- Benedict Wong - Detective Clarence 'Da' Shi
- Gerard Monaco - Collins
- Vedette Lim - Vera Ye
- Sun Yan - Commander Song
- Perry Yung - Ye Zhetai
- Li Fengxu - Shao Lin
- Guy Burnet - Rufus
- Emily Kimball - Poppy
- ?? - Computer Scientist 2
- Yin Wang - Red Guard Student
- Ben Schnetzer - Young Mike Evans
- Adrian Edmondson - Denys Porlock
- Eve Ridley - Follower
- Tom Wu - Count of the West
- Russell Yuen - Emperor Zhou
- John Dagleish - Felix
- Hon Ping Tang - Sentry 1
- Kevin Eldon - Sir Thomas More
- Shalini Peiris - Colleague
- Rhys Bevan-John - Researcher
- Carlotta Banat - Olivia
- Mark Gatiss - Isaac Newton
- Reece Shearsmith - Alan Turing
- Conleth Hill - Pope Gregory XIII
- Phil Wang - Aristotle
- Adrian Greensmith - Galileo
- Ulrich Brandhoff - Gisler
- Jordan Alexandra - Siobhan
- Nitin Ganatra - Ranjit Varma
- Shaheen Khan - Priya Varma
- Aidan Cheng - Reg
- Naoko Mori - Marie Curie
- Avital Lvova - Ramanujan
- Jason Forbes - Omar Khayyam
- Stacy Abalogun - Thelma
- Edmund Kingsley - Jeremiah
- Joe Biden - Self (archive footage) (uncredited)
- Rishi Sunak - Self (archive footage) (uncredited)
- Maryam Moshiri - BBC Anchorwoman
- CCH Pounder - Secretary General Lilian Joseph
- Jason Barnett - Eugene
- Em Thane - Tech 1
- Hywel Morgan - Selwyn Pugh
- Lainy Boyle - Mother of Theo
- Jarlan Bogolubov - Theo
- Lucy Russell - Sally
- Hélène Viviès - Lecompte
- Stephen Rahman Hughes - Anwar Suleiman
- Bea Svistunenko - Laeticia
- Bilal Hasna - Edgar
- Dustin Demri-Burns - Ted
- Sagar Arya - One Earth Official
- Sarah Malin - Doctor
- Jim Howick - Harry
- Florence Bell - Roxanne
- Josh Brener - Kent
- Adam Silver - Assassin
- Lily Newmark - Nora
- Jose Palma - Roberto
- Bobak Ferdowsi - Mission Director
- Richard James-Neale - Soldier
- Clem Cheung - General Hou Bolin
- Salem Murphy - Leyla Ariç
- Jake Tapper - Jake Tapper
- Abby Phillip - Abby Phillip
- John Bradley - Jack Rooney
- Zine Tseng - Young Ye Wenjie
- Lan Xiya - Tang Hongjing
- Jonathan Pryce - Mike Evans
- Liu Cixin
- Andrew Stanton
- Hameed Shaukat
- Brad Pitt
- Robert Sterne
- Rian Johnson
- Ken Liu
- Tim Kimmel
- Alex Gerbrandt
- Randy Wilson
- Gary Calamar
- William Kellerman
- Jason Charbonneau
Clem Cheung hace el papel de General Hou Bolin.
Jonathan Pryce interpreta a Mike Evans en la serie.
Jovan Adepo interpreta a Saul Durand en la serie.
Rosalind Chao hace el papel de Ye Wenjie.
Liam Cunningham interpreta a Thomas Wade en la serie.
Eiza González interpreta a Auggie Salazar en la serie.
Jess Hong interpreta a Jin Cheng en la serie.
Marlo Kelly interpreta a Tatiana Haas en la serie.
Alex Sharp hace el papel de Will Downing.
Sea Shimooka interpreta a Sophon en la serie.
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