- Adrian Harris - State Manager
- Sharon Wilkins - Nurse
- Andrea Savage - Helen Basch
- Richard Griffiths - Julian Bullard
- Ben Miller - Ben Miller
- William Hope - Matt's Agent
- Sarah Sharman - Network Executive
- Gerard Monaco - Paparazzo
- Rachel Shelley - Kendra
- Jane Perry - Charity Woman
- Joseph Balderrama - Tour Guide
- John Chancer - Editor
- Eros Vlahos - 'Pucks!' Boy
- Rhashan Stone - Howard
- Martin McDougall - Assistant Director
- Anna Maria Everett - Florinda
- Lou Hirsch - Wallace
- Ronan Summers - Hair Guy
- Paul Leonard - Waiter
- Tom Bell - Autograph Man
- Albie Selznick - Golf Coach
- Jamie Denbo - Bethany
- Katherine Ryan - Merc's Assistant
- Kenneth Collard - SFX Guy
- Trevor White - Assistant Director
- James Michael Tyler - James Michael Tyler
- Demetri Goritsas - Director
- Bruce Lester-Johnson - Roger
- Jacob Anderson - Kevin
- James Purefoy - Rob
- Brandon Ford Green - Cop 1
- Bruno Amato - Cop 2
- Humphrey Ker - Writer
- Virginia Montero - Mirtala
- Fiona Glascott - Diane
- J. Omar Castro - Delivery Guy
- Sam Palladio - Stoke
- Suzanne Sena - News Reporter
- Merrin Dungey - Tonight Show Producer
- Jay Leno - Jay Leno
- Nancy Lenehan - Sex Therapist
- Damaris Justamante - Journalist 1
- Wayne Lopez - Journalist 2
- Tom Lenk - Publicist
- Stacie Greenwell - Journalist 3
- Alex Lewis - Journalist 4
- Ben Zelevansky - TV Critic
- Genevieve O'Reilly - Jamie Lapidus
- Harry McEntire - Jason
- Lucien Laviscount - Brian
- Tracy Spiridakos - Dawn
- Sophie Rundle - Labia
- Morgan Gingerich - Michael
- Ravi Smith - Aiden
- Max Curnin - Kenny
- Fernando Rivera - Joe
- Rufus Jones - Anthony Powner Smith
- Daniel Adegboyega - Kick Boxer
- John Ross Bowie - Psychiatrist
- David Armand - Maurice
- David Armand - Another Executive
- Katherine Jakeways - Castor's Assistant
- Caroline Aaron - Linda
- Alex Rocco - Dick LeBlanc
- Chris Diamantopoulos - Castor Sotto
- Sharon Sachs - Berta Nissick
- Oliver Kieran-Jones - Andrew Lesley
- Scarlett Rose Patterson - Wendy
- Scarlett Rose Patterson - Wendy (voice)
- Roger Bart - Matt's Agent
- Leslie Moonves - Himself
- Jed Aukin - US Customs Official
- Freddy John James - Studio Security Guard
- Jonathan Howard - Assistant Director
- Jessica Chaffin - Nina
- Jenny Bede - Studio Office Manager
- Lauriane Gilliéron - Attractive Woman
- Michael Brandon - Elliot Salad
- Nigel Planer - Sanford Shamiro
- Michael S. Siegel - Rabbi
- Ray Callaghan - Ancient Crew Guy
- Jon Glover - Lawyer
- Andrea Rosen - Eileen Jaffee
- Ella Kenion - Matt's Publicist
- Geoffrey McGivern - Bob
- Tom Price - Aaron
- Daisy Haggard - Myra Licht
- Laurie Paul Calvert - Carol's Assistant
- Alistair Brammer - Eric
- Gilbert Gottfried - Gilbert Gottfried
- Shauna Shim - Waitress
- Victor Jenkins
- Jeffrey Klarik
- David Crane
- Kelly Valentine Hendry
- Jimmy Mulville
- Oli Julian
Caroline Aaron interpreta a Linda en la serie.
Matt LeBlanc hace el papel de Matt LeBlanc.
Tamsin Greig interpreta a Beverly Lincoln en la serie.
Stephen Mangan interpreta a Sean Lincoln en la serie.
John Pankow interpreta a Merc Lapidus en la serie.
Kathleen Rose Perkins interpreta a Carol Rance en la serie.
Mircea Monroe interpreta a Morning Randolph en la serie.
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