - George / The Marriage Demon / Bat Demon / The Manager
- Rodney Richardson - Tommy Boutella
- Sanjit De Silva - Neil Benton
- Tom Riis Farrell - Darryl Croce
- Dakin Matthews - Father Augustus
- Matt Deangelis - Brian Cadelago
- Hannah Hodson - Naomi Clark
- Danny Burstein - D.A. Lewis Cormier
- John Glover - Byron Duke
- Laura Kai Chen - Marianne Jacobs
- De'Adre Aziza - Fiona Plemmons
- Manoel Felciano - Jackson Orbinson
- Dascha Polanco - Patti Hitchens
- Luke Judy - Eric McCrystal
- Michael Stahl-David - Tom McCrystal
- Timothy Stickney - William Hopkins
- Gregg Edelman - Rodney Match
- Nelson Lee - Daniel Ling
- Clark Johnson - Father Amara
- Annaleigh Ashford - Bridget Farrell
- Rocco Sisto - Silvio
- Evelyn Giovine - Linda
- Pedro Carmo - Vincent
- Dan Bittner - Dwight Farrell
- Anthony Alessandro - Mateo
- Nana Mensah - Esther
- Christiani Pitts - Annie Commerce
- Jenn Colella - Cori
- Vondie Curtis-Hall - Leon Acosta
- Noah Robbins - Sebastian Lewin
- Karen Pittman - Caroline Hopkins
- Graham Rowat - Detention Guard Adam Gardner
- Jennifer Ferrin - Judith Lemonhead
- Jeremy Shamos - Dr. Phillip Lynch-Giles
- James Udom - Father Walsh
- Sophia Anne Caruso - Emma
- Julia Nightingale - Olivia
- Alison Cimmet - Sister Elena
- Steve Routman - Doctor Collin Marks
- Gbenga Akinnagbe - Lando Mutabazi
- Nedra Marie Taylor - Dr. Alexa Ham
- John Bolton - Edgar Loudermilk
- Ciara Renée - Abbey (voice)
- Peter Scolari - Bishop Thomas Marx
- Brandon J. Dirden - Raymond
- Dylan Baker - Father Kay
- Brian Stokes Mitchell - Father Mulvehill
- Ben Rappaport - Brian Castle
- Zuleikha Robinson - Jane Castle
- Nicole Shalhoub - Vanessa Dudley
- Fredric Lehne - Mick Carr
- Heather Lind - Sarah McCrystal
- Ato Essandoh - Nathan Katsaris
- Kristen Connolly - Mira Byrd
- Wayne Duvall - Louie Wolff
- Corey Cott - Officer Jim Turley
- Alexandra Socha - Fenna
- Frank Wood - Brother Jacob
- Kenneth Tigar - Winston
- Michael Esper - Scientist
- Darren Pettie - Orson LeRoux
- Meera Simhan - Liyana Shakir
- Francesca Faridany - Dr. Cara Autry
- Julienne Hanzelka Kim - Anita Iota
- Gus Halper - Graham Lucian
- Renée Elise Goldsberry - Renée Harris
- Jenny Sterlin - Sister Gertrude
- Ruthie Ann Miles - Dr. Beverly Swan
- Branden Lindsay - Technician
- Jeffrey Schecter - Dr. Lyon
- Joel de la Fuente - Bash
- Uly Schlesinger - Renold
- Brooke Bloom - Emily LeRoux
- Kellie Overbey - Renold's Mom
- Jay Will - Phoebus
- Scott Chan - Dying Man
- Ao Lan Guo - Wife
- Fenton Li - Doctor
- Ebony Marshall-Oliver - Middle-Aged Mother
- John Wu - Chinese Official
- Kayli Carter - Amalia
- Taylor Louderman - Malindaz
- Amir Malaklou - Demo Club Head
- Alexandra Templer - Taylor
- Chad Burris - Front Desk Clerk
- John Jellison - Dr. Bell
- Annie Golden - Traci
- KeiLyn Durrel Jones - Jason Moss
- Jennean Farmer - Jacqueline Moss
- Joe Cassidy - Contractor Pete
- Benjamin Magnuson - Russ Owlman
- Madeline Wise - Jessica Atterbury
- Anthony DeSando - Father Rodrigo Katagas
- James Cusati-Moyer - Matthew
- Dennis Creaghan - Father Aaron Gray
- Darius Fraser - The Manager's Secretary
- David Lansbury - Father Barnaby
- Malachy Cleary - Pastor Phil Nowell
- Philip Hoffman - Rabbi Gary Bockman
- Dipti Mehta - Nurse Abbas
- Tanya Perez - Emergency Worker #1
- Alexander Molina - Emergency Worker #2
- Thomas Silcott - Kevin Messersmith
- Christiane Noll - Gal Berganza
- Malina Weissman - Candace Berganza
- Lena Hall - Marie Taylor
- Lilli Stein - Katie
- Stephen Dexter - Male Shopper / Fry Guy
- Stephen Dexter - Fry Guy
- Noa Beckham-Chasnoff - Wallpaper Girl
- Baylen D. Bielitz - Little Mike
- Felicia Boswell - Young Woman
- Kaitlyn Davidson - Margarita Mommy
- Carter Gill - The Great Heller / Jordan Heller
- Maribel Martínez - Jealous Jean
- Amelia McClain - Perfect Patty
- Nandita Shenoy - Father Helper
- Scott Whitehurst - Father Helper
- Michael Chernus - Dr Paul Wimsimer
- Gia Crovatin - Renee
- Patrick Page - Father Luke
- Anoop Desai - Larry
- Ismenia Mendes - Carsie
- Diane Davis - Brandi
- David Aaron Baker - Joel Venegas
- Christina Rouner - Mrs. Venegas
- Aaron Yoo - Li Zhang
- Charlie Semine - Logan Wendig
- Lauren Norvelle - Valerie Wendig
- Euan Morton - George (voice)
- Jeff Hiller - Chuck
- Juliette Kenn de Balinthazy - Charlotte
- Kenny Chin - Minister Xi
- Matilda Lawler - Mathilda Mowbray
- Matilda Lawler - Brenda
- Francois Battiste - Brandon Metellus
- Montego Glover - Mrs. Metellus
- Brian d'Arcy James - Victor LeConte
- Patrice Johnson - Miss Marie
- Raul Torres - Father Diego
- Nate Mann - Henry Trezza
- Heidi Armbruster - Tamara Hale
- Sohina Sidhu - Karima Shakir
- Steve Key - Zach
- Brandon Ford Green - Policeman / James Diver
- Raymond Neil Hernandez - Security Guard / Tim Crawford
- Fabrizio Brienza - Father Damian
- Li Jun Li - Grace Ling
- Patrick Brammall - Andy Bouchard
- Wallace Shawn - Father Francis Ignatius
- Quincy Tyler Bernstine - Sheila Gibson
- Dana Gourrier - Yasmine
- Tim Matheson - Edward Tragoren
- Molly Brown - Sheryl's Assistant Leslie
- Joe Grifasi - Lombino
- Jack Berenholtz - Bobby
- Antonio Watson - Aaron Gibson
- Rose Decker - Toddler (uncredited)
- Taylor Trensch - Mitch Otterbean
- Kevin William Paul - Owen Venegas
- Peter Mark Kendall - Dr. Ethan Parquet
- Carra Patterson - Emily Reinhardt
- Donathan Walters - Luis Rivera
- Patch Darragh - Seth Tolford
- Jeremy Crutchley - Father Agostino La Russo
- Victor Cruz - Mateo Marcus
- Danny Mastrogiorgio - Greg Bruni
- Chukwudi Iwuji - Father Dominic Kabiru
- Andrew Rein - Interrogating Lawyer
- Samuel H. Levine - T.J.
- Maurice Jones - Harley Elfman
- John Sanders - Bishop Jim Logger
- John Sanders - Marriage Demon (voice)
- Michelle Wilson - Dr. Anita Marley
- Brent Langdon - Testing Supervisor
- Tony Plana - Chet Garcia
- Carson Elrod - Larry Bibb
- Tara Summers - Nurse Linda Bloch
- David Alford - Baxter
- Rose Jackson Smith - Mary
- Annabelle Zasowski - Sarah
- Lilla Crawford - Ruth
- Sean Grandillo - Cody
- Malcolm Callender - Grim Male
- Ron Domingo - Doctor Finn
- Luca R Stagnitta - Red-Faced Man
- Abraham Alvarez - Judge
- Marc Webster - Guard (Randy)
- Thirsa van Til - Female Patient (Judy)
- Cristala Carter - Nurse
- Boris McGiver - Monsignor Matthew Korecki
- Boris McGiver - Monsignor Matthew Korecki (voice)
- Joel Harlow - Joel Harlow
- Marcus Ho - Doctor
- Melissa Joyner - Angela Clark
- Kevin Pariseau - Coroner
- Sean Phillips - Cleveland
- Shiloh Verrico - Girl
- Jayson Wesley - Bearded Man
- Amy Hohn - Judge Katrina Linden
- Audrey Bennett - Jeannie McCrystal
- Scott Ian - Butcher
- David Adkins - Pierre Halley
- Jake Ryan Lozano - Dougie Martin
- Lizan Mitchell - Crying Aunt
- Sharon Gee - Chinese Woman
- Baylen Thomas - Controller
- Stephen Cefalu - Jonathan
- Conor Proft - Incel
- Aisha de Haas - Singer
- Gabrielle McClinton - Singer
- Yinka Adeboyeku - Singer
- Patrice Bell - Receptionist
- Kyle Selig - Process Server
- Laila Drew - Girl in Cafeteria
- Alexa Shae Niziak - Girl in Cafeteria
- Q. Smith - Choir Director
- Megan Ketch - Judy James
- Paton Ashbrook - Nurse Karen Piper
- Kevin Keppy - Qareen
- Kevin Keppy - Demon of Words
- Marcus Callender - Harlan Zephyrs
- Michael Mulheren - Father Gary Douglas
- Michael Charles Roman - Chris Simmons
- Nivek Ogre - Ghoul Orderly
- Jordana Spiro - Ema Serpagli
- Michael Hayden - Dr. Hal Docker
- Kevin Chapman - The Manager (voice)
- Kevin Chapman - Demon of Words (voice)
- Derek Gaines - Stand Up Comedian
- Emayatzy Corinealdi - Sonia Kamanzi
- Jayne Houdyshell - Judge Sara Carl Shire
- Laura Heisler - Eleanor Chakiris
- Jane Dashow - Nun
- Jessie Mueller - Anya
- Hampton Fluker - Kevin
- John Zdrojeski - Tom
- Monica Ramirez - Younger Nun
- Sevan Greene - Sheikh Majed
- Charlie McElveen - Colin
- Ruibo Qian - Mila
- Christopher Innvar - Duke Sawyer
- Welker White - Michelle Sawyer
- Leon Addison Brown - Minister
- Danny Wolohan - Vlad
- Eric Berryman - Logan
- James Murtaugh - Zach Neville
- Brian Keane - Mr. Hamlin
- Kemo Coleman - CongoRun Employee
- Stan Demidoff - CongoRun Employee
- Joe Lanza - CongoRun Worker
- Rob McClure - Emanuel
- Greg Keller - Father Thomas
- Brad Heberlee - Priest (DNA Test)
- Ben Jackson Walker - Clayton Salmon
- Jacob Daniel Smith - Stephen Flint
- April Matthis - Captain Cassie Sampson
- Malika Samuel - Asha
- Marceline Hugot - Head Nun
- Carolee Carmello - Colonel Tremé
- Carly Street - RSM Client
- Piper Rae Patterson - Receptionist
- Amy Keum - Tamara
- Reed Birney - Father Thunderland
- Keith Buterbaugh - Alex
- Trevor Van Uden - Daryl
- Celeste Arias - Whitney Festa
- Michael Izquierdo - Travis Festa
- Michael Laurence - Gregory Beale
- Elijah M. Cooper - Elijah Katsaris
- Zachary Golinger - Sebi Festa
- Gibson Frazier - Asa Linden
- Gregory Porter Miller - Charles
- Nik Sadhnani - Luke
- Ray DeMattis - Aging Priest
- Philip Goodwin - Ancient Bishop
- Megan Haley - Heather
- Greg Wood - Stern Priest
- Patrick Breen - Father Dement
- Joe Carroll - Stuart Lawry
- Kate Arrington - Jennifer Lawry
- Segun Oduolowu - Newscaster
- Sydney Lemmon - Tori
- Bryce Pinkham - Marcus Finch
- Adrianna Mitchell - Shannon
- Kalyne Coleman - Lucy
- Reg Rogers - Aiden Flowers
- Vincenzo Amato - Sternest Priest
- Darrin Baker - Father Jeffries
- Andrew Breving - Ghost Pilot Lemire
- Mary Cavett - Vicki Finch
- Jennifer Mogbock - Katherine Orlander
- Andy Mientus - Tober Lucas
- Delaney Williams - Father Zimmer
- Robert Montano - Hossam
- Sahr Ngaujah - Father Addiso
- Greg Hildreth - Father Brass
- Oberon K.A. Adjepong - General Girma
- Sara Esty - Marcy
- Julian Joseph - Military Guard
- Sarah Ellen Stephens - Ethiopian Nun #2
- Jolina Javier - Dancer #5
- Jefferson White - Tyrus
- Sean Patrick Thomas - Tyler
- Roslyn Ruff - Daniella
- Austin Elle Fisher - Steph
- Devin White - Painter
- Sebastian Delascasas - Thomas
- Santino Fontana - Jakob
- Arnie Burton - Dr. Howard Doggett
- Brandon E. Burton - Congorun Driver
- Ka-Ling Cheung - Nurse
- Patrick Cummings - Officer Peter Wolfe
- Isabel Ferrer - Astrology Girl
- Jon Norman Schneider - Doctor
- Eric Leviton - Mr. Lichtenberg
- Anna Chlumsky - Ellie
- Fedor Steer - Massive Stick Demon
- Fedor Steer - George / Massive Stick Demon
- Fedor Steer - Boop Demon / Ghostly Figure
- Fedor Steer - The Manager / Qareen
- Fedor Steer - The Manager
- Fedor Steer - Jinn / Qareen
- Richard Kind - Judge Jared Jeter
- John Carroll Lynch - Henry Stick
- Tom Titone - Justin Trapper
- Twinkle Burke - Nurse Sandy
- Paul Guilfoyle - Archbishop Kirby
- Nate Corddry - Paul Stolee
- Hannah Cabell - Vivian
- T. Ryder Smith - Hairy Demon
- Fred Inkley - Gray Man
- Fred Inkley - The Grey Man
- Denis O'Hare - Father Giovanni De Vita
- Paco Lozano - Father Augusta
- Christian Borle - Neil
- John Christopher Jones - Johan Taupin
- Jeffrey Bean - Dr. Weinberg
- Sarah Lyddan - Beverly Bridges
- Abbie Mueller - Female Soloist
- Sophie von Haselberg - Brittany
- Ben Livingston - Dr. Floyd C. Hopper
- Milo Alosi - Marco
- Craig Wesley Divino - Chuck Liptak
- Blair Lewin - Carpool Mom
- Karine Plantadit - Mother Midnight
- Anita Abdinezhad - Seraph
- Jake Schwencke - Pissed Pete
Joe Grifasi hace el papel de Lombino.
Wayne Duvall interpreta a Louie Wolff en la serie.
Katja Herbers interpreta a Dr Kristen Bouchard en la serie.
Mike Colter interpreta a David Acosta en la serie.
Aasif Mandvi interpreta a Ben Shakir en la serie.
Michael Emerson interpreta a Dr Leland Townsend en la serie.
Brooklyn Shuck hace el papel de Lynn Bouchard.
Skylar Gray interpreta a Lila Bouchard en la serie.
Maddy Crocco interpreta a Lexis Bouchard en la serie.
Dalya Knapp interpreta a Laura Bouchard en la serie.
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