- Alberto Frezza - Ryan Tanner
- Carlos Miranda - Theo Ruiz
- Miguel Sandoval - Pruitt Herrera
- Josh Randall - Sean Beckett
- Merle Dandridge - Natasha Ross
- Pat Healy - Michael Dixon
- Cameron Cowperthwaite - Mason Bishop
- Talia Jackson - Zoe
- Nyle DiMarco - Dylan
- Patrick Duffy - Terry
- Randee Heller - Maria
- Joely Fisher - Denise
- Vanessa Marano - Molly
- Flex Alexander - Evan Forrester
- Stefanie Black - Sgt. Brit Logue
- Carol Locatell - Evelyn
- Ramón De Ocampo - Jaime
- Elimu Nelson - Liam
- Tom Costello - Gregory Dougal
- Matthew Boylan - Employee
- Ellen Wroe - Officer Elle Kingsley
- Rebecca Field - Hannah Sherwood
- Troy Winbush - Clark
- Isabella Acres - Parker Sherwood
- Sprague Grayden - Mary
- Hector Luis Bustamante - Jimmy
- Gina Gallego - Ruth
- Leah Lewis - Shannon
- Barry Shabaka Henley - Oscar Delgado
- Jackie Chung - Margaret Chen
- Dermot Mulroney - Greg Tanner
- Michael Welch - Harold
- Jon Curry - Reese
- David Barrera - Kenneth
- Michelle Arthur - British Woman Tenney
- Barbara Eve Harris - Ifeya Miller
- Jeffrey D. Sams - Bill Miller
- Birgundi Baker - Yemi Miller
- JoBeth Williams - Reggie
- Christine Lakin - Emmanuelle
- Scott Rinker - Josh
- Sam Anderson - Elliott
- Jasika Nicole - Mila
- Hermie Castillo - Graham
- Lisseth Chavez - Kathleen Noonan
- Dohn Norwood - Captain Ted Conlin
- Karishma Ahluwalia - Shireen Varma
- Greta Jung - Gwen
- Phillip Garcia - Nate
- Bre Blair - Jennifer Ripley
- Joe Nieves - Incident Commander
- Chelsea Harris - Nikki
- Alex Blue Davis - Casey Parker
- Ann Cusack - Joan
- Billy Doyle - Don
- K.J. Powell - Young Ben
- Dee Rogers - Michael
- Tara Robinson - Ruby
- Greg Germann - Dr. Thomas Koracick
- Chelsea Kurtz - Shauna
- JF Davis - Martin
- Emily C. Chang - Penelope
- Nida Khurshid - Hima
- Heather McComb - Rachel Burke
- Bob Bancroft - Joe
- Amber Friendly - Elaine
- Josh Kelly - Kyle
- Jonathan Kehoe - Jimmy
- Elayn J. Taylor - Marion Hughes
- Garrett Morris - Earl Davis
- Marie-Françoise Theodore - Millie
- Alex Benjamin - Frederick
- Alex Landi - Dr. Nico Kim
- Shane Blades - Chef Dominic
- Jorge-Luis Pallo - Beto
- Brian Letscher - Agent Prine
- Remy Nozik - Alicia
- Mac Brandt - Agent Baxter
- Hollis W. Chambers - Todd
- Brandon Brown - Tamil
- Monette Moio - Dara Agate
- Jonathan Silverman - Ted
- Bob Levitan - Jerry
- Jake Borelli - Dr. Levi Schmitt
- Jesse Williams - Dr. Jackson Avery
- Peter Paige - Cooper
- Rebekah Kennedy - Melly Wyatt
- Mark Collier - Gary
- Matthew Downs - Officer Reaser
- Brenda Arteaga-Walsh - Officer Marinis
- Tracie Thoms - Dr. Diane Lewis
- Jayne Taini - Marsha Smith
- Ellen Pompeo - Dr. Meredith Grey
- Kelly LaMarr - Jeff
- Brandon Win - David
- Brendan Ford - Jones
- Kenajuan Bentley - Tony
- Brett Gipson - Chuck
- Tangie Ambrose - Mrs. Monroe
- Jacleen Haber - Ryan's Mother
- Dylan Rourke - EMT Todd
- Frederick Dawson - Chaplain
- Kevin Scott Allen - Henry
- Steven Allerick - Marco
- Toby Grey - Ernie
- Lily Fisher - Sarah
- Bodhi del Rosario - Cal
- Joseph Piccuirro - David Mayhorn
- Joseph Piccuirro - Station 23 Firefighter
- Blanca Araceli - Sofia
- Chuck McCollum - Neighbor
- Lovlee Carroll - Reporter
- Johnny Jay Lee - Mason
- Greg Christopher Smith - Coach
- Phylicia Rashād - Pilar
- Lenny Jacobson - Jeff
- Jamie Brewer - Rose
- Michael James Bell - Roman
- Zion Broadnax - Cute Kid
- Kareem Lewis - Sports Fool 1
- Josiah Lipscomb - Sports Fool 2
- Gina Ravera - Claudia Flores
- Drew Rausch - John Finch
- Joe Holt - Nate
- Erica Shaffer - News Weather Person
- Erica Shaffer - News Anchor
- Kelly Thiebaud - Eva Vasquez
- Zach Tinker - Greg
- Adam Kang - Tom
- Brenda Song - JJ
- Jim Hanna - Steve
- Michael Shen - Charlie
- Michela Crayton - Teen Vic
- Jaidyn Triplett - Eight Year Old Victoria
- Kelly McCreary - Dr. Maggie Pierce
- Patrick Gallagher - Keller
- Anthony D. Washington - Jimi
- Remington Hoffman - Sting Ray
- Alex Pires - Neal
- Hunter Womack - Luke
- Rigo Sanchez - Rigo Vasquez
- Teemaree - Latina Woman
- Dan Lauria - Walter Morewall
- Lalia Susini - Young Andy
- Emma Fuhrmann - Rachel Morewall
- Monnae Michaell - Mrs. Brady
- Peter Onorati - Snuffy Souza
- Peter Onorati - Snuffy
- Ireland Richards - Kiki
- Drew Powell - Fowler
- Nathan Wallace - Banks
- Tess Aubert - Billie
- Sherry Vine - Rainbow Trout
- Jaicy Elliot - Dr. Taryn Helm
- D.J. 'Shangela' Pierce - Ruby Red Slippers
- Kim Raver - Dr. Teddy Altman
- Justin Ellings - Frankie
- Roxy Wood - Izzy Packing
- Vivian Nixon - Hannah Brody
- Matthew Erick White - Conor
- Camden Garcia - Elizabeth Gaylor
- Ivana Shein - Katherine Bishop
- Reginald VelJohnson - Charlie Irwin
- Jack Conley - Captain Lawrence
- Jennifer Kim - TV Reporter
- Jennifer Kim - Darcie
- Caterina Scorsone - Dr. Amelia Shepherd
- Michael B. Silver - Parker Lowther
- Brett Tucker - Lucas Ripley
- Kevin McKidd - Dr. Owen Hunt
- BJ Tanner - William George 'Tuck' Bailey-Jones
- V. Vieux - Rosalind
- James Pickens Jr. - Dr. Richard Webber
- Sophina Brown - Joyce
- Michael Patrick McGill - Bob
- Dionne Audain - Sharon
- Scott William Winters - Schneider
- Chris Coy - Wicklund
- Yindra Zayas - Shanice
- Sarayu Blue - Audrey
- Alex Désert - Oliver
- Jennifer Lauren DiBella - Sophia
- Matthew Jain - Captain 42
- Chandra Wilson - Dr. Miranda Bailey
- James Eckhouse - Pete Sorenson
- Sterling Sulieman - Grant
- Jee Young Han - Charlotte Dearborn
- Al Carabello - Greg
- Samantha Cardona - Police Officer Jen
- Patricia De Leon - Elena Herrera
- Patricia De Leon - Elena
- Marco Da Silva - Firefighter 15
- James Logan - Construction Worker
- Elaine Lockhart - Receptionist
- Joseph Michael Harris - Instructor
- Chelese Belmont - Nurse
- Amari O'Neil - Max Forrester
- Amir O'Neil - Max Forrester
- Christine Corpuz - Officer Vu
- Nadine Griffith - Nurse Dominique
- Michael Cassidy - Peter
- Suzy Nakamura - Susan
- Linara Washington - Mary
- Annie Tedesco - Carla
- John Eddins - Station 23
- Roy Vongtama - Nurse John
- Peter James Smith - Vince
- Faline England - Janet
- Juliet Donenfeld - Lindy Dougal
- Giacomo Gianniotti - Dr. Andrew DeLuca
- Colleen Foy - Inara
- Robert Curtis Brown - Paul Montgomery
- Lachlan Buchanan - Emmett Dixon
- John Ales - Brother John
- Ezra Buzzington - Jerry
- Jonathan Bennett - Michael
- Sylvia Kwan - Dr. Mabel Tseng
- Tom Wright - Battalion Chief Gregory
- Stephanie Kurtzuba - Opal
- Dhruv Uday Singh - Eric
- Joaquin Veizaga - Steven Garcia
- Janeshia Adams-Ginyard - Officer Conn
- Janeshia Adams-Ginyard - Tactical Commander
- Walker Bryant - Young Jack
- Reed Shannon - Blake
- Nina Millin - Dayna Rutledge
- Cary Christopher - Towheaded Boy
- John Ross Bowie - Paul
- Joshua Benard - Teenager
- Harry Shum Jr. - Dr. Benson Kwan
- Jenny O'Hara - Judith
- Shari Belafonte - Gertrude
- Nancy Linehan Charles - Shirley
- Anna Daines - Brooke
- Sharon Gless - Dottie
- Andrew Borba - Officer Smith
- Jennifer Jalene - Luisa Berrol
- Shane Hartline - John Maddox
- Rob Heaps - Eli Stern
- Lindsey Gort - Ingrid Saunders
- Camila Rodriguez - Lupe
- Riley Smith - Drew Farris
- Tricia O'Kelley - Kitty Dixon
- Emerson Brooks - Robel Osman
- Tara Karsian - Phyllis
- Kapil Talwalkar - Sanjay
- Charley Koontz - Chef Wolf
- John Shartzer - Kevin
- Holger Moncada Jr. - News Reporter
- Kevin Daniels - Kyle Martin
- Symone - Mary Mint
- Kat Cunning - Sienna
- Siya - Jazzy
- Ryan Salazar - Drew
- Kyle Dondlinger - Collin
- Tim Storms - Security Detail Officer
- Trenton Rostedt - Protester
- Kiele Sanchez - Kate Powell
- Deirdre Lovejoy - Connie
- Jamie Denbo - Grace Beckett
- Spencer Garrett - James Beckett
- Spencer Treat Clark - James Beckett Jr.
- Jay Jay Warren - Sam
- Francis Capra - Neighbor
- Angelica Amor - Gloria
- Sean Patrick Murray - Police Officer
- Paul Archer - Clinic Patient
- Shelby Rabara - Hallie
- Lou Beatty Jr. - Stu
- Antonio Leon - Eduardo
- Timothy Davis-Reed - Homeowner
- Niko Terho - Dr. Lucas Adams
- Diana Tanaka - Ivy
- David W. Thompson - Ethan
- Quinn McPherson - Bryan
- Graciella Evelina Martinez - Frantic Neighbor
- Frances Nichols - Nurse Karen
- Luke Loving - Assistant Deputy Chief Kel
- Yuji Hasegawa - Gerald
- James Hyde - Matt's Dad
- Thalia Tran - Maddy
- Will Leong - Steve
- Joey Anaya - Tow Truck Driver
- Erika L. Holmes - Doctor
- Manny Spero - Employee
- Timothy Brundidge - Matt
- Elaine Ann Hu - Lisa
- Kimia Behpoornia - Karen Reis
- Kimia Behpoornia - Officer Karen Reis
- Anissa Borrego - Cammy
- Dennis Keiffer - Random Guy
- Patrick Cage - Raphael
- Danielle Larracuente - Liz
- Kenneth Meseroll - Dad Montgomery
- Kenneth Meseroll - Paul Montgomery
- Annie Sertich - Peggy Knox
- Gabriel Rissa - EMT
- Gabriel Rissa - Medic #1
- Chloe Carabasi - Factory Worker
- Ethan Rains - Jonathan Bright
- Samantha Ashley - Sophie Santos
- Arianne Martin - Isabel
- Philip Maurice Hayes - Capt. Dan Greer
- Brianna Reed - Davila
- Christabelle Grace Marbun - Katherine O'Hare
- Stephen Hailo - Omar
- Riley Triggs - Coles
- Jodi Hou - Paige Lim
- Ben Browder - Fire Captain
- Michael Grant Terry - Officer Jones
- Arvin Lee - Officer Brown
- West Montez - Jamal
- Laura Cerón - Tia Sandra Alvarez
- Laura Cerón - Tia Sandra
- Ekeobong - Police Officer
- Michael Thomas Wallace - Officer Williams
- Antonio Jaramillo - Tomás
- Onahoua Rodriguez - Mari
- Carlos Sanz - Julio
- Lidia Porto - Abuela
- Anthony Hill - Neil
- Anthony Hill - Dr. Winston Ndugu
- Dinora Walcott - Pam Williams
- Dave Florek - Vince Beckett
- Jearnest Corchado - Joanie
- Geoffrey Rivas - Mr. Ortega
- Octavio Solorio - Shop Patron
- Christian Torres Villalobos - Shop Patron
- Anthony Robertson - Morgan
- Johnny Wactor - Lt. Cooper
- Chloe Lanier - Clara
- Jesse Posey - Firefighter James
- Emma Hunton - Monica
- Michael Dempsey - Captain Josh Mesnik
- Elena Campbell-Martinez - Mrs. Ortega
- Joel McKinnon Miller - Reggie Paulson
- Lulu Antariksa - Sara Grossman
- Chris Brochu - Brenton
- Randy Vasquez - Captain Vinnie
- Derek Smith - Jim Neely
- Lucius Baybak - Gabe Neely
- Katie Walder - Nancy
- Ely Henry - Devon
- Maxwell Acee Donovan - Kyle
- Evan Nikolas Fields - Tim
- Gustavo Escobar - Will
- Skylar St. John - Mac
- Dale Dickey - June Hardy
- Kira Sternbach - Lucy
- Steve Wilcox - Taylor
- Andrew Yackel - Milo
- Jetta Juriansz - Olivia
- Jeanne Sakata - Nari Montgomery
- Jeanne Sakata - Nari
- Brigid Brannagh - Moira
- James Read - Jonathan Clifton Tucker
- Alejandra Flores - Edna Gherkes
- Grace Powell - Margot Ford
- Holly J. Barrett - Paige Donahue
- Stacey Moseley - Shauna
- Amie MacKenzie - Judi
- Joe Corzo - Greene
- Jennifer Field - News Host
- Robert Gant - Matt
- Amanda Wyss - Laura
- Andrew Lutheran - Cody
- Lyman Chen - TV Reporter
- Taia Sophia - Kelsey
- Amelia Hensley - Lila
- Jennifer Shelton - Reporter
- Susan Pingleton - Election Worker
- Paulina Alvarez - Nanette
- Zac Titus - Yancy
- Laura Linda Bradley - Paramedic
- Shaun Heard - Dan Barnes
- Jason Catron - Larsson
- Rodney Gardiner - Waiter
- Erica Piccininni - Tiffany
- Ashlee Füss - Becca
- Marla Gibbs - Edith
- Leslie Hope - Battalion Chief Frankel
- Jack Axelrod - Mr. Paige
- Keli Daniels - Principal Linsley
- Caleb Alexander Smith - Seth
- Paula Rebelo - Cop
- Kaden Cole - Grant Posley
- Marcia Ann Burrs - Inez
- Iman Benson - Dallas
- McKayla Witt - Teen
- Peri Gilpin - Sue
- Megan Gallagher - Deborah
- Abby Miller - Lynn
- Benjamin Thys - Marshall
- Carlos Arellano - Clay
- Sean-Michael Boozer - Fallen Officer
- Chelsea Ricketts - Finley
- Phoebe Neidhardt - Piper
- Brad Beyer - Cole Edmonds
- Nicole Hayden - Allison
- Radek Lord - Chris
- Wyndoline Landry - Caitlyn
- Martin Martinez - Sean
- Stuart Allan - Brian
- Jared Egusa - Bartender
- Tom Riordan - Tac Officer
- Jonathan Kells Phillips - Cyclist
- Trinecia Moore-Pernell - Claire
- Debra Cardona - Officer
- Emir García - Business Man
- Alfredo Tavares - Steve
- Samantha Lee - Reporter
- Hina Khan - Sarla
- Anjali Bhimani - Dr. Mukerji
- April Adams - Old Lady
- Nayeli Esparza - Commuter
- Alexander G. Eckert - Wil
- Kyla-Drew - Ellie
- Sarah Oh - Jenna Matson
- Emanuel Borria - William
- Corey Dorris - EMT
- Keylor Leigh - Rachel
- Tanedra Howard - Date 2
- Tyler Clark - Polished Date
- Brian Tichnell - Trevor
- Alek Cole - Zander
- Vivien Lyra Blair - Penny
- Tia Valentine - Slumber Partier
- Williemgc - Lucas Herrera
- Boone Platt - Firefighter Cook
- Chris Wu - Employee
- Sarah Benoit - Nurse Julia
- DeJean Brown - ER Nurse
- Ethan Corn - Firefighter Jeremy
- Ursula Burton - SFD Chaplain
- Euanton Dotson - Chief Fireman
- Gregory Garcia - Bartender
- Seth Vernon - Husband
- Matthew Jones - Proctor
- Nelson Mashita - George
- Christina Moses - Wendy Wilson
- Christina Moses - Nina's Mother
- Ritesh Rajan - Clarke Wright
- Ritesh Rajan - Clarke Wright (voice)
- Blaze Robert Stow - Firefighter
- Earnestine Phillips - Diane
- Sir Brodie - Big Guy
- Jacob Timothy Manown - Jesse
- Jeff Houkal - Police Officer
- Julienne Irons - Police Officer
- Josh Archer - Police Officer
- Adam J. Harrington - Lane Bishop
- Steve Mize - Scott Burke
- Ryan Babcock - Marshall
- Motown Maurice - Drunk Bro
- Jay Jackson - Commissioner Clark
- Kim Evey - Police Officer
- Brent Pope - Driver
- Emily Elmore - Stage Hand
- Rajni Kareer - Chairwoman
- Katy Sullivan - Dr. Alba
- Scott Cooper Ryan - Brant
- Brandon Sutton - USAR Captain
- Max Phyo - Chief Sato
- Cynthia Quiles - Monica
- Tim Redmond - Bomb Squad Captain
- Rodnesha Green - Police Officer
- Robert Picardo - Mr. Nelligan
- Paul Syre - Kayden
- Ozy Reigns - Prison Guard One
- Lombardo Boyar - Johnny Alvarez
- Suanne Spoke - Yvonne Boyd
- Melissa Marty - Michelle Alvarez
- Elizabeth Phoenix Caro - Young Michelle
- Debbie Fan - Meeting Leader
- Mark Edward Smith - Commission Chairman
- Haskell V. Anderson III - Annoyed Neighbor
- Nicole LaLiberte - Gina
- Ryan Dorsey - Eddie
- David Banks - Semple
- Susan James Berger - Onlooker
- Jen Mears - Onlooker
- John Barbolla - Onlooker
- Anthony Molinari - Patterson
- Heather Schlitt - Opal Look-Alike
- Will Allan - Angry Man
- Jeff Doucette - Dr. Warren Sterman
- Miguel Cohen - Officer Buckner
- Steve Bannos - Officer Garza
- Neil Haskell - Gideon
- Khalilah Joi - Condola Vargas
- Gabriella Pession - Dr. Gabriella Aurora
- Eric Staves - Tad
- Zach Villa - Charlie
- Zachary Conneen - Rick
- Justin Lee - Josh
- Tina Ivlev - Libby
- Ida Anderson - Bystander
- Nikea Gamby-Turner - Concerned Woman
- Jeff Brody - Neighbor
- Lisa Schurga - Karissa
- Kevin Berntson - Shayne
- Cullen Arbaugh - Driver
- Rick Worthy - Anthony Hughes
- John Billingsley - Lloyd
- Bonita Friedericy - Suzie
- Kash Abdulmalik - Wayne
- Tiffany Daniels - Nancy
- Maria Carmen - ER Nurse
- Francois Battiste - Father
- Jakari Fraser - Corey
- Sahjanan Nasser - Young Vic
- ??? - Petra Lau
- Anil Kumar - Dr. Clark Kabir
- Robert Dill - Guardsman
- Wilky Lau - Henry Lau
- Darri Ingolfsson - Matthew
- Farah Merani - Sonia
- Hilary Ward - Ben's Mom
- Toccarra Cash - Lisa
- Barry Brisco - Dr. Reid
- Jonathon Buckley - B-Shifter 2
- Svetlana Efremova - Lenya Hughes
- Golden Brooks - Vivienne
- Rodrigo Rojas - Miguel
- Teddy Van Ee - Sawyer
- Ian Stanley - Officer Anderson
- Larry Poindexter - Chief McAllister
- Castulo Guerra - Juan Carlos Garcia
- Briella Guiza - Erica Garcia
- Leslie Lluvet - Belinda Garcia
- Marina Pincus - Abuelita
- Anne Yatco - Flower Delivery Woman
- Alain Uy - Captain Pat Aquino
- Alexis Raich - Tara Brown
- Alexander Neher - Will
- Matthew Haddad - Popcorn Passerby
- Kalup Allen - Mac
- Angela Elayne Gibbs - Ms. Debbie
- Paula Rhodes - Helen
- Carlos Antonio - Luis
- Rose Han - Bartender
- Camille Chen - Ari Lan
- Lauren Bowles - Max's Mother
- Jim Cashman - Delivery Guy
- Lucas Armendariz - Max
- Bamm Ericsen - Ameen Deng
- Xochitl Romero - Mel
- Ron Roggé - Dad
- Mark Mandia - Davey
- Nia Vardalos - Patricia
- Paul Schulze - Tony
- Joey Medina - Driver
- Havon Baraka - Myles Anthony Trudeau
- Eric Scanlan - Larry
- John Gowans - Elderly Man
- Natasha Ward - Deja Duval
- Kimberley Peterson - Aaliyah
- Sharron Shayne - Elderly Woman
- Charlie Magdaleno - Burn Patient
- Lindsay Mendez - Lawyer
- Sarah Cortez - Ivy
- Jock McKissic - Terrence Tillerman
- Stacie Greenwell - Delilah Tillerman
- Andrea Bowen - Amy
- Michael Emery - Greg
- Crystal Gix - Robyn Tillerman
- Zakai Biagas Bey - Rory Tillerman
- Yohance Biagas Bey - Tommy Tillerman
- Michael Mourra - Aarón
- Meredith Scott Lynn - Hattie
- Danny Woodburn - Tobias
- Michael Liu - Cory
- Jim Ortlieb - Harry
- Cynthy Wu - Anna
- John Bishop - Hank
- Nitya Vidyasagar - Tabitha Salzman
- Christie Lynn Smith - Judy / Aston's Mom
- Melanie Minichino - Sam
- Lanny Joon - Justin Park
- Ricky Garcia - Aston
- Alyson Reed - Virginia
- Rene Moran - Ricky
- Danny Brown - Stella
- Jag Singh - Target
- Daniel Di Tomasso - Jeremy
- Helen Madelyn Kim - Brenda
- Woody Schultz - Henderson
- Sydney Mae Estrella - Abby
- Steven Culp - Detective Berarducci
- Rob Evors - Officer Williams
- George Tsai - Detective Chen
- Bourke Floyd - Officer Roscoe
- Lily Tricano - Young Andy
- Faye Nightingale - Mai
- Sal Viscuso - Mr. Phillips
- Mike Eshaq - Captain Khalidi
- Martin Morales - Pablo
- Robert Dominick Jones - Judge
- Romy Rosemont - Jane
- Grant Harvey - Joshua
- Cullen Douglas - Errol
- Ben Bode - Bryan
- Eric Allan Kramer - Randall
- Kurt Yaeger - Carl Swaminathan
- Lily Mae Harrington - Holly
- Vien Hong - Phillip Dang
- Bob Glouberman - James Pope
- Aiden Arnold - Edgar
- Bryson JonSteele - Field Trip Kid
- Isidoro Perez - Oliver
- Arthur Richardson - Owner
- Johnny Sibilly - Dominic Amaya
- Brent Sexton - Gerry
- Tim Ransom - Charles
- Erinn Westbrook - Lacy
- Tyler Lofton - Mac
- Jackson Kelly - Stu
- George Wyner - Morris Hapgood
- Scotty Tovar - Arlo
- Sophie Ross - Margaret
- Mallory Corinne - Leeland
- Gregory Cruz - Captain Elliott Henderson
- Cameron Esposito - Paula Kelly
- Kimberly Guerrero - Julie
- Jonathan Del Arco - Steve
- Azita Ghanizada - Ms. Reed
- Nanrisa Lee - Eleanor
- Michael Bow - Tyler
- Alexandra Daniels - Emma
- Sabrina Saleha - Rose
- ??? - Jeonghee Lee
- Cinthya Carmona - Beatriz
- Victor Manso - Luis
- Alyshia Ochse - Leigh
- Kimberli Flores - Blanca
- Ryan Anderson Lopez - Rafael
- Benito Martinez - Chief Gonzalez
- Azie Tesfai - Eliza Meacham
- Marisela Zumbado - Maritza Zamora
- Ashlee Brian - Matthew Richards
- Christy Meyers - Rebecca
- Jarvis W. George - Christopher
- Natasha Elías - Freya
- Tyler Schnabel - Bill Meacham
- Anton Narinskiy - Scott
- Shon McGregory - Greene
- Betsy Beers
- Krista Vernoff
- Paris Barclay
- Shonda Rhimes
Jenny O'Hara interpreta a Judith en la serie.
Castulo Guerra hace el papel de Juan Carlos Garcia.
Joely Fisher interpreta a Denise en la serie.
Spencer Treat Clark interpreta a James Beckett Jr. en la serie.
Jaina Lee Ortiz interpreta a Andy Herrera en la serie.
Jason George hace el papel de Ben Warren.
Boris Kodjoe interpreta a Robert Sullivan en la serie.
Barrett Doss interpreta a Victoria Hughes en la serie.
Jay Hayden hace el papel de Travis Montgomery.
Danielle Savre interpreta a Maya Bishop en la serie.
Capítulo disponible en las siguientes plataformas:
