- Mary McCormack - Kathy DeSantis
- Leslie Hendrix - Carolyn
- Dominic Fumusa - Jeremy
- Annabelle Zasowski - Cecily
- Barbie Ferreira - Ella
- Geoffrey J.D. Payne - Parent (uncredited)
- Jeffrey DeMunn - Max Brodkin
- Dean Winters - Tony Silvercreek
- Maddie Corman - Carla Menotti
- Jim Bracchitta - George Valdito
- Frank Whaley - Carson Hodges
- Geoffrey Owens - Gerald
- Olek Krupa - Gustav
- Rick Crom - Don
- Francis Jue - Mickey Burgess
- Penny Balfour - Karen Jacobs
- Allyson Morgan - Bridal Woman
- Marko Caka - Art Patron (uncredited)
- Yul Vazquez - Craig Anders
- Alex Wolff - Cole
- Gillian Vigman - Janice
- Jorge Chapa - Sebastian
- Danny Garcia - Gabriel
- Izzie Steele - Sheila
- Michael Rosete - Jeffrey
- Tommy Kang - Barista
- J. Smith-Cameron - Elaine Campbell
- Hazel Anne Raymundo - Natalie
- Molly Lloyd - Ellen
- Dave Shalansky - Brad Zimmer
- Nicholas Feitel - Nick Jr.
- Keisha Zollar - Grace
- Mitch Tebo - Party Guest
- George Salazar - Ref
- Nia Minott - Sophie
- Adam Smith Jr. - Man
- Blanca Camacho - (voice)
- Crystal Bock - Patient
- Jessica Cherniak - Basketball Player (uncredited)
- Ethan Coskay - Student (uncredited)
- Michael Nagl - Parent (uncredited)
- Jemaine Clement - Julian Renaut
- Robert Forster - Donald
- Stephen DeRosa - Silent Partner
- Cade Lappin - Little Boy
- Ashlie Atkinson - Woman
- Teo Rapp-Olsson - Stuttering Stockboy
- Renes Rivera - Day Laborer
- Renes Rivera - Carlos (uncredited)
- Renes Rivera - Carlos
- Scott Drummond - Police Officer
- Kelly Aaron - Diane's Friend (uncredited)
- Esther Friedman - Gallery Goer (uncredited)
- Juri Henley-Cohn - Peter Luther
- Stephen Wallem - Mitch
- Washington Kirk - Jeb
- Linwood Brown - Train Conductor
- Stacey Alyse Cohen - Basketball Parent (uncredited)
- Barbara Ann Davison - Shopper on Scooter (uncredited)
- Steven Pasquale - Andrew
- Ian Unterman - Mr. Klapper
- Terra Mackintosh - Waitress
- Aiden Linkov - Student (uncredited)
- Jessica VanOss - Cultural Fair Student (uncredited)
- James Colby - Tall Drunk Man
- Desmin Borges - Officer Walker
- Teresa Yenque - Ilona
- Joseph Castillo-Midyett - Diane's Lawyer
- Susan Kelechi Watson - Victoria Tuckson
- Joanna Adler - Vendela
- Shana Solomon - Barbara
- Paul Woodburn - Ted
- Amy Russ - Black Eye Couple Woman
- Audrie Neenan - Peg
- Andrew Law - Brian
- Ismael Cruz Cordova - Clerk
- Dorothy Lyman - Bridget
- Lizzy DeClement - Riley
- John Harrington Bland - Rick
- Kathleen Mary Carthy - Pastor
- Libby George - Ethel
- Jenny Sterlin - Julian's Mother
- Andy Bustillos - Salesman
- Sarita Choudhury - Courtney
- Daniel Gerroll - Emmett Schaab
- Andrew Sellon - Reverend
- Julia Terranova - University Student
- Roslyn Ruff - Sylvia
- Gopal Divan - Gurbaksh
- Dudley Findlay Jr. - Bank Manager
- Carrie McCrossen - Housewife
- Amy Sedaris - Cathy
- Stephen Payne - Frank
- Lizzy Jutila - Art Gallery Woman
- Sarah Baskin - Art Gallery Woman
- Ryan McCarthy - Guy
- Kennebrow Taylor - Sales Girl
- Nick Sullivan - Bathroom Guy
- Mary Joy - Marla
- Harrison Chad - Ice Rink Guard
- Tom Lipinski - Ted
- Gizel Jimenez - Waitress
- Marton Csokas - Skip Zakarian
- Roger DeWitt - Auctioneer
- Aurelien Gaya - Tennis Coach
- Jade Wu - Katie's Mom
- Midori Francis - Katie
- Phillip Chorba - FedEx Guy
- Marcia DeBonis - Michelle
- Wally Dunn - FBI Agent
- Peter Linari - Dwayne
- Lavon Fisher-Wilson - Corrections Officer
- Alexandra Rey - Shop Assistant
- James Vincent Boland - Young Artist
- James Dinonno - Corrections Officer
- James Lesure - Henry
- Timothy Britten Parker - Leo
- Patricia Dunnock - Bev
- Mary Testa - Doctor
- Greta Lee - Insurance Adjuster
- Isaac Josephthal - Cole
- A.J. Franklin - Delivery Man
- Crystal De La Cruz - Lady Raider Basketball Player
- Erika Robel - Pregnant Mother
- Uly Schlesinger - Jason Campbell
- Marisa Ryan - Ursula
- Deidre Goodwin - Mimi
- Julie Halston - Sharon
- Paul Bartholomew - Bennett
- James Rutledge - Man at Restaurant
- Tuffy Questell - Jessop
- Harris Yulin - Gordon
- Mercedes Griffeth - Taylor
- Garth Kravits - School Counselor
- Nozipho McLean - Olivia
- Michelle Sohn - Renter Mom
- Jock McKissic - DelRoy
- Brendan Egan - High School Student
- Samantha Kudler - Student
- Caroline Kaplan - Michelle
- Deborah Offner - Cristella
- Alexei Bondar - Bird Watcher Dad
- Ilana Levine - Cassidy
- Aaron Serotsky - Aaron
- Amy Stiller - Gwen
- Brian Luna - Lanigan Courtyard Employee
- Ariana Pérez - Monica
- Ashley Szczerbacki - Ruby
- Marnie Schulenburg - Dallas's Lawyer
- Joanna Herrington - Psychiatry Board Member
- Anand Ray - Bennett's Lawyer
- Delissa Reynolds - Donna
- Salma Shaw - Neighbor Woman
- Wendey Stanzler
- Jesse Peretz
- Janicza Bravo
- Scott Ellis
- Jamie Babbit
- Beth McCarthy-Miller
- Tom Scharpling
- Hayes Davenport
- Adam Resnick
- Stuart Zicherman
- Kristen Lange
- Marina Franklin
- Sarah Jessica Parker
- Aaron Kaplan
- Paul Simms
- Deb Dyer
- Alison Benson
- Sharon Horgan
Sarah Jessica Parker interpreta a Frances DuFresne en la serie.
Mary McCormack interpreta a Kathy DeSantis en la serie.
Thomas Haden Church interpreta a Robert DuFresne en la serie.
Molly Shannon interpreta a Diane en la serie.
Talia Balsam interpreta a Dallas en la serie.
Charlie Kilgore hace el papel de Tom DuFresne.
Sterling Jerins interpreta a Lila DuFresne en la serie.
Tracy Letts hace el papel de Nick.
Becki Newton hace el papel de Jackie.
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