- Joshua J. Williams - Kel Reeve
- Jeremy Bobb - Detective Ronald McKinney
- Shahadi Wright Joseph - Ruby Emory
- Shahadi Wright Joseph - Ruby Lee Emory
- Jeremiah Birkett - Da Tap Dance Man
- Michael Harney - Otto Haber
- Dale Dickey - The Woman
- P.J. Byrne - Stuart Berks
- Malcolm M. Mays - Calvin
- Paula Jai Parker - Hazel Emory
- Anika Noni Rose - Ella Mae Johnson
- Cranston Johnson - Grafton
- Christopher Heyerdahl - The Black Hat Man
- Wayne Knight - Lieutenant Schiff
- Carlito Olivero - Detective Joaquin Diaz
- Iman Shumpert - Corey
- Shane Johnson - Investigator Phillips
- Charles Brice - Reggie Marks
- Tamika Shannon - Rhonda
- Eddie Park - Victor
- Ella McKenzie Gross - So-Young
- Sung Yun Cho - Kyong-Ah
- Stephen Louis Grush - James Stenson
- Chantal Maurice - Destiny
- Robert Curtis Brown - Dr. Gaines
- Elena Campbell-Martinez - Ernestina
- Oscar Daniel Reyez - Benny
- Liam McIntyre - Clarke Wendell
- Lindsey Kraft - Midge Pruitt
- Pat Healy - Marty Dixon
- Brooke Smith - Helen Koistra
- John Patrick Jordan - Earl Denton
- Dirk Rogers - Miss Vera
- Abbie Cobb - Nat Dixon
- Max Barsness - Dale Pruitt
- Kim Shaw - Carol Lynn Denton
- Bailey Noble - Marlene
- Mia Komsky - Dina
- Ally Dixon - Bus Stop Girl
- Peyton Nicole Morton - Nancy
- Ilana Becker - Greta
- Natalie Britton - Dottie
- Zakary Risinger - Tommy
- Jon Ryckman - Sears Delivery Man
- Derek Phillips - Sergeant Bull Wheatley
- Sophie Guest - Doris
- Tim Russ - The Custodian
- Ryan Kennedy - Gary
- Kyrie McAlpin - Young Ruby
- Leslie L. Miller - Black Patient (as Leslie Miller)
- Leslie L. Miller - Black Patient
- Tom Fitzpatrick - Shopkeeper
- Riley Baron - Officer Byrne
- Paul David Story - Officer Rollins
- Mary Garripoli - Mrs. Perkins
- Urian Ross - Disfigured Soldier
- Sheria Irving - Cynthia
- J. Mallory McCree - Junius Emory
- Devyn Placide - Eddie
- M.J. George - Delroy
- Joseph Winford Warren - Portly Clerk
- David Alen - Bus Driver
- Sonia Jackson - Elderly Black Woman
- Maurice J. Irvin - Roland Johnson
- Lisa Banes - Esther Haber
- Peter MacKenzie - Mr. Stoat
- Kari Perdue - Janet
- Flor de Maria Chahua - Consuela
- Spencer Watson - Barry
- Shaw Jones - City Planner
- Van Epperson - Banker
- Barry Livingston - Real Estate Commissioner
- David Bowe - Mitch
- Christopher Murray - Murray
- Burl Moseley - Emmett
- Justin Coach - Roland Johnson
- Ethan Coach - Charlie Johnson
- Bobbie Lee Jr. - Woody
- David Terrell - Shorty
- Scott Alan Smith - Fuller
- Latarsha Rose - Arnette Beaumont
- Samantha Sherman - Marjorie Wallinger
- Sarah Benoit - Stern Nurse
- Spencer Kramber - Orderly
- Rueben Grundy - Carter Beaumont
- Justin Claiborne - Carlisle Beaumont
- Kate McNeil - Dr. Frances Moynihan
- Nona Parker Johnson - Martha
- Melinda Page Hamilton - Elder Sara
- Gene Silvers - Elder Luther
- J. Paul Boehmer - Elder James
- Summer H. Howell - Elder Cora
- Sarah Minnich - Maud
- Megan Hensley - Fenna
- Chris Bylsma - Bram
- Brandon O'Dell - Rio
- Deion Smith - Malcolm
- William J. Simmons - Shawn
- Derrick LeMont - Officer Davies
- Taisha Perez - Officer Sheila
- Avery Bigelow - Courtney
- Susan Wood - Stella
- Cindi Davis - Bernice Mott
- Brian Ashton Smith - Officer Terrence
- Darin Cooper - Detective Marsh
- Steven Sean Garland - Detective Simms
- Linda Boston - Diane
- Sarah Grace Elliott - Natalie
- Ricky Wayne - M.E. Furrow
- Billy Choi - Dong-Hyun
- Jenne Kang - Chae-Won
- Cuyle Carvin - Buzz Cut
- Brandon Lee Browning - Male Casting Assistant
- Ryan King - ER Doctor
- Brooke Jaye Taylor - Wendy McKinney
- Rebecca Lines - Adelle
- Mitch Westphal - Cop
- Joe Pistone - Evidence Room Detective
- Dominic Bell - Young Donovan
- Leland L. Jones - Pastor
- Jessica Fontaine - Medical Liaison
- Philip Covin - Detective Stevens
- Drew Matthews - Officer Becker
- Muretta Moss - Reporter
- Kariem Marbury - William Reeve
- Miguel A. Gaetan - Grim Faced Cop
- Steven Prinz
- Roy Lee
- Miri Yoon
- Little Marvin
Deborah Ayorinde hace el papel de Detective Dawn Reeve.
Pam Grier interpreta a Athena en la serie.
Luke James interpreta a Edmund Gaines en la serie.
Joshua J. Williams hace el papel de Kel Reeve.
Jeremy Bobb hace el papel de Detective Ronald McKinney.
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