- Addison Ross - Brooke Miller (Age 7)
- Laney Stiebing - Jessica Roach
- Robert Wisdom - Edmund Beaumont
- Santo Panzarella - Brendan
- Robyn Malcolm - Sammy Keene
- Lee Tergesen - Roger Nevins
- Carlo Alban - Chris Drysdale
- Christopher Berry - Judge
- T.C. Matherne - Lenny
- Logan Macrae - Schultz
- Stephen Louis Grush - Danny Dunn
- Cecilia Leal - Rochelle
- Kevin Pozzo - DEA Goon
- Jeff Grays - Emotional Inmate
- Cullen Moss - Detective Russ Aborn
- Cullen Moss - Russ Aborn
- Rudy Eisenzopf - Jeff Steinbeck
- Robert Walker Branchaud - Malcolm Winslow
- Fred Davis - FCI Guard
- Jenny Ballard - Andrea Miller
- Robert Diago DoQui - Sheriff Pat Hartshorn
- Sam Malone - Drayton Jeffries
- Jason Edwards - Detective Boyd
- Jason Bayle - Detective Johansen
- Jake McLaughlin - Gary Hall
- Michael Aaron Milligan - Mackowski
- Joe Williamson - CO Carter
- Brett Gentile - Agent Mark Ellenberg
- Eric Esteban - Wabash Police Chief
- Brandon Sutton - Hogan
- Ryan Broussard - Strack
- Kwajalyn Brown - Judge Diane Wood
- John Jabaley - CO Burden
- Kiley Casciano - Lynne Keene
- Kiley Casciano - Young Lynne Keene
- Dominique McClellan - CO Guest
- Melanie Nicholls-King - Dr. Amelia Hackett
- Tony Amendola - Vincent 'The Chin' Gigante
- Christopher B. Duncan - Dr. Aaron Zicherman
- James DuMont - Sheriff Charnitski
- Peter Jaymes Jr. - Vomiting Inmate
- Zach Rogers - Self Harm Inmate
- Joey Bicicchi - Percy
- Lawrence Turner - Stoned Prisoner
- Jeff Robins - Donny
- Walker Babington - Falco
- Trazi Lashawn - CO Holt
- Christopher Backus - Young James 'Big Jim' Keene
- Charles Green - Robert Hall
- Bernard Hocke - Priest
- Cade Tropeano - Young Larry Hall
- Blue Clarke - Young Jimmy Keene
- Braxton Alexander - Teenage Jimmy
- Karsen Liotta - Audrey Hansen
- Casey Groves - Young Mr. Roach
- Rachel Whitman Groves - Young Mrs. Roach
- Cooper Jack Rubin - Little Boy
- Meghan Wolfe - Jessica Roach's Sister
- Bill Martin Williams - John DIckey
- Brandon Morales - CO Charlie
- Austin Naulty - Surly Con
- Taylor Davidson - Waitress
- James Keene - CO #8
- Holly Bonney - Flight Attendant
- Hillel Levin
- David Diliberto
- Alexandra Milchan
- Kary Antholis
- Michaël R. Roskam
- Jim McKay
- Joe Chappelle
- Stuart Braithwaite
- Dominic Aitchison
- Martin Bulloch
- Barry Burns
Taron Egerton hace el papel de James 'Jimmy' Keene.
Paul Walter Hauser hace el papel de Larry Hall.
Sepideh Moafi hace el papel de Lauren McCauley.
Greg Kinnear interpreta a Brian Miller en la serie.
Ray Liotta interpreta a James 'Big Jim' Keene en la serie.
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