- Gabrielle Miller - Molly Simon
- Sarah Strange - Henrietta / Hank
- A.J. Cook - Lindsay Tilden
- Katharine Isabelle - Denise
- Katharine Isabelle - Elizabeth
- Sarah Chalke - Chloe Wells
- Camille Sullivan - Diana Black
- C. Ernst Harth - Mel Ludwig
- Sean Day Michael - Biker Leader
- Andre Benjamin - Soldier
- Jennifer Jasey - Dr.Giddings
- Jennifer Jasey - Second Lieutenant Amy Lopez
- Ben Derrick - S.A.R. Manager
- Ben Derrick - Cop
- Terry Barclay - Doctor
- Terry Barclay - Factory Manager
- Terry Barclay - Doctor / Raven Nation Soldier (uncredited)
- Myron Natwick - Emmett Mayhew
- Rick Ravanello - First Lieutenant Joel Langley
- Rick Ravanello - Anton
- Eric Schneider - Alexander Dray
- Laurie Paton - Mrs. Hitchens
- Charles Payne - Orderly
- Terry Arrowsmith - Alien
- Richard Sargent - Alien
- George Josef - Cop
- Ken Kirzinger - Cop
- Marco Roy - Friend
- Michelle Hart - Friend
- Paul Raskin - Roland Kelso
- Tim Progosh - Dean Hormeth
- Rebecca Reichert - Amsa
- Aundrea MacDonald - Amsa
- Heath Stevenson - Hulking Man
- Heather Hanson - Lara
- David Lovgren - Elliot
- Richard Newman - Dr. Allenson
- Keegan Connor Tracy - Nicole
- Gillian Barber - Dr. Rita Hagen
- Julie Patzwald - Vanessa
- Robert Moloney - Drew
- Joanna Piros - TV Reporter
- Sue Astley - Waitress
- Andrew Bailey - Humanoid Alien
- Walter Marsh - Leonard
- Doris Chillcott - Patricia
- Ellen Dubin - Sarah Washburne
- Rob Freeman - Doctor Ken
- Danny Virtue - Redneck
- Paul Moniz de Sa - Rookie Cop
- Mar Andersons - Young Leonard
- Gordon Currie - Elton Beleye
- Tara Spencer-Nairn - Cassandra
- George Buza - Zachary
- Jenny Mitchell - Mary
- Dean Barrett - Jack
- Dana Pemberton - Guard
- Dana Brooks - Colonel Grace
- Lorena Gale - Alice Gundry
- Eric Pospisil - Cody
- Emmanuelle Vaugier - Esther
- Paul McGillion - Raphael
- Rebecca Toolan - Aunt Judy
- Mitchell Kosterman - State Trooper
- Ian Carter - Aide
- William S. Taylor - DA Warren Phips
- Leslie Hopps - Mary
- Amber Rothwell - Abbey
- Christina Cox - Jody Nolan
- Steve Woodley - Dog Handler Deputy
- Kavan Smith - Tommy Cranston
- Rick Burgess - Cop
- Rick Burgess - Glenn Harris
- Ingrid Kavelaars - Darcy
- Brennan Elliott - Danny
- Tobias Mehler - Jason
- Leigh Rachel Faith - Girl
- Peter Hanlon - Elroy Dunn
- Anne Openshaw - Lady Lumina
- Ingrid Torrance - Mary
- Lauren K. Robek - Stacy
- Natassia Malthe - Maid
- Yolanda Jessel - Trooper
- Sean Campbell - Officer
- Mark Holden - Officer
- Robert A. Duncan - Morgan
- Margot Finley - Julia Hartman
- Susan Hogan - Megan Loomis
- Carolyne Maraghi - Caroline
- Tanja Reichert - Nikki
- Stevie Vallance - Nurse Kelly
- Peter Yunker - Headmaster
- Rachel Hayward - Susan Tannen
- Jonathan Walker - Jeff Draper
- Scott Nicholson - Apostle
- Scott Nicholson - Hulking Man
- David Fredericks - Frankie DeSalvo
- Alfonso Quijada - Raoul
- Bill Switzer - Nick Patterson
- Iris Quinn - Joanne Patterson
- Fred Henderson - Ron Patterson
- Rheta Hutton - Mrs. Gimmell
- Brandy Ledford - Michelle
- David Allan Pearson - Sam
- Catherine Smith - Ethel
- Kevin Conway - Policeman
- Aaron Pearl - Det. Mike Olanski
- John Novak - Det. Freddie Ludlow
- Stephen Spender - Officer Gavin
- Joely Collins - Anita
- Robert Wisden - James Dutton
- Jill Teed - Talia
- Allan Franz - Harry
- Allan Franz - Field Officer
- Steve Bacic - Paul
- Brock Johnson - Calvin
- Kathryn Anderson - Pauline Lamott
- Garry Chalk - Sheldon Lamott
- Stefanie von Pfetten - Waitress
- Stefanie von Pfetten - Samantha Ray
- Brenda Crichlow - Alice Moody
- Peter Bryant - Moody
- Hiro Kanagawa - John Tran
- Marc Baur - Detective
- Pamela Martin - Newscaster
- Rochelle Greenwood - Margaret
- Khaira Ledeyo - Nurse Cho
- Enuka Okuma - Alikah
- Peter Flemming - Grant
- Peter Flemming - Quinn
- Michasha Armstrong - Bartender
- Michasha Armstrong - Choker Husk
- Zachary Ansley - Fergus McKay
- David Glyn-Jones - Garth
- Nicole Oliver - Lawyer
- Nicole Oliver - Charlene Fay
- Kevin McNulty - Ryan
- Don Thompson - Sheriff O'Connor
- Coco Yares - Glynis
- Jennifer Copping - Kat Keith
- Peter Wilds - Preston Barry
- Tyler Labine - Billy
- Wezley Morris - Fig
- Tom Butler - Bill Blaylock
- Tom Butler - Sheriff Robey
- Chris Wilding - Jelani
- John McConnach - Bouncer
- Jorge Vargas - Stephen Kim
- Saskia Gould - Angelic Woman
- Saskia Gould - Acolyte
- Yôko Sakai - Stephen's mother
- Phillip Mitchell - Gua Agent
- Rena Marlette Lesnar - Lucas
- Robin Avery - Robert Sterling
- Robin Avery - Malone
- Tiffany Lyndall-Knight - Gua Technician
- Michael Ryan - Senator Sterling Preston
- Donny Lucas - Franklin Garver
- Joe Pascual - Luis 'Vicente' Miranda
- David Storch - Vernon
- Anaya Farrell - Dominique
- Michelle Harrison - Melissa
- Ken Tremblett - Sheriff Randy Smithers
- L. Harvey Gold - Judge R. Maxwell
- L. Harvey Gold - Gua Judge
- Michael Langlois - Nick Randolph
- Tyron Leitso - David
- Tyron Leitso - Peter
- Ernie Jackson - Apostle
- Jim Dunn - Apostle
- Dave Hospes - Apostle
- Rob Lee - Bert Samuel
- Rob Lee - Gua Agent
- Ian Robison - Hal
- Ian Robison - Everett Paul
- Gerald Paetz - Apostle
- Michael Tayles - George Sidowski
- Karen Holness - Rachel Cates
- Tim Henry - FBI Agent
- Tim Henry - Officer Nash
- Zook Matthews - Flannel Poolshark
- Alexander Pervakov - Meathead
- Terry Howson - Policeman
- Mark Schooley - Policeman
- Bob Frazer - Nate Barlowe
- Art Kitching - Graydon
- Patricia Drake - Ellen
- Patricia Drake - Cade's Mother
- Shawn Reis - Acolyte
- Garwin Sanford - Trevor Hyams
- Garwin Sanford - Nathan Brown
- Will Sanderson - Ross Braxton
- Will Sanderson - Clement
- Allan Morgan - Major Birch
- Woody Jeffreys - First Lieutenant Trevor Payne
- Peter Kent - Sergeant Plimpton
- Scott Heindl - Second Lieutenant Jordan Vincent
- Russell Ferrier - Colonel John Russell
- Kelly Dean Sereda - Lieutenant Alex Harkin
- Adam Beach - Alex Sherman
- Brent Stait - Dan McGuire
- Graham Greene - Lonetree
- Glen Gould - Dealer
- Corrie Clark - Disgusted Wife
- Monika Schnarre - Harlie Daniels
- Stephen E. Miller - Sheriff Haddock
- Stephen E. Miller - Sgt Chernovsky
- Christian Bocher - Richie Black
- Michael Sunczyk - Clown
- Andrew Airlie - Dr.Reid
- Andrew Airlie - Dr. Bern Galloway
- Lalainia Lindbjerg - Francesca Dutton
- Kim Hawthorne - Agent Simon
- Guy Jellis - Cop
- Guy Jellis - Gua Guard
- Blu Mankuma - Special Agent Haley Burbitt
- Bernard Cuffling - Frederick Lansing
- Patrick McManus - JJ Reed
- Jerry Wasserman - Dr. Markowitz
- Jerry Wasserman - Sammy 'The Horse' Kozack
- Anthony Ulc - Hank
- Elizabeth Thai - Clerk
- Mark Humphrey - Trent
- Alex Zahara - Gregory
- William deVry - Karl
- Sarah Deakins - Alicia
- Mackenzie Gray - The Minister
- John MacDonald - Male Husk
- Nickolas Baric - Male Husk Lover
- Carla Boudreau - Female Husk Lover
- Kendall Cross - Jenny
- Kendall Cross - Erin Sullivan
- Darryl Scheelar - Pete
- Darryl Scheelar - Gua Agent
- Kirby Morrow - Quentin Billup
- Steve Makaj - Ned
- Steve Makaj - Deputy Graham
- Andrew Johnston - Sheriff
- Ryan Taylor - Trevor Jenkins
- Anthony Harrison - Coach Glen Jenkins
- Shane Vajda - Lionel
- Anne Marie DeLuise - Lena Hansen
- Mark Gibbon - Guard
- Mark Gibbon - Koch
- Paul Johansson - Hatcher
- Claudette Mink - Allegra
- Claudette Mink - Shasha
- Colin Lawrence - Terrence
- Jake T. Roberts - Cop
- J. Douglas Stewart - Deputy Brad Crowley
- J. Douglas Stewart - Detective Neely
- J. Douglas Stewart - Terry Smythe
- Sean Orr - Acolyte
- Daniella Evangelista - Laura Bennett
- Birkett Turton - Robbie Harlock
- Michael Hogan - Mr. Bennett
- Glenn Morshower - Sheriff John Holden
- Lisa Marie Caruk - Sondra
- Merrilyn Gann - Dr. Crane
- Ellie Harvie - Marianne
- Greg Thirloway - Herman Garrett
- Christopher Shyer - Lon
- Sam Vincent - Stanley Spencer
- Tim Bissett - Bert J. Franken
- Kate Luyben - Mimi
- Suzy Joachim - Gua Agent
- Darcy Belsher - Henry
- Sarah Lind - Dawn
- David Paetkau - Elias
- Michael Tiernan - Barry
- Michael Tiernan - Gua Doctor
- Jeff Seymour - Psychiatrist
- Sylvesta Stuart - Security Guard
- Lisa Howard - Renee Ashford
- Ben Bass - Russ
- D. Harlan Cutshall - Guard
- D. Harlan Cutshall - Cop
- A.C. Peterson - Detective Walter
- Elizabeth Carol Savenkoff - Yvonne
- Teryl Rothery - Dr. Heather LeGuin
- Jim Shield - Agent Chris Mitchell
- Nadine Wright - Agent Olivia Tomalin
- Campbell Lane - Uncle Harry
- Francis Boyle - Reporter
- Paul Eckstein - Omar Healy
- Adrian Holmes - Jim
- Adrian Holmes - Beckham
- Barbara Tyson - Dr. Mira Ruben
- Brenda James - Rae
- John Tierney - Burgess
- Andrew Keilty - Mutated Husk
- Venus Terzo - Gua Supervisor
- Kevan Ohtsji - Technician
- Brent Fidler - Harold Shanley
- Brent Fidler - Empiricist
- Andrew Moxham - Acolyte
- Desiree Zurowski - Sophia
- Bill Croft - Agent Dixon
- Jano Frandsen - Jack Mitchum
- Victoria Pratt - Claire Wilson
- Richard Stroh - Gua Prison Guard
- Ben Cotton - Gua Police
- John Kapelos - Phil Tennant
- Allison Hossack - Gwen
- Miranda Frigon - Tina
- Doug Abrahams - Officer Cronin
- Derek Morrison - Cop
- Adam J. Harrington - Acolyte
- Vincent Gale - Peter Mincer
- John B. Lowe - Priest
- Samantha Ferris - Alice
- Murray Lowry - Vince
- Donna White - Cemetary Woman
- Patrick Keating - Coroner
- Neil Denis - Skater
- Harrison Coe - Guard
- Ona Grauer - Olivia
- Ona Grauer - Taryn
- Jason Low - Guard
- Simon Webb - Professor Engel
- Jody Racicot - Chemist
- Ray Galletti - Defiant Man
- Chris Duggan - Guard
- Helene Joy - Dr. Victoria Kelly
- Trevor Devall - Tim Furlong
- Darrin Klimek - Jagger
- Byron Lucas - Samuels
- Claude Knowlton - Cole
- Chris Nelson Norris - MP
- Chris Kramer - Acolyte
- Leanne Adachi - Acolyte
- Nancy Sorel - Susan
- Garvin Cross - Francis Jeffries
- Lisa Bunting - Francis Jeffries
- Connor Widdows - Patrick
- Charles Zuckermann - Lanning
- Alex Green - Handyman
- Allan Gray - Alistair Tilden
- Ian Tracey - Garvin
- Jason Gray-Stanford - Willet
- Kurt Max Runte - Finn
- Suzanne Ristic - Coroner
- Darryl Quon - Morgue Attendant
- Patricia Dahlquist - Martha Levi
- Tom McBeath - Dr. Zahn
- Stephen Park - Lorenzo
- Guy Bews - Brown's Driver
- J. B. Bivens - Orderly Coogan
- Boyan Vukelic - Vincent
- Mikela Jay - Anna Griffin
- Howard Dell - Gua Detective
- David Christensen - Detective Saunders
- Aaron Craven - Cop
- Janine Cox - Alana MacAfee
- Michael Puttonen - Sgt. Charlie Cobb
- Winston Rekert - Horace Burke
- John Tench - Jim
- Johnny Mah - Grant
- Brian Jensen - Adjunct General Stephen
- Norman Armour - General Len
- Wendel Meldrum - Ann Berman
- Kirsten Zien - Emily
- Brett Delaney - Cop
- Dean Marshall - Cop
- Steve Best - Gua
- Claude Duhamel - Raven Nation
- Marcia Laskowski - Dr. Eldridge
- Jay Brazeau - Speidel
- Chris Humphreys - Bishop
- David Palffy - Head of Security
- Sonny Surowiec - Arms Dealer
- Brad Kelly - Guard
- Dario Delacio - Guard
- Jim Byrnes - Tyler Greer
- Peter Wingfield - Dr. Rook
- Eric Breker - Robert Foster
- Joel Palmer - Young Cade Foster
- Bill Mondy - Gua Associate
- Maria Louisa Figura - Tara Barton
- Andrew Jackson - Davis
- Terence Kelly - Keenan
- Scott Swanson - Jordan's Father
- Michael St. John Smith - Gua Technician
- Craig Norton - Gua Technician
- Malcolm Stewart - Dr. Pierce Malcolm
- Brenda Campbell - Gua Prisoner
- Scott Bellis - Jinks Davis
- James Kidnie - Max Sterman
- Roger Cross - Joshua
- Roger Cross - Joshua Bridges
- Roger Cross - Cain
- Roger Cross - Joshua Bridges / Cain
- David Millbern - George
- Ron Selmour - Colonel Nathan Pace
- Duncan Fraser - Gen. Kendricks
- Douglas O'Keeffe - Tanetti
- William B. Davis - Sagon
- Byron Lawson - Acolyte
- Andee Frizzell - Acolyte
- April Telek - Gibson
- Johnny Cuthbert - Heckler
- Christopher Judge - Xevallah
- Warren Takeuchi - Soldier
- Nuno Antunes - Soldier
- Stacy Grant - Hannah Foster
- Traci Lords - Jordan Radcliffe
- Sandra P. Grant - Katherine Hutchinson
- Rod Wilson - Mabus / Dr. Oldham
- Russell Porter - Evan
- Ty Olsson - Richard
- David Bloom - Francis Jeffries
- Steve Byers - Medical Assistant (as Stephen Byers)
- Kevin Hayes - TV Reporter
- Larry Sugar
- Francis Ford Coppola
Emmanuelle Vaugier interpreta a Esther en la serie.
Rob LaBelle hace el papel de Crazy Eddie.
Sebastian Spence interpreta a Cade Foster en la serie.
Capítulo disponible en las siguientes plataformas:
