- Tom Amandes - Harold Abbott
- Reiley McClendon - Travis
- Carter Jenkins - David Beck
- Jessica Collins - Cameron
- Jensen Buchanan - Roxanne Maxwell
- Ryne Sanborn - Young Colin Hart
- Derek Webster - FBI Agent
- Joanna Cassidy - Evelyn Rowser
- Luke Askew - Marvin Harrison
- Lamont Thompson - Brian
- Walter Olkewicz - Mike O'Connell
- Anne Heche - Amanda Hayes
- Joseph Bologna - Max Barrett
- Jason Beghe - John Hayes
- Charles Durning - Eugene Brown
- Olesya Rulin - The Drunk Girl
- Simon Rex - Cliff Fenton
- Keith David - Brian
- Nia Long - Cassie
- Philip Baker Hall - Dr. Donald Douglas
- Jessica Tuck - Bonnie
- Brooke Nevin - Ellie
- Albie Selznick - Dr. Albert Franco
- Christopher Egan - Nick Bennett
- Margo Harshman - Maura
- Kim Morgan Greene - Mrs. Thompson
- Tamara Taylor - Dr. Lence
- Jess Weixler - Nikki
- Brenda Strong - Julia Brown
- Beth Grant - Miss Violet
- Leslie Hope - Laurie Fields
- Douglas Smith - Gavin Curtis
- Tom Virtue - Juilliard Administrator
- Ernie Hudson - Bill Hoover
- Chris Penn - Frank Sullivan
- Adam Beach - Mr. Grey Cloud
- Kristen Bell - Stacey Wilson
- Drew Osborne - Swimmer
- John Savage - Daniel Maxwell
- Claudia Christian - Young Edna
- Melinda Page Hamilton - Mary Kelly
- Mark Rydell - Jacob Hoffman
- Elizabeth Mitchell - Sara Beck
- Noah Bastian - The Guy
- Sarah Lancaster - Madison Kellner
- Richard Herd - Herb Roberts
- Eyal Podell - Justin
- James Earl Jones - Will Cleveland
- Victoria Justice - Thalia Thompson
- Mike Erwin - Colin Hart
- Kathryn Joosten - Mrs. Hammerhill
- Steven R. McQueen - Kyle Hunter
- Lee Garlington - Brenda Baxworth
- Bill Erwin - Ollie
- Laura Regan - Ruth
- Elizabeth Bond - Kate
- David Eigenberg - Chris Templeman
- Gina Hecht - Gastroenterologist
- Gary Basaraba - Mr. Curtis
- Bret Loehr - Magilla
- Erick Avari - James Gellar
- Denise Dowse - Laura Hoover
- J.K. Simmons - Phil Drebbles
- Jimmy Bennett - Sam Feeney
- Melinda Clarke - Sally Keyes
- Kevin Tighe - Joe Morris
- John Aylward - Walter Cunningham
- Doris Belack - Ruth Hoffman
- Justin Baldoni - Reid Bardem
- Philipp Karner - Josh Walker
- Gina Ravera - Stacey
- Beau Bridges - Daniel Sullivan
- Freda Foh Shen - Dr. Chao
- Vicki Davis - Beth
- Jon Lindstrom - Bill Schmicker
- Betty White - Carol Roberts
- Justin Kirk - James Carmody
- Nora Zehetner - Laynie Hart
- Camille Guaty - Serena
- Dendrie Taylor - Mrs. Thomson
- Dylan Walsh - Carl Feeney
- Wayne Dalglish - Young Bright Abbott
- Christopher Neiman - Coach Lewis
- Jane Krakowski - Dr. Gretchen Trott
- Chris Owen - Pierson
- Stephen Spinella - Father Patrick
- Michael McLafferty - Dave
- Kirsten Nelson - Ellie Beals
- Kellie Waymire - Helen McGinns
- Scott Wilkinson - Joe, Erin's Dad
- Nancy Everhard - Sharon Hart
- Maggie Baird - Mrs. Harcourt
- Haley McCormick - Susie Clark
- Ryan Hurst - Ed Carnahan
- Erica Gimpel - Dr. Gans
- Annie Burgstede - Pippi
- Tim DeKay - Reverend Keyes
- Kelly Carlson - Ada
- Kirby Heyborne - Mr. Perkins
- Ben Weber - Chris Beals
- Robert Peters - Marty Maxwell
- Clyde Kusatsu - Edward Ogawa
- Ann Bosler - Susie's Mom
- Joan McMurtrey - Mrs. Curtis
- Colleen Flynn - Chief of Human Resources
- Keone Young - Gino
- Michelle Nolden - Kathy Carmody
- Aaron Brown - Aaron Brown
- Tom Parker - Brian Hartman
- Charlie Weber - Jay
- Kate Mara - Kate Morris
- Lisa Howard - Leslie Hammond
- Brandon Osborne - Swimmer
- Stephen Warner - Teen #1
- Edna Pozer - Lady #1
- Hilda Doherty - Lady #2
- Stafford Lawrence - Greeley
- Al Holt - Mr. Saddlebrook
- Benjamin Barton - Carnival Spectator
- Cody McMains - Wendell
- Micaela Nelligan - Martha Thompson
- Brooks Bedore - Arnie
- Jan Broberg - Louise
- Chris White - Joe Crowell
- Melinda Haynes - Female Board Member
- Trevor Wright - Student #1
- Levi Larsen - Student #2
- Robert Conder - Commander Busto
- Jeremy Hoop - Chaplain Roth
- Michael Flynn - James Hart
- Christy Summerhays - Jenny Foster
- Chris Kendrick - Howard Foster
- Helen White - Elderly Woman
- Tim Whitaker - Mole
- JJ Neward - Minnie
- Derek Boone - Todd
- Paul Kiernan - Dr. Castle
- Paul Kiernan - Dr. Mason Lewis
- Eric Ian Goldberg - Ben O'Connell
- Curt Doussett - Police Officer
- Jonathan Rudy - Student
- Scott Silver - Student
- Deborah Lee Douglas - Nurse
- Gordon Johnson - Mr. Jensen
- Elizabeth Hansen - Lily
- J. Scott Bronson - Bud
- Joey Miyashima - Dr. Friesen
- Adam Clinton - Dwayne
- Adam Clinton - Cashier
- Adam Clinton - Waiter
- George Sullivan - Earl
- Nate Bynum - The Pot Man
- Jeanette Puhich - The Pot Woman
- Greg Ilk - Richie
- Greg Ilk - Ufologist
- Ilyse Mimoun - Mrs. Wilkins
- Steve O'Neill - Roger Murphy
- Steven Wayne Anderson - Thurman Revere
- Nick Praggastis - Ted
- Kate Pappas - Cute Girl
- Bruce Newbold - Dan Clark
- Bruce Newbold - Male Board Member
- Bruce Newbold - Councilman Morris
- Charlie Paddock - Audience Member
- Maria Carr - The Patient
- Ian Vogt - Matthew Lansing
- Katharine Clark Reilly - Ms. Marvin
- Liz Edmiston - Miss Rodionoff
- Marissa Porritt - Girl #2
- Scott Christopher - Coach Austin
- Scott Christopher - The Do-Gooder
- Sam Littlefield - Guy
- Oscar Rowland - Mort
- Adam Huss - Waiter
- Mitchell Watson - Mikey
- Bernie Diamond - Charlie
- Annette Wright - Mrs. Hanson
- Annette Wright - Everwoody
- Tom Markus - The Rabbi
- Rob Nagle - Joel Hurwitz
- Dan Merket - Chuck Dodd
- Dan Merket - The Largest Logger
- Dan Merket - The Fan
- Rachel Thorp - Young Amy Abbott
- Jennifer Erekson - Arnie's Mom
- Sara Jade Woodhouse - Pony Tail Guy
- Elizabeth Sands - Jenny
- Kim Landry - Betsy Dodd
- Reb Fleming - The Camper
- Alex Gerrish - Hank
- Anne Sward - Ms. Caleb
- Anne Sward - Teacher
- Whitney Lee - Brittany Clark
- Austin Archer - County Kid
- Michael Coe - New Lifeguard
- Michael Coe - Future Alcoholic
- Michael Coe - Clueless Student
- Cheryl White - Mrs. Wilson
- Patrick Stogner - Young Harold
- Jodi Russell - Debbie West
- Tod Huntington - Worker #1
- Tod Huntington - Frat Boy #2
- Nancy Peterson - Elisa's Mom
- Allan Groves - Chris
- Richard Blake - Rick Walzak
- Brenda Sue Cowley - Mrs. Clark
- Joyce Cohen - Millie Sullivan
- Joyce Cohen - Princetown Rep
- Sean Mahon - Pseudo Patient
- Mick Hilgers - Oscar
- Lincoln Hoppe - Aldo
- Dane Stevens - Wally
- Janice Knickrehm - Church Woman
- Matt Barker - Waiter
- Rick Fitzgerald - Rescue Worker
- James Jamison - Dr. Berdell
- James Jamison - Bypass Technician
- David H. Stevens - Denver
- Tim Threlfall - Priest
- Tim Threlfall - The Pharmacist
- Maeve Millard - Kirsten
- Joel Bishop - The Pharmacist
- Michelle Peterson - Nurse #2
- Michelle Peterson - The Professor
- Michelle Peterson - Anesthesiologist
- Tegan West - Jerry McGinns
- Roger Nelson - Father Ivers
- Paul Anthony McLean - Coach Spitzer
- Michael Birkeland - The Ticket Guy
- Martin Casaus - Wrestling Bad Guy (uncredited)
- Becky Harding - Roberta
- Josh Haber - The Waiter
- Melinda Renee - Concierge
- Melinda Renee - Juilliard Registrar
- Elisabeth Lund - Carrie
- K. Danor Gerald - The MC
- Lisa Waltz - Diane Shumacher
- Todd Davis - Glenn
- Kent Richards - Police Officer
- Martha Carter - The Stoned Girl
- Reese Phillip Purser - The Man
- Tom Wright - Carl's Lawyer
- Erinn Hayes - Mindy Wheeler
- Neal Barth - Judge Papert
- Elizabeth Johnson - Party Goer
- Nora Burns - The Receptionist
- Dustin Siler - The Jock Buddy
- Michael Todd Behrens - Gerry Block
- Robert Himber - The Regency Insurance Man
- K.C. Clyde - Future Achiever
- Ron Frederickson - Juilliard Judge
- Mowava Pryor - Circulating Nurse
- Alex Nibley - Radiologist
- Shane Morrisun - Graduating Student (uncredited)
- Brandy Snow - Maitre D'
- Liliana Arredondo - Ms. Sawaya
- Matthew Pohlson - Dean Kelly
- Ben Hammond - Sam Feeney
- Ben Hammond - Sam Feeney (voice)
- Brighton Hertford - Katie
- Kristin Alayna - Pool Party Girl
- Dhylan Meyer - Michael Beck
- Slate Holmgren - Mover
- Brooke Bloom - College Guide
- Anne Kathryn Parma - Patient
- Cameron Jones - Mikey
- Nancy Roth - Female Counselor
- Nancy Roth - Woman in Line
- Heather Beers - Julie
- Annie O'Donnell - Librarian
- Austin Tichenor - Dr. Bass
- Obba Babatundé - Jason
- Scott Williamson - Coach
- Joe Lookinland - Dougie Wilson
- Leslie Wing - Registration Woman
- Andrea Andes - Jillian
- Rhett Willman - Mr. Perch
- Melanie Nelson - Mrs. Lacey
- Lukas Behnken - Topher Cole
- Shawn Nottingham - Dr. Liu
- Brian Palermo - Rick
- Amy Rutberg - Sarah
- Ray DeMattis - Thomas the Doorman
- Jerry Dixon - Piano Player
- Bee-Be Smith - Gretta
- Brooks Almy - Clerk
- Matthew Bellows - MRI Technician
- Deborah Ellis - Jan
- Deborah Ellis - Secretary
- Todd Louiso - Equipment Buyer
- Gedde Watanabe - Art
- Brian Baumgartner - Contractor
- Patrick Fabian - Dr. Henry Validor
- Hawk Younkins - Tim Quills
- Yolanda Stange - The Nurse
- Frank Gerrish - Baker
- Victor Z. Isaac - Ethan Harcourt
- Phillip Jeanmarie - Pete Boroni
- Star LaPoint - Ellie
- Renée Taylor - Betty Barrett
- Teri Cowan - Insurance Woman
- Christian Jensen - Army Recruiter
- Gary Neilson - Science Man
- Susanne Sutchy - Jessica Hunter
- Kellie Hamilton - Alice
- Susan Dolan Stevens - Female Patient
- Margo Watson - Well-Dressed Woman
- Jayne Brook - Mrs. Rogers
- Hosea Chanchez - Student
- Roger Malaga - The Deejay
- Alesandra Durham - Emily
- Stacy Sobieski - Emily
- Gregory Alan Williams - James Cleveland
- Monnae Michaell - Madeleine
- Amy Stewart - Dr. Parsons
- Jamie Strange - Sandy
- Ivey Lloyd - Shannon
- Brenden Whitney - Classmate
- Scott Cowdrey - EMT #1
- Preston Sadleir - EMT #2
- Dee Macaluso - Adele
- Reggie Austin - Andre Harvey
- Diane Delano - Mary
- Ruby Chase O'Neil - Penny
- McNally Sagal - Adoption Agency Evaluator
- Kenny Beers - Beach Goer (uncredited)
- Elaine Kagan - Angela Bardem
- Terence Goodman - Winston
- Luciana Carro - Stephanie Meyer
- Rick Allen - Officer #1
- Stephen Rippey - Officer #2
- Rick Macy - Dr. Ricketts
- Darren Ewing - Usher (uncredited)
- Fenton Quinn - Don
- Greg Berlanti
- Michael Green
- Rina Mimoun
- Oliver Goldstick
Joanna Cassidy interpreta a Evelyn Rowser en la serie.
Philip Baker Hall interpreta a Dr. Donald Douglas en la serie.
Chris Penn hace el papel de Frank Sullivan.
Todd Louiso interpreta a Equipment Buyer en la serie.
Beau Bridges interpreta a Daniel Sullivan en la serie.
Charles Durning hace el papel de Eugene Brown.
Clyde Kusatsu interpreta a Edward Ogawa en la serie.
Treat Williams hace el papel de Andrew Brown.
Gregory Smith hace el papel de Ephram Brown.
Emily VanCamp interpreta a Amy Abbott en la serie.
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