- Chloe Bayliss - Hayley
- Charles Wu - Ken
- Miranda Tapsell - April
- Brittany Clark - Mia Halston
- Kate Jenkinson - Tara
- Dustin Clare - Jarrod
- Chris Bunton - Max
- Edmund Lembke-Hogan - George
- Mark Simpson - Dale
- Sarah Armanious - Emergency Doctor
- Giselle Da Silva - Nurse
- Aileen Beale - Dr. Koutofides
- Patrick Cullen - Male Patient
- Savannah Lamble - Jesse
- Emily Eskell - Gabrielle
- Rory Potter - Teenage Boy
- Mike Duncan - Quad Bike Driver
- Stephen Leeder - Mr. Tanner
- Octavia Barron-Martin - Sally Peacock
- Timothy Parsons - Drunk Guy #1
- Kyran Lynch - Drunk Guy #2
- Jaxon Graham-Wilson - Wanabe Doctor
- Michael Kotsohilis - Fifo Worker
- Michael Kotsohilis - Fifo Jazz
- Cassie Osborne - Kacey
- Peter Callan - Henry Goodearl
- Michelle Lim Davidson - Becky
- Jemma Rivera - Party Mum
- Jeremy Sims - Mike
- Aaron L. McGrath - Jai
- Martin Broome - Liam
- Mitch Garling - Injured Fifo
- Yure Covich - Ross
- Chum Ehelepola - Daniel
- Max Cullen - Martin
- Maggie Blinco - Deb
- Briallen Clarke - Erin
- Julia Savage - Theresa
- Julia Savage - Rachel
- Julia Savage - Schoolgirl
- Alice Lily Zahalka - Simone
- Sam Fraser - Glen
- Simon London - Travis
- Dave Eastgate - Joey
- Kimie Tsukakoshi - Shelley
- Tyler De Nawi - Ben
- Ally Henville - Hannah
- John Batchelor - Nathan
- Amy Kersey - Jane
- Wadih Dona - Dr. Ogilvy
- Jackie Murray - Bus Driver
- Janet Kingsbury - Old Lady
- Candice Storey - Nigella
- Matthew Okine - Dr. Lucas Fine
- Ana Maria Belo - Doctor
- Ella Scott Lynch - Celia
- Brendan Miles - Grizzled Farmer
- Brendan Miles - Fake Jim
- Nicola Parry - Surgeon
- Debbie Zukerman - Nurse
- Glen Robinson - Anaethetist
- Felicity Jurd - Harriet
- Mark Dessaix - Trainer
- Ainslie McGlynn - Henry's Lawyer
- Ainslie McGlynn - Carl (voice)
- Ainslie McGlynn - Ruth
- Ainslie McGlynn - Rita (voice)
- Matt Doran - Jack Howley
- Dan Eady - Gus
- Jacek Koman - Trevor
- Helen Thomson - Nora
- Sukhraj Deepak - Grey Nomad
- Darren Eastes - Car Crash Guy
- Lucy Durack - Tugger
- Shakira Clanton - Jodie
- Peter Corbett - Brian
- Ebony Vagulans - Jac
- Tony Lynch - Dead Pilot
- Aidan Gillett - Dead Passenger
- Jenni Baird - Hilda
- Olga Miller - Allie
- Angus McLaren - Dr. Toke
- Anne-Marie Mazza - Mrs. Kokkotas
- Hamish Michael - Tim
- James Lugton - Principal Collins
- James Cassells - Max's Dad
- Ben Stabile - Marble Kid
- Madeleine Madden - Millie
- Alice Parkinson - Dawn
- Lucy Heffernan - Stoner Girl
- Kelly Butler - Meryl's Mum
- Ben Wood - Craig
- Angela McDonald - Fan
- Mark Coles Smith - Dan
- Kenneth Ransom - David
- Susan Prior - Minnie
- David Callan - Anaesthetist
- Paul Armstrong - Retiree
- Paul Armstrong - Jeweller
- Paul Winchester - Hugh's Surgeon
- Maha Wilson - Doctor
- Brandon Burke - Dr Burke
- Marshall Napier - Bill
- Jenevieve Chang - Agent
- Jenevieve Chang - Kent's Mum
- Brenden Lovett - Sergeant Brian Atkins
- Rajan Velu - Senior Constable Sanjay
- Emma Kew - Constable Whelan
- Christian Manon - François
- Ellis Watts - Baby Jimmy
- Ellis Watts - Baby
- Luke Owen - Brian
- Ling Cooper Tang - Sophie
- Luke Davis - Farmer
- Michelle Doake - Debbie
- Annie Byron - Vivian
- Vince Colosimo - Carlito
- Kyle Rowling - Dog Owner
- Mathew Waters - Farmer
- John McNeill - Ronnie
- Zoe Ventoura - Kassie
- Camilla Ah Kin - Ginger
- Lynne McGimpsy - Sharon Eagle
- Kurt Goehner-Winter - Junky Kid
- Steve Maresca - Cop
- Steve Maresca - Carl
- Zoe Carides - Nancy Miller
- Zoe Carides - Jill
- Anna Phillips - Country Girl
- Margaret Rowe - Horny Lady
- Gus Murray - Psychologist
- Duncan Ragg - Nick
- Lester Morris - Gordon
- Lester Morris - Old Man
- Camila Ponte Alvarez - Intern
- Annabel Wolfe - Ivy Win
- Ed Wightman - Sam
- Andrea Demetriades - Dr. Pari Thompson
- Alan Flower - Joe Fiorini
- Amanda LaBonte - DOCS Lady
- Dane Carson - Publican
- Chantelle Jamieson - Sharna
- Darren McMullen - Wes
- Coco Jack Gillies - Larry
- Lincoln Younes - Tom
- Luke Bouchier - Phoenix
- Zara Michales - Solicitor
- Winta McGrath - Floyd
- Genevieve Hegney - Harriet
- Don Hany - Raph
- Aaron Bishop - Truck Driver
- Naomi Turvey - Truck Passenger
- Vanessa Buckley - Kimberly
- Vanessa Buckley - Kimberley
- Rob Flanagan - Farmer Giles
- Alice Ansara - Green Annie
- Mary-Anne Halpin - CEO
- Sara Zwangobani - Dr. Luisa
- Ron Smyck - Bruno
- Uli Latukefu - Darren
- Tim Potter - Eddie
- Jerome Velinsky - Val
- Indiana Kwong - Journalist
- Alan Dukes - Glen
- Deborah Jones - Radio Interviewer
- Robyn Nevin - Dinah
- Ari Boyland - Robbo
- Lucas Fatches - Patient
- Tasneem Roc - Amelia
- Ashley Douglass - Fiona the Friendly FIFO
- Izaak Love - Dancing FIFO
- Paul Pantano - Gazza
- Dean Kyrwood - FIFO Dave
- Stephanie King - Beverley
- Fiona Press - Dr. Khourdair
- William Zappa - Mr. Khourdair
- Patrick Wilson - Rod Eagle
- Jane Harders - Helen
- Suz Mawer - Reporter
- Sophie Cook - Mrs. Malouf
- Tara Brown - Newsreader
- Tori Garrett
- Jeremy Sims
- Erin White
- Kriv Stenders
- Lisa Matthews
- Ian Watson
- Tamara Asmar
- Josh Mapleston
- Liz Doran
- Alice Bell
- Timothy Lee
- Angela McDonald
- Claudia Karvan
- Ian Collie
- Jo Rooney
- Andy Ryan
Rodger Corser hace el papel de Hugh Knight.
Nicole da Silva interpreta a Charlie en la serie.
Ryan Johnson interpreta a Matt Knight en la serie.
Hayley McElhinney interpreta a Penny en la serie.
Belinda Bromilow hace el papel de Betty.
Tina Bursill interpreta a Meryl Knight en la serie.
Matt Castley interpreta a Ajax en la serie.
Chloe Bayliss interpreta a Hayley en la serie.
Charles Wu hace el papel de Ken.
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