- Kimberly Brooks - Dr. Maisha McStuffins (voice)
- Kimberly Brooks - Surfer Girl (voice)
- Gary Anthony Williams - Marcus McStuffins (voice)
- Gary Anthony Williams - Butch (voice)
- Loretta Devine - Nurse Hallie (voice)
- Loretta Devine - Hattie (voice)
- Robbie Rist - Stuffy Filbert McStuffins (voice)
- Robbie Rist - Snowpeep (voice)
- Lara Jill Miller - Lambie (voice)
- Lara Jill Miller - Hazel the Witch (voice)
- Lara Jill Miller - Mayella (voice)
- Lara Jill Miller - Snowpeep (voice)
- Jess Harnell - Chilly (voice)
- Jess Harnell - The Wicked King (voice)
- Jess Harnell - The Dude / Rodriguez / Snowpeep (voice)
- Jess Harnell - The Wicked King / Buddy (voice)
- Rio Mangini - Ian (voice)
- China Anne McClain - Tisha McStuffins (voice)
- Peter MacNicol - Egghead (voice)
- Rob Paulsen - Sir Kirby (voice)
- Kath Soucie - Celeste (voice)
- Kyla Kenedy - Tamara (voice)
- Jeffrey Nicholas Brown - Bronty (voice)
- Jeffrey Nicholas Brown - Ben (voice)
- Jeffrey Nicholas Brown - Otis / Tumbleweed (voice)
- Jack Conley - Dragon-Bot (voice)
- Wayne Knight - Viewy Stewie (voice)
- Laraine Newman - Professor Hootsburgh (voice)
- Laraine Newman - Southwest Sal (voice)
- Laraine Newman - Southwest Sal / Snowpeep (voice)
- Laraine Newman - Trina Triceratops (voice)
- Laraine Newman - Aurora / Professor Hootsburgh (voice)
- Laraine Newman - Aurora (voice)
- Laraine Newman - Trixie (voice)
- Audra McDonald - Itty Bitty Bess (voice)
- Julianne Buescher - Bella (voice)
- Damienne Merlina - Flora (voice)
- Adam Croasdell - Wildlife Will (voice)
- Grey DeLisle - Dress-Up Daisy (voice)
- Grey DeLisle - Bouncy Babies (voice)
- Tom Kenny - Charlie / Purple Monster (voice)
- Tom Kenny - Charlie (voice)
- Mitchell Whitfield - Oooey Gablooey (voice)
- Derek Phillips - Wyatt (voice)
- Jamie Sara Lewis - Calamity / Cheyenne (voice)
- Michael Gough - Officer Pete (voice)
- Michael Gough - Yul (voice)
- Zoe Pessin - Emmie (voice)
- Michelle Campbell - Sadie (voice)
- Jeff Fischer - Lenny (voice)
- Maeve Higgins - Gillian (voice)
- Rodger Bumpass - Army Al (voice)
- Deedee Magno - Snuggs (voice)
- Kat Feller - Dixie (voice)
- Ashley Edner - Pandora (voice)
- Cristina Milizia - Lala (voice)
- Kari Wahlgren - Maya McStuffins (voice)
- Kari Wahlgren - CeCe / Maya McStuffins (voice)
- Kari Wahlgren - Mrs. Sato / Suki (voice)
- Dawnn Lewis - Grandma McStuffins (voice)
- Eric Morgan Stuart - Flicker (voice)
- Dee Bradley Baker - Squibbles (voice)
- Dee Bradley Baker - Robot Ray (voice)
- Dee Bradley Baker - Squibbles / Zane (voice)
- Nika Futterman - Rosie (voice)
- Molly Ringwald - Darla (voice)
- G.K. Bowes - Melinda (voice)
- Lori Alan - Gloria Gorilla (voice)
- Mary Faber - Karaoke Katie (voice)
- Lucinda Clare - Queen Amina (voice)
- Ludacris - Gus (voice)
- Yvette Nicole Brown - Tracy Triceratops (voice)
- Darragh O'Connell
- Cathal Gaffney
- Gillian Higgins
- Theresa Mayer
- Chris Nee
- Kay Hanley
- Michelle Lewis
- Stuart Kollmorgen
Wayne Knight interpreta a Viewy Stewie (voice) en la serie.
Kiara Muhammad interpreta a Doc McStuffins (voice) en la serie.
Kimberly Brooks interpreta a Dr. Maisha McStuffins (voice) en la serie.
Gary Anthony Williams interpreta a Marcus McStuffins (voice) en la serie.
Loretta Devine interpreta a Nurse Hallie (voice) en la serie.
Jess Harnell interpreta a Chilly (voice) en la serie.
Robbie Rist hace el papel de Stuffy Filbert McStuffins (voice).
Lara Jill Miller interpreta a Lambie (voice) en la serie.
Jaden Betts interpreta a Donny McStuffins (voice) en la serie.
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