- Mary Mouser - Lacey Fleming
- Joanna Cassidy - Judge Joan Hunt
- Jeffrey Nordling - Todd Fleming
- Sam Robards - Bradford Paige
- Davis Desmond - Max
- Sunkrish Bala - Sanjit Singh
- Kate Jennings Grant - Jill Paige
- Bruce Altman - Dr. Howard Karasunis
- Bruce MacVittie - Mr. Swanson
- Joseph Sikora - Tom Hanson
- Steven Lee Merkel - Carl Young
- Jeremiah Kissel - Dr. Simon Ferrell
- Nancy Villone - Mrs. Swanson
- Martin Lee - Assistant ME #1
- Molly Schreiber - Assistant ME #2
- Heather Arthur - Angela Swanson
- Tyler Peck - Receptionist
- Barry Shabaka Henley - Al Chapman
- Brian J. White - Brian Hall
- Sherri Saum - Nina Wheeler
- Brenda Pressley - Laura Chapman
- Chance Kelly - Gary Miller
- Alexander Cendese - Eric Singleton
- Johnny Hopkins - Lonny Reed
- Steven DeMarco - Dave Piaseki
- Alex Winston - Uniformed Officer
- Tony Plana - Armando Rosas
- Yaya DaCosta - Holly Bennett
- Tobias Segal - Sean Wilcox
- Edoardo Ballerini - Jeremy Nichols
- Zach McGowan - Vincent Stone
- Charise Castro Smith - Elena Rosas
- Kelly AuCoin - Mike Walsh
- Abigail Hawk - Jenny Avery
- Tom Pelphrey - Dean Avery
- Kathy Searle - Irina Tomislava
- Pun Bandhu - Frank Ling
- Li Jun Li - Mira Ling
- Gary Galone - David
- Cindy Lentol - Wendy
- Cory Scott - CSU Tech
- Carolyn McCormick - Hospital Administrator Gwen Baldwin
- Marc Blucas - Dr. Mark Chandler
- Milena Govich - Mindy Harbinson
- Meta Golding - Nurse Nancy Follett
- Christina Hendricks - Karen Archer / Jessica Archer
- Dan Amboyer - George White
- Peter Jay Fernandez - Doug Hollis
- John Fiore - Henry
- Billy 'V' Vigeant - Uniform Officer
- Rachel Oyama - Mary
- Vincent J. Earnshaw - Homeless Man (uncredited)
- Nadia Dajani - Lauren Matthews
- Neal Bledsoe - Stephen Burkett
- Mam Smith - Daphne Zimmer
- Dan Shaked - Timmy Akers
- Lisa Yuen - Officer Spates
- Christopher Durham - Brendan Cavanaugh
- Phyllis Kay - Suzanne Pollato
- Richard Donelly - Jim Pollato
- Robert Walsh - Colin Lloyd
- Molly Price - Jen Russell
- Jake O'Connor - Mike Russell
- David Shumbris - Ed Russell
- Jay Klaitz - Neal Kendall
- Lou Sumrall - Jake Benjamin
- Anna Friedman - Betsy
- James Colby - Coach Lou Davis
- John Magaro - Chuck Foster
- Kathryn Meisle - Helen Salerno
- Thomas Schall - Professor Jack Elliott
- Victor Cruz - Victor Ramos
- Meg Chambers Steedle - Heather
- Fatima Ptacek - Becky
- Rebecca Blumhagen - Lizzy Adler
- Derek Russo - Joe Salerno
- Diane Guerrero - Sara Gonzales
- Erica McDermott - Uniform Officer
- Jill Eikenberry - Lillian Parkson
- Jo Armeniox - Sara Parkson
- Eric Sheffer Stevens - Billy Parkson
- Charlie Semine - Shane Rinaldi
- Mary Fegreus - Nikki Parkson
- John Hillner - Detective Dryer
- Jason Alan Carvell - Vice Principal Weaver
- Devon Diep - Makeup Artist
- Joelle Carter - Andrea Davidson
- Derek Phillips - Kevin Kaiser
- Danielle Bisutti - Vicki Hemington
- Christopher Wiehl - Bill Hemington
- Rick Fox - Ted Banning
- Jenn Korbee - Bethany
- Michelle Dionne - Carissa
- Jay Karnes - Martin Loeb
- Jessica Tuck - Alexandra Loeb
- Natalie Floyd - Erika Loeb
- Joey Adams - Thomas Loeb
- Alex Fernandez - Alan Wright
- Adrian Alvarado - Detective Dave Lopez
- Ransford Doherty - Detective Tim Bell
- Brad Standley - Patrick Deline
- Michael Dean Connolly - Steve Turtell
- Michael J. Sielaff - Larry
- Richard Cabral - Jorge
- Lisa Gershuny - Francine
- Cliff Curtis - FBI Special Agent Derek Ames
- Stephen Barker Turner - Tom Parker
- Keira Naughton - Jen Parker
- Slaine - Kevin Roban
- Stink Fisher - Jason Peterson
- Wrenn Schmidt - Rena Talbot
- Joey Auzenne - Oscar Mendez
- Kathleen York - Councilwoman Jill Bennett
- James Jordan - Alex Grant
- Nathalie Kelley - Dani Alvarez
- Justina Machado - Emily Burrows
- John Bishop - Mike Vranitch
- Marianne Muellerleile - Mary Vranitch
- James Edson - Rick Kavanaugh
- Matt Austin - Paul
- Terry Walters - Libby
- Mary Beth Evans - Lawyer
- Laurel Garner - Nancy
- Andi Carnick - Diane
- Vic Chao - Doctor
- Jordan Engle - Guy
- Jeff Sanders - Trash Truck Driver
- Terry Serpico - Arson Investigator Ray Easton
- Aaron Tveit - Arson Investigator Skip Rakoski
- Sean Cullen - Daniel Robinson
- Daniel Sauli - Mike Applebee
- Sara Botsford - Louisa Armstrong
- Ernesto Rosas - Toy Store Owner
- Ward Horton - James Savage
- Joshua Burrow - Stable Manager Mr. Brooks
- Andria Blackman - Bryn Walker
- Rhet Kidd - Dookie
- Ellen Foley - Evelyn
- Ursula Parker - Laila
- Jay O. Sanders - Harvey Brady
- Evan Wadle - Jake Brady
- Karen Culp - Esther Brady
- Daniel MK Cohen - David Morton
- Jeff Ward - Patrick Spradlin
- Luz Alexandra Ramos - 911 Operator
- Erica Piccininni - Beth
- Brianna Brown - Molly Anderson
- Brandon Keener - Chris Quinn
- Christopher Cousins - Dr. David Cryer
- Jason Brooks - Ben Allen
- Melanie Specht - 'Sassy'
- Loanne Bishop - Liz Green
- Fuschia! - Alice
- Noel Arthur - Airport Security Guard Sue Godfrey
- Patrick Hume - Animal Control
- Dana Davis - Med Student Dora Mason
- Gregory Harrison - Dr. Cameron Fischer
- Andrew J. West - Med Student Shane Smith
- Brian Tichnell - Med Student Doug Chase
- Adam Croasdell - Ronan Gallagher
- Ian Bohen - Mitch Barnes
- T.V. Carpio - Jinx (uncredited)
- Shana Dowdeswell - Maxine Hall (uncredited)
- Marshall Berenson - Homeless Man (uncredited)
- Michael Anthony Coppola - Internal Affairs Agent (uncredited)
- Kat Kilkenny - Theresa
- Jennifer DeFilippo - Receptionist
- Jodie Brunelle - Young Joan Hunt (uncredited)
- Mike Park - Calvin Chu
- Rubén Garfias - Frederic Peña
- Sharon Blynn - Cynthia Marks
- Ari Zagaris - Bartender
- Charles Malik Whitfield - Dave Stackhouse
- Michael McGrady - Colin MacGregor
- Chrishell Stause - Justine Befort
- Robert Irvine - Chef Leon Gould
- Jeff Yagher - Dr. Adam Farber
- Cornell Womack - Will Gleason
- Dominique Jennings - Linda Gleason
- Cheyenne Haynes - Maya Gleason
- Piper Curda - Alice
- Molly Gross - Cassie
- Frank Maharajh - Resident
- Karly Rothenberg - Nurse
- Brendan Hines - Marc Freston
- Patrick St. Esprit - Leonard Waxman
- Kevin McCorkle - Jack Cranston
- Kevin McCorkle - Jack Cranston (uncredited)
- Pedro Pascal - Zack Goffman
- Brianne Davis - Nurse Amy Patrick
- Mim Drew - Dr. Sarah Hughes
- Thor Edgell - Howard Freston
- Gwen Holloway - Emma Freston
- Emily C. Chang - Young Female Guest
- Julia Sanford - Female Guest #1
- Jennifer Bassey - Female Guest #2
- Lisa Howard - Mrs. Waxman (uncredited)
- Brett Cullen - Captain Perkins
- Deirdre Lovejoy - Jeannie Morris
- Mark Rolston - Detective Charlie Meeks
- Elena Evangelo - Carmen Castillo
- Charles Halford - Quentin Whitsett
- Gregor Manns - Bob Pinaulta
- Marcia Gay Harden - Sheila Temple
- Rita Wilson - Ruth Stone
- Jonathon Trent - Craig Bana
- Charley Rossman - Victor Malone
- Kara Pacitto - Itsy
- Amy Vorpahl - Fontana
- Amy Vorpahl - CSU Tech
- Katelyn Pacitto - Bitsy
- Michael Busch - P.A.
- Jay Jackson - Newscaster
- Azita Ghanizada - Annabelle Kip
- Donna Pescow - Maria Sanella
- Robert Picardo - Henry Pedroni
- Joseph Martino - Joe Sanella
- Roderick McCarthy - EMT
- Roderick McCarthy - Paramedic #2
- Duncan Bravo - ER Doctor
- Todd Feder - Lawyer
- Jamie Bamber - Aiden Welles
- Khandi Alexander - Health Commissioner Beverly Travers
- Sean Kingston - Cab Driver
- Jason Beghe - Harvey Brand
- Tanc Sade - Teddy Gorman
- Patrick Fischler - Joey Jablonsky
- James Carpinello - Sal Rubenstone
- Mark D. Espinoza - Antonio Diaz
- Brit Shaw - Mindy Harrison
- Brandon Gilberstadt - Ben
- Crystal Allen - Vanessa Winters
- John McGlothlin - Kyle Harrison (uncredited)
- Cody Christian - Greg Lux
- Tom Gallop - Owen Kreger
- Paul David Story - Travis Pope
- Casey Deidrick - Aaron Lux
- Rachael Kathryn Bell - Greg's Date
- Sloane Avery - Travis' Girlfriend
- Rachel Brett - Tyler's Girlfriend (uncredited)
- Kaylee Bryant - Musician (uncredited)
- Matt Servitto - Mr. Whirley
- Ann Cusack - Gail Whirley
- Steven Culp - Eric Greyson
- Dianne Curwick - Sue Greyson
- Rebecca Field - Suzie Foster
- Scott MacArthur - Rob Martin
- Gregg Martin - Jake
- Katie O'Connor - Chloe
- Anna Moon - Mary
- Diane Sellers - Charge Nurse
- Juan Alfonso - Paramedic #1
- Kim Estes - President [Awards Speaker]
- Luke Perry - Dr. Charlie Stafford, CDC
- Dean Norris - Special Agent Brendan Johnson
- Bridger Zadina - Terry McLeary
- Nick Stahl - Marcel Trevino
- Katie Gill - Wenda Poweii
- Jolie Jenkins - Julie Tompkins [Reporter]
- Ace Marrero - Dr. Miles Hart
- John Kelly - George Thompson
- Edita Brychta - Paula Thompson
- Rosemary Dominguez - Carla Reina
- Sena Rich - Julie Kim
- Mariah Iman Wilson - Jackie Reynolds
- Stephanie Maura Sanchez - Teacher
- Justin Welborn - Jacob Mount
- Justin Welborn - Terrorist
- Chriselle Almeida - Nurse
- Clyde Yasuhara - Attending
- Ciera Payton - Eve Johnson
- Susan Ortiz - Gina Alvarez
- Chris Fogleman - Gas Station Owner
- Chad McCord - Reporter #1
- Samantha Bennett - Female Cop
- Peter Stormare - Wilson Polley
- James Urbaniak - Daniel Grubstick
- Devon Graye - Jack Gordon
- Lindsey Shaw - Sophia Polley
- Vincent M. Ward - Guard Evan Arnold
- Natalie Turpin - Niki Schumaker
- Dwight Hicks - Warden Tom Miller
- Samantha Cope - Jazmin Montoya
- Kenneth Mitchell - Robert Riley
- Kay Wilson - Caren Pedroni
- Jennifer Stone - Hannah Banks
- Ray Wise - Michael Davis
- Derek Webster - Michael Avery
- Chet Grissom - David Caine
- Sandra Purpuro - Evelyn Russo
- Michael Nouri - Daniel Russo
- Alex Di Dio - Jaxon Ware
- Heather Olt - Maitre D'
- Brandon Molale - SWAT #1
- Alexi Hawley
- Christopher Murphey
- Ken Teaney
- Daniel Licht
- Frankie Pine
- Adrian van Velsen
Marianne Muellerleile interpreta a Mary Vranitch en la serie.
Peter Stormare interpreta a Wilson Polley en la serie.
John Carroll Lynch interpreta a Det. Bud Morris en la serie.
Marcia Gay Harden interpreta a Sheila Temple en la serie.
Joelle Carter hace el papel de Andrea Davidson.
Terry Serpico interpreta a Arson Investigator Ray Easton en la serie.
Dana Delany interpreta a Dr. Megan Hunt en la serie.
Jeri Ryan interpreta a Dr. Kate Murphy en la serie.
Geoffrey Arend interpreta a Dr. Ethan Gross en la serie.
Windell Middlebrooks interpreta a Dr. Curtis Brumfield en la serie.
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