- Andy Merrill - Brak (voice)
- Timothy Leary - Self
- Lee Meriwether - Self
- Alan Beckwith - Self
- Carol Channing - Self
- Dave Willis - Cyclo (voice)
- Bob Denver - Self
- Joel Hodgson - Self
- Schooly-D - Self
- Catherine Bach - Self
- Adam West - Self
- Russell Johnson - Self
- 'Weird Al' Yankovic - Self
- Tony Bennett - Self
- Dawn Wells - Self
- Ashley Judd - Self
- Don Kennedy - Tansut (voice)
- Rob Zombie - Rob Zombie
- Robin Gibb - Self
- Barry Gibb - Self
- Maurice Gibb - Self
- Kevin Meaney - Self
- Corri English - Galaxy Girl (voice)
- Daryl Dragon - The Captain (voice)
- Toni Tennille - Toni Tennille
- Jerry Springer - Self
- Sarah Jessica Parker - Self
- Jon Schnepp - C. Ling Tile (voice)
- Branford Marsalis - Self
- Fran Drescher - Self
- Alice Cooper - Self
- Michael Stipe - Self
- David Byrne - Self
- Donny Osmond - Self
- Jim Carrey - Self
- Penn Jillette - Self
- Teller - Self
- Carrot Top - Self
- Thurston Moore - Fred Cracklin
- Terry Jones - Self
- Glen Phillips - Self
- Joe Franklin - Self
- Kamal Ahmed - Self
- John G. Brennan - Self
- Joyce Brothers - Self
- Rich Hall - Self
- Danny Bonaduce - Self
- Sirajul Islam - Self
- Hulk Hogan - Self
- Slash - Self
- Sandra Bernhard - Self
- Matthew Sweet - Self
- Bobcat Goldthwait - Self
- Cassandra Peterson - Elvira
- Conan O'Brien - Self
- Beck - Self
- Judy Tenuta - Self
- Steve Smith - Red Green
- Charlton Heston - Self
- Björk - Self
- Robert Smigel - Triumph the Insult Comic Dog
- Joey Ramone - Self
- Johnny Ramone - Self
- Marky Ramone - Self
- CJ Ramone - Self
- Cindy Guyer - Self
- Dian Parkinson - Self
- Eartha Kitt - Self
- Chuck Russell - Self
- Sonny Sharrock
Sarah Jessica Parker hace el papel de Self.
Sandra Bernhard interpreta a Self en la serie.
Jim Carrey interpreta a Self en la serie.
George Lowe interpreta a Space Ghost (voice) en la serie.
C. Martin Croker hace el papel de Zorak / Moltar (voice).
Capítulo disponible en las siguientes plataformas:
