- Harry Morgan - Charlie
- Skip Ward - Lt. Ferguson
- Stuart Margolin - Lt. Miller
- Les Brown Jr. - Lt. Cobby
- Stafford Repp - Commodore
- Herbie Faye - Smitty
- Joe Higgins - Louie
- Joe Higgins - Chief Henly
- Jamie Farr - Penski
- Steve Franken - Ensign Clifford Bender
- Penny Santon - Mama Di Julio
- Robert Sorrells - White
- Robert Sorrells - Seaman Claude White
- Romo Vincent - Papa Di Julio
- Beau Bridges - Spicer
- Beau Bridges - Seaman Howard Spicer
- Charles Watts - Leslie
- Dub Taylor - Clerk
- Rosemary DeCamp - Leona
- Michael Ross - Gurney
- Shary Marshall - Nurse
- Ken Berry - Lt. Melton
- Ken Berry - Calucci
- Ken Berry - Melton
- Robert Emhardt - Rodney Frazer
- Howard Morris - Delacroix
- Bernard Fox - Hastings
- Philip Ahn - Low Kong
- James Hong - Headwaiter
- John McGiver - Arthur Ainsley
- Alan Caillou - Monte Cartwright
- Davis Roberts - Swain
- John Tarangelo - Whittaker
- Kelly Gordon - Harper
- Carol Christensen - Nancy
- Cynthia Chenault - Janie
- Jackie Loughery - Arlene
- Jackie Joseph - Mary Lou
- Don Beddoe - Admiral Hornsby
- Alan Reed Jr. - Malloy
- Sharon Hugueny - Juliet
- Doris Packer - Mrs. Atherton
- Émile Genest - Monti
- Bruno Della Santina - Proprietor
- Don Orlando - Waiter
- Eddie Peterson - Selby
- Eddie Peterson - Seaman
- Eddie Peterson - Peterson
- Cathy Lewis - Mrs. Stoner
- Murray Alper - Chief Wales
- Cal Bolder - Nathan
- Gary Crosby - Ensign Baxter
- Ransom M. Sherman - Congressman Torpin
- Ransom M. Sherman - Stanley Cobb
- Nita Talbot - Anna
- Martin Dean - Martin
- William Schallert - Douglas Harper
- Peter Leeds - Charlie Kahn
- Mike Farrell - Ferguson
- Stubby Kaye - Tubby Mason
- Dick Whittinghill - Announcer
- George Petrie - Lt. Commander Dickery
- Irene Tedrow - Mrs. Barnes
- William Kendis - Master of Ceremonies
- Jack Carter - Steve Turner
- Eddie Ryder - Al Shrieber
- Robert Kino - Mr. Yamada
- Mako - Yamada, Jr.
John McGiver interpreta a Arthur Ainsley en la serie.
Beau Bridges interpreta a Seaman Howard Spicer en la serie.
Harry Morgan interpreta a Charlie en la serie.
Dean Jones interpreta a Ensign O'Toole en la serie.
Jack Mullaney hace el papel de Lieutenant Rex St. John.
Harvey Lembeck hace el papel de Seaman Gabby Di Julio.
Jay C. Flippen interpreta a Chief Petty Officer Homer Nelson en la serie.
Jack Albertson hace el papel de Lieutenant Commander Virgil Stoner.
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