- Cree Summer - Karen (voice)
- Neil Patrick Harris - Todd Andrews
- Louis Gossett Jr. - Commander Clash (voice)
- Danny Glover - Dr. Apollo (voice)
- Richard Gautier - Okey Pinehead (voice)
- Ted Turner - Fred Learner (voice)
- Jonathan Winters - Eco the Clown (voice)
- Margot Kidder - Gaia (voice)
- Candi Milo - Billy Jean (voice)
- Ed Asner - Hoggish Greedly (voice)
- John Ratzenberger - Rigger (voice)
- Jeff Goldblum - Verminous Skumm (voice)
- Dean Stockwell - Duke Nukem (voice)
- Meg Ryan - Dr. Blight (voice)
- David Rappaport - MAL (voice)
- Sting - Zarm (voice)
- James Coburn - Looten Plunder (voice)
- Martin Sheen - Sly Sludge (voice)
- Mary Kay Bergman - Dr. Blight (voice)
- S. Scott Bullock - Argos Bleak (voice)
- Perry King - Ray (voice)
- Maurice LaMarche - Verminous Skumm (voice)
- Maurice LaMarche - Duke Nukem / Verminous Skumm (voice)
- Ed Gilbert - Looten Plunder (voice)
- Paul Williams - Kujo (voice)
- Melissa Manchester - Jane Green (voice)
- Earl Holliman - Milton (voice)
- Fred Schneider - Danny Dazzleduff (voice)
- Jim Cummings - Sly Sludge (voice)
- Dave Fennoy - Coach
- Danica McKellar - Lisa
- Elizabeth Taylor - Mrs. Andrews
- Andy Heyward
Whoopi Goldberg interpreta a Gaia (voice) en la serie.
Dean Stockwell interpreta a Duke Nukem (voice) en la serie.
Jeff Goldblum hace el papel de Verminous Skumm (voice).
Sting interpreta a Zarm (voice) en la serie.
Danny Glover hace el papel de Dr. Apollo (voice).
Joey Dedio interpreta a Wheeler (voice) en la serie.
LeVar Burton hace el papel de Kwame (voice).
Kath Soucie interpreta a Linka (voice) en la serie.
Scott Menville interpreta a Ma-Ti (voice) en la serie.
Janice Kawaye interpreta a Gi (voice) en la serie.
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