- Kate Mulgrew - Drew Finch
- Martha Plimpton - Intake Officer K. Faraday
- Sebastián Viveros - Mike The Mechanic
- Gerard Monaco - Officer Haugenoe
- Olivia-Mai Barrett - Alicia
- Christian Contreras - Officer Pearson
- Quelin Sepulveda - Vicki
- Felix Garcia Guyer - José Longhorn
- Jeff Mirza - Cabbie
- Anna Francolini - Ticket Agent
- David Sterne - Gent #1
- Morgan Deare - Gent #2
- Ricardo Castro - Hector
- Biz Lyon - Debra
- Jake Fairbrother - Paramedic
- Yumiko Hanasaka - Evelyn
- Nadia Albina - Young Entrepreneur
- Raji James - Rajiv
- Paudge Behan - Young Papel
- Angela Ashton - Ashleigh Fiore
- Giles Cooper - Staffer
- Richard Stirling - Bird Minder
- Chris Lew Kum Hoi - Inventor
- Vera Chok - Panelist #1
- Victor Alli - Danny Holland
- Yao Chin - TV Anchor
- Cornelius Booth - Professor Ellery Woads
- Joshua McGuire - Zach
- Sarah Quist - Jocelyn
- Sarah Hadland - Lucy
- Harriet Thorpe - Newsie Hat
- Montserrat Lombard - Ashleigh Fiore
- Florence Bell - Music Shop Employee
- Anthony Adjekum - Doctor
- Christopher Colquhoun - Teddy Sloane
- Juliet Stevenson - Sister Mary Lou
- Juliet Stevenson - Mary Lou Prescott
- Peter Pedrero - SWAT 1
- Kyle Abdullah - PMC Team Leader
- Kenton Thomas - Brian / Hunter killer (2022)
- Robert Daws - Wyant Bridge
- Patrick Poletti - Director of National Intelligence
- Joshua C. Whiting - SAS Lead
- Sally Rogers - Gail
- Adwoa Brown - Heather
- Jude Mack - Kat
- Josh Herdman - Terry
- Adrian Lukis - Edward Flood
- Tomi May - Aaron Bismark
- Mitchell Mullen - Director Wincamp
- Mitchell Mullen - CIA Director Wincamp
- Laurie Kynaston - Clive Flood
- Zoë Wanamaker - Watt
- Coral Messam - Faraday's Wife
- Tanya Moodie - Portia
- Art Malik - Henning Khan
- Victoria Smurfit - Penny Morgan
- Robert Jezek - Chief of Staff
- Paul Freeman - Gregory Papel
- Walter Tevis
- Jenny Lumet
- Heather Kadin
- Carl Beverly
- Sarah Timberman
- Rola Bauer
- Tim Halkin
Paul Freeman interpreta a Gregory Papel en la serie.
Chiwetel Ejiofor interpreta a Faraday en la serie.
Victoria Smurfit hace el papel de Penny Morgan.
Naomie Harris hace el papel de Justin Falls.
Annelle Olaleye interpreta a Molly Falls en la serie.
Clarke Peters interpreta a Josiah Falls en la serie.
Bill Nighy interpreta a Thomas Jerome Newton en la serie.
Jimmi Simpson interpreta a Spencer Clay en la serie.
Sonya Cassidy interpreta a Edie Flood en la serie.
Joana Ribeiro hace el papel de Lisa Dominguez.
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