- Tom Amandes - Harold Abbott
- Reiley McClendon - Travis
- Carter Jenkins - David Beck
- Jessica Collins - Cameron
- Jensen Buchanan - Roxanne Maxwell
- Ryne Sanborn - Young Colin Hart
- Derek Webster - FBI Agent
- Joanna Cassidy - Evelyn Rowser
- Luke Askew - Marvin Harrison
- Lamont Thompson - Brian
- Walter Olkewicz - Mike O'Connell
- Anne Heche - Amanda Hayes
- Joseph Bologna - Max Barrett
- Jason Beghe - John Hayes
- Charles Durning - Eugene Brown
- Olesya Rulin - The Drunk Girl
- Simon Rex - Cliff Fenton
- Keith David - Brian
- Nia Long - Cassie
- Philip Baker Hall - Dr. Donald Douglas
- Jessica Tuck - Bonnie
- Brooke Nevin - Ellie
- Albie Selznick - Dr. Albert Franco
- Christopher Egan - Nick Bennett
- Margo Harshman - Maura
- Kim Morgan Greene - Mrs. Thompson
- Tamara Taylor - Dr. Lence
- Jess Weixler - Nikki
- Brenda Strong - Julia Brown
- Beth Grant - Miss Violet
- Leslie Hope - Laurie Fields
- Douglas Smith - Gavin Curtis
- Tom Virtue - Juilliard Administrator
- Ernie Hudson - Bill Hoover
- Chris Penn - Frank Sullivan
- Adam Beach - Mr. Grey Cloud
- Kristen Bell - Stacey Wilson
- Drew Osborne - Swimmer
- John Savage - Daniel Maxwell
- Claudia Christian - Young Edna
- Melinda Page Hamilton - Mary Kelly
- Mark Rydell - Jacob Hoffman
- Elizabeth Mitchell - Sara Beck
- Noah Bastian - The Guy
- Sarah Lancaster - Madison Kellner
- Richard Herd - Herb Roberts
- Eyal Podell - Justin
- James Earl Jones - Will Cleveland
- Victoria Justice - Thalia Thompson
- Mike Erwin - Colin Hart
- Kathryn Joosten - Mrs. Hammerhill
- Steven R. McQueen - Kyle Hunter
- Lee Garlington - Brenda Baxworth
- Bill Erwin - Ollie
- Laura Regan - Ruth
- Elizabeth Bond - Kate
- David Eigenberg - Chris Templeman
- Gina Hecht - Gastroenterologist
- Gary Basaraba - Mr. Curtis
- Bret Loehr - Magilla
- Erick Avari - James Gellar
- Denise Dowse - Laura Hoover
- J.K. Simmons - Phil Drebbles
- Jimmy Bennett - Sam Feeney
- Melinda Clarke - Sally Keyes
- Kevin Tighe - Joe Morris
- John Aylward - Walter Cunningham
- Doris Belack - Ruth Hoffman
- Justin Baldoni - Reid Bardem
- Philipp Karner - Josh Walker
- Gina Ravera - Stacey
- Beau Bridges - Daniel Sullivan
- Freda Foh Shen - Dr. Chao
- Vicki Davis - Beth
- Jon Lindstrom - Bill Schmicker
- Betty White - Carol Roberts
- Justin Kirk - James Carmody
- Nora Zehetner - Laynie Hart
- Camille Guaty - Serena
- Dendrie Taylor - Mrs. Thomson
- Dylan Walsh - Carl Feeney
- Wayne Dalglish - Young Bright Abbott
- Christopher Neiman - Coach Lewis
- Jane Krakowski - Dr. Gretchen Trott
- Chris Owen - Pierson
- Stephen Spinella - Father Patrick
- Michael McLafferty - Dave
- Kirsten Nelson - Ellie Beals
- Kellie Waymire - Helen McGinns
- Scott Wilkinson - Joe, Erin's Dad
- Nancy Everhard - Sharon Hart
- Maggie Baird - Mrs. Harcourt
- Haley McCormick - Susie Clark
- Ryan Hurst - Ed Carnahan
- Erica Gimpel - Dr. Gans
- Annie Burgstede - Pippi
- Tim DeKay - Reverend Keyes
- Kelly Carlson - Ada
- Kirby Heyborne - Mr. Perkins
- Ben Weber - Chris Beals
- Robert Peters - Marty Maxwell
- Clyde Kusatsu - Edward Ogawa
- Ann Bosler - Susie's Mom
- Joan McMurtrey - Mrs. Curtis
- Colleen Flynn - Chief of Human Resources
- Keone Young - Gino
- Michelle Nolden - Kathy Carmody
- Aaron Brown - Aaron Brown
- Tom Parker - Brian Hartman
- Charlie Weber - Jay
- Kate Mara - Kate Morris
- Lisa Howard - Leslie Hammond
- Brandon Osborne - Swimmer
- Stephen Warner - Teen #1
- Edna Pozer - Lady #1
- Hilda Doherty - Lady #2
- Stafford Lawrence - Greeley
- Al Holt - Mr. Saddlebrook
- Benjamin Barton - Carnival Spectator
- Cody McMains - Wendell
- Micaela Nelligan - Martha Thompson
- Brooks Bedore - Arnie
- Jan Broberg - Louise
- Chris White - Joe Crowell
- Melinda Haynes - Female Board Member
- Trevor Wright - Student #1
- Levi Larsen - Student #2
- Robert Conder - Commander Busto
- Jeremy Hoop - Chaplain Roth
- Michael Flynn - James Hart
- Christy Summerhays - Jenny Foster
- Chris Kendrick - Howard Foster
- Helen White - Elderly Woman
- Tim Whitaker - Mole
- JJ Neward - Minnie
- Derek Boone - Todd
- Paul Kiernan - Dr. Castle
- Paul Kiernan - Dr. Mason Lewis
- Eric Ian Goldberg - Ben O'Connell
- Curt Doussett - Police Officer
- Jonathan Rudy - Student
- Scott Silver - Student
- Deborah Lee Douglas - Nurse
- Gordon Johnson - Mr. Jensen
- Elizabeth Hansen - Lily
- J. Scott Bronson - Bud
- Joey Miyashima - Dr. Friesen
- Adam Clinton - Dwayne
- Adam Clinton - Cashier
- Adam Clinton - Waiter
- George Sullivan - Earl
- Nate Bynum - The Pot Man
- Jeanette Puhich - The Pot Woman
- Greg Ilk - Richie
- Greg Ilk - Ufologist
- Ilyse Mimoun - Mrs. Wilkins
- Steve O'Neill - Roger Murphy
- Steven Wayne Anderson - Thurman Revere
- Nick Praggastis - Ted
- Kate Pappas - Cute Girl
- Bruce Newbold - Dan Clark
- Bruce Newbold - Male Board Member
- Bruce Newbold - Councilman Morris
- Charlie Paddock - Audience Member
- Maria Carr - The Patient
- Ian Vogt - Matthew Lansing
- Katharine Clark Reilly - Ms. Marvin
- Liz Edmiston - Miss Rodionoff
- Marissa Porritt - Girl #2
- Scott Christopher - Coach Austin
- Scott Christopher - The Do-Gooder
- Sam Littlefield - Guy
- Oscar Rowland - Mort
- Adam Huss - Waiter
- Mitchell Watson - Mikey
- Bernie Diamond - Charlie
- Annette Wright - Mrs. Hanson
- Annette Wright - Everwoody
- Tom Markus - The Rabbi
- Rob Nagle - Joel Hurwitz
- Dan Merket - Chuck Dodd
- Dan Merket - The Largest Logger
- Dan Merket - The Fan
- Rachel Thorp - Young Amy Abbott
- Jennifer Erekson - Arnie's Mom
- Sara Jade Woodhouse - Pony Tail Guy
- Elizabeth Sands - Jenny
- Kim Landry - Betsy Dodd
- Reb Fleming - The Camper
- Alex Gerrish - Hank
- Anne Sward - Ms. Caleb
- Anne Sward - Teacher
- Whitney Lee - Brittany Clark
- Austin Archer - County Kid
- Michael Coe - New Lifeguard
- Michael Coe - Future Alcoholic
- Michael Coe - Clueless Student
- Cheryl White - Mrs. Wilson
- Patrick Stogner - Young Harold
- Jodi Russell - Debbie West
- Tod Huntington - Worker #1
- Tod Huntington - Frat Boy #2
- Nancy Peterson - Elisa's Mom
- Allan Groves - Chris
- Richard Blake - Rick Walzak
- Brenda Sue Cowley - Mrs. Clark
- Joyce Cohen - Millie Sullivan
- Joyce Cohen - Princetown Rep
- Sean Mahon - Pseudo Patient
- Mick Hilgers - Oscar
- Lincoln Hoppe - Aldo
- Dane Stevens - Wally
- Janice Knickrehm - Church Woman
- Matt Barker - Waiter
- Rick Fitzgerald - Rescue Worker
- James Jamison - Dr. Berdell
- James Jamison - Bypass Technician
- David H. Stevens - Denver
- Tim Threlfall - Priest
- Tim Threlfall - The Pharmacist
- Maeve Millard - Kirsten
- Joel Bishop - The Pharmacist
- Michelle Peterson - Nurse #2
- Michelle Peterson - The Professor
- Michelle Peterson - Anesthesiologist
- Tegan West - Jerry McGinns
- Roger Nelson - Father Ivers
- Paul Anthony McLean - Coach Spitzer
- Michael Birkeland - The Ticket Guy
- Martin Casaus - Wrestling Bad Guy (uncredited)
- Becky Harding - Roberta
- Josh Haber - The Waiter
- Melinda Renee - Concierge
- Melinda Renee - Juilliard Registrar
- Elisabeth Lund - Carrie
- K. Danor Gerald - The MC
- Lisa Waltz - Diane Shumacher
- Todd Davis - Glenn
- Kent Richards - Police Officer
- Martha Carter - The Stoned Girl
- Reese Phillip Purser - The Man
- Tom Wright - Carl's Lawyer
- Erinn Hayes - Mindy Wheeler
- Neal Barth - Judge Papert
- Elizabeth Johnson - Party Goer
- Nora Burns - The Receptionist
- Dustin Siler - The Jock Buddy
- Michael Todd Behrens - Gerry Block
- Robert Himber - The Regency Insurance Man
- K.C. Clyde - Future Achiever
- Ron Frederickson - Juilliard Judge
- Mowava Pryor - Circulating Nurse
- Alex Nibley - Radiologist
- Shane Morrisun - Graduating Student (uncredited)
- Brandy Snow - Maitre D'
- Liliana Arredondo - Ms. Sawaya
- Matthew Pohlson - Dean Kelly
- Ben Hammond - Sam Feeney
- Ben Hammond - Sam Feeney (voice)
- Brighton Hertford - Katie
- Kristin Alayna - Pool Party Girl
- Dhylan Meyer - Michael Beck
- Slate Holmgren - Mover
- Brooke Bloom - College Guide
- Anne Kathryn Parma - Patient
- Cameron Jones - Mikey
- Nancy Roth - Female Counselor
- Nancy Roth - Woman in Line
- Heather Beers - Julie
- Annie O'Donnell - Librarian
- Austin Tichenor - Dr. Bass
- Obba Babatundé - Jason
- Scott Williamson - Coach
- Joe Lookinland - Dougie Wilson
- Leslie Wing - Registration Woman
- Andrea Andes - Jillian
- Rhett Willman - Mr. Perch
- Melanie Nelson - Mrs. Lacey
- Lukas Behnken - Topher Cole
- Shawn Nottingham - Dr. Liu
- Brian Palermo - Rick
- Amy Rutberg - Sarah
- Ray DeMattis - Thomas the Doorman
- Jerry Dixon - Piano Player
- Bee-Be Smith - Gretta
- Brooks Almy - Clerk
- Matthew Bellows - MRI Technician
- Deborah Ellis - Jan
- Deborah Ellis - Secretary
- Todd Louiso - Equipment Buyer
- Gedde Watanabe - Art
- Brian Baumgartner - Contractor
- Patrick Fabian - Dr. Henry Validor
- Hawk Younkins - Tim Quills
- Yolanda Stange - The Nurse
- Frank Gerrish - Baker
- Victor Z. Isaac - Ethan Harcourt
- Phillip Jeanmarie - Pete Boroni
- Star LaPoint - Ellie
- Renée Taylor - Betty Barrett
- Teri Cowan - Insurance Woman
- Christian Jensen - Army Recruiter
- Gary Neilson - Science Man
- Susanne Sutchy - Jessica Hunter
- Kellie Hamilton - Alice
- Susan Dolan Stevens - Female Patient
- Margo Watson - Well-Dressed Woman
- Jayne Brook - Mrs. Rogers
- Hosea Chanchez - Student
- Roger Malaga - The Deejay
- Alesandra Durham - Emily
- Stacy Sobieski - Emily
- Gregory Alan Williams - James Cleveland
- Monnae Michaell - Madeleine
- Amy Stewart - Dr. Parsons
- Jamie Strange - Sandy
- Ivey Lloyd - Shannon
- Brenden Whitney - Classmate
- Scott Cowdrey - EMT #1
- Preston Sadleir - EMT #2
- Dee Macaluso - Adele
- Reggie Austin - Andre Harvey
- Diane Delano - Mary
- Ruby Chase O'Neil - Penny
- McNally Sagal - Adoption Agency Evaluator
- Kenny Beers - Beach Goer (uncredited)
- Elaine Kagan - Angela Bardem
- Terence Goodman - Winston
- Luciana Carro - Stephanie Meyer
- Rick Allen - Officer #1
- Stephen Rippey - Officer #2
- Rick Macy - Dr. Ricketts
- Darren Ewing - Usher (uncredited)
- Fenton Quinn - Don
- Greg Berlanti
- Michael Green
- Rina Mimoun
- Oliver Goldstick
Joanna Cassidy interpreta a Evelyn Rowser en la serie.
Philip Baker Hall hace el papel de Dr. Donald Douglas.
Chris Penn hace el papel de Frank Sullivan.
Todd Louiso hace el papel de Equipment Buyer.
Beau Bridges interpreta a Daniel Sullivan en la serie.
Charles Durning interpreta a Eugene Brown en la serie.
Clyde Kusatsu interpreta a Edward Ogawa en la serie.
Treat Williams interpreta a Andrew Brown en la serie.
Gregory Smith interpreta a Ephram Brown en la serie.
Emily VanCamp hace el papel de Amy Abbott.
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