- Shohreh Aghdashloo - Nadia Maroni
- Theo Rossi - Dr. Julian Rush
- Michael Kelly - Johnny Viti
- Mark Strong - Carmine Falcone
- Eric Berryman - Dr. Desoto
- Alex Anagnostidis - Ray
- Myles Humphus - Dom
- Barrett Martin - Augustine Waiter
- Gerald Bunsen - Wounded Dealer
- Daren Donofrio - Blackgate Prison Guard
- Dean Meminger - Newscaster
- Roma Torre - Newscaster
- James Madio - Milos Grapa
- Joshua Bitton - Mickey Stone
- David H. Holmes - Nick Fuchs
- Daniel J. Watts - Bruno Tess
- Aleksa Palladino - Carla Viti
- Craig Walker - Det. Marcus Wise
- Tess Soltau - Tina Falcone
- Marié Botha - Magpie
- Ben Cook - Calvin
- Jayme Lawson - Bella Reál
- Aria Shahghasemi - Taj Maroni
- Ava Grey - Cinnamon
- Fajer Kaisi - Ervad
- Hunter Emery - Leo
- Jessie Pinnick - Roxy
- Victor Cruz - Cesar
- Mike Britt - Freddy's Bartender
- Greg Balla - French Bistro Waiter
- Jared Abrahamson - Squid
- François Chau - Feng Zhao
- Robert Lee Leng - Link Tsai
- Tyler Bunch - Dr. Trey Bloom
- Jose Guns Alves - Juan Aguilar
- Shirley Roeca - Elena Aguilar
- Alan Kelly - Tech Bro
- Jeremy Dash - Granary Driver
- Reese Madigan - Police Officer
- Victor Zheng - Triad Guard
- Nadine Malouf - Summer Gleeson
- Peter McDonald - William Kenzie
- Renée Stork - Ruth Hill
- T. Ryder Smith - Dr. Ventris
- Katie Kreisler - Attorney
- Con O'Neill - Chief Mackenzie Bock
- Mershad Torabi - Farhad
- Manoli Ioannidis - El Jefe
- Alexis Nichole Smith - Social Worker
- Bill Finger
- Bob Kane
- Colin Farrell
- Matt Reeves
- Dylan Clark
- Rafi Crohn
- Craig Zobel
- Daniel Pipski
Cristin Milioti interpreta a Sofia Falcone en la serie.
Rhenzy Feliz hace el papel de Victor Aguilar.
Michael Kelly hace el papel de Johnny Viti.
Shohreh Aghdashloo interpreta a Nadia Maroni en la serie.
Deirdre O'Connell interpreta a Francis Cobb en la serie.
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