- Spencer House - Chris 'Betts' Beton
- Jason Kravits - Dr. Anthony
- Danny Burstein - Ed Yarborough
- Dashiell Eaves - Stan Novak
- Greg Wood - Dr. Roman
- Dominic Burgess - Jerry Summers
- Fredric Lehne - Don Duntsch
- Hubert Point-Du Jour - Josh Baker
- Laila Robins - Amy Piel
- Maryann Plunkett - Madeline Beyer
- Marceline Hugot - Rose Keller
- John Wojda - Charlie Keller
- Grainger Hines - Earl Burke
- Medina Senghore - Kayla Gibson
- Pamela Dunlap - Mee-Maw
- Jennifer Kim - Stephanie Wu
- Cristala Carter - Shelley Brennan
- Molly Griggs - Wendy Young
- Kelsey Grammer - Dr. Geoffrey Skadden (voice)
- Kelsey Grammer - Dr. Geoffrey Skadden
- Grace Gummer - Kim Morgan
- Zabryna Guevara - Jill Deleone
- Kelly Kirklyn - Dorothy Burke
- Sheila Tapia - Cecilia
- Rachel Flynn - Lucy
- Laura Poe - Marilyn Henderson
- Sandra Daley - Medical Review Board
- Tracy Sallows - Susan Duntsch
- Alexander Pineiro - Martinez
- L'ogan J'ones - Connor
- Stink Fisher - Coach
- Ajay Naidu - Dr. Sasani
- Michael Genet - Dr. Lockett
- Christine Pedi - Elaine Johnson
- Catrina Ganey - Mrs. Demmings
- Brit Whittle - Dr. Andrew Phipps
- Faith Taylor - Anna
- Michael Levi Harris - Dr. Ilya Burkov
- Alexandra Lemus - Student
- Stephen Dexter - Banker
- AnnaSophia Robb - Michelle Shughart
- Norm Lewis - Dr. Bishara
- Sean Allan Krill - Dr. Timothy Darnton
- Pilar Witherspoon - Dr. Ivers
- Perry Strong - Joe Padua
- Miguel Cervantes - Craig James
- Michiko Sasaki - Anesthesiologist
- Tiffany Green - Nurse
- Sean Weil - Henry Aldrich
- Nesha Ward - Cindy Tremblay
- Lyndsay Kimball - Radiology Nurse
- Leslie Frye - Woman
- Erin Noel Grennan - Dr. Angela Rosario
- Samantha Jones - Allison
- James L. Ward - Reporter
- Dominique Allen Lawson - Intern
- Raphael Corkhill - Shawn
- Nixon Cesar - Ronny
- Linda Marie Larson - Nurse
- Diane Davis - Sarah Provost
- Earl Baker Jr. - Harold Brennan
- Jody Gelb - Janet Provost
- Alexandra Ternstroem - Sweedish police captain
- Tina Benko - Meredith Vieira
- Steve Tisch
- Aaron Hart
- Hernan Lopez
- Todd Black
- Jason Blumenthal
- Taylor Latham
AnnaSophia Robb hace el papel de Michelle Shughart.
Christian Slater interpreta a Dr. Randall Kirby en la serie.
Ajay Naidu interpreta a Dr. Sasani en la serie.
Edgar Ramírez interpreta a Dr. Paolo Macchiarini en la serie.
Mandy Moore interpreta a Benita Alexander en la serie.
Ashley Madekwe interpreta a Dr. Ana Lasbrey en la serie.
Gustaf Hammarsten hace el papel de Dr. Svensson.
Luke Kirby hace el papel de Dr. Nathan Gamelli.
Capítulo disponible en las siguientes plataformas:
