- Kylie Cantrall - Olivia
- Max Greenfield - Dr. Arthur Goldstein
- Barry Bostwick - Will
- Lehi Makisi Falepapalangi - Loto
- Clyde Yasuhara - Mr. Lim
- Eddie Lee Anderson - Policeman #2
- Linda Castro - Amy
- Amy Hill - Dr. Takushi
- Toby Meuli - Caleb
- David S. Jung - Rip Tide
- Nick Masciangelo - Bongos Guy
- Randall Park - Dr. Choi
- Magic Johnson - Magic Johnson
- Duane Char - Clerk
- Al Harrington - Uncle John
- Margaret Cho - Frankie
- Jae Suh Park - Patty
- Kaia Soul - Janelle
- Ty Simpkins - Anthony
- Kimee Balmilero - Jenny
- Jeri Lynn Endo - Bonnie
- Joe LoCicero - Anesthesiologist
- Andrew Tinpo Lee - Mr. Hsiao
- Jake Shimabukuro - Jake Shimabukuro
- Taylor Kowalski - Beach Attendant
- Taylor Kowalski - Evan
- Hudson Taylor - RT
- Missi Pyle - Ms. Crawford
- Riley Looc - Billy
- Jaki Valensi-Lauper - Donna
- Hayden Maher - Sonny
- Alyson Hannigan - Dawn
- Mara Marini - Mel
- Russell Satele - Bouncer
- Chris Moss - Mainland Mark
- Saint Thompson - Photographer
- Dirk Blocker - Gordon
- Pono Say - Little Kid
- Valen Ahlo - Sports Car Owner
- Allison Chu - Annoying Girl
- Nhumi Threadgill - Sasha
- Peter Togawa - Mr. Harawitz
- Ray Watters - Mr. Larson
- David Sheftell - Surgeon
- Daniel Dae Kim - Max Lee
- Kimiko Glenn - Kayla
- Mark Labella - Bryson
- Noah Beck - Matty Bubb
- Nolan Hong - Patient
- Milo Manheim - Nico
- Dani Spieler - Paige
- Alex Aiono - Walter Taumata
- Dann Seki - Akamu
- David E. Kelley
- Steven Bochco
- Kourtney Kang
- Matt Kuhn
- Justin McEwen
- Dayna Kalins
- Jake Kasdan
- Jesse Bochco
Missi Pyle interpreta a Ms. Crawford en la serie.
Peyton Elizabeth Lee interpreta a Lahela 'Doogie' Kamealoha en la serie.
Emma Meisel interpreta a Steph Denisco en la serie.
Matthew Sato hace el papel de Kai Kamealoha.
Wes Tian interpreta a Brian Patrick Kamealoha en la serie.
Jeffrey Bowyer-Chapman hace el papel de Charles.
Mapuana Makia interpreta a Noelani en la serie.
Kathleen Rose Perkins interpreta a Dr. Clara Hannon en la serie.
Jason Scott Lee interpreta a Benny Kamealoha en la serie.
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