- Kim Fields - Rochelle
- Lou Myers - Deacon Peabody
- Robert Horry - Jalen
- Daphne Zuniga - Mrs. King
- Julio Iglesias, Jr. - Self
- Kylie Bax - Self
- DMX - Xenon
- Pamela Paulshock - Georgia
- Daphne Maxwell Reid - Frances Hunter
- Jodi Lyn O'Keefe - Lucy
- Antonio Fargas - Uncle Jerry
- Robert Picardo - Professor Dunson
- Patrick Kerr - Phillip
- Sharif Atkins - Grant
- Kellie Shanygne Williams - Lynn
- Bart Johnson - Anthony
- Faune Chambers Watkins - Bianca
- Omar Gooding - Lazy G
- Penny Johnson Jerald - Beverly Williams
- Jennifer Dorogi - Rachel
- Amy Hill - Maribel
- Cherie Johnson - Angela
- Josie Davis - Melanie Van Lowe
- Darius McCrary - Jamal
- Carmen Electra - Zan
- Maya Gilbert - Salesperson
- Clifton Powell - Yusef
- Yaya DaCosta - Ms. Jenkins
- Queen Latifah - Simone
- Deanna Hurst - Barbara
- Willam Belli - Waiter
- Phil LaMarr - Coleman
- Jazsmin Lewis - Dani
- Reggie Gaskins - Marty
- Ella Joyce - Mama Pearl
- Jillian Warry Barberie - Shannon
- Sterling Knight - Noah
- Bumper Robinson - Mark
- Perry King - Jackson
- Craig Gellis - Blade
- Brooke Burke - Self
- Robert Verdi - Self
- Alexia Robinson - Tamara
- Pete Gardner - Man in Theater
- Dagney Kerr - Woman in Theater
- Martavious Gayles - Usher
- Johari Johnson - Party Guest
- Corey Reynolds - Malcolm 'Khalif' Davis
- Tembi Locke - Cammie
- Cris Judd - Salsa Man
- Darlena Tejeiro - Trina
- Izzy Diaz - Beer Guy
- Mike Siegel - Waiter
- Marisol Ramirez - Club Girl
- Maisha Dyson - Club Girl
- Derek Fisher - Trevor
- Sean Faris - Chip
- Wilmer Calderon - Cameraman
- Mario López - Roberto
- Missy Elliott - Self
- Stacey Dash - Corryn
- Ron Pearson - Chuck
- Richard Gant - Andrew Hunter
- Kelly Rowland - Cleo
- Erinn Hayes - Fiona
- Renée Taylor - Ms. Berkowitz
- Boris Kodjoe - Kevin
- Nicole Richie - Karen
- Matt J. Rogers - Clerk
- Ryan O'Quinn - George
- Cedric the Entertainer - Self
- Christie Lynn Smith - Woman
- Sofía Vergara - April Perez
- Greg Pitts - Mark
- Victor Raider-Wexler - Nick's Boss
- Jadakiss - Self
- Lee Reherman - Turbo
- Kristin Richardson - Carmen
- Morris Day - Rodney P
- Jerome Benton - Sugar-Free
- Bishop Don Magic Juan - Comfort
- Rib Hillis - James
- Michele Nordin - Kimmy
- David Zepeda - Waiter
- Napiera Groves - Yvonne
- Chris W. King - Busboy
- Malcolm David Kelley - Martin
- Marc D. Wilson - Drew
- Beverly DeLoatch - Clubber
- Beverly DeLoatch - Mia
- Shawn Harrison - Peaches
- Trisha Mann - Tiffany
- Denee Busby - Trish
- George Frangides - Host
- Anthony DeSantis - Cop
- Cristián de la Fuente - Dr. Anderson
- Andres Hudson - Victor
- Betsy C. Spear - Nurse
- Jameelah McMillan - Waitress
- Biz Markie - Cable Repairman
- Danica McKellar - Claudia
- Julie Mintz - Nicky
- Vanessa Born - Girl
- Jeff Tschida - Usher
- Maria McCann - Sandy
- Donna Pieroni - Woman
- Bob Rumnock - Shopper
- Amaury Nolasco - Adrian
- Henry Kingi Jr. - Ike
- Carlos Ponce - Joe
- Chrystee Pharris - Courtney
- Porscha Coleman - Lisa
- Janell Inez - Miranda
- Benjamin Patterson - Clay
- Phil Abrams - Earl
- Richard Pierre-Louis - Kevin
- Adam Huss - Wally
- Mark Simich - Guy
- David Carradine - Kung Fu Master
- Vivica A. Fox - Self
- Tanya Roberts - Rebecca
- Vernee Watson-Johnson - Laverna
- Jane Carr - Patricia
- Daryl Mitchell - Damien
- Allen Nabors - Zane
- Shvona Lavette Chung - Sandy
- Kelly Mantle - Rudy
- Samm Levine - Ben
- Miguel Coleman - Chaz
- Jarvis W. George - Detective
- Jarvis W. George - Ralph
- Iqbal Theba - Bob
- Golden Brooks - Nurse LaDonna
- Gwendolyn Osborne-Smith - Monica
- Andrea De Oliveira - Amy Mae
- Kitana Baker - LaTanya
- Ludacris - Rufus
- Alicia R. Cole - Denise
- J. Nicole Brooks - Carol
- Taneka Johnson - Laura
- Vanessa Branch - Imogene
- Kylee Russell - Shelly - Age 7
- Damani Roberts - Miles
- Meeghan Holaway - Mrs. Buchanan
- Caroline Fogarty - Liz
- Yeni Alvarez - Gloria
- Nicole Pantenburg - Woman
- Joyce Tolbert - Woman
- Liesl Ehardt - Lindsay
- Ayda Field - Carla
- Hayden Adams - Photographer
- Tom Joyner - Tom Joyner
- Devika Parikh - Delilah
- Myra J. - Myra J.
- J. Anthony Brown - J. Anthony Brown
- Jay Manuel - Jay Manuel
- Donnie Jeffcoat - Torian
- Lauren Sánchez - Aramanda De La Cruz
- Lee Zagari - Manny
- Thomas Anthony Jones - Galloway
- Andre Pitre - Brad
- Elyse Mirto - Gloria
- Brooklyn McLinn - Mike
- Brooke Paller - Kristen
- Tom Williams - Baby Ella (voice)
- Ruben Studdard - Paul
- Reginald VelJohnson - Rev. Everett
- Terrence Hardy Jr. - Edgar
- Rebeka Montoya - Lisa
- LeShay N. Tomlinson - Brianna
- Joey Nader - Dwayne
- Lenise Sorén - Brenda
- Rebecca Metz - Phyllis
- Christie Insley - Emma
- Terence Mathews - Frank
- Kehli O'Byrne - Emcee
- Maria Tornberg - Noelle Bellefeuille
- William-Christopher Stephens - Waiter
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