- Paul Campbell - Scott
- Trish Allen - Nurse Doreen
- Jeananne Goossen - Molly
- Xavier Lopez - Resident Dr.
- Harry Lennix - Tim Dupre
- Catherine Barroll - Joyce Barnes
- Brittany Ishibashi - Kelly Hamata
- Christine Willes - E.R. Nurse
- Mark Ghanimé - Jamie Albagetti
- Yoshie Bancroft - Nurse Sunny
- Emily Holmes - Vicky
- Brady Rubin - Mrs. Ellish
- Chelah Horsdal - Marian Kramden
- Christian Tessier - Leo
- Michelle Harrison - Jessica
- Zach Martin - Jockey Orthopedist
- Lissa Neptuno - Imelda Andaya
- Marlowe Percival - Julia
- Marci T. House - Cardio Nurse
- Sachin Sahel - Male Orderly
- Natalie Skye - Abbey
- Brendon Zub - Dan
- Dan Zukovic - School Official
- Bess Rous - Margo
- Dick Latessa - Max Mullins
- Adam Korson - Adam
- Levi Fiehler - Gabe Mullins
- Laci J. Mailey - Kylie
- Tanja Dixon-Warren - Another Nurse
- Jerry Wasserman - Dr. Morehead
- Babak A. Motamed - Anesthesiologist
- Brad Dryborough - Perfusionist
- Julia Sarah Stone - Frizzy Haired Girl
- Julia Sarah Stone - Abbey
- Camille Atebe - Cardio Nurse
- Daniela Bobadilla - Payson Sorriano
- Lee Garlington - Donna Fisher
- Geoffrey Rivas - Mr. Soriano
- Brett DelBuono - Damon
- Sarah-Jane Redmond - Damon's Mother
- Genevieve Buechner - Sophie
- Miranda Frigon - Candace Fisher
- Keith MacKechnie - Larry Fisher
- Graem Beddoes - Male Addict Patient
- Leslie Hopps - Mother
- Taylor Russell - Mean Girl
- Marie V. Sharp - Mean Girl
- Virginia Williams - Ellen
- Sunita Prasad - Amira Garang
- Dejan Loyola - Sushil Garang
- Tony Mirrcandani - Mr. Garang
- Veena Sood - Mrs. Garang
- Meg Roe - Claire
- Sebastian Spence - Ellen's Husband
- Chris Coy - Conor McCall
- Marcus Coloma - Officer Rick Malone
- Tanya Clarke - Karen Ballard
- Lane Edwards - Luke Ballard
- Sean Michael Kyer - Sam
- Eva Bourne - Tracy
- Hiro Kanagawa - Nobu Chiba
- Zahf Paroo - Asad Tauana
- Shaine Jones - Anesthesiologist
- Theresa Wong - O.R. Nurse
- Ian Anthony Dale - Kyle Putnam
- James Immekus - Peter
- Emma Lahana - Hannah
- Myk Watford - Mr. Reeser
- Reagan Dale Neis - Kate Reeser
- Nicola Anderson - Nurse Christina
- Nicola Anderson - EMT Tech
- Patricia Belcher - Dolores
- Richard Keats - Dr. Fitzgerald
- Catherine Lough Haggquist - Gloria
- Eli Goree - Intern Bomount
- Michael McMillian - Blake
- Carlos Sanz - Manuel Cuestas
- Bruce Salomon - Randy Cuestas
- Dee Jay Jackson - Marty
- Suzanne Ristic - Lina
- Marc Senior - Delivery Man
- Shaker Paleja - Bobby
- Glynis Davies - Didi
- Bruce Harwood - Anesthesiologist
- Jesse Reid - Rotating Nurse
- Rachel DiPillo - Allison McCleary
- Anna Van Hooft - Sierra La Roche
- T.J. Ramini - Kostas Pagonis
- Jeffrey Ballard - Ori
- Eric Breker - Mr. McCleary
- Tatiana Turner - Marlaina
- Jesse Wheeler - EMT
- Khaira Ledeyo - E.R.Nurse
- Ivan Wanis-Ruiz - EMT
- Vee Dubois - Trauma Nurse
- Dan Joffre - Jimmy
- Benita Ha - Anesthesiologist
- Lucia Walters - Dr. Milford
- Kwesi Ameyaw - Trauma Surgeon
- D.B. Woodside - Evan Hammond
- Michelle Hurd - Diana Calder
- Mathew St. Patrick - John Calder
- K Callan - Lorraine Parks
- Geoff Gustafson - Tom Mendelson
- Carrie Ruscheinsky - Stacey Parks
- Jill Morrison - Lynn
- Samantha Ferris - Marian Camphill
- Daniel Bacon - Dr. Poran
- Candus Churchill - E.R. Nurse
- Farhad Khan - Yoga Teacher
- Christie Laing - Another Nurse
- J.R. Ramirez - AJ Aquino
- Brett Dier - Henry
- Barclay Hope - Frank
- Merrilyn Gann - Gail Duroux
- Wanda Cannon - Helen
- Greyston Holt - Mr. Duroux
- Patricia Drake - Nurse Dottie
- Lisa MacFadden - Lisa
- Gary Sekhon - Resident Fenta
- Jennifer Kitchen - Nurse Julie
- Chris Shields - Redinald Beal
- Matthew MacCaull - Steve Siddah
- Artin John - Intern Matson
- Donna Yamamoto - Anesthesiologist
- Tracie Thoms - Natalia Gorgia
- Tyler Jacob Moore - Jared
- Jocko Sims - Sean
- Doc Shaw - Ethan Gorgia
- Chad Riley - X-Ray Tech
- Kayvon Kelly - Cameraman
- Freda Perry - Irene (President)
- Don MacKay - Old Man
- Elan Ross Gibson - Old Woman
- Kelly Konno - Assistant
- Myndy Crist - Nicole
- Tiya Sircar - Chloe
- Greg Finley - Dan Nelson
- Eric Keenleyside - Mr. Nelson
- Julian Christopher - Lenny
- Elizabeth Thai - Nurse Ida
- Craig Meester - Victim
- Katherine Ramdeen - Relative
- Shane Symons - Young Man
- Ellie Harvie - NICU Doctor
- Tara Pratt - NICU Nurse
- Alexandra Krosney - Liz Barnes
- J. August Richards - George Morgan
- Alyson Reed - Mrs. Bednevik
- Jenny O'Hara - Julia
- Randee Heller - Maggie
- Kristen Ariza - Ashley Morgan
- Lee Majdoub - Officer Hewitt
- Jessica Harmon - Diana
- Maggie Ma - Female Customer
- Tarun Keram - Barista
- Nimet Kanji - Dr. Klein
- Janet Glassford - Orderly
- Dan Jinks
- Bharat Nalluri
Mamie Gummer interpreta a Emily Owens en la serie.
Justin Hartley hace el papel de Will Collins.
Michael Rady interpreta a Micah Barnes en la serie.
Aja Naomi King interpreta a Cassandra Kopelson en la serie.
Necar Zadegan interpreta a Gina Bandari en la serie.
Kelly McCreary hace el papel de Tyra Dupre.
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