- Stephen Oyoung - Barry / Tectonic
- Gregg Lowe - Briggs / Flaming Fist
- Aidan McGraw - Young Brandon
- Sharon Belle - Iron Orchid
- Stéphane Julien - Primate Crew
- Kevan Kase - Primate Crew
- Tyler Williams - Primate Crew
- Al Bayan - Security Guard
- Jessica Sipos - Sunny
- John Bourgeois - Percy
- Murray Furrow - Van Dyke
- Kathryn Davis - Vera / Phase Out
- Adam Waxman - Harried Working Man
- Philicia Saunders - Waitress
- Jhene Erwin - Katherine Morris
- Robert B. Kennedy - Officer Parsons
- Jaime Slater - Karen Bishop
- Clyde Whitham - Priest
- Nneka Elliott - Reporter #1
- Ajay Fry - Reporter #3
- Noah Dalton Danby - Linus
- Robert Maillet - Big Man
- Genevieve DeGraves - Margaret Rinsdale / Mary Rinsdale
- Eric Woolfe - Dr. Schöpfer
- Jesse Buck - Photographer
- Geraldine Ronan - Servant
- Mich Todorovic - Sergei Kulakov
- Bart Badzioch - Vasily Kulakov
- Franco Lo Presti - Nick of Time
- Katharine King So - Kaitlyn / Slipstream
- Jennifer de Lucia - Leighton
- Scott McCord - John Ducarmont
- Em Siobhan McCourt - Emma Ducarmont
- David Fraser - Carl
- Jane Moffat - Florence
- Steve Wilsher - Older Man
- Matt Bois - Photographer
- Michael Dyson - Proprietor
- Piper Howell - Little Girl
- Meg Chambers Steedle - Jane
- Paul Amos - Barnabas
- Nigel Bennett - Hobbs
- Brian Tree - Cuthbert
- Darlene Cooke - Birdie
- Gracie Dzienny - Ruby Red
- Kurtwood Smith - Old Man Miller
- Kara Royster - Janna / Ghost Beam
- Micah Karns - Baryon
- Daniel Williston - Chip
- Aiza Ntibarikure - Sierra / Ectoplex
- Jake Lewis - Jay / Vulcaner
- Michael Ayres - Austin / Shatterheart
- Rob Archer - Reaver
- Paolo Mancini - Crewman #1
- Tyrone Benskin - Willie Small
- Paulino Nunes - Clyde
- Matthew MacFadzean - Roscoe
- James Hicks - Young Tough #1
- Christopher Di Meo - Young Tough #2
- Richard Blackburn - Chester
- Conrad Coates - Captain Borges
- Daniel Kash - Haddo
- Tony Nappo - Welbeck
- Nabil Rajo - Axmed
- Celeste Insell - Fitz's Grandmother
- Nola Martin - George's Mother
- Brendan Murray - Grace's Uncle
- Adrian Spencer - Phillip
- Tyler Mane - Blackstar
- Tenika Davis - Petra / The Flare II
- David Julian Hirsh - Richard Conrad / Blue Bolt
- Ian Quinlan - Hutch
- Anna Akana - Raikou
- Humberly González - Gabriella / Neutrino
- Fred Tatasciore - Additional Voices (voice)
- Jess Salgueiro - Jacinda / Shockwave
- Morgan David Jones - Jack Frost
- Hannah Rosner
- Mark Millar
- Frank Quitely
- James Middleton
- Sang Kyu Kim
- Akela Cooper
- Steven S. DeKnight
- Dan McDermott
- Lorenzo di Bonaventura
Kurtwood Smith interpreta a Old Man Miller en la serie.
Josh Duhamel interpreta a Sheldon Sampson / The Utopian en la serie.
Ben Daniels interpreta a Walter Sampson / Brainwave en la serie.
Leslie Bibb interpreta a Grace Sampson / Lady Liberty en la serie.
Andrew Horton interpreta a Brandon Sampson / Paragon en la serie.
Elena Kampouris hace el papel de Chloe Sampson.
Mike Wade hace el papel de Fitz Small / The Flare.
Matt Lanter hace el papel de George Hutchene / Skyfox.
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