- Kate Mulgrew - Drew Finch
- Martha Plimpton - Intake Officer K. Faraday
- Sebastián Viveros - Mike The Mechanic
- Gerard Monaco - Officer Haugenoe
- Olivia-Mai Barrett - Alicia
- Christian Contreras - Officer Pearson
- Quelin Sepulveda - Vicki
- Felix Garcia Guyer - José Longhorn
- Jeff Mirza - Cabbie
- Anna Francolini - Ticket Agent
- David Sterne - Gent #1
- Morgan Deare - Gent #2
- Ricardo Castro - Hector
- Biz Lyon - Debra
- Jake Fairbrother - Paramedic
- Yumiko Hanasaka - Evelyn
- Nadia Albina - Young Entrepreneur
- Raji James - Rajiv
- Paudge Behan - Young Papel
- Angela Ashton - Ashleigh Fiore
- Giles Cooper - Staffer
- Richard Stirling - Bird Minder
- Chris Lew Kum Hoi - Inventor
- Vera Chok - Panelist #1
- Victor Alli - Danny Holland
- Yao Chin - TV Anchor
- Cornelius Booth - Professor Ellery Woads
- Joshua McGuire - Zach
- Sarah Quist - Jocelyn
- Sarah Hadland - Lucy
- Harriet Thorpe - Newsie Hat
- Montserrat Lombard - Ashleigh Fiore
- Florence Bell - Music Shop Employee
- Anthony Adjekum - Doctor
- Christopher Colquhoun - Teddy Sloane
- Juliet Stevenson - Sister Mary Lou
- Juliet Stevenson - Mary Lou Prescott
- Peter Pedrero - SWAT 1
- Kyle Abdullah - PMC Team Leader
- Kenton Thomas - Brian / Hunter killer (2022)
- Robert Daws - Wyant Bridge
- Patrick Poletti - Director of National Intelligence
- Joshua C. Whiting - SAS Lead
- Sally Rogers - Gail
- Adwoa Brown - Heather
- Jude Mack - Kat
- Josh Herdman - Terry
- Adrian Lukis - Edward Flood
- Tomi May - Aaron Bismark
- Mitchell Mullen - Director Wincamp
- Mitchell Mullen - CIA Director Wincamp
- Laurie Kynaston - Clive Flood
- Zoë Wanamaker - Watt
- Coral Messam - Faraday's Wife
- Tanya Moodie - Portia
- Art Malik - Henning Khan
- Victoria Smurfit - Penny Morgan
- Robert Jezek - Chief of Staff
- Paul Freeman - Gregory Papel
- Walter Tevis
- Jenny Lumet
- Heather Kadin
- Carl Beverly
- Sarah Timberman
- Rola Bauer
- Tim Halkin
Paul Freeman interpreta a Gregory Papel en la serie.
Chiwetel Ejiofor hace el papel de Faraday.
Victoria Smurfit interpreta a Penny Morgan en la serie.
Naomie Harris interpreta a Justin Falls en la serie.
Annelle Olaleye interpreta a Molly Falls en la serie.
Clarke Peters interpreta a Josiah Falls en la serie.
Bill Nighy hace el papel de Thomas Jerome Newton.
Jimmi Simpson hace el papel de Spencer Clay.
Sonya Cassidy hace el papel de Edie Flood.
Joana Ribeiro hace el papel de Lisa Dominguez.
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