- June Squibb - Patient 54
- Dave Coulier - Dave Coulier (voice)
- Geoffrey Arend - Brandon / Patient 86
- Dan Gill - Rod / Patient 103
- Mary Lynn Rajskub - Patient 46
- Liam Neeson - Joey in the Center of Her Mind (voice)
- Eugene Cordero - Patient 37
- Karen Brundage - Lunch Lady (voice)
- Vanessa Celso - Denise (voice)
- Stephnie Weir - Diane
- Breeda Wool - Mother (voice)
- Carol Herman - Nana (voice)
- Stephanie Allynne - Joey
- Cleo King - General Jim Joynose, Jr. / Patient 13
- Tucker Smallwood - General Jim Joynose, Sr. (voice)
- Natalie Morales - Patient 6
- G.K. Bowes - Chinnamasta (voice)
- Jane Singer - Dream Nana (voice)
- Ivy George - Missing Child (voice)
- Darrell Hammond - Bill 'Wild Bill' Ruff
- Tessa Goss - Patient 95
- Craig Robinson - Mr. Simzer
- Taj Speights - Patient 56
- Brent Sexton - Patient 88's Father (voice)
- Michael Trucco - Franky, Jr. Jr. IV (voice)
- Camille Ramsey - Laura Brackensmith (voice)
- Jesse Merlin - Dream Fish (voice)
- Maria Bamford - Norf Norf (voice)
- Iqbal Theba - Patient 75
- Allyn Rachel - Patient 66
- William Baldwin - Patient 66's Father (voice)
- Toby Kebbell - Leslie Krux / Patient 101
- Aidan Wallace - Young Leslie Krux (voice)
- Jonathan Bray - U.S. Marshal
- Jon Huck - Patient 101's Father (voice)
- Theresa June-Tao - Stage Manager (voice)
- Daniella Pineda - Patient 31
- Jo Farkas - Louise
- Simon Rhee - Limo Driver
- Darin Cooper - Priest (voice)
- Aaron Coleman - Minister (voice)
- Jason Liles - Patient 84
- Rupert Friend - Patient 62
- Sam Richardson - Patient 44
- Yimmy Yim - Lydia Wright
- Karan Soni - Patient 27
- Mo Collins - Patient 30
- Thomas Middleditch - Virgil Bottoms
- Mindy Sterling - Birdy Bottoms
- Tim Sitarz - Bruno (uncredited)
- Jimmi Simpson - Patient 21
- Megan Ferguson - Bea
- Baron Vaughn - Corporate Training Video Presenter
- Emily Hinkler - Peg / Patient 69
- Elizabeth Hinkler - Meg / Patient 96
- Bobby Lee - Tricky Ricky
- Glenn McCuen - Gymnast (uncredited)
- Glenn McCuen - Gymnast
- Salina EsTitties - Vogue Dancer
- Tiffany Panhilason - Work Out Lady
- Sunita Mani - Margot Daly
- Stephen Merchant - T.E.R.R.Y. (voice)
- Walter Newman
- Cameron Tang
- Stephen Merchant
- Nick Rutherford
- John Krasinski
- Paige Boudreaux
Liam Neeson hace el papel de Joey in the Center of Her Mind (voice).
Jon Gries hace el papel de Dr. Roberts.
Ahmed Bharoocha interpreta a Ahmed en la serie.
Mark Proksch interpreta a Randy Blink en la serie.
Capítulo disponible en las siguientes plataformas:
