- Reggie Watts - REJGIE (voice)
- Flula Borg - Joe Troplong (voice)
- Margaret Cho - Mulan (voice)
- Paul Rugg - Napoleon (voice)
- Josh Keaton - Wilbur Wright ?(voice)
- Eric Bauza - Galileo ?(voice)
- Eric Bauza - Additional Voices
- Richard Epcar - ?(voice)
- Melanie Minichino - Queen Isabella ?(voice)
- Dee Bradley Baker - Mozart (voice)
- Dee Bradley Baker - ?(voice)
- Farris Patton - Lady Godiva ?(voice)
- Joshua Rush - Wheels (voice)
- Joshua Rush - ?(voice)
- Jane Lynch - Bernadette Steel ?(voice)
- Missi Pyle - Catherine the Great ?(voice)
- John DiMaggio - George Stephenson ?(voice)
- Eliza Schneider - ?(voice)
- Grace Kaufman - ?(voice)
- Sunil Malhotra - Sweet Tune Swami ?(voice)
- Brian Baumgartner - King Hotu Matu'a ?(voice)
- Nolan North - Jesse James ?(voice)
- Nolan North - Marco Polo (voice)
- Nolan North - John Sutter ?(voice)
- Nolan North - Alexander Cartwright ?(voice)
- Daniel Henney - Akashi Shiganosuke ?(voice)
- Carlos Alazraqui - Ponce de Leon ?(voice)
- Jeff Bennett - Mark Twain ?(voice)
- Jeff Bennett - Harry Houdini ?(voice)
- Jeff Bennett - John Harrington ?(voice)
- Michael-Leon Wooley - George Crum ?(voice)
- Michael-Leon Wooley - ?(voice)
- Michael-Leon Wooley - Ziryab ?(voice)
- Bob Dorough - ?James Madison (voice)
- Grey DeLisle - Cleopatra ?(voice)
- Grey DeLisle - Mary Anning ?(voice)
- Grey DeLisle - Eunice Butters ?(voice)
- Jared Harris - Bigfoot ?(voice)
- Tom Kenny - ?(voice)
- Tom Kenny - Blackbeard ?(voice)
- Tom Kenny - Nicholas-Joseph Cugnot ?(voice)
- Jeff Ross - Aristophanes ?(voice)
- Gary Busey - Alternate Universe Peabody ?(voice)
- Dave B. Mitchell - Frédéric Bartholdi ?(voice)
- Haley Tju - ?(voice)
- Fred Tatasciore - Genghis Khan ?(voice)
- Fred Tatasciore - Winston Churchill ?(voice)
- Fred Tatasciore - Robert Edwin Perry ?(voice)
- Fred Tatasciore - Zeus ?(voice)
- Fred Tatasciore - Leif Erikson ?(voice)
- Fred Tatasciore - David Bushnell ?(voice)
- Fred Tatasciore - Charles Dickens ?(voice)
- Kari Wahlgren - Ada Lovelace ?(voice)
- Kari Wahlgren - Lucy Walker ?(voice)
- Kari Wahlgren - Queen Hatshepsut ?(voice)
- Kari Wahlgren - Annie Oakley ?(voice)
- Andrew Kishino - Koikawa Harumachi ?(voice)
- Daran Norris - Allan Pinkerton ?(voice)
- Danny Jacobs - Enrico Caruso ?(voice)
- Kate Higgins - Belle Starr ?(voice)
- Gary Anthony Williams - Additional Voices
- Kevin Michael Richardson - Mansa Musa ?(voice)
- Kevin Michael Richardson - Gaius Maecenas ?(voice)
- Stephen Fry - Uncle Duke ?(voice)
- David Koechner - ?(voice)
- Phil LaMarr - ?(voice)
- Marsai Martin - ?(voice)
- Keone Young - ?(voice)
- Fred Stoller - Peter Cooper ?(voice)
- Steve Blum - Edgar Allan Poe ?(voice)
- Eddie Pepitone - ?(voice)
- Amy Hill - ?(voice)
- Tress MacNeille - Sacagawea ?(voice)
- Ania O'Hare
Gary Busey interpreta a Alternate Universe Peabody ?(voice) en la serie.
Missi Pyle interpreta a Catherine the Great ?(voice) en la serie.
Chris Parnell interpreta a Mr. Peabody (voice) en la serie.
Max Charles hace el papel de Sherman (voice).
Dieter Jansen interpreta a Mr. Hobson (voice) en la serie.
Da'Vine Joy Randolph interpreta a Christine (voice) en la serie.
David P. Smith interpreta a Mrs. Hughes / Orchoptitron (voice) en la serie.
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