- Loni Anderson - Herself (voice)
- June Foray - Lezah the Wicked (voice)
- Amy Brassette - Jamie Wynters (voice)
- Jeff Bennett - Goozer (voice)
- Jeff Bennett - Crowd Member (voice)
- Kevin Michael Richardson - Agent Roboto (voice)
- Tom Jones - Tom Jones (voice)
- Kelly Ripa - The New Cadet (voice)
- Dom DeLuise - Roy Serpenti (voice)
- Macy Gray - Lady Chanticleer (voice)
- Brian Wilson - Brian Wilson (voice)
- Genndy Tartakovsky - Cyber Pirate of the Future (voice)
- Mako - Happy Cat (voice)
- Mako - Happy Cat / Ah-Choo (voice)
- Tim Curry - Magnificent Rogue (voice)
- Henry Winkler - Dr. Maniac (voice)
- Lewis Black - Manobrain (voice)
- Quentin Tarantino - Master Moloch (voice)
- Burt Reynolds - Royal Serpenti (voice)
- Dave Mustaine - Himself (voice)
- Marc Singer - Kirk Manlord (voice)
- Jim Cummings - Tazmanian Devil / Father (voice)
- John O'Hurley - Star Johnson (voice)
- Grey DeLisle - Computer (voice)
- Grey DeLisle - Catapoid (voice)
- Candi Milo - Rikki Roundhouse (voice)
- Paul Dini
- Tom Jones
- Robert J. Kral
- The Flaming Lips
Joe Alaskey hace el papel de Duck Dodgers / The Martian Commander (voice).
Bob Bergen hace el papel de The Eager Young Space Cadet (voice).
Richard McGonagle interpreta a Dr. I.Q. Hi (voice) en la serie.
Tia Carrere interpreta a The Martian Queen (voice) en la serie.
Michael Dorn hace el papel de Centurion Robot (voice).
Capítulo disponible en las siguientes plataformas:
