- Mehmet Oz - Dr. Oz
- Callan Farris - Very Sweet Kid
- Benton Jennings - Middle-Aged Patient
- Stephen Tobolowsky - Joe
- Alonzo Bodden - Bouncer
- Barak Hardley - Cellmate
- David Theune - Mr. Kontos
- Lauren Lakis - Wasted Woman
- Rene Moran - Narc
- Shelby Rabara - Dancer
- Nick Drago - Dancer
- John Maholm - Tim
- Marty Penate - Music Teacher
- Betsy Sodaro - Sonja
- James Urbaniak - James Miller
- Alexis Rhee - In-Sook
- Brandon Alan Makovy - Muscular Doctor
- Eva Fisher - Female Doctor
- Anil Margsahayam - Rick
- Marques Ray - Juan-Julio
- Ethan Drake Davis - Kid
- Will Yun Lee - Kevin O'Connell
- Nicole Sun - Narrator
- John Ruby - Austin
- Toby Huss - Captain Spooky
- Jeff Marlow - Salesman
- Wil Garret - Elderly Patient
- Noelle Messier - Officer
- Christopher Darga - Security Guard
- Michael Rothhaar - Horst Beckenbauer
- Wyatt Nash - Hot Doctor
- Margaret Cho - Dr. Wendi
- Amanda Perez - P.A.
- Lili Fuller - Hostess
- Mark Muñoz - Caller
- Clyde Kusatsu - Jerry
- Jeanne Sakata - Pam
- Lance Barber - Phil Stockton
- Kristen O'Meara - Gate Agent
- Marsha Kramer - Thelma
- David Grant Wright - Mr. Morton
- Beth Crosby - Barb Rutledge
- Morgan Peter Brown - Andy Rutledge
- Jozef Fahey - Delivery Guy
- Frank Drank - Guy
- Eli Jane - Bride
- Rodney J. Hobbs - Delivery Guy
- Joel McHale - Ross
- Danny Pudi - Topher
- Isabella Kai - Emma
- Garrett Westton - Ben
- Joy Jacobson - Irene
- Margaret Newborn - Patient
- Todd Grinnell - Dr. Mitch Tuttle
- Stephen Guarino - Connor
- Ian Chen - Henry
- Jill Basey - Mrs. Pancake
- Luke Kim - Young Ken
- Nick Jaine - Man
- Chris Moss - Asst. Choreographer
- David Valdes - Sean
- Danielle Bisutti - Denise
- Jackie Joyner - Lynda
- Megan McGown - Janell
- Cassidy Mack - Kate
- Jill E. Alexander - Karen
- George Wyner - Dicky Wexler
- Vanessa Ragland - Kate
- Kristin Carey - Dr. Humes
- Joseph Keane - Dr. Sawyer
- Joseph Keane - Mr. Sampson
- Jim Rash - Devon Drake
- Melissa Greenspan - Librarian
- Melissa Greenspan - Jane
- Scot Zeller - Defense Attorney
- Brenda Ballard - Court Reporter
- Rachael Markarian - Ms. Aslanian
- Nancy Friedrich - Grace
- Randall Park - Gary Chon
- Jae Suh Park - Jill
- David Lengel - Mr. Davis
- David Lengel - Patient
- Peter Jae - Hwan
- Danny Cho - Jae
- Kevin Shea - Kevin
- Denell Johnson - Officer
- Andy St. Clair - Madonna Guy
- Andy St. Clair - Random Doctor
- Jeff Ross - Doug
- Frazer Smith - MC
- Emily Happe - Clown Nurse
- Jake Regal - Pathologist
- Jessie Cohen - Yoga Instructor
- Jerry Minor - Eric
- Beth Triffon - Waitress
- Parker Lewis - Shark
- Marissa Heart - Mulgwishin
- Charles Rahi Chun - Jung-Do
- Tom Yi - Bum-Kun
- Nancy J. Lee - Mrs. Ahn
- Vana Kim - Mrs. Pae
- Joshua Elijah Reese - Troy
- Patrick O'Sullivan - Surgeon
- Patrick O'Sullivan - Dr. O'Sullivan
- Eddie Park - Kid
- Mark Cuban - Mark Cuban
- Lori Greiner - Lori Greiner
- Robert Herjavec - Robert Herjavec
- Daymond John - Daymond John
- Kevin O'Leary - Kevin O'Leary
- Doug Cox - Mr. Dempsey
- Kenna Wright - P.A.
- Julie Brister - Security Rep (voice)
- Gillian Vigman - Megan
- Veronica Mannion - Technician
- Bob Clendenin - Mr. Hubert
- Justin Chon - Jae
- Ryan Michelle Bathe - Miss Flanagan
- Marty Ryan - Bowling Captain
- Sam Lloyd - Gary
- Rose Abdoo - Librarian
- Meagen Fay - Virginia
- Mark Bloom - Curt
- Jailen Bates - Bigger Kid
- Gemma Brooke Allen - Little Girl
- Gillian Jacobs - Erin
- Robert Clivillés - Robert Clivillés
- Yvette Nicole Brown - Amy
- Irene Roseen - Mrs. Swenson
- Staci Lynn Fletcher - Ms. Ashburn
- Zak Henri - Danny
- Kurt Scholler - Marcus
- Ursula Burton - Kathy
- Vincent Washington - Brayden
- T.W. Leshner - Phil
- Lisa Marie - Rain
- Cheryl Lynn Bowers - Receptionist
- Jonathan Banks - Dr. Erwin
- Sarah Baker - Kylie
- Amy Tolsky - Patient
- Rhys Darby - Charles Evans
- Jason McNichols - Stoner
- Pat Monahan - Pat Monahan
- Dan Harmon - Dan Harmon
- Alison Brie - Alison Brie
- Nia Vardalos - Tiffany
- Richard Erdman - Richard Erdman
- Erik Charles Nielsen - Erik Charles Nielsen
- Luke Youngblood - Luke Youngblood
- Danielle Kaplowitz - Danielle Kaplowitz
- Steve Levy - Steve Levy
- Ken Whittingham
- Scott Ellis
- Jean Sagal
- Rob Schiller
- Beth McCarthy-Miller
- Anthony Joseph Rich
- Erik Sommers
- Paul A. Kaplan
- Mark Torgove
- Hilary Winston
- Mike Sikowitz
- Jim Brandon
Jonathan Banks interpreta a Dr. Erwin en la serie.
Stephen Tobolowsky interpreta a Joe en la serie.
Ken Jeong interpreta a Dr. Ken en la serie.
Clyde Kusatsu interpreta a Jerry en la serie.
Suzy Nakamura interpreta a Allison Park en la serie.
Dave Foley interpreta a Pat en la serie.
Tisha Campbell interpreta a Damona en la serie.
Jonathan Slavin hace el papel de Clark.
Albert Tsai hace el papel de Dave.
Krista Marie Yu interpreta a Molly en la serie.
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