- Gary Busey - Mad Dog (voice)
- John Ashton - Instructor (voice)
- Allison Janney - Laura (voice)
- Elizabeth Perkins - Ruth Brown / Sherilyn (voice)
- Stephen Tobolowsky - Dr. Benson / Burt Halverstrom (voice)
- Brad Pitt - Patch Boomhauer (voice)
- Johnny Hardwick - Dale Gribble (voice)
- Sally Field - Junie Harper (voice)
- Christopher Lloyd - Smitty (voice)
- Milla Jovovich - Serena Shaw (voice)
- Kathleen Turner - Miss Liz Strickland (voice)
- William H. Macy - Dr. Rubin (voice)
- Tony Denman - Sterno / Benji (voice) (uncredited)
- Gailard Sartain - Case Manager (voice)
- Chris Rock - Roger 'Booda' Sack (voice)
- Johnny Depp - Yogi Victor (voice)
- Laura Linney - Marlene (voice)
- Carl Reiner - Gary Kasner (voice)
- Bernie Mac - Mack (voice)
- Elijah Wood - Jason (voice)
- Billy Bob Thornton - Boyce Hubert (voice)
- Reese Witherspoon - Debbie (voice)
- Owen Wilson - Rhett Van Der Graaf (voice)
- Castulo Guerra - (voice)
- Jennifer Aniston - Pepperoni Sue / Stephanie (voice)
- Lucy Liu - Tid Pao (voice)
- David Carradine - Junichiro (voice)
- Buddy Ebsen - Chet Elderson (voice)
- Kyle Chandler - Tucker Mardell (voice) (uncredited)
- Laura Dern - Serving Wench (voice)
- Jeff Goldblum - Dr. Vayzosa (voice)
- Michael Keaton - Trip Larsen (voice)
- Larry Miller - Doctor Tabor (voice)
- Robert Stack - Reynolds Penland (voice) (uncredited)
- Ajay Naidu - Delivery Guy / Malik (voice)
- John Goodman - Tommy (voice)
- David Cross - Ward Rackley (voice)
- Alan Rickman - King Philip (voice)
- Dennis Hopper - Dennis Hopper (voice)
- Anna Faris - Stoned Hippie Chick / Teen Girl Hippie (voice)
- Chris Elliott - Ed Burnett (voice)
- Brian Doyle-Murray - Jack (voice)
- Lauren Tom - Minh Souphanousinphone (voice)
- Ashley Gardner - Nancy Hicks Gribble (voice)
- Anthony Chun
- Martin Archer Jr.
- Martin Archer
- Adam Kuhlman
- Tony Kluck
- Cyndi Tang
- Greg Cohen
- John Altschuler
- Dave Krinsky
- David Zuckerman
- Dave Schiff
- Erin Ehrlich
Gary Busey interpreta a Mad Dog (voice) en la serie.
John Ashton interpreta a Instructor (voice) en la serie.
Allison Janney hace el papel de Laura (voice).
Elizabeth Perkins hace el papel de Ruth Brown / Sherilyn (voice).
Stephen Tobolowsky interpreta a Dr. Benson / Burt Halverstrom (voice) en la serie.
Brad Pitt hace el papel de Patch Boomhauer (voice).
Johnny Hardwick hace el papel de Dale Gribble (voice).
Sally Field interpreta a Junie Harper (voice) en la serie.
Christopher Lloyd interpreta a Smitty (voice) en la serie.
Milla Jovovich interpreta a Serena Shaw (voice) en la serie.
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