- Tim Donnelly - Fireman Chet Kelly
- Peter Palmer - George Antonio
- Peter Brocco - Professor
- Barbara Bosson - Mrs. Collins
- Jack Hogan - Deke
- Bruno Kirby - Ken (as B. Kirby Jr.)
- Vic Tayback - Driver
- Nick Nolte - Fred
- Lance Kerwin - Wheeler Boy
- Michael Lerner - Martin Noble
- Gretchen Corbett - Mary Lynn Smith
- Coleen Gray - Clair Brightweiser
- Howard McGillin - Paramedic Dwyer - LACoFD (uncredited)
- Bette Ford - Juen Edwards
- Dick Butkus - Dave 'The Animal'
- Suzanne Charny - Mrs. Butler
- Paul Picerni - Ed Duran
- Joe E. Tata - Neighbor
- Marla Adams - Soap Opera Patient (uncredited)
- Virginia Gregg - Wilma Jacobs, R.N.
- Arnold Stang - Dick (uncredited)
- Joan Shawlee - Heather
- Joan Shawlee - Wife
- Frank Maxwell - Captain #110
- Cheryl Miller - Rochelle Kayner
- Jane Merrow - Lady Rossman
- Don 'Red' Barry - Dave Grogan
- Sid Haig - Spike
- Frank Aletter - Roger Mundell
- Lillian Lehman - Carol Williams
- Brooke Bundy - Lyla Caine
- Cicely Tyson - Mrs. Johnson
- Warren Berlinger - Mr. Winthrop
- Anne Schedeen - Carol
- Joseph V. Perry - Mike
- Ronnie Schell - Harold Peterson
- Anne Seymour - Mille Eastman - Former Head Nurse
- Ruth Gordon - Lenore
- Paul Fix - Gus 'Pop' Williams
- Paul Fix - Maxwell Hart
- Larry Storch - Ben Wesley
- Jock Mahoney - Hoyt Herrold
- Dorothy Green - Mother
- Dave Barry - Tom Jensen
- Matthew Beard - Bar Owner
- Ann Dusenberry - Candy Striper
- Kedric Wolfe - Duke
- Brian Byers - Gerald
- Fintan Meyler - Dorothy Teal
- Ann Prentiss - Cindy's Mother
- Ann Prentiss - Fran Lillington
- Ann Morgan Guilbert - Cora
- Karl Swenson - Gus
- Dick Van Patten - Carter Merkle
- Bert Williams - Carter
- Dennis Patrick - Mr. Hollister
- Gil Peterson - Frank
- Jenifer Shaw - Student Nurse (uncredited)
- Terry Burke - David Larson
- Roger Herren - Guy in Striped Tank-Top (uncredited)
- Gary Crosby - Tom Wheeler
- Gary Crosby - John Conway
- William Katt - Wally Lytton
- George Brenlin - Mort
- Richard Bakalyan - Dewey
- Richard Bakalyan - Charley
- Lillian Bronson - Winifred Lenover
- Helen Page Camp - Mrs. Murphy
- Helen Page Camp - Mother
- Helen Page Camp - First Woman
- Burt Mustin - Old Man
- Aneta Corsaut - Chuck's Wife
- Nick Dimitri - Orderly (uncredited)
- Christopher S. Nelson - Amy's Boyfriend
- Christopher S. Nelson - Arnie
- Christopher S. Nelson - Danny Zimmerman
- Deidre Hall - Nurse Sally Lewis
- Elizabeth Baur - Sister Barbara
- Carole Cook - Nurse
- Morgan Jones - Captain, Engine *43, LACoFD (uncredited)
- John Smith - Capt. Hammer
- Jeff Donnell - Katie
- Art Balinger - Chief Conrad, Battalion 14 (uncredited)
- Art Balinger - Chief Conrad, Battalion 14
- Eric Laneuville - Tim Johnson
- Henry Jones - Dr. Alexander Knott
- Jack DeLeon - Billy Zimmer (uncredited)
- Beth Brickell - Susan
- Robert Patten - Police Sergeant, LAPD
- Bob Hastings - Man (In Robe)
- Tony Dow - Motorcycle Rider
- Trent Lehman - Andy
- George Sawaya - Dr. Duncan (uncredited)
- George Sawaya - Injured Stuntman (uncredited)
- Mort Sahl - Burglar
- Don Ross - Guard
- Bill Quinn - Haley
- Victor Mohica - Steve
- Ronne Troup - Lisa Hill
- Ronne Troup - Pam
- Ronne Troup - Judy
- Stanley Kamel - Harry Rivers
- Michael Ross - Job Foreman (uncredited)
- Marion Ross - Margaret
- Mariette Hartley - Vera Mannering
- Anthony Eisley - Jake Mannering
- Pat Buttram - Hermit
- Ray Ballard - Floor Cleaner (uncredited)
- Walter Brooke - James Barnes
- Brendon Boone - Wayne (uncredited)
- Anne Whitfield - Mrs. Lawson
- Anne Whitfield - Pam Parker
- Anne Whitfield - Patricia Epps
- Anne Whitfield - Betty Johnson
- Anne Whitfield - Chirley Gentry
- Philip Baker Hall - Dr. Scott
- Ted Gehring - Construction Foreman
- Ted Gehring - Peter Euben
- Ted Gehring - Barney McMillian
- J. Pat O'Malley - Grandpaw Ryerson
- J. Pat O'Malley - Old Bill
- J. Pat O'Malley - Joe Wilson
- Virginia Vincent - Martha Gilmore
- Vince Howard - Police Officer Vince (uncredited)
- Vince Howard - Police Officer Vince, LASD
- Vince Howard - 1st Deputy
- Vince Howard - Deputy
- Vince Howard - 2nd Officer
- Vince Howard - Police Officer (uncredited)
- Vince Howard - 1st Policeman
- Vince Howard - Deputy Jenkins
- Vince Howard - Policeman
- Vince Howard - Police Officer Vince
- Vince Howard - Police Officer Vince - LASD (uncredited)
- Susan Seaforth Hayes - Nancy Dickson
- Harlen Carraher - Jimmy
- Chuck Bowman - Reporter (uncredited)
- Craig Chudy - Police Officer (uncredited)
- Craig Chudy - Injured Firefighter
- Roger Perry - Russ Gentry
- Richard Jaeckel - Defense Attorney
- Gary Clarke - Mr. Peters
- Victor Izay - Judge
- Charlie Picerni - Worker (uncredited)
- Charlie Picerni - Junkyard Worker #1 (uncredited)
- John Travolta - Chuck Benson
- John Anderson - Captain Bob Roberts
- Del Monroe - Walt
- Del Monroe - Steve Carson
- Dub Taylor - Old Man
- Dub Taylor - George
- Bob Harks - Workman (uncredited)
- Bob Harks - TV Crew Member (uncredited)
- Bob Harks - Cafeteria Patron (uncredited)
- Philip Brown - Mickey Brydon
- Lynn Carlin - Mrs. Patterson
- Mark Russell - Doctor (uncredited)
- Mark Russell - Stuntman (uncredited)
- Lucille Benson - Annie
- Lucille Benson - Martha
- Jean Allison - Mrs. Brydon
- Jean Allison - Dorothy Clark
- Jean Allison - Grace
- Jean Allison - Mrs. Conroy
- Sharon Gless - Sculptor
- Sharon Gless - Sheila
- Dawn Lyn - Kathy Thelen
- Dawn Lyn - Jean Clark
- Milton Frome - Joe the Grocer (uncredited)
- Milton Frome - The Salesman
- Milton Frome - Jed Roland
- Claude Johnson - Paramedic (uncredited)
- Randy Boone - Bill Stagg
- Frank Bonner - Walt
- Hank Jones - Stan Wilson
- Bill Zuckert - Charley
- Bill Zuckert - Jason Bennett
- Kenneth Tobey - Capt. Gordon Trigg
- Kenneth Tobey - Doug Barton
- Kenneth Tobey - Crane Operator
- Florence Lake - Martha Wilson
- Florence Lake - Maggie
- Anthony Herrera - Paramedic Rocky Morrow
- George Wyner - Medic One Doctor
- Rosalind Chao - Kathy
- John de Lancie - Dr. DeRoy
- Eve Brent - Alice
- Liam Dunn - Amos
- Gene Raymond - J.P. Dumont
- Paul Brinegar - Husband (Tom)
- Paul Brinegar - Grady
- Paul Brinegar - Max
- Ruth Buzzi - Amy Merkle
- Thomas Bellin - Grant Elder
- Elizabeth Kerr - Mrs. Evans
- Pamela McMyler - Oona Crim
- Linda Kelsey - Pam Burke
- Dennis Burkley - Biker (uncredited)
- John Dennis Johnston - Biker (uncredited)
- Paul Sorensen - Mike
- Paul Bryar - Battalion 5
- Paul Bryar - Husband
- James McEachin - Lt. Crockett
- Denny Miller - Brock Caine
- Peter Kastner - Marty Thompson
- Jack Webb
Coleen Gray interpreta a Clair Brightweiser en la serie.
Kent McCord hace el papel de Officer Jim Reed.
Joan Shawlee interpreta a Wife en la serie.
Philip Baker Hall hace el papel de Dr. Scott.
Michael Lerner hace el papel de Martin Noble.
Nick Nolte hace el papel de Fred.
Jack Kruschen interpreta a State Assemblyman Michael Wolski en la serie.
Robert Fuller interpreta a Kelly Brackett en la serie.
Julie London interpreta a Dixie McCall en la serie.
Bobby Troup interpreta a Joe Early en la serie.
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