- Addison Ross - Brooke Miller (Age 7)
- Laney Stiebing - Jessica Roach
- Robert Wisdom - Edmund Beaumont
- Santo Panzarella - Brendan
- Robyn Malcolm - Sammy Keene
- Lee Tergesen - Roger Nevins
- Carlo Alban - Chris Drysdale
- Christopher Berry - Judge
- T.C. Matherne - Lenny
- Logan Macrae - Schultz
- Stephen Louis Grush - Danny Dunn
- Cecilia Leal - Rochelle
- Kevin Pozzo - DEA Goon
- Jeff Grays - Emotional Inmate
- Cullen Moss - Detective Russ Aborn
- Cullen Moss - Russ Aborn
- Rudy Eisenzopf - Jeff Steinbeck
- Robert Walker Branchaud - Malcolm Winslow
- Fred Davis - FCI Guard
- Jenny Ballard - Andrea Miller
- Robert Diago DoQui - Sheriff Pat Hartshorn
- Sam Malone - Drayton Jeffries
- Jason Edwards - Detective Boyd
- Jason Bayle - Detective Johansen
- Jake McLaughlin - Gary Hall
- Michael Aaron Milligan - Mackowski
- Joe Williamson - CO Carter
- Brett Gentile - Agent Mark Ellenberg
- Eric Esteban - Wabash Police Chief
- Brandon Sutton - Hogan
- Ryan Broussard - Strack
- Kwajalyn Brown - Judge Diane Wood
- John Jabaley - CO Burden
- Kiley Casciano - Lynne Keene
- Kiley Casciano - Young Lynne Keene
- Dominique McClellan - CO Guest
- Melanie Nicholls-King - Dr. Amelia Hackett
- Tony Amendola - Vincent 'The Chin' Gigante
- Christopher B. Duncan - Dr. Aaron Zicherman
- James DuMont - Sheriff Charnitski
- Peter Jaymes Jr. - Vomiting Inmate
- Zach Rogers - Self Harm Inmate
- Joey Bicicchi - Percy
- Lawrence Turner - Stoned Prisoner
- Jeff Robins - Donny
- Walker Babington - Falco
- Trazi Lashawn - CO Holt
- Christopher Backus - Young James 'Big Jim' Keene
- Charles Green - Robert Hall
- Bernard Hocke - Priest
- Cade Tropeano - Young Larry Hall
- Blue Clarke - Young Jimmy Keene
- Braxton Alexander - Teenage Jimmy
- Karsen Liotta - Audrey Hansen
- Casey Groves - Young Mr. Roach
- Rachel Whitman Groves - Young Mrs. Roach
- Cooper Jack Rubin - Little Boy
- Meghan Wolfe - Jessica Roach's Sister
- Bill Martin Williams - John DIckey
- Brandon Morales - CO Charlie
- Austin Naulty - Surly Con
- Taylor Davidson - Waitress
- James Keene - CO #8
- Holly Bonney - Flight Attendant
- Hillel Levin
- David Diliberto
- Alexandra Milchan
- Kary Antholis
- Michaël R. Roskam
- Jim McKay
- Joe Chappelle
- Stuart Braithwaite
- Dominic Aitchison
- Martin Bulloch
- Barry Burns
Taron Egerton interpreta a James 'Jimmy' Keene en la serie.
Paul Walter Hauser interpreta a Larry Hall en la serie.
Sepideh Moafi interpreta a Lauren McCauley en la serie.
Greg Kinnear hace el papel de Brian Miller.
Ray Liotta interpreta a James 'Big Jim' Keene en la serie.
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