- Paul Collins - Dr. Dean Carver
- Ivar Brogger - Dr. Paul Galasyn
- Priscilla Barnes - Liz Morgan
- Jon Polito - Eddie The Mammoth
- Jay Acovone - O'Ryan
- Joel Bissonnette - Arnaud De Fehrn
- Dan Cashman - Dr. Halliday
- Richard Neil - Michael Burton
- Denis Forest - Dante
- William Bassett - Benjamin Scarborough
- Casey Biggs - Shane Waring
- Adam Donshik - MP #1
- Bob Papenbrook - Mishka
- John Beck - Mason Fawkes / Forrester Purdue
- Frederick Coffin - Charlie Fogerty
- Georgia Emelin - Ivy Anne Petersen
- John Fujioka - Sifu / Dr. Fong
- Armin Shimerman - Tommy Walker / Augustin Gaither
- Dennis Lipscomb - Dr. Mick Callahan
- Tucker Smallwood - Anders
- Michael Welch - Adam Reese
- Joe Spano - Father Tom Moore
- Elya Baskin - Dimitri Yevchenko
- Jenny Gago - Mr. White
- Steven Flynn - Luke Lawson
- Molly Hagan - Dr. Day
- Kimberley Davies - Elaine Lowe
- Keone Young - Loh Ming
- Nan Martin - Gloria Howard
- Catherine Dent - Dr. Elizabeth Rendell
- Monica Louwerens - Receptionist
- Alexander Enberg - Manny Merrick
- Spencer Garrett - Jarod Stark
- Gary Weeks - Security Guy
- Aloma Wright - Nurse Cathy
- Mark Sheppard - Yuri Gregorov
- Vanessa Branch - Amanda / Mandy
- Landry Allbright - Jessica Semplar
- Joel Polis - John Castagnacci
- Deron McBee - Mandeville
- Christopher Neame - Dr. Henrick
- Robert Romanus - GAO Agent
- Daphnée Duplaix Samuel - Rachel
- David Taylor - Teen #1
- Gloria Stuart - Madeline Fawkes
- Clare Carey - Vivian Alburn
- Bob Morrisey - Paul Grant
- Jeremy Roberts - Huiclov
- Brian Tee - Mallon
- Leonard Stone - Old Man
- Jeanne Chinn - Melanie Jones
- Hugh Holub - Fullerton
- Idalis DeLeon - Allianora
- David Burke - Kevin Fawkes
- Idalis DeLeon - La Llorona / Helen Black
- Jack Brewer - Brock
- Adam Storke - Prisoner in Cell
- Nicholas Guest - Ted Stanhope
- Christopher Cousins - Jack Carelli
- Bryan Fisher - Jaimie Monger
- Mel Winkler - Walter
- Miranda Kwok - Nurse
- Ryan Drummond - Mime
- Ryan Drummond - Man
- Zoe McLellan - Dr. Kate Easton
- Kim Rhodes - Eleanor Stark
- Danny Goldring - SWRB Chief
- Don Kurt
Elya Baskin interpreta a Dimitri Yevchenko en la serie.
Leonard Stone interpreta a Old Man en la serie.
Vanessa Branch interpreta a Amanda / Mandy en la serie.
Jon Polito interpreta a Eddie The Mammoth en la serie.
Vincent Ventresca hace el papel de Darien Fawkes.
Paul Ben-Victor interpreta a Robert Albert Hobbes en la serie.
Eddie Jones interpreta a Charles Borden / The Official en la serie.
Shannon Kenny hace el papel de Claire Keeply / The Keeper.
Brandy Ledford hace el papel de Alex Monroe.
Michael McCafferty interpreta a Albert Eberts en la serie.
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