- Andrea Powell - Sharon Burnham
- Ryan Paynter - Teen
- Jaime Ray Newman - Kathe Sackler
- Rebecca Wisocky - Cynthia McCormick
- Mare Winningham - Diane Mallum
- Ian Unterman - Jonathan Sackler
- Jake McDorman - John Brownlee
- Phillipa Soo - Amber Collins
- Brendan Patrick Connor - Howard Udell
- Andrea Frankle - Beth Sackler
- Lawrence Arancio - Raymond Sackler
- Arischa Conner - Leah Turner
- Raúl Esparza - Paul Mendelson
- Winsome Brown - Theresa Sackler
- Andrés Erickson - Mortimer D.A. Sackler
- Ray McKinnon - Jerry Mallum
- Deadra Moore - Karen Johnson
- Carolee Carmello - Drea Price
- Rick Espaillat - Dr. Alan Spanos
- Amy Parrish - Judy Cohen
- Adam Fristoe - James Comey
- Aaron Serotsky - David Haddox
- Caitlin Mehner - Paula Greene
- Nicholas Logan - Walt
- Mark Jacoby - Dr. Hershel Jick
- Tricia Hawn - Shelly Finnix
- Audrey Moore - Maureen Sara
- Austin Freeman - Grant Simmons
- Erin Dangler - Marianne Skolek
- Paden Fallis - Louis Melton
- Spencer Garrett - Larry Berger
- Trevor Long - Rudy Giuliani
- Meagen Fay - Sister Beth Davies
- Amy Rutberg - Alice Fisher
- Kenneth Tigar - Arthur Sackler
- Helen Goldsby - Regina Carter
- Beth Macy
- Mandy Safavi
- Barry Levinson
- Karen Rosenfelt
- Ann Johnson
- Graham Scott Littlefield
- Jane Bartelme
- Ryan Collins
- Mike Pipgras
- Lorne Balfe
- Nick Offord
- Brittany DuBay
- Sarah Monat
Michael Keaton interpreta a Samuel Finnix en la serie.
Ray McKinnon interpreta a Jerry Mallum en la serie.
Peter Sarsgaard interpreta a Rick Mountcastle en la serie.
Michael Stuhlbarg interpreta a Richard Sackler en la serie.
Kaitlyn Dever hace el papel de Betsy Mallum.
Will Poulter interpreta a Billy Cutler en la serie.
Rosario Dawson hace el papel de Bridget Meyer.
John Hoogenakker interpreta a Randy Ramseyer en la serie.
Will Chase interpreta a Michael Friedman en la serie.
Capítulo disponible en las siguientes plataformas:
