- Tammy Lauren - Marilyn Keaton
- Dan Hedaya - Joe Moore
- Rosalind Cash - Maya Thompson
- Suzanne Snyder - Tricia Armstrong
- Christian Clemenson - Mr. Flaherty
- Brownie McGhee - Eddie Dupre
- Scott Valentine - Nick Moore
- Tracy Pollan - Ellen Reed
- Anne Seymour - May Keaton
- David Paymer - Larry Harris
- Priscilla Morrill - Kate Donnelly
- Brian McNamara - Greg
- Joseph Gordon-Levitt - Dougie
- Christina Pickles - Mrs. Ruth Hobart
- Chris Hebert - Young Alex
- Geena Davis - Karen Nicholson
- Wil Wheaton - Timothy Higgins
- Jami Gertz - Jocelyn Clark
- Brad Kesten - Brad Hallinan
- Jonna Lee - Tammy Okun
- James Cromwell - John Hancock
- Alexandra Powers - Erin
- Melinda Culea - Rebecca Ryan
- Campbell Scott - Eric Matthews
- Gloria Gifford - Akila
- Joshua John Miller - Kenneth
- Tracy Nelson - Deena Marx
- Rain Phoenix - Ashley Berkhart
- John McCook - Tuxedo Man
- Nancy Parsons - Nurse
- Ethel Ayler - Ms. Daniels
- Byron Thames - Josh Wakefield
- Terry Farrell - Liz Obeck
- Barbara Barrie - Aunt Rosemary
- Constance McCashin - Evelyn Mitchum
- Barry Sobel - Petey Gordon
- Maura Tierney - Darlene
- George Newbern - Eric
- Edith Atwater - Trudy Harris
- Matthew Barry - Scott
- William Boyett - Policeman
- Lyman Ward - John Willis
- Julie Harris - Margaret
- Carolyn Seymour - Lorraine Ferrar
- Haviland Morris - Sharon McElroy
- Suzie Plakson - Doris
- David Faustino - Keith Bailey
- Doris Belack - Mrs. Willis
- Kurt Smildsin - Waiter
- Talia Balsam - Carrie Newman
- Noah Hathaway - Adam Galardner
- Hilary Shepard - Yvette
- Joshua Shelley - Sam
- Jennifer Salt - Mrs. Kluger
- John J. York - Matthews
- Courteney Cox - Lauren Miller
- Kate Vernon - Christy
- Kathleen Wilhoite - Kathy
- Mason Adams - Professor Lloyd Rhodes
- Pete Schrum - Nick
- Danielle von Zerneck - June
- Nancy Everhard - Robin Green
- Judith Light - Stacey Hughes
- Molly Cheek - Frances Wilder
- River Phoenix - Eugene Forbes
- Toni Sawyer - Mrs. Emily Blanton
- Deborah Foreman - Mary Catherine Robbins
- Pamela Springsteen - Gail
- Peter Scolari - Paul Kenter
- Jeremy Schoenberg - Justin Perkins
- Robert Desiderio - Richie Schofield
- Anne Haney - Mrs. Matthews
- Grant Heslov - Doug
- John Randolph - Jake Keaton
- Julie Payne - Lynn Sullivan
- Mark Moses - Rick Albert
- Peter Jurasik - Max Brown
- Tom Hanks - Ned Donnelly
- Alex Henteloff - Coach
- Martha Plimpton - Jessie Blake
- Ronny Cox - Franklin Reed
- Betsy Russell - The Girl
- Miriam Flynn - Mrs. Carpenter
- Amy Steel - Stephanie Brooks
- Jack Riley - Earl Quigley
- Helen Page Camp - Vera
- Meg Wyllie - Mrs. Leahy
- Bibi Besch - Dr. Hewitt
- Jack Blessing - Leonard
- Richard Venture - Agent Bert Carlyle
- Marc Price - Skippy Handelman
- Barry Jenner - David Campbell
- John Lavachielli - Waiter
- Bruce Jarchow - Ted
- Kaleena Kiff - Young Mallory
- Marianne Muellerleile - Cecelia
- Margaret Nagle - Jill
- Stuart Pankin - Marv
- Daniel Baldwin - Holworthy
- Marsha Warfield - Doris Bradshaw
- Beverly Archer - Sue Barker
- Jay Thomas - Jerry DiNello
- Rosanna Huffman - Alice
- Philip Baker Hall - Dr. Harrison
- James Karen - Philip
- Douglas Seale - Joseph Simmons
- Granville Van Dusen - Mr. Carter
- James Sutorius - Richard
- Gail Strickland - Dorothy Canell
- Alisan Porter - Child
- Michael Currie - Mr. Halifax
- Liz Sheridan - Ginny McCoy
- Reid Shelton - Charles Okun Jr.
- Susan Bay Nimoy - Julia Newman
- Stephen Lee - Mr. Parker
- Dana Stevens - Val
- Robert Klein - Roger "Eggy" Erdman
- Michelle Collins - Louise
- Tate Donovan - Clancy
- Mari Gorman - Nurse
- Peter Hobbs - Professor Walter Jenkins
- Corey Feldman - Walter
- Larry Hankin - Walter
- Cindy Fisher - Kimberly Blanton
- Moosie Drier - Arnie
- Carlos Lacámara - Petey
- Jack Somack - Mr. Adler
- Lee Montgomery - Eric Morrison
- Sal Viscuso - Richard Jacobs
- Sal Viscuso - Richard Grasso
- Mary Jackson - Edna
- Philip Charles MacKenzie - Dan Matthews
- Stephen Baldwin - Bobby
- Lois de Banzie - Rose Handelman
- Maryedith Burrell - Young May Keaton
- Sam Whipple - Jack Driscoll
- Sam Whipple - Bill
- Daphne Zuniga - Rachel Miller
- Philip Sterling - Mr. Winkler
- Carolyn Mignini - Peggy Vincent
- Jay Tarses - Ron Davis
- Frances Bay - Mrs. Florence Menlo
- Jaclyn Bernstein - Marla
- Danny Nucci - Rick
- Richard Stahl - Stu Devin
- Garn Stephens - Elizabeth Davidson
- Rebecca Balding - Karen Banks
- Joan McMurtrey - Mrs. Kaufman
- Penelope Ann Miller - Joyce
- Darrell Thomas Utley - Josh Richards
- Josh Clark - Ray Davis
- William Cort - Dr. Hubert Witt
- Jeff Perry - David Simmons
- Elsa Raven - Mildred Atkins
- Dick Sargent - Charlie
- Macon McCalman - Professor Spanos
- Belita Moreno - Bernice
- Belita Moreno - Mrs. Pedroza
- Bruce French - Dr. Rogers
- Don Amendolia - Tom
- Rick Podell - Jackie Jackerman
- Dan Gilvezan - Officer Steele
- Edith Fields - Mrs. Sharon Fletcher
- Janice Lynde - Monica
- Christina Applegate - Kitten
- Julia Louis-Dreyfus - Susan "Raindrop" White
- Robert Torti - Jack McDowell
- Lee Garlington - Beth Davis
- Warren Munson - Fred Lambert
- Gracie Harrison - Mrs. Hillman
- Robert Pine - Dean Ian McCall
- Ellen Hamilton Latzen - Michelle Davis
- Marie Denn - Eva Martin
- Diana Bellamy - Dr. Eileen Davidson
- Mark L. Taylor - Phil
- Jack O'Leary - The Guard
- Amy O'Neill - Brenda
- Molly David - Mrs. Jones
- Maurice Marsac - Roger
- Brooke Alderson - Suzanne Davis
- Jeff Cohen - Dougie Barker
- Jeff Cohen - Marv Jr.
- David Spielberg - Arthur Press
- Andrew J. Lederer - Howie
- Nancy Lenehan - Roberta
- Randy Lowell - Bobby Cahill
- Alan Haufrect - Customer
- William G. Schilling - Customer
- Ann Nelson - Mrs. Crenshaw
- Pat McNamara - Officer Becker
- Charles Levin - Dr. "Crazy Larry" Waxman
- Bridgette Andersen - Young Mallory
- Cristen Kauffman - Cindy Sullivan
- Lisa Lucas - Sherry Marshall
- Robin Evans - The Girl
- Woody Eney - Rob Peterson
- Eda Reiss Merin - Woman at Airport
- John Dukakis - Jeff Wakefield
- Irene Yah-Ling Sun - Tanly Nguyen
- Michael Spound - Neil
- John Putch - Neil
- John Putch - Pete Drucker
- Kerry Noonan - Mary Margaret Dunne
- Charles Douglass - Alternate Head Judge
- Chris Nash - Victor
- Kelly Ann Conn - Sherry
- Bob Tzudiker - Mr. Needham
- Edward Edwards - Mr. Ruben Tedesco
- Earl Boen - Ticketing Counter Attendant
- Earl Boen - Ed Barker
- Frank Dent - Ed Hanson
- Sarah Abrell - Heather
- Donald Reiker - Phillip
- John Hancock - Gus Thompson
- Hannah Cutrona - Melissa Ferrar
- Tanya Fenmore - Arlene
- Donna McKechnie - Cynthia
- Isabell O'Connor - Waitress
- Crispin Glover - Doug
- Eileen Seeley - Roxanne
- Debbie Gilbert - Buffy
- Bill Gratton - Janitor
- Kate Charleson - Sandy
- Thomas Byrd - Rick Harmon
- Lenora May - Margo
- Susan Isaacs - Linda
- Richard McGonagle - Brother Timothy (uncredited)
- Richard McGonagle - Male Customer
- Milt Oberman - Andy
- Timothy Busfield - Doug
- Timothy Busfield - Young Matt Gilbert
- Sam Kwasman - Dennis McKay
- Walter Olkewicz - Bill Channing
- Walter Olkewicz - Walter Luskin
- Walter Olkewicz - Howie (uncredited)
- John Hostetter - The Heckler
- John Hostetter - Stage Manager
- Bunny Summers - Mrs. Binney
- Bunny Summers - Barbara
- Bunny Summers - Mrs. Stein
- Bunny Summers - Customer
- Raleigh Bond - Harry Handelman
- Arthur Taxier - The Dealer
- Seth Jaffe - The Pit Boss
- Charles Walker - The Waiter
- Ben Piazza - Mr. Wertz
- Ben Piazza - Ed Nelson
- Michael McGuire - Professor Bronski
- Alison La Placa - Barbara
- Jeffrey Joseph - James Jarrett
- Jane Alden - Ms. Janice Worthy
- Jane Adams - Marty Brodie
- Jane Adams - Andrea
- Shawn Schepps - Darlene Driscoll
- Marcianne Warman - Ellen Barker
- Michael Zorek - Flaum
- Billy Campbell - Lyle
- Toni Gerry - Doug's Mother
- Ernest Harada - Pastor
- Lily Mariye - Eleanor
- Michelle Meyrink - Jane
- Anne Ramsey - Mrs. Warfield
- Christopher Rydell - Craig Duvall
- Rick Gibbs - Don Caruthers
- Isabelle Walker - Donna Barros
- Julie Fulton - Suzie Harris
- Karlene Crockett - Marge
- Enid Kent - Phyllis Evans
- Enid Kent - Robin
- Enid Kent - Susan Alexander
- Enid Kent - Norma Coleman
- Kevin Dunn - Glen
- Kevin Dunn - Bob Dunphy
- Stan Roth - Doctor
- Ron Karabatsos - Bud Carlson
- Matthew Faison - Raymond
- Matthew Faison - Dr. Skip Williamson
- Matthew Faison - Mr. Cromwell
- Shirley Prestia - Receptionist
- Wyatt Knight - William
- Steven Peterman - Man in Restaurant
- Radha Delamarter - Woman in Restaurant
- Adam Carl - Young Steven Keaton
- Norman Parker - Robert Keaton
- John Petlock - Ted Waterman
- John Petlock - Mr. Heaney
- John Petlock - Mr. Preston Blanton
- John Petlock - Reverend Wilson
- Michael Alldredge - Young Jake Keaton
- Hanna Landy - Mrs. Kretzer
- Wiley Harker - Mr. Kretzer
- Rob Steinberg - Neighbor
- Barbara Minkus - Neighbor
- Terry Wills - Dr. Schulte
- Terry Wills - Cabbie
- Terry Wills - Don Bradford
- Terry Wills - Dwane
- Terry Wills - Desk Clerk
- Peter Van Norden - Janitor
- Dan Ponce - Shoeshine Boy
- Raymond Singer - Cameron Wallace
- Raymond Singer - Buffaloed Bill
- Raymond Singer - Dean Hutchinson
- John Scott Clough - David
- Jesse Welles - Ms. Deborah Henley
- Bronwyn Thomas - Roberta
- Robert Costanzo - Carmine
- Robert Costanzo - Max Schneider
- Robert Costanzo - Sam
- Robert Costanzo - Larry Briganti
- Robert Costanzo - Andrew the Waiter
- Kim Sebastian - Eunice
- Michael David Wright - Young Steven Keaton
- Michael David Wright - Kevin Jenkins
- George Coe - Justin Phillips
- Cynthia Carle - Betty Boswell
- Suzanne Lederer - Dr. Sylvia
- Jerry Hardin - Mr. Bidney
- Alan Blumenfeld - George Bellack
- Alan Blumenfeld - Man at Garage Sale
- Alan Blumenfeld - Mr. Gleason
- Alan Blumenfeld - Lou Stone
- Alan Blumenfeld - Mr. Krewson
- Albert Macklin - Ivan Rozmirovich
- George Pentecost - Eric Nordstrom
- Todd Jeffries - Eddie
- Anthony Tyler Quinn - Clete
- Harvey Jason - Pierre
- Christine Belford - Victoria Hurstenberg
- Anne Marie McEvoy - Alice
- Laura Jacoby - Jill
- Willie Garson - Walter
- Ashley Bank - Rhonda
- Kerry Remsen - Reenie Crawford
- Margaret Marx - Young Elyse Donnelly
- Bernadette Birkett - Carol
- Bernadette Birkett - Mrs. Cromwell
- Bruce Toms - Gregg
- David Wohl - Psychiatrist (voice)
- David Wohl - Oscar
- David Wohl - Ralph Boswell
- David Wohl - Zane Axelrod
- John Ingle - Justice of the Peace
- Larry Cox - Mike
- Tony Carreiro - Terry Bridgeman
- Tom Bresnahan - Brian Elliott
- Christopher Bradley - Dave Rubin
- Lisa Sloan - Professor Marshall
- Amy Benedict - Eve Kimball
- Jane Downs - Photographer
- Robin Morse - Allison King
- Marietta DePrima - Simone
- Julie Cobb - Maureen Keaton
- Wendel Meldrum - Kathy Brady
- Chad McCann - Delivery Boy
- Jonathan Emerson - Colin Spencer
- Ken Lerner - Mr. Feinman
- Sonia Curtis - Amy Sussman
- Lucy Butler - Christine
- Tim Haldeman - Roger
- Milton James - Waiter
- Karen Landry - Michele
- Dana Andersen - Monica
- Bill Allen - Roger Sloate
- Alyson Croft - Brooke
- Gino De Mauro - Zack Phillips
- Heather Hobbs - Stacie Connors
- Amy Lynne - Chrissy Nardino
- Annie O'Donnell - Blue Mama
- Jason Naylor - Simon Wickerson
- Tony Crane - Roger
- Lilly Moon - Nancy
- Max Segar - Mr. Carlisle
- Sandy Ward - Carl Norback
- Laura Leigh Hughes - Cindy
- Tracy Camilla Johns - Dana
- Kim Gillingham - Karen
- Maria Bradley - Constance
- Ira Heiden - Sam
- Howard Renensland - Bernie Packer
- Jack Heller - Chaim
- Victor DiMattia - Eddie
- Rod McCary - Dr. Jeff Cooper
- Jennifer Flackett - Connie
- Ray Reinhardt - Bill
- Richard Brestoff - Professor Webster
- Stephen Dorff - Martin
- Anne Bellamy - Boardwoman
- Anne Bellamy - Dean McHugh
- Rachel Jacobs - Jill
- Matt Levin - Billy
- Joseph Della Sorte - Mr. Parsons
- Adrian Sparks - Man at School Board Meeting
- Mike Hagerty - Vinnie
- Gwen Banta - Beth
- Terri Hanauer - Miss Metcalf
- Susan Kohler - Mrs. Richards
- Malachi Pearson - Eugene
- Debra Engle - Jamie Carter
- Hank Azaria - Joe
- Kaylan Romero - Rocco
- Kathleen Dennehy - Janie
- Richard Kuss - Mr. Meyers
- Bever-Leigh Banfield - Nurse
- Baillie Gerstein - Mrs. Hummier
- Baillie Gerstein - Woman Customer
- Linda Klein - Anesthesiologist
- Trevor Eyster - Young Alex
- Shannon Macpherson - Young Mallory
- Nick Rutherford - Young Skippy
- John Marshall Jones - Sgt. Tom Davis
- Tom Isbell - Dr. Austin
- Carol Mansell - Woman with Cats
- Ron Jarvis - Clown
- Scott LaRose - Lobster
- Paul McIsaac - Judge Cameron
- Minnie Summers Lindsey - Rosemary
- Mimi Cozzens - Mrs. Clark
- Christine Jansen - Jessica Foster
- Billy Morrissette - Paul Corman
- Gary Grubbs - Mr. Willis
- Vic Polizos - Dave McPhee
- Florence Sundstrom - Woman
- Karyn O'Bryan - Pippi
- Keith Amos - Michael Thompson
- Jane Daly - Christine Chadway
- Betsy Randle - Nancy
- Charles Bouvier - Officer Larson
- Barry Heins - Mr. Hilgenburg
- Nina Mann - Mrs. Williams
- Alex Zuckerman - Davey
- Marissa Rosen - Child
- Nichole Francois - Child
- Duncan Ross - Dean Memminger
- Gary David Goldberg
- Alan Uger
- Marc Lawrence
- Lloyd Garver
- Ruth Bennett
- Carol Himes
- June Galas
- Michael J. Weithorn
Bibi Besch interpreta a Dr. Hewitt en la serie.
Willie Garson interpreta a Walter en la serie.
Ronny Cox hace el papel de Franklin Reed.
Tom Hanks interpreta a Ned Donnelly en la serie.
Marianne Muellerleile hace el papel de Cecelia.
Crispin Glover hace el papel de Doug.
Michelle Meyrink interpreta a Jane en la serie.
Philip Baker Hall hace el papel de Dr. Harrison.
Earl Boen hace el papel de Ed Barker.
Julie Harris interpreta a Margaret en la serie.
Capítulo disponible en las siguientes plataformas:
