- Benedict Wong - Detective Clarence 'Da' Shi
- Gerard Monaco - Collins
- Vedette Lim - Vera Ye
- Sun Yan - Commander Song
- Perry Yung - Ye Zhetai
- Li Fengxu - Shao Lin
- Guy Burnet - Rufus
- Emily Kimball - Poppy
- ?? - Computer Scientist 2
- Yin Wang - Red Guard Student
- Ben Schnetzer - Young Mike Evans
- Adrian Edmondson - Denys Porlock
- Eve Ridley - Follower
- Tom Wu - Count of the West
- Russell Yuen - Emperor Zhou
- John Dagleish - Felix
- Hon Ping Tang - Sentry 1
- Kevin Eldon - Sir Thomas More
- Shalini Peiris - Colleague
- Rhys Bevan-John - Researcher
- Carlotta Banat - Olivia
- Mark Gatiss - Isaac Newton
- Reece Shearsmith - Alan Turing
- Conleth Hill - Pope Gregory XIII
- Phil Wang - Aristotle
- Adrian Greensmith - Galileo
- Ulrich Brandhoff - Gisler
- Jordan Alexandra - Siobhan
- Nitin Ganatra - Ranjit Varma
- Shaheen Khan - Priya Varma
- Aidan Cheng - Reg
- Naoko Mori - Marie Curie
- Avital Lvova - Ramanujan
- Jason Forbes - Omar Khayyam
- Stacy Abalogun - Thelma
- Edmund Kingsley - Jeremiah
- Joe Biden - Self (archive footage) (uncredited)
- Rishi Sunak - Self (archive footage) (uncredited)
- Maryam Moshiri - BBC Anchorwoman
- CCH Pounder - Secretary General Lilian Joseph
- Jason Barnett - Eugene
- Em Thane - Tech 1
- Hywel Morgan - Selwyn Pugh
- Lainy Boyle - Mother of Theo
- Jarlan Bogolubov - Theo
- Lucy Russell - Sally
- Hélène Viviès - Lecompte
- Stephen Rahman Hughes - Anwar Suleiman
- Bea Svistunenko - Laeticia
- Bilal Hasna - Edgar
- Dustin Demri-Burns - Ted
- Sagar Arya - One Earth Official
- Sarah Malin - Doctor
- Jim Howick - Harry
- Florence Bell - Roxanne
- Josh Brener - Kent
- Adam Silver - Assassin
- Lily Newmark - Nora
- Jose Palma - Roberto
- Bobak Ferdowsi - Mission Director
- Richard James-Neale - Soldier
- Clem Cheung - General Hou Bolin
- Salem Murphy - Leyla Ariç
- Jake Tapper - Jake Tapper
- Abby Phillip - Abby Phillip
- John Bradley - Jack Rooney
- Zine Tseng - Young Ye Wenjie
- Lan Xiya - Tang Hongjing
- Jonathan Pryce - Mike Evans
- Liu Cixin
- Andrew Stanton
- Hameed Shaukat
- Brad Pitt
- Robert Sterne
- Rian Johnson
- Ken Liu
- Tim Kimmel
- Alex Gerbrandt
- Randy Wilson
- Gary Calamar
- William Kellerman
- Jason Charbonneau
Clem Cheung hace el papel de General Hou Bolin.
Jonathan Pryce hace el papel de Mike Evans.
Jovan Adepo hace el papel de Saul Durand.
Rosalind Chao hace el papel de Ye Wenjie.
Liam Cunningham interpreta a Thomas Wade en la serie.
Eiza González interpreta a Auggie Salazar en la serie.
Jess Hong hace el papel de Jin Cheng.
Marlo Kelly hace el papel de Tatiana Haas.
Alex Sharp interpreta a Will Downing en la serie.
Sea Shimooka interpreta a Sophon en la serie.
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