- William Ragsdale - Dan
- Anthony Clark - Will Davies
- Oprah Winfrey - Therapist
- Shawn Christian - Danny
- Angie Dickinson - Betsy
- Leslie Jordan - Top Studio Executive
- Jada Pinkett Smith - Ellen Screen Test #3
- Mary Steenburgen - Self (uncredited)
- Robert Gant - Dr. Garber
- Patrick Bristow - Peter Barnes
- Jerry Penacoli - Richard
- Bradley Whitford - Doug
- Patrick Cranshaw - Irving
- Eric Lutes - Greg
- Joey Slotnick - Mr. Selman
- Clyde Kusatsu - Judge Mitchell Sung
- Doris Belack - Cora
- Elya Baskin - Sergei
- Kathy Griffin - Peggy
- Barry Corbin - Jack Penney
- Gregory Sierra - General Colon
- Elinor Donahue - Delores Warwell
- Giovanni Ribisi - Cashier
- Lane Davies - Nate
- Tracy Tweed - Tara
- Don Lake - Bob
- Sully Díaz - Maria
- Peter Krause - Tim
- Christopher Darga - Officer
- Kurt Fuller - Dr. Collins
- Tommy Hinkley - Steve
- Harriet Sansom Harris - Claire
- Kaley Cuoco - Little Ellen
- Mary Page Keller - Sarah
- Jann Arden - Self (uncredited)
- Meshell Ndegeocello - Self (uncredited)
- Derek McGrath - Stanley Peck
- Brandon Maggart - Harry
- Laraine Newman - The Over-Supportive Parent (uncredited)
- Greg Germann - Rick
- Bruce Campbell - Ed Billik
- Bea Arthur - Bea Arthur
- Ted Danson - Self (uncredited)
- Brian Doyle-Murray - Burt Kovak
- Andrea Parker - Joanna
- Jane Carr - Glynnis
- Kate Hodge - Stephanie
- William Bumiller - Roger
- John Riggi - Manager
- Toni Tennille - Tennille (uncredited)
- Brittany Paige Bouck - Head Dolphin
- Florence Henderson - Madeline
- Peter Michael Goetz - Dr. Haddassi
- Helen Hunt - Ellen Screen Test #2
- Steven Houska - Waiter
- Connie Stevens - Paige's Mom
- Todd Waring - William
- Patty Toy - Engineer's Wife
- Cristine Rose - Susan
- Jill Talley - Infomercial Woman
- Sirena Irwin - Cherry-O
- Steven Flynn - Joe
- Kathleen Noone - Ferne Kovak
- Lisa Darr - Laurie Manning
- Dennis Burkley - Nestor Biggs
- Harland Williams - Ticket Taker
- Chuck Mavich - Roy
- Molly Shannon - Woman
- Connie Britton - Heather
- Nick Bakay - Lloyd
- Concetta Tomei - Professor Bass
- Bonnie Raitt - Bonnie Raitt
- Queen Latifah - Queen Latifah (uncredited)
- Brett Butler - Grace Kelly
- Drew Carey - Drew Carey
- Wayne Newton - Doctor
- Eileen Heckart - Grandma
- Vance DeGeneres - Guitarist at audition
- Vance DeGeneres - Erik Matthew Marshall
- Jean Speegle Howard - Bernadette
- Kat Cressida - Instructor #1
- Jennifer Grant - Erin
- Aaron Neville - Self (uncredited)
- Aaron Neville - Aaron Neville
- Christine Taylor - Karen Lewis
- Kate Williamson - Mrs. Rodgers
- Brian George - Ranjit Sudar
- Lise Simms - Lesly
- Alice Hirson - Lois Morgan
- Bob Glouberman - Sean
- Steven Gilborn - Harold Morgan
- Laura Dern - Susan
- Molly David - Sweet Old Woman
- Jaime Hubbard - Melissa
- Rachel Duncan - Little Girl
- Gregory White - Man
- Phil Leeds - Comedian
- Jim Doughan - Camera Assistant
- Orson Bean - Gameshow Contestant
- Glenn Close - Glenn Close
- Tim Conway - Comedian
- Cindy Crawford - Ellen Screen Test #1
- Christine Lahti - Ellen Screen Test #4
- Julianna Margulies - Ellen Screen Test #5
- Allan Murray - Announcer #1
- John O'Hurley - Announcer #2
- Tony Carreiro - Jackson
- Ann Talman - Beth
- Jeff Weatherford - Teddy
- Eliza Coyle - Karen (uncredited)
- Eve Gordon - Adam's Date (uncredited)
- Brian Leckner - Karl
- Daniel Edward Mora - Deliveryman (uncredited)
- Daniel Edward Mora - Water Delivery Man
- Patrick Warburton - Jack
- Patrick Warburton - Brent
- Wendle Josepher - Saleswoman
- Eve Brent - Lovely Old Woman (uncredited)
- Bryn Erin - Girl (uncredited)
- Judy Kain - Nurse
- Fiona Hale - Grandmother
- Dailyn Matthews - Pregnant Woman
- Sandra Kinder - Saleslady
- Colleen Wainwright - Woman
- Kim Kim - Korean Woman
- Matt Landers - Photographer
- Shaun Duke - Man in Line
- John Mueller - Brad
- Michael Chieffo - Bank V.P.
- Brenda Varda - Lawyer
- Jerry Sroka - Engineer
- Rosie Taravella - Clerk
- Gene Weygandt - Gallery Owner
- Patrick Mickler - Officer
- Jordan Bond - Student
- Scott Sites - Delivery Man
- Joanna Daniels - Tracy
- Jan Eddy - Big Ed
- Michael Shamus Wiles - Bartender
- Jim Cody Williams - Biker
- David Driver - Customer
- Steve Kehela - Jeff
- Barry Wiggins - Herbert
- Lisa Stahl - Delila
- Don Stark - Repairman
- Steven Marcus - Agitated Man
- Dorian Spencer - Young Man
- David Brisbin - Manager
- John Mulrooney - Fight Fan
- Amy Jo Weinstein - Woman
- Jo Steele - Woman
- Steve Albert - Fight Announcer (voice)
- Harley Venton - David 'Dave' Ellis DDS
- Blaire Baron - Waitress
- Christine Romeo - Woman
- Brian McGovern - Romantic Guy
- Alicia Anne - Pretty Girl
- Leonard Kelly-Young - Customer
- Kymberly Newberry - Dignified Woman
- Lisa Inouye - Clipboard Woman
- Darla Haun - Beautiful Woman
- Kenneth Kimmins - Phil
- Chad Einbinder - Bob
- Helen Siff - Sharon
- Paul Marin - Mr. Phillips
- Andrea Leithe - Marion
- Jim Jackman - Man
- Stephen James Carver - Detective
- Garret Davis - Detective
- Larry Poindexter - Don
- Milt Tarver - Passenger
- Matt Letscher - Steven Morgan
- Rebecca Staab - Cindy
- Scott LaRose - Jack
- Mark L. Taylor - Charles
- Ryan Holihan - Billy
- Nicki Vannice - Debbie
- Jill Baker - Mrs. Thompson
- J. Patrick McCormack - Reverend Engler
- Bill Calvert - Patrick
- Karen Maruyama - Kate
- Brian Cousins - Billy
- Patience Cleveland - Maisie
- Billye Ree Wallace - Polly
- Chris Douridas - Chad
- Harry Shearer - Ted Layton
- Nita Talbot - Mrs. Koger
- Marianne Muellerleile - Edna
- Damian London - Funeral Director
- Crystal Carson - Gwen
- Matt McKenzie - Officer
- Rick Scarry - Funeral Guest
- Andrew Shaifer - Party Guest
- David Sederholm - Patrick
- Jeffrey Alan Chandler - Cookie Man
- Zack Eginton - Bud
- Jonathan Emerson - Lucky Customer
- Laurel Green - Lorraine
- Lisa Harrison - Bambi
- Patricia Lentz - Joanne
- Mark McCracken - Richard
- Joyce Sylvester - Cookbook Woman
- Gregory Paul Martin - Roger
- Peter Kim - Korean Man
- Alex Trebek - Alex Trebek (voice)
- Ken Olandt - Alternate Juror
- Ralph P. Martin - Tony
- Marcia Mitzman Gaven - Debby
- Molly Cheek - Sylvia
- Felicity Waterman - Lauren
- Kimberly Russell - Tonya
- Patrick S. Harrigan - Customer
- Kevin Mangold - Bear
- Elaine Hendrix - Maya
- Spencer Rochfort - Jerry
- Scott Fowler - Sam
- Eric Allan Kramer - Detective Gil Ryan
- David DeLuise - Robber in Hat
- Jamie Marsh - Robber in Jacket
- Paxton Whitehead - Dr. Whitcomb
- Rick Charles - The Andrae Crouch Singers
- Kristle Murden - The Andrae Crouch Singers
- Kathy Hazzard - The Andrae Crouch Singers
- Linda McCrary - The Andrae Crouch Singers
- Danny Lee Clark - Nitro
- Lori Fetrick - Ice
- Jackie Roberts - Debbie
- Mike Adamle - Mike Adamle
- W. Earl Brown - Customer
- Jeffrey Lampert - Customer
- Connie Needham - Waitress
- Lee Reherman - Hawk
- Jeff Sanders - Contestant
- Tom Billett - American Gladiator
- Dann Florek - Mr. Woodruff
- Kathy Najimy - Theresa
- Kathy Najimy - Lorna Irons
- Brittany Ashton Holmes - Julie
- Christine Elise - Rosie
- Mike White - Instructor
- Dean Fortunato - Man
- Scotch Ellis Loring - Walter
- Ruth Manning - Customer
- Rick Fitts - Reporter
- Maurice Chasse - Neighbor
- Jim Haynie - Jake Hilfiger
- Hal Landon Jr. - Bus Driver
- Kevin Light - Contractor
- David Wells - Mousy Man
- Tommy Bertelsen - Kid
- Paddi Edwards - Smoking Woman
- Paul Bates - Kenny Burke
- K.T. Vogt - Junker Woman
- Shaun Toub - Foreign Man
- Jay Johnston - Transition Guy
- Jamie Kennedy - Tad
- Jimmy Galeota - Little Doctor
- Beverly Garland - Eva
- Bruce Thomas - Mike Lyons
- Mara Holguin - Katie
- Martha Stewart - Martha Stewart
- Don Yesso - The Robber
- Don Yesso - Fight Fan
- Jack Plotnick - Barrett
- Stephanie Erb - 'Alien' Denise
- Carrie Fisher - Carrie Fisher
- Michael Maynard - Colin
- Matthew Sullivan - Salesman
- Linda Ellerbee - Interviewer
- Linda Ellerbee - Linda Ellerbee
- Ron Palillo - Ron Palillo
- Dan Gauthier - Matt Liston
- Ron Canada - Detective Sutterman
- Eric Menyuk - Jim Hogan
- Wayne Wilderson - Ronnie Williams
- Nick Toth - Earl
- Raymond Forchion - Customer
- Raymond Forchion - Smitty
- Scott Mosenson - Josh Patterson
- Bari K. Willerford - Delivery Man
- Robert Briscoe Evans - Driver
- Ebick Pizzadili - Mia
- Don Amendolia - Mr. Koundakian
- Mary Tyler Moore - Mary Tyler Moore
- Paul Dooley - Thomas Kelsey
- Wesley Thompson - Kevin Brown
- Andy Houts - Brett Sellman
- Judith Scarpone - Sydelle
- Carol Kane - Lily Penney
- Lawrence Hilton-Jacobs - Lawrence Hilton-Jacobs
- Charlie Brill - Del Shapiro
- Mitzi McCall - Rochelle Shapiro
- Tera Hendrickson - Barb
- Cynthia Lamontagne - Lesly
- Bodhi Elfman - Surfer Dude
- Elizabeth Keener - Trendy Woman
- Nick Edenetti - Caberet Singer
- Dan Finnerty - Tom
- Dan Finnerty - Crew Member Dan
- Dan Finnerty - Doorman
- Ruth Carlsson - Xylophone Woman
- Janeane Garofalo - Chloe Korban
- Thea Vidale - Technician
- Mina Kolb - Nurse
- Michole Briana White - Alyssa
- Susan Powell - Salon Lady
- Nancy Serrano - Art Student
- Shae D'Lyn - Debbie Johnson
- Timothy Elwell - Security Guy
- Jonathan Stark - Gus
- Jeff Dunham - Starky
- Kimmy Robertson - Brandy
- Greg Collins - Agent Chamberlain
- Perry Anzilotti - Minister
- Brian McNamara - Jim
- Earl Boen - Hubert Warwell
- Dan Sachoff - Brian
- Mariska Hargitay - Dara
- Willie C. Carpenter - Officer Wilson
- Dave Florek - Officer
- Edward Blanchard - Mugger
- Rob Moore - Witness
- Nancy Lenehan - Margaret
- Curtis Armstrong - Tom
- Larry Hankin - Larry
- Michael Des Barres - Nigel the Director
- Michael Des Barres - The Patient
- Gregory McKinney - Officer
- Sarah Dampf - Willa
- Dena Burton - Thirsty Customer
- Chris D'Arienzo - Customer
- Pat Crawford Brown - Rose
- John Petlock - Uncle Jim
- John David Conti - Tom
- Chris Hogan - Stevie (voice)
- Paul Crowder - Trendy Man
- Paul Crowder - Drummer at audition
- Eddie Fisher - Eddie Fisher
- Richard Roat - Mortgage Broker
- Juanita Jennings - Therapist
- Anne Rice - Anne Rice
- Roger Eschbacher - Derek
- Roger Eschbacher - Cop
- Carol Barbee - Megan
- Ashley Peldon - Little Paige
- Romy Rosemont - The Woman
- Fred Ornstein - Camp Director
- Harvey Korman - Therapist
- Anne DeSalvo - Waitress
- Lyle Waggoner - Vic
- Debra Mooney - Barbara
- Lori Heuring - The Cowgirl
- Gene Park - Man
- Gene Park - Salesman
- Gene Park - Waiter
- Julie Janney - The Receptionist
- Dana Gould - Mike
- Marilyn Kagan - Therapist
- Jim Ward - Emcee
- Joe Flaherty - Perry
- Danny Breen - Homeless Guy
- Jeff Feringa - Edna
- Trisha Yearwood - Trisha Yearwood
- John Del Regno - Walter Denbo
- John Cervenka - Art
- Juliana Schiavo - Lesbian's Daughter
- Juliana Schiavo - Latte Customer
- Esther Scott - Ruby
- Jonathan Fuller - The Instructor
- Michael McDonald - The Guy
- Philippe Bergeron - Maitre d'
- David Fenner - Waiter
- Rick Hall - Contractor
- Marie-Alise Recasner - Kim
- Mindy Sterling - June Haddassi
- Tim Bagley - The Wine Maker
- Gary Schwartz - Gary
- Bridget Sienna - The Nurse
- Michael Hagiwara - The Doctor
- Tricia Leigh Fisher - Megan
- Tricia Leigh Fisher - Joanie
- David Crosby - David Crosby
- Andy Kindler - Hesh Finkleman
- Anthony Natale - Brian
- Deanne Bray - Juliet
- J. Karen Thomas - The Operator
- Mitch Gibney - Customer
- Iqbal Theba - Dalai Rajhavaari
- Judy Nazemetz - Alice
- Read Scot - Caesar
- Clive Rosengren - Mitch
- Paulette Braxton - The Nurse
- Everett Greenbaum - The Older Man
- Steven Eckholdt - Richard
- k.d. lang - Janine
- James Hong - The Waiter
- Catherine Paolone - The Mother
- Chaz Bono - The Moderator
- Liza D'Agostino - Joanne
- Gina Mari - Carley
- Suzanne Lanza - Waitress
- Dedee Pfeiffer - Lisa
- Andrea Bendewald - Sherry
- Loretta Fox - Dena
- Shannon Frank - Cafe Waitress
- John Capodice - Tony
- Georgia Ragsdale - Woman
- Constance Zimmer - Riot Girl
- Martin Charles Warner - Old Man
- Louis Gossett Jr. - Sgt. Timko
- Paul Feig - Peterson
- Jim O'Heir - Kelsy
- Hap Lawrence - Herbison
- Charles Rahi Chun - Joey Chen
- John Cirigliano - Lincoln
- Kayla Murphy - Holly Manning
- Emma Thompson - Emma Thompson
- Army Archerd - Army Archerd
- Helen FitzGerald - Alice
- Seth Jaffe - Manager
- Kevin McDonald - Chuck
- Susan Norfleet - Julie
- Del Hunter-White - Woman
- Sarah McLachlan - Sarah McLachlan
- Amy Ray - Amy Ray / Indigo Girl
- Emily Saliers - Emily Saliers / Indigo Girl
- Rena Sofer - Jean
- Rachel Rosenthal - Tarot Woman
- Tyler Layton - Leah
- Justin Jon Ross - Lie Detector Kid
- Tim DeKay - John
- Candy Ann Brown - Sue
- Larry Cedar - Desk Clerk
- Kenneth Zavayna - Bell Captain
- Bobby Edner - The 'Can I Touch your Boobs' Kid
- Cyd Strittmatter - Kid's mother
- Linda Kash - Sue
- Marcia Wright - Emily
- David Youse - Clipboard Guy
- Raymond Hanis - Wesson
- Brett Miller - Smith
- Priscilla Inga Taylor - Melanie
- Marcelo Tubert - Mr. Patel
- Jennifer Balgobin - Mrs. Patel
- Harvey Fierstein - Harvey Fierstein
- Neil Flynn - George
- Lee Everett - Cindy
- Bunny Summers - Mom
- Jo Farkas - Mom
- Charles C. Stevenson Jr. - Dad
- Anne Heche - Karen
- Andrew Hill Newman - Male Nurse
- Cynthia Martells - Doctor
- Cindy Ambuehl - Candy
- Jazz Raycole - Angela
- Steven Anderson - Bookish Man
- Diahann Carroll - Diahann Carroll
- Kelly Ryan - Radio Call-In Girl
- Trent Walker - Man
- Judge Reinhold - Trevor
- Ed Begley Jr. - Ed Begley Jr.
- Krissy Carlson - Girl
- Jane Brucker - Mimi Samuel
- James Krag - Peace Corps Guy
- Shawn Pyfrom - Boy Scout
- Amzie Strickland - Old Woman
- Diana Theodore - Young Woman
- Jack Kehler - Manager
- Kiva Dawson - Cinnamon
- Jon Simmons - Minister
- Lawrence Broch
- David Flebotte
- Dava Savel
Glenn Close interpreta a Glenn Close en la serie.
Harriet Sansom Harris interpreta a Claire en la serie.
Elya Baskin interpreta a Sergei en la serie.
Kathy Griffin interpreta a Peggy en la serie.
Orson Bean hace el papel de Gameshow Contestant.
Phil Leeds hace el papel de Comedian.
Mary Steenburgen interpreta a Self (uncredited) en la serie.
Laura Dern hace el papel de Susan.
Elinor Donahue interpreta a Delores Warwell en la serie.
Clyde Kusatsu interpreta a Judge Mitchell Sung en la serie.
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