- William Shatner - Eric Tegman
- Paul Richards - Devery Shay
- Robert Vaughn - A. Dunster Lowell
- Eli Wallach - Manny Jacobs
- Yvonne Craig - 'Mary'
- Gloria Vanderbilt - Connie Carmichael
- Michael Fox - Attorney
- Lloyd Nolan - Vernon Clay
- Angie Dickinson - Judy Maxwell
- Paul Newlan - Driver
- Suzanne Pleshette - Marta Rinaldi
- Russ Brown - Isaiah
- Patricia Breslin - Susan Baird
- Ed Kemmer - Peter Brett
- John Payne - James J. Fitts
- Joey Bishop - Walter
- Jim Backus - Monte
- Rosemary Clooney - Melissa
- Gregory Peck - Self - Guest Host
- Nina Foch - Ginny Thatcher
- Hazel Court - Pamela Carter
- Susan Kohner - Miriam Marks
- Mabel Albertson - Dr. Whitehall
- Ricardo Montalban - Stephen Baird
- Anthony Franciosa - Charlie Harris
- Ronald Reagan - Rex Kent
- Jackie Coogan - Shopkeeper
- Larry Blyden - Lou Marks
- Lee Marvin - Finn
- Kim Hunter - Ruth Jacobs
- Claude Akins - Police Lieutenant
- Edgar Bergen - Eugene Swanson
- Barbara Stanwyck - Irene Phillips
- Theodore Bikel - Captain Bellini
- Theodore Bikel - Nicholas Simonakis
- Inger Stevens - Anna Beza
- Michael Rennie - Inspector Marshall
- Michael Rennie - General Conrad Munday
- William Challee - Dr. Clement Connell
- Milt Kogan - Jerry Sindell
- Hank Weaver - Casey
- Peter Falk - Aristede Fresco
- Peter Falk - Martin
- Peter Falk - Dr. Alan Keegan
- Ricky Cooper - Young Cocky Cowboy
- Carolyn Jones - Julie Greer
- Carolyn Jones - Hannah Cole
- Alejandro Rey - Perez
- Alejandro Rey - Ysidro Astouga
- Tony Barr - Nick Orsini
- John Damler - Fletcher
- John Larch - Sam Baker
- Joseph Mell - Luky
- Mickey Rooney - Mike Zampini
- Mickey Rooney - Augie Miller
- Mickey Rooney - Putt-Putt Higgins
- Sam Edwards - Broken Leg
- David Niven - Self / Host
- Carol Lynley - Elise
- Fred Beir - Don
- Fred Essler - Mr. Potovsky
- Marjorie Bennett - Landlady
- Jackie Cooper - Judd Rogers
- Jackie Cooper - John Reardon
- Jackie Cooper - Self - Host
- Alan Carney - Harry
- Hazel Shermet - Gert
- June Allyson - Self - Host
- June Allyson - Jeri Brenr
- June Allyson - Rosalind Cramer
- June Allyson - Julie Stevens
- Jean Hale - First Girl
- Marlene Willis - Second Girl
- Buddy Lewis - Truck Driver
- Harry Wilson - Wino
- Will J. White - 1st Officer
- Paul Sorensen - 2nd Officer
- Bee Tompkins - Young Couple Girl
- Mike Farrell - Young Couple Boy
- Matty Jordan - Chef
- Glenn Ford - Self - Guest Host
- Robert F. Hoy - Officer
- Berkeley Harris - Bleaker
- Dana Andrews - Paul Oakland
- Dana Andrews - Nat Keough
- Vera Miles - Stella Calman
- Rip Torn - Joel Coles
- Barry Sullivan - Miles Calman
- Steve McQueen - Self - Host (uncredited)
- Steve McQueen - Self - Guest Host
- David Janssen - Kenneth 'Ken' Morgan
- Tuesday Weld - Leslie Clark
- Tuesday Weld - Stacy Palmer
- Jana Lund - Cashier
- Dick Powell
Ricardo Montalban interpreta a Stephen Baird en la serie.
Joey Bishop interpreta a Walter en la serie.
Peter Falk hace el papel de Dr. Alan Keegan.
Glenn Ford interpreta a Self - Guest Host en la serie.
Russ Brown interpreta a Isaiah en la serie.
Dick Powell interpreta a Self - Host en la serie.
Mickey Rooney interpreta a Putt-Putt Higgins en la serie.
Tuesday Weld hace el papel de Leslie Clark.
Eli Wallach interpreta a Manny Jacobs en la serie.
Angie Dickinson interpreta a Judy Maxwell en la serie.
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