- Froy Gutierrez - Josh Flores
- Jason Michael Snow - Usher
- Ness Bautista - Police Officer
- Gabrielle Elyse - Dani
- Emily Hinkler - Margaux
- Benjamin A. Hoyt - Bernard (as Benjamin Hoyt)
- Connie Jackson - Doctor
- Eliza Shin - Nurse
- A.J. Tannen - Aaron
- Tony Plana - Berto Riera
- James Martinez - Victor Alvarez
- Pam Trotter - Ariana
- George W. Bush - Self (voice) (archive sound) (uncredited)
- Emiliano Díez - Padre Jose
- Santina Muha - Beth
- Ariela Barer - Carmen
- Aaron Coleman - Priest
- Terryn Westbrook - Barb Flores
- Olivia Liang - Suehee
- Ed Quinn - Max Ferraro
- Melissa Fumero - Estrellita Reyes
- Mackenzie Phillips - Pam Valentine
- India de Beaufort - Avery
- Stephanie Beatriz - Pilar
- Gloria Estefan - Mirtha
- Ray Romano - Brian
- Alex Quijano - Mateo
- Jolie Jenkins - Nikki
- Haneefah Wood - Jill Riley
- Judy Reyes - Ramona
- Sachie Alessio - Sachie
- Matisha Baldwin - Matisha
- Jennifer Candy - Jennifer
- Eric Nenninger - Scott
- Fiona Gubelmann - Lori
- Emanuel Gironi - Dave
- Kaylin Hayman - Emma
- Jay Hayden - Ben
- Thomas Barbusca - Finn
- Felix Solis - Ron
- Marc Valera - Sammy
- Eden Riegel - Lucy
- Rebeka Montoya - Rebecca
- Steven Lee Allen - Dirk
- Santino Jimenez - Pedro
- Krishna Smitha - Sharina
- Ivonne Coll - Esme
- Susan Grace - Mrs. McGurb
- Georgia Engel - Sister Barbara
- Celeste Pechous - Mrs. Wallace
- Tim Bagley - Henry
- Mindy Sterling - Delia
- Timm Sharp - Nurse Wally
- Liz Torres - Tia Bitchy
- Josh Latzer - Stu
- Danny Pino - Tito
- Matthew Henerson - Bruce
- Nicky Endres - Cynthia
- Travis Greer - Security Guard
- Glenn Scarpelli - Chad
- Tristen Bankston - Bill
- Joshua Hoover - Adam
- Liesel Kopp - Estelle
- Mo Zelof - Steve
- Karly Rothenberg - Mrs. Homer
- Alan Ruck - Lawrence Schneider
- Gloria Calderón Kellett - Nicole
- Tyler Derench - Bartender
- Joe Manganiello - Nick
- Lindsay Chambers - Vanessa
- Greice Santo - Ana Maria
- Livia Treviño - Tia Inez
- David Clayton Rogers - Sebastian
- Sally Pressman - Nurse Sasha
- Eugene Byrd - Salesman
- Andrew Leeds - Bryce
- Adam Rodriguez - Danny
- Marla Gibbs - Mrs. Jones
- Jeirmarie Osorio - Melba
- Reggie Watts - Mr. Mann
- Erik Griffin - Carl
- Reid Cox - Stick Girl
- Eve Sigall - Birdie
- Cedric Yarbrough - Jerry
- Lisseth Chavez - Young Lydia
- Paul Karmiryan - Young Berto
- Peter Banifaz - Tyler
- Polina Frantsena - Abby
- Jermaine Jacox - Hot UPS Guy
- Krys Marshall - Kristen
- Lily Rains - Michelle
- Lin-Manuel Miranda - Juanito
Justina Machado interpreta a Penelope Alvarez en la serie.
Rita Moreno hace el papel de Lydia Riera.
Isabella Gómez interpreta a Elena Alvarez en la serie.
Marcel Ruiz interpreta a Alex Alvarez en la serie.
Todd Grinnell interpreta a Pat Schneider en la serie.
Stephen Tobolowsky interpreta a Dr. Berkowitz en la serie.
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