- Rafi Gavron - Ernie Nuzi
- Demi Singleton - Margaret Johnson
- Jason Alan Carvell - Malcolm X
- Louis Cancelmi - Richie Zambrano
- Taylor Selé - Big Earl Ison
- Jazmine Sullivan - Mary Wells
- Method Man - Sam Christian
- Sonja Sohn - Nell
- Deric Augustine - Cassius Clay
- Whoopi Goldberg - Miss Willa
- Annabella Sciorra - Fay Bonnano
- A$AP Ferg - Reggie
- Grace Porter - Betty Shabazz
- Michael Chenevert - Feo Gomez
- Billy Wirth - Detective Kramer
- Johnny Hopkins - Detective Ryan Clark
- Aloe Blacc - Lionel
- Patrick Murney - Sergeant Christopher Hollis
- David Deblinger - Sol Fidler
- Haaron Hines - Doug Jones (uncredited)
- Nneoma Sampson - Widow
- Jared Kemp - Virgil
- Christina Shea-Wright - Beverly
- Sean Allan Krill - Lester Wolff
- Markuann Smith - Junie Byrd
- Luis Guzmán - Alejandro 'El Guapo' Villabuena
- Roslyn Ruff - Delia Greene
- Tramell Tillman - Bobby Robinson
- Steve Vinovich - Senator John McClellan
- Richard Petrocelli - Joseph Valachi
- T.J. Atoms - Black Kid
- Nikkole Salter - Flossie
- Joanne Kelly - Amy Vanderbilt
- Korey Jackson - Livingston Wingate
- Clifton Davis - Honorable Elijah Muhammad
- Leopold Manswell - Captain Henry
- Patricia R. Floyd - Esther James
- Rony Clanton - Cecil
- Michael Raymond-James - Joe Colombo
- Justin Bartha - Robert Morgenthau
- Ralph Brown - President Lyndon Johnson
- Peter Francis James - Archie Gaines
- Maurice Jones - Captain Omar
- Arthur J. Nascarella - Carlo Gambino
- Louis Vanaria - Lombardi
- Evander Duck Jr. - Brother Clinkscale
- Paul Sorvino - Frank Costello
- Kathrine Narducci - Olympia Gigante
- Bo Dietl - Thomas Lucchese
- Richard D'Alessandro - Gaspar Digregorio
- Craig DiFrancia - Gio
- Francesca Shipsey - Sophia
- Mister Fitzgerald - Bumpy Soldier
- Lorenzo Pozzan - Franco
- Elvis Nolasco - Nat Pettigrew
- Yul Vazquez - José Miguel Battle
- Richard Topol - Jonah Fineman
- Evelyn Howe - Madrina
- CJ Williams - Bone
- Giorgio Panetta - Colombo Driver
- Josue Louis-Charles - Kingston Campbell
- Kenneth Nance Jr. - Stokes
- Nick Chinlund - Gary D'Alessandro
- Ronald Isley - Dixon
- Hudson Oz - ADA Jonathan Pike
- David McKittrick - Sheriff
- Maria Rodríguez Soto - Flamenco Dancer
- Arturo del Puerto - Che Guevara
- Isaach De Bankolé - Monsieur 98
- Shane Patrick - Officer O'Mally
- Joseph DeVito - Officer Delano
- Jamil Zraikat - Hotel Security Guard
- Fady Kerko - Doctor
- Eric Berryman - Carvens Aldridge
- Katya Martín - Marina
- Ruben Rivera - Reuben
- Edward Carnevale - Umberto
- Tyson Hall - The Vein
- Natalie Kaye Clater - Waitress
- Dominic Fumusa - Father Louis Gigante
- Joel Marsh Garland - 'Wild Bill' Harvey
- Francois Battiste - Mr. Marshall
- Adrienne D. Williams - Khadijah
- DeLance Minefee - Waiter
- Kim Brockington - Lillian Gaines
- Samantha Rivers Cole - Secretary
- Bowman Wright - Alex Haley
- Mark Epperson - News Anchor
- Ro Boddie - Mr. Gilford
- José Luis Rodríguez - Javier
- DeShawn Harold Mitchell - Brother Daniels
- Brandon Lamar - Man in Car
- Matt Hopkins - Prison Guard #1
- Mu-Shaka Benson - Brother Benjamin X
- Jason Nuzzo - Unknown Man
- Ronald Guttman - Jean Jehan
- Jack Donnelly
- Guillermo Navarro
- Joe Chappelle
- Lily Mariye
- Rob J. Greenlea
- Carl Seaton
- Dean Imperial
- Michael Panes
- Moise Verneau
- Angelica Chéri
- Zach Calig
- James Acheson
- Paul Eckstein
- Forest Whitaker
- Christina M. Fitzgerald
- Nina Yang Bongiovi
- Markuann Smith
Whoopi Goldberg interpreta a Miss Willa en la serie.
Forest Whitaker interpreta a Ellsworth 'Bumpy' Johnson en la serie.
Giancarlo Esposito interpreta a Adam Clayton Powell Jr. en la serie.
Isaach De Bankolé interpreta a Monsieur 98 en la serie.
Erik LaRay Harvey interpreta a Delbert C. 'Del' Chance en la serie.
Ilfenesh Hadera hace el papel de Mayme Johnson.
Antoinette Crowe-Legacy interpreta a Elise Johnson en la serie.
Lucy Fry interpreta a Stella Gigante en la serie.
Jason Alan Carvell hace el papel de Malcolm X.
Capítulo disponible en las siguientes plataformas:
