- Lauren Tom - Minh Souphanousinphone (voice)
- Ashley Gardner - Nancy Hicks Gribble (voice)
- Gailard Sartain - Case Manager (voice)
- Laurie Metcalf - Cissy Cobb (voice)
- Sally Field - Junie Harper (voice)
- Tammy Wynette - Tilly Hill (voice)
- Ani DiFranco - Emily (voice)
- Lynne Thigpen - Judge (voice)
- Kathy Ireland - Sylvia (voice)
- Matthew McConaughey - Rad Thibodeaux (voice)
- Mary Tyler Moore - Reverend Karen Stroup (voice)
- Emily Erwin - Rose (voice)
- Drew Carey - Hal (voice)
- Heather Locklear - Peggy Donovan (voice)
- Maura Tierney - Tanya (voice)
- Teri Garr - Laney (voice)
- Tony Danza - Self (voice)
- Carlos Alazraqui - Mexican Police Officer / Mr. Ortiz (voice)
- Eliza Schneider - Charisse (voice)
- Caitlyn Jenner - (voice)
- Alan Rickman - King Philip (voice)
- Jack Carter - Irwin Linker (voice)
- Cynthia Stevenson - Sister Mary Catherine / Claire (voice)
- Kid Rock - Kid Rock (voice)
- Jennifer Aniston - Pepperoni Sue / Stephanie (voice)
- Martin Starr - Andrew / Tommy (voice)
- David Cross - Ward Rackley (voice)
- Gene Simmons - Jessie (voice)
- Deana Carter - Sally (voice)
- Pat Fraley - Customer (voice)
- Elijah Wood - Jason (voice)
- Marg Helgenberger - Mrs. Hanover / Pretty Student (voice)
- Gary Cole - Vance Gilbert (voice)
- Ricki Lake - Lila (voice)
- John Goodman - Tommy (voice)
- Will Arnett - Portis (voice)
- Rue McClanahan - Bunny (voice)
- Andy Richter - Wesley Cherish (voice)
- Paget Brewster - Myrna (voice)
- Kate Walsh - Katt Savage (voice)
- Janet Waldo - Mrs. Tobbis (voice)
- Julie Hagerty - Ally (voice)
- Lisa Kudrow - Amy Pittman (voice)
- Phyllis Diller - Lillian (voice)
- Ajay Naidu - Delivery Guy / Malik (voice)
- Sarah Michelle Gellar - Marie (voice)
- Ryan Phillippe - Wally (voice)
- Brian Doyle-Murray - Jack (voice)
- Jennifer Coolidge - Miss Kremzer (voice)
- Tom Poston - Mr. Popper (voice)
- Ellen Barkin - Lenore (voice)
- Natasha Melnick - (voice)
- Gary Busey - Mad Dog (voice)
- Snoop Dogg - Alabaster Jones (voice)
- Nathan Fillion - Frisbee Guy (voice)
- Janeane Garofalo - Sheila (voice)
- Topher Grace - Chris (voice)
- Freeda Foreman - Self (voice)
- Tone Loc - Bouncer (voice)
- Marion Ross - Ms. Wakefield (voice)
- Big Boi - Reverend Nealey (voice)
- Dawnn Lewis - Sharona Johnson (voice)
- Jennifer Jason Leigh - Amy (voice)
- Paul Rodríguez - Jacinto (voice)
- Orlando Jones - Kidd Mookie (voice)
- Carol Alt - Marci (voice)
- Iqbal Theba - Dr. Bhudamanjur (voice)
- Gabrielle Carteris - Julie / Rita Bevacqua (voice)
- J. Evan Bonifant - (voice)
- Reese Witherspoon - Debbie (voice)
- Andy Dick - Griffin (voice)
- Sydney Pollack - Grant Trimble (voice)
- Lisa Hartman - Self (voice)
- James Brown - Digby Wilkins (voice)
- Lupe Ontiveros - Anne (voice)
- Ed Asner - Stinky (voice)
- Megan Mullally - Teresa (voice)
- Dan Butler - Attorney (voice)
- Dan Butler - Daniel (voice)
- Milla Jovovich - Serena Shaw (voice)
- Scott Hamilton - Scott Hamilton (voice)
- John Ritter - Eugene Grandy (voice)
- Travis Tritt - Walt (voice)
- Dena Dietrich - Marge (voice)
- Dena Dietrich - Tilly's Friend (voice)
- Johnny Depp - Yogi Victor (voice)
- Christopher Lloyd - Smitty (voice)
- Earl Houston Bullock - Dave (voice)
- Earl Houston Bullock - Heck Dorland (voice)
- Jane Wiedlin - Kate (voice)
- Jane Wiedlin - (voice)
- Shannon Elizabeth - Candee (voice)
- Billy Gibbons - Billy Gibbons (voice)
- Randy Poffo - Gorilla (voice)
- Clint Black - Chad (voice)
- Clint Black - Self (voice)
- Stephen Tobolowsky - Dr. Benson / Burt Halverstrom (voice)
- Soon-Tek Oh - Monk (voice)
- Buddy Ebsen - Chet Elderson (voice)
- Stephanie Hodge - Wendy (voice)
- Mary Scheer - Gracie (voice)
- Mary Scheer - Ms. Bittner / Bank Teller (voice)
- Stephnie Weir - Nureen (voice)
- Natalie Maines - Violetta (voice)
- K Callan - Tilly Hill (voice)
- Michael McShane - Mountain Man (voice)
- Ann Richards - Ann Richards (voice)
- Harry Groener - Dr. Tate / Larry (voice)
- Michael Clarke Duncan - Coach Webb (voice)
- Paul Teutul, Jr. - Paul Teutul, Jr. (voice)
- George Foreman - Self (voice)
- Jason Bateman - Dr. Leslie (voice)
- Erik Estrada - Mexican Judge (voice)
- Martie Maguire - Lily (voice)
- Vicki Lewis - Kate (voice)
- Martina McBride - Self (voice)
- Brad Paisley - Chip (voice)
- Larry Miller - Doctor Tabor (voice)
- Jack De Sena - Kevin (voice)
- Jason Konopisos-Alvarez - Commissioner #2 (voice)
- Barry Corbin - Fire Chief (voice)
- Karen Maruyama - Buddhist (voice)
- Allison Janney - Laura (voice)
- Tom McGowan - Dr. Newman / Dave (voice)
- Tom Petty - Lucky (voice)
- Tom Petty - Lucky (voice) (uncredited)
- Tom Petty - Lucky / Mud Dobber (voice)
- Tom Arnold - Norm Glidewell (voice)
- Bruce Dern - Randy Strickland (voice)
- Owen Wilson - Rhett Van Der Graaf (voice)
- Don Meredith - Self (voice)
- Kathleen Turner - Miss Liz Strickland (voice)
- Norm Hiscock - (voice)
- Renée Zellweger - Tammy Duvall (voice)
- Brad Pitt - Patch Boomhauer (voice)
- George Strait - Cornell (voice)
- Madeline Zima - (voice)
- Madeline Zima - Susan Clemmons (voice)
- Phil Buckman - Chad (voice)
- Danny Masterson - Cory (voice)
- Gwen Stefani - Gwen Stefani (voice)
- Carmen Electra - Angela (voice)
- Romy Rosemont - Margo (voice)
- Paul F. Tompkins - Professor Twilley (voice)
- Meryl Streep - Aunt Esme Dauterive (voice)
- Howie Long - Terrell Cartwright (voice)
- Jeff Garlin - Dan (voice)
- Dave Buzzotta - Waiter / Frat Guy (voice)
- John Schneider - The Ace (voice)
- Terry Bradshaw - Preston Rogers (voice)
- Pamela Anderson - Cyndi (voice)
- Neil Flynn - Turpin (voice)
- Brendan Fraser - David Kalaiki-Alii (voice)
- Brendan Fraser - Irv Bennett / Jimmy Beardon (voice)
- Debra Messing - Mrs. Hilgren-Bronson (voice)
- Eliza Dushku - Jordan Hilgren-Bronson (voice)
- Randy Travis - Self (voice)
- Wynonna Judd - Self (voice)
- Kix Brooks - Self (voice)
- Angela Kinsey - Angela (voice)
- Angela Kinsey - Angela (voice) (uncredited)
- Kyle Chandler - Tucker Mardell (voice) (uncredited)
- Kathryn Harrold - (voice)
- Kathryn Harrold - Mother Superior / Mrs. Bonter (voice)
- Lindsay Lohan - Jenny Medina (voice)
- Yakov Smirnoff - Yakov Smirnoff (voice)
- Wallace Shawn - Philip Ny (voice)
- Carl Reiner - Garry Kasner (voice)
- Carl Reiner - Gary Kasner (voice)
- Adrian Young - Adrian Young (voice)
- Ted Danson - Tom Hammond (voice)
- Billy West - Cigarenders Leader (voice) (uncredited)
- Billy West - Clerk (voice)
- Billy West - Sergeant Barber (voice)
- Billy West - Mr. Holloway (voice)
- Billy West - Golfer (voice)
- Vince Gill - Boomhauer's Singing Voice (voice)
- Vince Gill - Assistant Pastor Larry (voice)
- Amy Hill - Michiko (voice)
- Amy Hill - Mrs. Kalaiki-Alii (voice)
- Amy Hill - Mrs. Laoma Souphanousinphone (voice)
- Elizabeth Perkins - Mrs. Ashmore (voice)
- Elizabeth Perkins - Ruth Brown / Sherilyn (voice)
- Elizabeth Perkins - Jan Shaw (voice)
- Henry Gibson - Bob Jenkins (voice)
- Henry Gibson - Bob Jenkins / Travis (voice)
- Lane Smith - Charlie Fortner (voice)
- Lane Smith - Nate Hashaway (voice)
- Diedrich Bader - Dirk (voice)
- Diedrich Bader - Doctor (voice)
- Diedrich Bader - Ray Roy (voice)
- Trace Adkins - Elvin Mackleston (voice)
- Trace Adkins - Big John (voice)
- Monica Keena - Rain / Maria (voice)
- Monica Keena - Becky / Bartender (voice)
- Mac Davis - Sports Jock / Announcer (voice)
- Mac Davis - Jock (voice)
- Mac Davis - Sheriff Buford (voice)
- Anna Faris - Stoned Hippie Chick / Teen Girl Hippie (voice)
- Anna Faris - Lisa (voice)
- Joanna Gleason - Maddy Platter (voice)
- Joanna Gleason - Marie's Mother (voice)
- Joanna Gleason - Operator (voice)
- Joanna Gleason - Nurse (voice)
- Joanna Gleason - Receptionist (voice)
- Mo Collins - Ella / Melinda (voice)
- Mo Collins - Ms. Clark (voice)
- Mo Collins - Receptionist / Woman with Dog (voice)
- Mo Collins - Carly / Felicia (voice)
- Dave Thomas - Lane Pratley (voice)
- Dave Thomas - (voice)
- Dave Thomas - Lane Prately (voice) (uncredited)
- Dave Thomas - Wayne (voice)
- Dave Thomas - Jimsey (voice)
- Dave Thomas - Toothless Loser (voice)
- Dave Thomas - Gretta / Lane Pratley (voice)
- Dave Thomas - Steve Goodman / T. Anderson Kearney (voice)
- Dave Thomas - Ambrose (voice)
- Dave Thomas - Lane Pratley / Mr. Burton (voice)
- Laura Dern - Katherine (voice)
- Laura Dern - Serving Wench (voice)
- Betty White - Dorothy / Ellen (voice)
- Betty White - Delia (voice)
- Maurice LaMarche - (voice)
- Maurice LaMarche - Fire Chief / Reverend Thomason (voice)
- Maurice LaMarche - Professor John Lerner (voice)
- Maurice LaMarche - Funeral Speaker (voice)
- Maurice LaMarche - Radio Announcer (voice)
- Maurice LaMarche - Reverend Thomason (voice)
- Maurice LaMarche - Gary (voice)
- Phil LaMarr - (voice)
- Phil LaMarr - Roger 'Booda' Sack (voice)
- Phil LaMarr - Roger 'Booda' Sack / Waiter (voice)
- Phil LaMarr - Judge (voice)
- Phil LaMarr - Emergency Worker (voice)
- Phil LaMarr - Referee (voice)
- Phil LaMarr - Hart / Early / Pa (voice)
- Phil LaMarr - Texas Ranger Payton (voice)
- Phil LaMarr - Earl / Bennett (voice)
- Phil LaMarr - Ramsey (voice)
- Phil LaMarr - Vietnam War Veteran (voice)
- Phil LaMarr - Torch Carrier #2 (voice)
- Phil LaMarr - Travis (voice)
- Beth Grant - Nurse (voice)
- Beth Grant - Tilly Hill (voice)
- Beth Grant - (voice)
- Beth Grant - Nurse (voice) (uncredited)
- Beth Grant - Doris (voice)
- Beth Grant - Blanche (voice)
- Amy Adams - (voice)
- Amy Adams - Misty (voice)
- Amy Adams - Dawn's little Musician (voice)
- Amy Adams - Merilynn / Sunshine (voice)
- Chris Elliott - Chris Sizemore (voice)
- Chris Elliott - Ed Burnett (voice)
- Chris Elliott - Rob Holguin (voice)
- Danny Trejo - Enrique (voice)
- Danny Trejo - Octavio (voice) (uncredited)
- Danny Trejo - Victor Velasquez (voice)
- Danny Trejo - Enrique / Octavio (voice)
- Danny Trejo - Lifeguard / Waiter (voice)
- Danny Trejo - (voice)
- Tony Denman - Sterno / Benji (voice) (uncredited)
- Tony Denman - (voice)
- Tony Denman - Jeremy (voice)
- Tara Strong - Eric (voice)
- Tara Strong - James (voice)
- Tara Strong - Billy (voice)
- Tara Strong - Kimmi (voice)
- Tara Strong - Debby (voice)
- Tara Strong - Jane #1 (voice)
- Castulo Guerra - (voice)
- Castulo Guerra - Old Man (voice) (uncredited)
- Castulo Guerra - Magistrate (voice)
- Mitchel Musso - Curt (voice)
- Mitchel Musso - Surf Kid (voice) (uncredited)
- Justin Long - Cashier / Troy (voice)
- Justin Long - Adam / Kid #1 (voice)
- Justin Long - Student Teacher (voice)
- Danica McKellar - Misty (voice)
- Danica McKellar - Sharona (voice)
- Jamie Kennedy - Fudgie / Police Chief (voice)
- Jamie Kennedy - Dr. Tim Rast (voice)
- Charlie Daniels - Charlie Daniels (voice)
- Charlie Daniels - Self (voice)
- David Herman - (voice)
- David Herman - Jimmy Witchard (voice)
- David Herman - Eustis Miller (voice)
- David Herman - (voice) (uncredited)
- David Herman - Les (voice)
- David Herman - Gayle (voice)
- David Herman - Gilbert Dauterive (voice)
- David Herman - Buckley / Eustis Miller (voice)
- David Herman - Gladstone (voice)
- David Herman - Bruce Tuttle / Davy Crockett / Gerald Charping (voice)
- David Herman - Ticket Taker (voice)
- David Herman - Pastor K (voice)
- David Herman - Brock (voice)
- David Herman - Terrence Pope (voice)
- David Herman - Brubaker / Weaver #1 (voice)
- David Herman - Lumpy (voice)
- David Herman - Father (voice)
- David Herman - The Astounding Herrerra (voice)
- David Herman - Anthony Page (voice)
- David Herman - Postal Worker (voice)
- David Herman - Gen-Y Geek / The Dow Genius (voice)
- David Herman - Gnome On the Range Employee (voice)
- David Herman - Mr. Webber (voice)
- David Herman - Teenager (voice)
- David Herman - Frisbee Hippie (voice)
- David Herman - Carlo (voice)
- David Herman - Anthony (voice)
- David Herman - Dog Owner (voice)
- David Herman - Jimmy Witchard / Johnson (voice) (uncredited)
- David Herman - Jim (voice)
- David Herman - Draper / Gary / Resident (voice)
- David Herman - Big Terry (voice)
- David Herman - Pat Flannery (voice)
- David Herman - Mr. Hickey (voice)
- David Herman - Lloyd Vickers (voice)
- David Herman - Miguel Hernandez (voice)
- David Herman - Fitzy (voice)
- David Herman - Spencer / Dennis / Byrne / Actor (voice)
- David Herman - David / Emcee (voice)
- David Herman - Keith (voice)
- David Herman - Conductor Nolan / Lawrence Robbins (voice)
- David Herman - McVie Hilgren-Bronson (voice)
- David Herman - Stu (voice)
- David Herman - Consulate Guy / Mitch (voice)
- David Herman - Auctioneer (voice)
- David Herman - Brent Cobb (voice)
- David Herman - Dolphin Trainer (voice)
- David Herman - Mud Dobber (voice)
- David Herman - Earl / J.J. (voice)
- David Herman - Science Teacher (voice)
- David Herman - Miles Burton (voice)
- David Herman - Dog Trainer (voice)
- David Herman - Rusty (voice)
- David Herman - T. Beck Minzenmyer (voice)
- David Herman - Charlie / Booster #1 (voice)
- David Herman - Bradford / Umpire (voice)
- David Herman - Deprogrammer (voice)
- David Herman - Skycap (voice)
- David Herman - Buckley / Matt (voice)
- David Herman - Konrad Meinhoffer IV (voice)
- David Herman - City Councilman (voice)
- David Herman - Monroe (voice)
- David Herman - Timmol (voice)
- David Herman - Alien Urine Salesman (voice)
- David Herman - Craig T. (voice)
- David Herman - Meat Guy / Steve (voice)
- David Herman - Joe / Kris / Otto (voice)
- David Herman - Rodeo Announcer (voice)
- David Herman - Bodhi (voice)
- David Herman - Old Man #1 / Oskar / Sports Guy (voice)
- David Herman - Enrique (voice)
- David Herman - Army Doctor (voice)
- David Herman - Bartender / Math Teacher / Really Old Bartender (voice)
- David Herman - Bloomers / Mankiller / Waiter (voice)
- David Herman - Bazooms Manager / Dealer #1 / Man on TV (voice)
- David Herman - Ted T. Ganaway (voice)
- David Herman - Buckley / Eustis / Additional Voices (voice)
- David Herman - Bug Gribble / Juan Pedro (voice)
- David Herman - Muscular Man (voice)
- David Herman - Rico (voice)
- David Herman - Jonathan (voice)
- David Herman - Junior Monk (voice)
- David Herman - Eustis Miller / Randy Miller (voice)
- David Herman - Booster (voice)
- David Herman - Cap (voice)
- David Herman - Miguel Hernandez / Mr. Terkelsen (voice)
- David Herman - Tim (voice)
- David Herman - Ex-President Jimmy Carter (voice)
- Breckin Meyer - (voice)
- Breckin Meyer - Joseph Gribble / Kid #2 (voice)
- Breckin Meyer - Joseph Gribble / Mr. Haggerty (voice)
- Johnny Knoxville - Peter Sterling (voice)
- Johnny Knoxville - Hoyt Platter (voice)
- Marissa Jaret Winokur - Nurse (voice)
- Marissa Jaret Winokur - Sunshine (voice)
- Marissa Jaret Winokur - Melinda / Woman (voice)
- Marissa Jaret Winokur - Doreen / Girl in Crowd (voice)
- Andrea Bowen - Teen Girl (voice)
- Andrea Bowen - (voice)
- Andrea Bowen - Sandy (voice)
- Jeff Goldblum - Dr. Vayzosa (voice)
- Laura Linney - Marlene (voice)
- Ashley Johnson - Emily (voice)
- Ashley Johnson - (voice)
- Ashley Johnson - Emily / Jamie (voice)
- Ronnie Dunn - Ronnie Dunn (voice)
- Lucy Liu - Tid Pao (voice)
- Victor Aaron - John Redcorn (voice)
- Paul Butcher - Kenny (voice)
- Paul Butcher - Caleb (voice)
- Paul Butcher - Arrow Kid #2 / Robin (voice)
- Willie Nelson - Willie Nelson (voice)
- James Sie - (voice)
- James Sie - Nguc Phong (voice)
- James Sie - Phonsawan (voice)
- James Sie - Doctor (voice)
- James Sie - Mitchell Lee / Asian Man (voice)
- James Sie - General Gum (voice)
- James Sie - Sheila's Assisant (voice)
- James Sie - Nozawa (voice)
- Dennis Hopper - Dennis Hopper (voice)
- Chuck Mangione - Chuck Mangione (voice)
- Steven Banks - Dr. Morley (voice)
- Nicky Katt - (voice)
- Nicky Katt - Artist / Voice on the Phone (voice)
- Nicky Katt - Dr. Brown / Old Man (voice)
- Sal Lopez - Employee / First Mate / Waiter #2 (voice)
- Sal Lopez - (voice)
- Cheryl Holliday - Randy Miller (voice)
- Cheryl Holliday - (voice)
- Cheryl Holliday - Velma Throckmorton (voice)
- Neil Giuntoli - Wheezie (voice)
- Neil Giuntoli - Closer #2 (voice)
- David Zuckerman - Group Leader (voice)
- James Carville - Judge (voice)
- Dax Shepard - Derek (voice)
- Dax Shepard - Asa (voice)
- Dax Shepard - Zack (voice)
- Patricia Childress - Andy Maynard / Crying Kid (voice)
- Steve Vinovich - Salesman (voice)
- Billie Joe Armstrong - Face (voice)
- Mike Dirnt - Zeus (voice)
- Eloy Casados - Enrique (voice)
- Eloy Casados - (voice)
- Tre Cool - Kane Skretteberg (voice)
- Stockard Channing - Mrs. Holloway (voice)
- Burt Reynolds - M.F. Thatherton (voice)
- Debi Derryberry - Kid (voice)
- Troy Aikman - Troy Aikman (voice)
- Brent Forrester - Leon Petard (voice)
- Brent Forrester - Dealer (voice)
- Peabo Bryson - National Anthem Singer (voice)
- Jim Cummings - (voice)
- Jim Cummings - Bounty Hunter / Jimmy Helstrom (voice)
- Jim Cummings - Pops (voice)
- Jim Cummings - C. Everett Koop (voice)
- Jim Cummings - Mark McJimsey / Customer / Presenter #1 (voice)
- Chris Rock - Roger 'Booda' Sack (voice)
- Peri Gilpin - Jo Rita (voice)
- Peri Gilpin - Gwen St. James (voice)
- Peri Gilpin - Mary Ellen (voice)
- Peri Gilpin - Judy (voice)
- John Amos - Glen Johnson (voice)
- Patrick Bristow - P.J. (voice)
- Patrick Bristow - (voice)
- Jonathan Joss - John Redcorn (voice)
- Jonathan Joss - John Redcorn / Driver #2 (voice)
- Jonathan Joss - John Redcorn (voice) (uncredited)
- Mary Kay Place - Helen Pell (voice)
- Mary Kay Place - Mrs. Stovall (voice)
- Mary Kay Place - Melly-Anne (voice)
- Dennis Burkley - Principal Moss (voice)
- Dennis Burkley - Principal Moss / Trucker (voice)
- Dennis Burkley - Principal Moss / William B. Travis (voice)
- Dennis Burkley - (voice)
- Dale Earnhardt - Dale Earnhardt (voice)
- Alan Freedland - Firefighter (voice)
- William H. Macy - Dr. Rubin (voice)
- John Ashton - Instructor (voice)
- Fred Willard - Officer Brown (voice)
- Fred Willard - Chairman / Geiger (voice)
- Fred Willard - Ranger Bradley / Reclining Hippie (voice)
- Billy Bob Thornton - Boyce Hubert (voice)
- Phil Hendrie - (voice)
- Phil Hendrie - Burl Arlington / Harv Judd / Roddy Rae Biffel (voice)
- Phil Hendrie - Rent-a-Cop / Big Tex (voice)
- Phil Hendrie - Big Willie Lane / Bear (voice)
- Phil Hendrie - Announcer / Coach Palmer / Salesman (voice)
- Phil Hendrie - Roddy Rae Biffel (voice)
- Phil Hendrie - Tom Chick / TV Announcer / Fireman Gennaro (voice)
- Phil Hendrie - Dr. Schiff / Tom Chick (voice)
- Phil Hendrie - Greta / Little John (voice) (uncredited)
- Phil Hendrie - Guard / Police Officer #1 / Gordon (voice)
- Phil Hendrie - Jewel Crawford (voice)
- Phil Hendrie - Big Jim (voice)
- Phil Hendrie - Chairman / Pete / Dr. Wallis (voice)
- Phil Hendrie - Big Jim / City Inspector (voice)
- Phil Hendrie - Epperson (voice)
- Phil Hendrie - Lawyer (voice) (uncredited)
- Phil Hendrie - Coach Sauers (voice)
- Phil Hendrie - Roger (voice)
- Phil Hendrie - Commander (voice)
- Dwight Yoakam - Lane Pratley (voice)
- Sam Saletta - (voice)
- Will Ferrell - Coach Lucas (voice)
- Jim Dauterive - Jason Adderly (voice)
- Jim Dauterive - Cockroach (voice) (uncredited)
- Nick Jameson - Director (voice)
- Uta Hagen - Maureen (voice)
- Pauly Shore - Deejay (voice)
- Julianne Buescher - (voice)
- Lisa Jane Persky - (voice)
- Wally Wingert - Curator / Sheriff (voice)
- Warren Lieberstein - (voice)
- Steven Barr - Cole (voice)
- Andrew Lawrence - (voice)
- Andrew Lawrence - Rodeo Kid (voice)
- Terri Clark - Terri Clark (voice)
- Jeanine Jackson - (voice)
- Jim Ward - (voice)
- Myra Dent - (voice)
- Lorna Scott - (voice)
- Natalie Canerday - Miriam Caney (voice)
- Bertila Damas - Maria Montalvo (voice)
- Bertila Damas - (voice)
- Bertila Damas - Customer #2 (voice)
- Paul Giamatti - Mr. McKay (voice)
- Chelcie Ross - Councilman Fred Ebberd (voice) (uncredited)
- Robert Stack - Reynolds Penland (voice) (uncredited)
- Tom Dumont - Tom Dumont (voice)
- Marcelo Tubert - (voice)
- Marcelo Tubert - Marty Mendez (voice)
- Tony Kanal - Tony Kanal (voice)
- Kathy Bates - Patrol Officer Jane Cooper (voice)
- Patricia Place - Betty (voice)
- John C. McGinley - One-Armed Ronnie / Ranger (voice)
- Peter Kwong - Mr. Ho (voice)
- Denice Kumagai - (voice) (uncredited)
- Glenn Morshower - (voice)
- Glenn Morshower - Shelwyn (voice)
- Glenn Morshower - Bud Ferguson (voice)
- Alie Ward - Becky (voice) (uncredited)
- Keone Young - (voice)
- Annie O'Donnell - (voice)
- David Carradine - Junichiro (voice)
- ???? - Reporter (voice)
- Amanda Carlin - Matriarch (voice)
- Joel McCrary - Cop (voice)
- Dan McGrath - Jamaican Radio Rapper (voice) (uncredited)
- Michael Keaton - Trip Larsen (voice)
- George Foreman III - George Foreman III (voice)
- Kyle Howard - Steve (voice)
- Bernie Mac - Mack (voice)
- Deryck Whibley - Youth Group Member (voice)
- Steve Jocz - Youth Group Member (voice)
- Jason McCaslin - Youth Group Member (voice)
- Dave Baksh - Trent - Youth Group Member (voice)
- Dave Allen - Appleseed (voice)
- Dave Allen - Jesse (voice)
- Rini Bell - Jane (voice)
- Rini Bell - Dawn (voice)
- Rini Bell - Waitress (voice)
- Rini Bell - Olivia (voice)
- Ben Stiller - Rich (voice)
- Christina Applegate - Colette / Attorney (voice)
- Melissa Etheridge - Topaz / Singing Hippie (voice)
- Bru Muller - Gay Waiter (voice) (uncredited)
- Bru Muller - Big Jock (voice)
- Ruth Livier - Yolanda (voice)
- Ruth Livier - Cristina (voice)
- Kelly Clarkson - Kelly Clarkson / Dawn (voice)
- Ben Stein - Quizmaster (voice)
- Ernie Grunwald - (voice)
- Ernie Grunwald - Ken Hayashi / Mitchell / Bookstore Cashier (voice)
- Alyson Hannigan - Stacey Gibson (voice)
- Laura Prepon - April (voice)
- Henry Winkler - Henry Winkler (voice)
- Cynthia Mann - Sally (voice)
- Anthony 'Citric' Campos - Enrique's Brother in Law (voice)
- Maurissa Tancharoen - Yuppie Woman #1 (voice)
- Timm Sharp - Sprinter (voice)
- Timm Sharp - Man with Snake (voice)
- Scott Klace - (voice)
- Scott Klace - (voice) (uncredited)
- Scott Klace - Mikey / Randy / Proud Father (voice)
- Scott Klace - Barry Rollins / Cook (voice)
- Scott Klace - Duckworth / Walker Lee (voice)
- Scott Klace - Mikey / Randy / Proud Father (voice) (uncredited)
- Scott Klace - Gerald / Tax Assessor (voice)
- Scott Klace - Eric Dwyer (voice)
- Scott Klace - Johnny K (voice)
- Scott Klace - Dr. Weissman (voice)
- Scott Klace - Commissioner #3 (voice)
- Scott Klace - Dr. Stratton / Weatherman (voice)
- Scott Klace - Rusty Shackleford (voice)
- Scott Klace - Male Deacon #1 (voice)
- Scott Klace - Craig / Jacob (voice)
- Scott Klace - Jim (voice)
- Scott Klace - Gilstead / Older Man (voice)
- Dan Finnerty - Darryl (voice)
- Wayne Federman - (voice)
- Paul Teutul, Sr. - Paul Teutul, Sr. (voice)
- Michael Jamin - Carolyn (voice)
- Randal Reeder - Customer (voice)
- Randal Reeder - Redneck (voice)
- Randal Reeder - Coach (voice)
- Randal Reeder - (voice)
- Randal Reeder - Rollo / Customer (voice)
- Randal Reeder - Bob Choate (voice)
- Randal Reeder - Moose (voice)
- Randal Reeder - Frat Guy #2 (voice)
- Frank Beard - Frank Beard (voice)
- Dusty Hill - Dusty Hill (voice)
- Lisa Edelstein - Alexis (voice)
- Wyatt Cenac - (voice)
- Wyatt Cenac - Cameraman / Dr. Stephens (voice)
- Wyatt Cenac - Football Announcer / Tough-Looking Guy (voice)
- Wyatt Cenac - Guard (voice)
- Josh Keaton - (voice)
- Josh Keaton - Harkey (voice)
- Mikey Kelley - (voice)
- Mikey Kelley - Radio Broadcaster 2 (voice)
- Jacob Zachar - (voice)
- Jillian Bowen - Lori / Melissa / Mrs. Dorsey (voice)
- Jillian Bowen - Lori / Shelly (voice)
- Jillian Bowen - Amy (voice)
- Steve Gunderson - (voice)
- Melinda Clarke - Charlene (voice)
- Alicia Sixtos - Inez (voice)
- Ed Begley Jr. - Stephens Davies (voice)
- Alex Alexander - (voice)
- David Koechner - Frank (voice)
- Abby Elliott - Hipster Girl (voice)
- Abby Elliott - Clerk #1 (voice)
- Abby Elliott - Melrose (voice)
- Tom Jourden - Headmaster / Announcer (voice)
- Colleen Smith - 911 Operator / Brunette Waitress (voice)
- Jeremy Suarez - Jack (voice)
- Jeremy Suarez - Arrow Kid #1 (voice)
- Jeremy Suarez - (voice)
- Jake Steinfeld - Thunder (voice)
- Bob Elliott - Edgar Hornsby (voice)
- Jerry Lambert - J.J. Womack / Police Officer #2 (voice)
- Jerry Lambert - Judge Hawthorne (voice)
- Will Schaub - (voice)
- Sugar Lyn Beard - (voice)
- Georgie Kidder - (voice)
- Lori Nasso - (voice)
- April Winchell - Instructor / Second Mother (voice)
- Stephen Stanton - Heck Dorland (voice)
- Duff Goldman - Duff Goldman (voice)
- Anthony Chun
- Martin Archer Jr.
- Martin Archer
- Adam Kuhlman
- Tony Kluck
- Cyndi Tang
- Greg Cohen
- John Altschuler
- Dave Krinsky
- David Zuckerman
- Dave Schiff
- Erin Ehrlich
Gary Busey interpreta a Mad Dog (voice) en la serie.
John Ashton interpreta a Instructor (voice) en la serie.
Allison Janney hace el papel de Laura (voice).
Elizabeth Perkins hace el papel de Ruth Brown / Sherilyn (voice).
Stephen Tobolowsky interpreta a Dr. Benson / Burt Halverstrom (voice) en la serie.
Brad Pitt interpreta a Patch Boomhauer (voice) en la serie.
Johnny Hardwick interpreta a Dale Gribble (voice) en la serie.
Sally Field interpreta a Junie Harper (voice) en la serie.
Christopher Lloyd interpreta a Smitty (voice) en la serie.
Milla Jovovich interpreta a Serena Shaw (voice) en la serie.
Capítulo disponible en las siguientes plataformas:
